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Volumn 28, Issue 4, 2014, Pages 1568-1581

Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle

Author keywords

Cell polarity; Ovarian development; Premature ovarian failure; Sex determination

Indexed keywords

BETA CATENIN; CONNEXIN 43; DOXYCYCLINE; GELATINASE A; LAMININ; MUELLERIAN INHIBITING FACTOR; NERVE CELL ADHESION MOLECULE; WNT4 PROTEIN;

EID: 84901033489     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-233247     Document Type: Article
Times cited : (50)

References (50)
  • 1
    • 0033521967 scopus 로고    scopus 로고
    • Female development in mammals is regulated by wnt-4 signalling
    • Vainio, S., Heikkila, M., Kispert, A., Chin, N., and McMahon, A. P. (1999) Female development in mammals is regulated by wnt-4 signalling. Nature 397, 405-409
    • (1999) Nature , vol.397 , pp. 405-409
    • Vainio, S.1    Heikkila, M.2    Kispert, A.3    Chin, N.4    McMahon, A.P.5
  • 2
    • 77952317137 scopus 로고    scopus 로고
    • Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development
    • Naillat, F., Prunskaite-Hyyrylainen, R., Pietila, I., Sormunen, R., Jokela, T., Shan, J., and Vainio, S. J. (2010) Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum. Mol. Genet. 19, 1539-1550
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 1539-1550
    • Naillat, F.1    Prunskaite-Hyyrylainen, R.2    Pietila, I.3    Sormunen, R.4    Jokela, T.5    Shan, J.6    Vainio, S.J.7
  • 3
    • 0041508536 scopus 로고    scopus 로고
    • Endothelial and steroidogenic cell migration are regulated by wnt4 in the developing mammalian gonad
    • Jeays-Ward, K., Hoyle, C., Brennan, J., Dandonneau, M., Alldus, G., Capel, B., and Swain, A. (2003) Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130, 3663-3670
    • (2003) Development , vol.130 , pp. 3663-3670
    • Jeays-Ward, K.1    Hoyle, C.2    Brennan, J.3    Dandonneau, M.4    Alldus, G.5    Capel, B.6    Swain, A.7
  • 4
    • 23844544781 scopus 로고    scopus 로고
    • The partial female to male sex reversal in wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action
    • Heikkila, M., Prunskaite, R., Naillat, F., Itaranta, P., Vuoristo, J., Leppaluoto, J., Peltoketo, H., and Vainio, S. (2005) The partial female to male sex reversal in wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action. Endocrinology 146, 4016-4023
    • (2005) Endocrinology , vol.146 , pp. 4016-4023
    • Heikkila, M.1    Prunskaite, R.2    Naillat, F.3    Itaranta, P.4    Vuoristo, J.5    Leppaluoto, J.6    Peltoketo, H.7    Vainio, S.8
  • 7
    • 0141785399 scopus 로고    scopus 로고
    • Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: Evidence for selective up-regulation in luteinized granulosa cells
    • Hsieh, M., Mulders, S. M., Friis, R. R., Dharmarajan, A., and Richards, J. S. (2003) Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells. Endocrinology 144, 4597-4606
    • (2003) Endocrinology , vol.144 , pp. 4597-4606
    • Hsieh, M.1    Mulders, S.M.2    Friis, R.R.3    Dharmarajan, A.4    Richards, J.S.5
  • 8
    • 73249124003 scopus 로고    scopus 로고
    • Wnt signaling in ovarian follicle biology and tumorigenesis
    • Boyer, A., Goff, A. K., and Boerboom, D. (2010) WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol. Metab. 21, 25-32
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 25-32
    • Boyer, A.1    Goff, A.K.2    Boerboom, D.3
  • 10
    • 4143139955 scopus 로고    scopus 로고
    • A wnt4 mutation associated with müllerian-duct regression and virilization in a 46,xx woman
    • Biason-Lauber, A., Konrad, D., Navratil, F., and Schoenle, E. J. (2004) A WNT4 mutation associated with müllerian-duct regression and virilization in a 46,XX woman. N. Engl. J. Med. 351, 792-798
    • (2004) N. Engl. J. Med. , vol.351 , pp. 792-798
    • Biason-Lauber, A.1    Konrad, D.2    Navratil, F.3    Schoenle, E.J.4
  • 11
    • 33845599605 scopus 로고    scopus 로고
    • Wnt4 deficiency: A clinical phenotype distinct from the classic mayer-rokitansky-kuster-hauser syndrome-A case report
    • Biason-Lauber, A., De Filippo, G., Konrad, D., Scarano, G., Nazzaro, A., and Schoenle, E. J. (2007) WNT4 deficiency: a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome -A case report. Hum. Reprod. 22, 224-229
    • (2007) Hum. Reprod. , vol.22 , pp. 224-229
    • Biason-Lauber, A.1    De Filippo, G.2    Konrad, D.3    Scarano, G.4    Nazzaro, A.5    Schoenle, E.J.6
  • 12
    • 40849126622 scopus 로고    scopus 로고
    • Identification and functional analysis of a new wnt4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: A french collaborative study
    • Philibert, P., Biason-Lauber, A., Rouzier, R., Pienkowski, C., Paris, F., Konrad, D., Schoenle, E., and Sultan, C. (2008) Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and müllerian duct abnormalities: a French collaborative study. J. Clin. Endocrinol. Metab. 93, 895-900
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 895-900
    • Philibert, P.1    Biason-Lauber, A.2    Rouzier, R.3    Pienkowski, C.4    Paris, F.5    Konrad, D.6    Schoenle, E.7    Sultan, C.8
  • 13
    • 79959720658 scopus 로고    scopus 로고
    • Molecular analysis of wnt4 gene in four adolescent girls with müllerian duct abnormality and hyperandrogenism (atypical mayer-rokitansky-kuster-hauser syndrome)
    • Philibert, P., Biason-Lauber, A., Gueorguieva, I., Stuckens, C., Pienkowski, C., Lebon-Labich, B., Paris, F., and Sultan, C. (2011) Molecular analysis of WNT4 gene in four adolescent girls with müllerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-Kuster-Hauser syndrome). Fertil. Steril. 95, 2683-2686
    • (2011) Fertil. Steril. , vol.95 , pp. 2683-2686
    • Philibert, P.1    Biason-Lauber, A.2    Gueorguieva, I.3    Stuckens, C.4    Pienkowski, C.5    Lebon-Labich, B.6    Paris, F.7    Sultan, C.8
  • 14
    • 77953166301 scopus 로고    scopus 로고
    • Expression of e-cadherin and n-cadherin in perinatal hamster ovary: Possible involvement in primordial follicle formation and regulation by follicle-stimulating hormone
    • Wang, C., and Roy, S. K. (2010) Expression of E-cadherin and N-cadherin in perinatal hamster ovary: possible involvement in primordial follicle formation and regulation by follicle-stimulating hormone. Endocrinology 151, 2319-2330
    • (2010) Endocrinology , vol.151 , pp. 2319-2330
    • Wang, C.1    Roy, S.K.2
  • 16
    • 77957989339 scopus 로고    scopus 로고
    • Theca: The forgotten cell of the ovarian follicle
    • Young, J. M., and McNeilly, A. S. (2010) Theca: the forgotten cell of the ovarian follicle. Reproduction 140, 489-504
    • (2010) Reproduction , vol.140 , pp. 489-504
    • Young, J.M.1    McNeilly, A.S.2
  • 17
    • 3543013755 scopus 로고    scopus 로고
    • A novel basal lamina matrix of the stratified epithelium of the ovarian follicle
    • Irving-Rodgers, H. F., Harland, M. L., and Rodgers, R. J. (2004) A novel basal lamina matrix of the stratified epithelium of the ovarian follicle. Matrix Biol. 23, 207-217
    • (2004) Matrix Biol. , vol.23 , pp. 207-217
    • Irving-Rodgers, H.F.1    Harland, M.L.2    Rodgers, R.J.3
  • 18
    • 59349094157 scopus 로고    scopus 로고
    • Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary
    • Da Silva-Buttkus, P., Jayasooriya, G. S., Mora, J. M., Mobberley, M., Ryder, T. A., Baithun, M., Stark, J., Franks, S., and Hardy, K. (2008) Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary. J. Cell Sci. 121, 3890-3900
    • (2008) J. Cell Sci. , vol.121 , pp. 3890-3900
    • Da Silva-Buttkus, P.1    Jayasooriya, G.S.2    Mora, J.M.3    Mobberley, M.4    Ryder, T.A.5    Baithun, M.6    Stark, J.7    Franks, S.8    Hardy, K.9
  • 20
    • 84861330616 scopus 로고    scopus 로고
    • Antimüllerian hormone: An ovarian reserve marker in primary ovarian insufficiency
    • Visser, J. A., Schipper, I., Laven, J. S., and Themmen, A. P. (2012) Antimüllerian hormone: an ovarian reserve marker in primary ovarian insufficiency. Nat. Rev. Endocrinol. 8, 331-341
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 331-341
    • Visser, J.A.1    Schipper, I.2    Laven, J.S.3    Themmen, A.P.4
  • 21
    • 84898665906 scopus 로고    scopus 로고
    • Diagnosis and management of premature ovarian failure
    • Arora, P., and Polson, D. (2011) Diagnosis and management of premature ovarian failure. Obstetr. Gynaecol. 13, 67-72
    • (2011) Obstetr. Gynaecol. , vol.13 , pp. 67-72
    • Arora, P.1    Polson, D.2
  • 22
    • 1842426431 scopus 로고    scopus 로고
    • Granulosa cell-specific inactivation of follistatin causes female fertility defects
    • Jorgez, C. J., Klysik, M., Jamin, S. P., Behringer, R. R., and Matzuk, M. M. (2004) Granulosa cell-specific inactivation of follistatin causes female fertility defects. Mol. Endocrinol. 18, 953-967
    • (2004) Mol. Endocrinol. , vol.18 , pp. 953-967
    • Jorgez, C.J.1    Klysik, M.2    Jamin, S.P.3    Behringer, R.R.4    Matzuk, M.M.5
  • 23
    • 58549106975 scopus 로고    scopus 로고
    • Ovarian histological findings in an adult patient with the steroidogenic acute regulatory protein (star) deficiency reveal the impairment of steroidogenesis by lipoid deposition
    • Kaku, U., Kameyama, K., Izawa, M., Yamada, M., Miyamoto, J., Suzuki, T., Sasano, H., and Hasegawa, Y. (2008) Ovarian histological findings in an adult patient with the steroidogenic acute regulatory protein (StAR) deficiency reveal the impairment of steroidogenesis by lipoid deposition. Endocr. J. 55, 1043-1049
    • (2008) Endocr. J. , vol.55 , pp. 1043-1049
    • Kaku, U.1    Kameyama, K.2    Izawa, M.3    Yamada, M.4    Miyamoto, J.5    Suzuki, T.6    Sasano, H.7    Hasegawa, Y.8
  • 24
    • 80053143669 scopus 로고    scopus 로고
    • Mutant forkhead l2 (foxl2) proteins associated with premature ovarian failure (pof) dimerize with wild-type foxl2 leading to altered regulation of genes associated with granulosa cell differentiation
    • Kuo, F. T., Bentsi-Barnes, I. K., Barlow, G. M., and Pisarska, M. D. (2011) Mutant forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation. Endocrinology 152, 3917-3929
    • (2011) Endocrinology , vol.152 , pp. 3917-3929
    • Kuo, F.T.1    Bentsi-Barnes, I.K.2    Barlow, G.M.3    Pisarska, M.D.4
  • 26
    • 73249147327 scopus 로고    scopus 로고
    • Generation of an allele to inactivate wnt4 gene function conditionally in the mouse
    • Shan, J., Jokela, T., Peltoketo, H., and Vainio, S. (2009) Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse. Genesis 47, 782-788
    • (2009) Genesis , vol.47 , pp. 782-788
    • Shan, J.1    Jokela, T.2    Peltoketo, H.3    Vainio, S.4
  • 27
    • 70549111148 scopus 로고    scopus 로고
    • Mapping of the fate of cell lineages generated from cells that express the wnt4 gene by time-lapse during kidney development
    • Shan, J., Jokela, T., Skovorodkin, I., and Vainio, S. (2010) Mapping of the fate of cell lineages generated from cells that express the Wnt4 gene by time-lapse during kidney development. Differentiation 79, 57-64
    • (2010) Differentiation , vol.79 , pp. 57-64
    • Shan, J.1    Jokela, T.2    Skovorodkin, I.3    Vainio, S.4
  • 28
    • 0028588919 scopus 로고
    • Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by wnt-4
    • Stark, K., Vainio, S., Vassileva, G., and McMahon, A. P. (1994) Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by wnt-4. Nature 372, 679-683
    • (1994) Nature , vol.372 , pp. 679-683
    • Stark, K.1    Vainio, S.2    Vassileva, G.3    McMahon, A.P.4
  • 29
    • 0036842115 scopus 로고    scopus 로고
    • Requirement of bmpr1a for müllerian duct regression during male sexual development
    • Jamin, S. P., Arango, N. A., Mishina, Y., Hanks, M. C., and Behringer, R. R. (2002) Requirement of Bmpr1a for müllerian duct regression during male sexual development. Nat. Genet. 32, 408-410
    • (2002) Nat. Genet. , vol.32 , pp. 408-410
    • Jamin, S.P.1    Arango, N.A.2    Mishina, Y.3    Hanks, M.C.4    Behringer, R.R.5
  • 30
    • 81055126764 scopus 로고    scopus 로고
    • Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors
    • Heinonen, K. M., Vanegas, J. R., Brochu, S., Shan, J., Vainio, S. J., and Perreault, C. (2011) Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood 118, 5163-5173
    • (2011) Blood , vol.118 , pp. 5163-5173
    • Heinonen, K.M.1    Vanegas, J.R.2    Brochu, S.3    Shan, J.4    Vainio, S.J.5    Perreault, C.6
  • 31
    • 35548932872 scopus 로고    scopus 로고
    • A global double-fluorescent cre reporter mouse
    • Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., and Luo, L. (2007) A global double-fluorescent Cre reporter mouse. Genesis 45, 593-605
    • (2007) Genesis , vol.45 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, L.4    Luo, L.5
  • 32
    • 33750797163 scopus 로고    scopus 로고
    • Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development
    • Schulte, D. M., Shapiro, I., Reincke, M., and Beuschlein, F. (2007) Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development. Gene Express. Patterns 7, 72-81
    • (2007) Gene Express. Patterns , vol.7 , pp. 72-81
    • Schulte, D.M.1    Shapiro, I.2    Reincke, M.3    Beuschlein, F.4
  • 33
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
    • Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25, 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 34
    • 70349316240 scopus 로고    scopus 로고
    • Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis
    • Myers, M., Middlebrook, B. S., Matzuk, M. M., and Pangas, S. A. (2009) Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis. Dev. Biol. 334, 458-467
    • (2009) Dev. Biol. , vol.334 , pp. 458-467
    • Myers, M.1    Middlebrook, B.S.2    Matzuk, M.M.3    Pangas, S.A.4
  • 35
    • 77950204176 scopus 로고    scopus 로고
    • Female mice expressing constitutively active mutants of fsh receptor present with a phenotype of premature follicle depletion and estrogen excess
    • Peltoketo, H., Strauss, L., Karjalainen, R., Zhang, M., Stamp, G. W., Segaloff, D. L., Poutanen, M., and Huhtaniemi, I. T. (2010) Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. Endocrinology 151, 1872-1883
    • (2010) Endocrinology , vol.151 , pp. 1872-1883
    • Peltoketo, H.1    Strauss, L.2    Karjalainen, R.3    Zhang, M.4    Stamp, G.W.5    Segaloff, D.L.6    Poutanen, M.7    Huhtaniemi, I.T.8
  • 36
    • 84857782237 scopus 로고    scopus 로고
    • Developmental programming: Prenatal testosterone excess disrupts anti-müllerian hormone expression in preantral and antral follicles
    • Veiga-Lopez, A., Ye, W., and Padmanabhan, V. (2012) Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles. Fertil. Steril. 97, 748-756
    • (2012) Fertil. Steril. , vol.97 , pp. 748-756
    • Veiga-Lopez, A.1    Ye, W.2    Padmanabhan, V.3
  • 37
    • 47349089698 scopus 로고    scopus 로고
    • Wnt-11 signaling leads to down-regulation of the wnt/betacatenin, jnk/ap-1 and nf-kappab pathways and promotes viability in the cho-k1 cells
    • Railo, A., Nagy, I. I., Kilpelainen, P., and Vainio, S. (2008) Wnt-11 signaling leads to down-regulation of the Wnt/betacatenin, JNK/AP-1 and NF-kappaB pathways and promotes viability in the CHO-K1 cells. Exp. Cell Res. 314, 2389-2399
    • (2008) Exp. Cell Res. , vol.314 , pp. 2389-2399
    • Railo, A.1    Nagy, I.2    Kilpelainen, P.3    Vainio, S.4
  • 38
    • 69049096989 scopus 로고    scopus 로고
    • Genomic response to wnt signalling is highly context-dependent: Evidence from dna microarray and chromatin immunoprecipitation screens of wnt/tcf targets
    • Railo, A., Pajunen, A., Itaranta, P., Naillat, F., Vuoristo, J., Kilpelainen, P., and Vainio, S. (2009) Genomic response to Wnt signalling is highly context-dependent: evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets. Exp. Cell Res. 315, 2690-2704
    • (2009) Exp. Cell Res. , vol.315 , pp. 2690-2704
    • Railo, A.1    Pajunen, A.2    Itaranta, P.3    Naillat, F.4    Vuoristo, J.5    Kilpelainen, P.6    Vainio, S.7
  • 39
    • 0025150536 scopus 로고
    • Polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol in vivo and in vitro
    • Iguchi, T., Fukazawa, Y., Uesugi, Y., and Takasugi, N. (1990) Polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol in vivo and in vitro. Biol. Reprod. 43, 478-484
    • (1990) Biol. Reprod. , vol.43 , pp. 478-484
    • Iguchi, T.1    Fukazawa, Y.2    Uesugi, Y.3    Takasugi, N.4
  • 40
    • 34547118106 scopus 로고    scopus 로고
    • Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo
    • Chen, Y., Jefferson, W. N., Newbold, R. R., Padilla-Banks, E., and Pepling, M. E. (2007) Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo. Endocrinology 148, 3580-3590
    • (2007) Endocrinology , vol.148 , pp. 3580-3590
    • Chen, Y.1    Jefferson, W.N.2    Newbold, R.R.3    Padilla-Banks, E.4    Pepling, M.E.5
  • 41
    • 70349318439 scopus 로고    scopus 로고
    • Estrogen can signal through multiple pathways to regulate oocyte cyst breakdown and primordial follicle assembly in the neonatal mouse ovary
    • Chen, Y., Breen, K., and Pepling, M. E. (2009) Estrogen can signal through multiple pathways to regulate oocyte cyst breakdown and primordial follicle assembly in the neonatal mouse ovary. J. Endocrinol. 202, 407-417
    • (2009) J. Endocrinol. , vol.202 , pp. 407-417
    • Chen, Y.1    Breen, K.2    Pepling, M.E.3
  • 42
    • 72149090718 scopus 로고    scopus 로고
    • The primordial pool of follicles and nest breakdown in mammalian ovaries
    • Tingen, C., Kim, A., and Woodruff, T. K. (2009) The primordial pool of follicles and nest breakdown in mammalian ovaries. Mol. Hum. Reprod. 15, 795-803
    • (2009) Mol. Hum. Reprod. , vol.15 , pp. 795-803
    • Tingen, C.1    Kim, A.2    Woodruff, T.K.3
  • 44
    • 83755206284 scopus 로고    scopus 로고
    • Rock1-directed basement membrane positioning coordinates epithelial tissue polarity
    • Daley, W. P., Gervais, E. M., Centanni, S. W., Gulfo, K. M., Nelson, D. A., and Larsen, M. (2012) ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity. Development 139, 411-422
    • (2012) Development , vol.139 , pp. 411-422
    • Daley, W.P.1    Gervais, E.M.2    Centanni, S.W.3    Gulfo, K.M.4    Nelson, D.A.5    Larsen, M.6
  • 45
    • 59949090255 scopus 로고    scopus 로고
    • Wnt signaling pathways meet rho gtpases
    • Schlessinger, K., Hall, A., and Tolwinski, N. (2009) Wnt signaling pathways meet rho GTPases. Genes Dev. 23, 265-277
    • (2009) Genes Dev. , vol.23 , pp. 265-277
    • Schlessinger, K.1    Hall, A.2    Tolwinski, N.3
  • 46
    • 21644435742 scopus 로고    scopus 로고
    • Serum anti-müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome
    • Piltonen, T., Morin-Papunen, L., Koivunen, R., Perheentupa, A., Ruokonen, A., and Tapanainen, J. S. (2005) Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. Hum. Reprod. 20, 1820-1826
    • (2005) Hum. Reprod. , vol.20 , pp. 1820-1826
    • Piltonen, T.1    Morin-Papunen, L.2    Koivunen, R.3    Perheentupa, A.4    Ruokonen, A.5    Tapanainen, J.S.6
  • 48
    • 73349115872 scopus 로고    scopus 로고
    • Testosteroneinduced downregulation of anti-müllerian hormone expression in granulosa cells from small bovine follicles
    • Crisosto, N., Sir-Petermann, T., Greiner, M., Maliqueo, M., Moreno, M., Aedo, P., and Lara, H. E. (2009) Testosteroneinduced downregulation of anti-müllerian hormone expression in granulosa cells from small bovine follicles. Endocrine 36, 339-345
    • (2009) Endocrine , vol.36 , pp. 339-345
    • Crisosto, N.1    Sir-Petermann, T.2    Greiner, M.3    Maliqueo, M.4    Moreno, M.5    Aedo, P.6    Lara, H.E.7


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