The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency

Journal of Biological Chemistry

Volumn 289, Issue 20, 2014, Pages 13708-13716

  Nemec, Antonia A ^a   Murphy, Drew L ^a   Donigan, Katherine A ^a   Sweasy, Joann B ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PATHOLOGY; POLYMERIZATION; REPAIR; TUMORS;

BASE EXCISION REPAIRS; CATALYTIC RATES; CELLULAR TRANSFORMATION; CHROMOSOMAL ABERRATION; COLORECTAL TUMORS; INTERMEDIATE SUBSTRATES; POLYMERIZATION ACTIVITY; POLYMERIZATION RATES;

DNA;

DNA DIRECTED DNA POLYMERASE BETA; DNA; NUCLEOTIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARCINOGENESIS; CATALYSIS; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMOSOME ABERRATION; COLON TUMOR; CONTROLLED STUDY; DNA STRAND BREAKAGE; DNA SYNTHESIS; EMBRYO; EXCISION REPAIR; GENOMIC INSTABILITY; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; CANCER STAGING; CELL LINE; CHEMISTRY; DNA REPAIR; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BASE SEQUENCE; CARCINOGENESIS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; COLONIC NEOPLASMS; DNA; DNA POLYMERASE BETA; DNA REPAIR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOMIC INSTABILITY; HUMANS; KINETICS; MICE; MUTATION; NEOPLASM STAGING; NUCLEOTIDES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84901036048     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.550400     Document Type: Article

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