KIR4.1 antibodies as biomarkers in multiple sclerosis

Frontiers in Neurology

Volumn 5 APR, Issue , 2014, Pages

  Wunsch, Marie ^a   Rovituso, Damiano M ^a   Kuerten, Stefanie ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

CNS antigen; Epiphenomenon; KIR4.1; MS; Parietal cells

Indexed keywords

AQUAPORIN 4 ANTIBODY; AUTOANTIBODY; BIOLOGICAL MARKER; CORTICOSTEROID; IMMUNOGLOBULIN G; KIR4.1 ANTIBODY; POTASSIUM CHANNEL; POTASSIUM CHANNEL KIR4.1; UNCLASSIFIED DRUG;

ANAMNESIS; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY SCREENING; ARTICLE; ASTROCYTE; CORTICOSTEROID THERAPY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; MULTIPLE SCLEROSIS; MYELOOPTIC NEUROPATHY; NONHUMAN; PATHOGENICITY; SENSITIVITY AND SPECIFICITY; STOMACH ACID SECRETION; STOMACH PARIETAL CELL;

EID: 84901034830     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2014.00062     Document Type: Article

References (17)

1. Howell OW, Reeves CA, Nicholas R, Carassiti D, Radotra B, Gentleman SM, et al. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain (2011) 134:2755-71. doi:10.1093/brain/awr182.
2. Kuerten S, Schickel A, Kerkloh C, Recks MS, Addicks K, Ruddle NH, et al. Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response. Acta Neuropathol (2012) 124:861-73. doi:10.1007/s00401-012-1023-3.
3. Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, Puopolo M, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain (2007) 130:1089-104. doi:10.1093/brain/awm038.
4. Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med (2008) 358:676-88. doi:10.1056/NEJMoa0706383.
5. Weber MS, Prod'homme T, Patarroyo JC, MolnarfiN, Karnezis T, Lehmann-Horn K, et al. B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity. Ann Neurol (2010) 68:369-83. doi:10.1002/ana.22081.
6. Bielekova B, Martin R. Development of biomarkers in multiple sclerosis. Brain (2001) 127:1463-78. doi:10.1093/brain/awh176.
7. Srivastava R, Aslam M, Kalluri SR, Schirmer L, Buck D, Tackenberg B, et al. Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med (2012) 367:115-23. doi:10.1056/NEJMoa1110740.
8. Hirst BH. K+ recycling and gastric acid secretion. J Physiol (2002) 540:1. doi:10.1113/jphysiol.2002.017632.
9. Kaufhold MA, Krabbenhöft A, Song P, Engelhardt R, Riederer B, Fährmann M, et al. Localization, trafficking, and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels. Gastroenterology (2008) 134:1058-69. doi:10.1053/j.gastro.2008.01.033.
10. Song P, Groos S, Riederer B, Feng Z, Krabbenhöft A, Manns MP, et al. Kir4.1 channel expression is essential for parietal cell control of acid secretion. J Biol Chem (2011) 286:14120-8. doi:10.1074/jbc. M110.151191.
11. Banati M, Csecsei P, Koszegi E, Nielsen HH, Suto G, Bors L, et al. Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system. Eur J Neurol (2013) 20(11):1492-5. doi:10.1111/ene.12072.
12. Hughes LE, Smith PA, Bonell S, Natt RS, Wilson C, Rashid T, et al. Cross-reactivity between related sequences found in Acinetobacter sp., Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis. J Neuroimmunol (2003) 144:105-15. doi:10.1016/S0165-5728(03)00274-1.
13. Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest (2001) 108:1097-104. doi:10.1172/JCI200114235.
14. Kiziltas S, Imeryüz N, Gürcan T, Siva A, Saip S, Dumankar A, et al. Corticosteroid therapy augments gastroduodenal permeability to sucrose. Am J Gastroenterol (1998) 93:2420-5. doi:10.1016/S0002-9270(98)00578-4.
15. Jarius S, Franciotta D, Paul F, Ruprecht K, Bergamaschi R, Rommer PS, et al. Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance. J Neuroinflammation (2010) 7:52. doi:10.1186/1742-2094-7-52.
16. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med (2005) 202:473-7. doi:10.1084/jem.20050304.
17. Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, et al. Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells. Biochem Biophys Res Commun (2010) 394:205-10. doi:10.1016/j.bbrc.2010.02.157.