Discriminative and Affective Touch: Sensing and Feeling

Neuron

Volumn 82, Issue 4, 2014, Pages 737-755

  McGlone, Francis ^a,c   Wessberg, Johan ^b   Olausson, Håkan ^d  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; ENDORPHIN; OXYTOCIN; SEROTONIN;

AFFECT; AGGRESSION; ALLODYNIA; BRAIN CORTEX; EMOTIONAL ATTACHMENT; HUMAN; MATERNAL BEHAVIOR; MECHANICAL STIMULATION; MECHANORECEPTOR; NERVE CELL DIFFERENTIATION; NERVE FIBER MEMBRANE POTENTIAL; NERVE INJURY; NEUROCHEMISTRY; NONHUMAN; PAIN; PLEASURE; PRIORITY JOURNAL; REVIEW; REWARD; SENSORY NERVE; SENSORY NERVE CONDUCTION; SKIN NERVE; SKIN SENSITIVITY; SOCIAL INTERACTION; SPINAL CORD; STIMULUS RESPONSE; TACTILE DISCRIMINATION; TACTILE STIMULATION; TOUCH;

AFFERENT PATHWAYS; CENTRAL NERVOUS SYSTEM; DISCRIMINATION (PSYCHOLOGY); EMOTIONS; HUMANS; NERVE FIBERS, UNMYELINATED; NEURAL CONDUCTION; PSYCHOPHYSICS; SKIN PHYSIOLOGICAL PHENOMENA; TOUCH;

EID: 84901020024     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.05.001     Document Type: Review

References (222)

1. Abraira V.E., Ginty D.D. The sensory neurons of touch. Neuron 2013, 79:618-639.
2. Ackerley R., Backlund Wasling H., Liljencrantz J., Olausson H., Johnson R.D., Wessberg J. Human C-tactile afferents are tuned to the temperature of a skin-stroking caress. J.Neurosci. 2014, 34:2879-2883.
3. Ainsworth M.D. Object relations, dependency, and attachment: a theoretical review of the infant-mother relationship. Child Dev. 1969, 40:969-1025.
4. Ainsworth M.D. Infant-mother attachment. Am. Psychol. 1979, 34:932-937.
5. Alagna F.J., Whitcher S.J., Fisher D.J., Wicas E.A. Evaluative reaction to interpersonal touch in a counseling interview. J.Couns. Psychol. 1979, 26:465-472.
6. Andrew D. Quantitative characterization of low-threshold mechanoreceptor inputs to lamina I spinoparabrachial neurons in the rat. J.Physiol. 2010, 588:117-124.
7. Anstey M.L., Rogers S.M., Ott S.R., Burrows M., Simpson S.J. Serotonin mediates behavioral gregarization underlying swarm formation in desert locusts. Science 2009, 323:627-630.
8. Arabin B., Bos R., Rijlaarsdam R., Mohnhaupt A., van Eyck J. The onset of inter-human contacts: longitudinal ultrasound observations in early twin pregnancies. Ultrasound Obs. Gynecol. 1996, 8:166-173.
9. Augustine J.R. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res. Brain Res. Rev. 1996, 22:229-244.
10. Backlund Wasling H., Norrsell U., Göthner K., Olausson H. Tactile directional sensitivity and postural control. Exp. Brain Res. 2005, 166:147-156.
11. Baranek G.T. Autism during infancy: a retrospective video analysis of sensory-motor and social behaviors at 9-12months of age. J.Autism Dev. Disord. 1999, 29:213-224.
12. Bartholomew K. From childhood to adult relationships: attachment theory and research. Learning about Relationships. Understanding Relationship Processes Series 1993, Volume 2:30-62. Sage Publications, Thousand Oaks. S. Duck (Ed.).
13. Bartocci M., Bergqvist L.L., Lagercrantz H., Anand K.J. Pain activates cortical areas in the preterm newborn brain. Pain 2006, 122:109-117.
14. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 1984, 7:309-338.
15. Bastiaansen J.A., Thioux M., Keysers C. Evidence for mirror systems in emotions. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2009, 364:2391-2404.
16. Bennet R.H., Bolling D.Z., Anderson L.C., Pelphrey K.A., Kaiser M.D. fNIRS detects temporal lobe response to affective touch. Soc. Cogn. Affect. Neurosci. 2013, 9:470-476.
17. Bentley I.M. The synthetic experiment. Am. J. Psychol. 1900, 11:405-425.
18. Bessou P., Burgess P.R., Perl E.R., Taylor C.B. Dynamic properties of mechanoreceptors with unmyelinated (C) fibers. J.Neurophysiol. 1971, 34:116-131.
19. Bilderbeck A.C., McCabe C., Wakeley J., McGlone F., Harris T., Cowen P.J., Rogers R.D. Serotonergic activity influences the cognitive appraisal of close intimate relationships in healthy adults. Biol. Psychiatry 2011, 69:720-725.
20. Bilderbeck A.C., Wakeley J., Godlewska B.R., McGlone F., Harris T., Cowen P.J., Rogers R.D. Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships. Soc. Cogn. Affect. Neurosci. 2013, Published online August 31, 2013. 10.1093/scan/nst135.
21. Björnsdotter M., Löken L., Olausson H., Vallbo A., Wessberg J. Somatotopic organization of gentle touch processing in the posterior insular cortex. J.Neurosci. 2009, 29:9314-9320.
22. Blakemore S.J., Bristow D., Bird G., Frith C., Ward J. Somatosensory activations during the observation of touch and a case of vision-touch synaesthesia. Brain 2005, 128:1571-1583.
23. Blanke O., Ortigue S., Landis T., Seeck M. Stimulating illusory own-body perceptions. Nature 2002, 419:269-270.
24. Bobel C. The Paradox of Natural Mothering 2002, Temple University Press, Philadelphia.
25. Bolanowski S.J., Gescheider G.A., Verrillo R.T., Checkosky C.M. Four channels mediate the mechanical aspects of touch. J.Acoust. Soc. Am. 1988, 84:1680-1694.
26. Bottorff J.L. The use and meaning of touch in caring for patients with cancer. Oncol Nurs. Forum 1993, 20:1531-1538.
27. Bowlby J. Attachment, Volume 1, Attachment and Loss 1970, Hogarth, London.
28. Bowlby J. Separation: Anxiety and Anger, Volume 2, Attachment and Loss 1973, Hogarth, London.
29. Burgoon J.K. Relational message interpretations of touch, conversational distance, and posture. J.Nonverbal Behav. 1991, 15:233-259.
30. Burgoon J.K., Walther J.B., Baesler E.J. Interpretations, evaluations, and consequences of interpersonal touch. Hum. Comm. Res. 1992, 19:237-263.
31. Bystrova K. Novel mechanism of human fetal growth regulation: a potential role of lanugo, vernix caseosa and a second tactile system of unmyelinated low-threshold C-afferents. Med. Hypotheses 2009, 72:143-146.
32. Bystrova K., Ivanova V., Edhborg M., Matthiesen A.S., Ransjö-Arvidson A.B., Mukhamedrakhimov R., Uvnäs-Moberg K., Widström A.M. Early contact versus separation: effects on mother-infant interaction one year later. Birth 2009, 36:97-109.
33. Carter C.S. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 1998, 23:779-818.
34. Cascio C.J. Somatosensory processing in neurodevelopmental disorders. J Neurodev Disord 2010, 2:62-69.
35. Cascio C., McGlone F., Folger S., Tannan V., Baranek G., Pelphrey K.A., Essick G. Tactile perception in adults with autism: a multidimensional psychophysical study. J.Autism Dev. Disord. 2008, 38:127-137.
36. Casler L. Maternal deprivation: a critical review of the literature. Monogr. Soc. Res. Child Dev. 1961, 26:1-64.
37. Cauna N. The free penicillate nerve endings of the human hairy skin. J.Anat. 1973, 115:277-288.
38. Champagne F.A., Meaney M.J. Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behav. Neurosci. 2007, 121:1353-1363.
39. Clarke A.S., Ebert M.H., Schmidt D.E., McKinney W.T., Kraemer G.W. Biogenic amine activity in response to fluoxetine and desipramine in differentially reared rhesus monkeys. Biol. Psychiatry 1999, 46:221-228.
40. Cole J.D., Sedgwick E.M. The perceptions of force and of movement in a man without large myelinated sensory afferents below the neck. J.Physiol. 1992, 449:503-515.
41. Cole J., Bushnell M.C., McGlone F., Elam M., Lamarre Y., Vallbo A., Olausson H. Unmyelinated tactile afferents underpin detection of low-force monofilaments. Muscle Nerve 2006, 34:105-107.
42. Cools R., Roberts A.C., Robbins T.W. Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn. Sci. 2008, 12:31-40.
43. Craig A.D. How do you feel? Interoception: the sense of the physiological condition of the body. Nat. Rev. Neurosci. 2002, 3:655-666.
44. Craig A.D. Interoception and emotion. Handbook of Emotions 2008, 272-288. Guilford Publications, New York. Third Edition. M. Lewis, J.M. Haviland-Jones, L.F. Barrett (Eds.).
45. Crucianelli L., Metcalf N.K., Fotopoulou A.K., Jenkinson P.M. Bodily pleasure matters: velocity of touch modulates body ownership during the rubber hand illusion. Front. Psychol. 2013, 4:703. 10.3389/fpsyg.2013.00703.
46. Crusco A.H., Wetzel C.G. The Midas touch: the effects of interpersonal touch on restaurant tipping. Pers. Soc. Psychol. Bull. 1984, 10:512-517.
47. Cushing B.S., Kramer K.M. Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids. Neurosci. Biobehav. Rev. 2005, 29:1089-1105.
48. Deakin J.F., Graeff F.G. 5-HT and mechanisms of defence. J.Psychopharmacol. (Oxford) 1991, 5:305-315.
49. Deakin J.F., Pennell I., Upadhyaya A.J., Lofthouse R. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation. Psychopharmacology (Berl.) 1990, 101:85-92.
50. Delfini M.C., Mantilleri A., Gaillard S., Hao J., Reynders A., Malapert P., Alonso S., François A., Barrere C., Seal R., et al. TAFA4, a chemokine-like protein, modulates injury-induced mechanical and chemical pain hypersensitivity in mice. Cell Rep. 2013, 5:378-388.
51. Delmas P., Hao J., Rodat-Despoix L. Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat. Rev. Neurosci. 2011, 12:139-153.
52. Depue R.A., Morrone-Strupinsky J.V. A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. Behav. Brain Sci. 2005, 28:313-350. discussion 350-395.
53. Di Chiara G., North R.A. Neurobiology of opiate abuse. Trends Pharmacol. Sci. 1992, 13:185-193.
54. DiCicco-Bloom E., Lord C., Zwaigenbaum L., Courchesne E., Dager S.R., Schmitz C., Schultz R.T., Crawley J., Young L.J. The developmental neurobiology of autism spectrum disorder. J.Neurosci. 2006, 26:6897-6906.
55. Dölen G., Darvishzadeh A., Huang K.W., Malenka R.C. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature 2013, 501:179-184.
56. Dong X., Han S., Zylka M.J., Simon M.I., Anderson D.J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 2001, 106:619-632.
57. Douglas W.W., Ritchie J.M. Nonmedullated fibres in the saphenous nerve which signal touch. J.Physiol. 1957, 139:385-399.
58. Drew L.J., MacDermott A.B. Neuroscience: Unbearable lightness of touch. Nature 2009, 462:580-581.
59. Dum R.P., Levinthal D.J., Strick P.L. The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. J.Neurosci. 2009, 29:14223-14235.
60. Dunbar R.I. Coevolution of neocortical size, group size and language in humans. Behav. Brain Sci. 1993, 16:681-735.
61. Dunbar R.I. Grooming, Gossip and the Evolution of Language 1997, Faber & Faber, London.
62. Dunbar R.I. Gossip in evolutionary perspective. Rev. Gen. Psychol. 2004, 8:100-110.
63. Dunbar R.I. The social role of touch in humans and primates: behavioural function and neurobiological mechanisms. Neurosci. Biobehav. Rev. 2010, 34:260-268.
64. Ebisch S.J., Perrucci M.G., Ferretti A., Del Gratta C., Romani G.L., Gallese V. The sense of touch: embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch. J.Cogn. Neurosci. 2008, 20:1611-1623.
65. Edin B.B. Quantitative analysis of static strain sensitivity in human mechanoreceptors from hairy skin. J.Neurophysiol. 1992, 67:1105-1113.
66. Edin B.B. Cutaneous afferents provide information about knee joint movements in humans. J.Physiol. 2001, 531:289-297.
67. Edin B.B., Johansson N. Skin strain patterns provide kinaesthetic information to the human central nervous system. J.Physiol. 1995, 487:243-251.
68. Eghbal-Ahmadi M., Avishai-Eliner S., Hatalski C.G., Baram T.Z. Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake. J.Neurosci. 1999, 19:3982-3991.
69. El Mestikawy S., Wallén-Mackenzie A., Fortin G.M., Descarries L., Trudeau L.E. From glutamate co-release to vesicular synergy: vesicular glutamate transporters. Nat. Rev. Neurosci. 2011, 12:204-216.
70. Ellingsen D.-M., Wessberg J., Chelnokova O., Olausson H., Laeng B., Leknes S. In touch with your emotions: oxytocin and touch change social impressions while others' facial expressions can alter touch. Psychoneuroendocrinology 2014, 39:11-20.
71. Essick G.K., James A., McGlone F.P. Psychophysical assessment of the affective components of non-painful touch. Neuroreport 1999, 10:2083-2087.
72. Essick G.K., McGlone F., Dancer C., Fabricant D., Ragin Y., Phillips N., Jones T., Guest S. Quantitative assessment of pleasant touch. Neurosci. Biobehav. Rev. 2010, 34:192-203.
73. Field T. Touch 2001, MIT Press, Cambridge.
74. Field T., Lang C., Yando R., Bendell D. Adolescents' intimacy with parents and friends. Adolescence 1995, 30:133-140.
75. Fleming A.S., Korsmit M., Deller M. Rat pups are potent reinforcers to the maternal animal - effects of experience, parity, hormones, and dopamine function. Psychobiol. 1994, 22:44-53.
76. Foerster O.E. Die afferenten Bahnen. Handbuch der Neurologie 1936, Volume 5:239-379. Verlag von Julius Springer, Berlin. O. Bumke, O. Foerster (Eds.).
77. Foerster O., Breslau O., Gagel O. Die Vorderseitenstrangdurchschneidung beim Menschen: Eine klinisch-patho-physiologisch-anatomische Studie. Z.Gesamte Neurol. Psychiatr. 1932, 138:1-92.
78. Forget R., Lamarre Y. Rapid elbow flexion in the absence of proprioceptive and cutaneous feedback. Hum. Neurobiol. 1987, 6:27-37.
79. Francis S., Rolls E.T., Bowtell R., McGlone F., O'Doherty J., Browning A., Clare S., Smith E. The representation of pleasant touch in the brain and its relationship with taste and olfactory areas. Neuroreport 1999, 10:453-459.
80. Gallace A., Spence C. The science of interpersonal touch: an overview. Neurosci. Biobehav. Rev. 2010, 34:246-259.
81. Gazzola V., Spezio M.L., Etzel J.A., Castelli F., Adolphs R., Keysers C. Primary somatosensory cortex discriminates affective significance in social touch. Proc. Natl. Acad. Sci. USA 2012, 109:E1657-E1666.
82. Gescheider G.A., Sklar B.F., Van Doren C.L., Verrillo R.T. Vibrotactile forward masking: psychophysical evidence for a triplex theory of cutaneous mechanoreception. J.Acoust. Soc. Am. 1985, 78:534-543.
83. Gescheider G.A., Wright J.H., Verrillo R.T. Information Processing in the Tactile Sensory System: A Psychophysical and Physiological Analysis 2010, Psychology Press, New York.
84. Giummarra M.J., Fitzgibbon B.M., Georgiou-Karistianis N., Nicholls M.E., Gibson S.J., Bradshaw J.L. Ouch! My phantom leg jumps/hurts when you stab "my" virtual hand. Perception 2010, 39:1396-1407.
85. Gordon I., Voos A.C., Bennett R.H., Bolling D.Z., Pelphrey K.A., Kaiser M.D. Brain mechanisms for processing affective touch. Hum. Brain Mapp. 2013, 34:914-922.
86. Grandin T. An insider view of autism. High-Functioning Individuals with Autism 1992, 105-124. Springer, New York. E. Schoplerand, G.B. Mesibov (Eds.).
87. Grandin T., Scariano M.M. Emergence: Labeled Autistic 1986, Arena Press, Novato.
88. Griffin J.W., McArthur J.C., Polydefkis M. Assessment of cutaneous innervation by skin biopsies. Curr. Opin. Neurol. 2001, 14:655-659.
89. Grudt T.J., Perl E.R. Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. J.Physiol. 2002, 540:189-207.
90. Hagbarth K.E., Vallbo A.B. Mechanoreceptor activity recorded percutaneously with semi-microelectrodes in human peripheral nerves. Acta Physiol. Scand. 1967, 69:121-122.
91. Hanson R.F., Spratt E.G. Reactive Attachment Disorder: what we know about the disorder and implications for treatment. Child Maltreat. 2000, 5:137-145.
92. Harlow H.F., Harlow M.K. The effect of rearing conditions on behavior. Bull. Menninger Clin. 1962, 26:213-224.
93. Harlow H.F., Zimmermann R.R. The development of affective responsiveness in infant monkeys. Proc. Am. Phil. Soc. 1958, 102:501-509.
94. Heinrichs M., Domes G. Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans. Prog. Brain Res. 2008, 170:337-350.
95. Hellstrom I.C., Dhir S.K., Diorio J.C., Meaney M.J. Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2012, 367:2495-2510.
96. Henazi S.P., Barrett L. The value of grooming to female primates. Primates 1999, 40:47-59.
97. Hertenstein M.J., Keltner D., App B., Bulleit B.A., Jaskolka A.R. Touch communicates distinct emotions. Emotion 2006, 6:528-533.
98. Hooker D. Reflex activities in the human fetus. Child Behavior and Development 1943, 17-28. McGraw-Hill, New York. R. Barker, J.S. Kounin, H.F. Wright (Eds.).
99. Hooker D. The Prenatal Origin of Behaviour 1952, University of Kansas Press, Lawrence.
100. Humphrey T. The development of trigeminal nerve fibers to the oral mucosa, compared with their development to cutaneous surfaces. J.Comp. Neurol. 1966, 126:91-108.
101. Hurley L.M., Devilbiss D.M., Waterhouse B.D. A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks. Curr. Opin. Neurobiol. 2004, 14:488-495.
102. Iggo A. Cutaneous mechanoreceptors with afferent C fibres. J.Physiol. 1960, 152:337-353.
103. Iggo A., Kornhuber H.H. A quantitative study of C-mechanoreceptors in hairy skin of the cat. J.Physiol. 1977, 271:549-565.
104. Insel T.R., Winslow J.T. Serotonin and neuropeptides in affiliative behaviors. Biol. Psychiatry 1998, 44:207-219.
105. Jean A.D., Stack D.M., Fogel A. A longitudinal investigation of maternal touching across the first 6months of life: age and context effects. Infant Behav. Dev. 2009, 32:344-349.
106. Johansson R.S., Landström U., Lundström R. Responses of mechanoreceptive afferent units in the glabrous skin of the human hand to sinusoidal skin displacements. Brain Res. 1982, 244:17-25.
107. Johansson R.S., Trulsson M., Olsson K.A., Westberg K.G. Mechanoreceptor activity from the human face and oral mucosa. Exp. Brain Res. 1988, 72:204-208.
108. Jones R., Quigney C., Huws J. First-hand accounts of sensory perceptual experiences in autism: a qualitative analysis. J.Intell. Dev. Dis. 2003, 28:112-121.
109. Kaiser M.D., Hudac C.M., Shultz S., Lee S.M., Cheung C., Berken A.M., Deen B., Pitskel N.B., Sugrue D.R., Voos A.C., et al. Neural signatures of autism. Proc. Natl. Acad. Sci. USA 2010, 107:21223-21228.
110. Kaitz M., Lapidot P., Bronner R., Eidelman A.I. Parturient women can recognize their infants by touch. Dev. Psychol. 1992, 28:35-39.
111. Kandel E.R., Schwartz J.H., Jessell T.M., Siegelbaum S.A., Hudspeth A.J. Principles of Neural Science 2013, McGraw-Hill, New York.
112. Kern J.K., Trivedi M.H., Grannemann B.D., Garver C.R., Johnson D.G., Andrews A.A., Savla J.S., Mehta J.A., Schroeder J.L. Sensory correlations in autism. Autism 2007, 11:123-134.
113. Keverne E.B., Martensz N.D., Tuite B. Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships. Psychoneuroendocrinology 1989, 14:155-161.
114. Keysers C., Wicker B., Gazzola V., Anton J.L., Fogassi L., Gallese V. A touching sight: SII/PV activation during the observation and experience of touch. Neuron 2004, 42:335-346.
115. Kida T., Shinohara K. Gentle touch activates the prefrontal cortex in infancy: an NIRS study. Neurosci. Lett. 2013, 541:63-66.
116. Kiser D., Steemers B., Branchi I., Homberg J.R. The reciprocal interaction between serotonin and social behaviour. Neurosci. Biobehav. Rev. 2012, 36:786-798.
117. Knox S.S., Uvnäs-Moberg K. Social isolation and cardiovascular disease: an atherosclerotic pathway?. Psychoneuroendocrinology 1998, 23:877-890.
118. Korner A.F., Grobstein R. Visual alertness as related to soothing in neonates: implications for maternal stimulation and early deprivation. Child Dev. 1966, 37:867-876.
119. Krämer H.H., Lundblad L., Birklein F., Linde M., Karlsson T., Elam M., Olausson H. Activation of the cortical pain network by soft tactile stimulation after injection of sumatriptan. Pain 2007, 133:72-78.
120. Kumazawa T., Perl E.R. Primate cutaneous sensory units with unmyelinated (C) afferent fibers. J.Neurophysiol. 1977, 40:1325-1338.
121. Lahuerta J., Bowsher D., Lipton S., Buxton P.H. Percutaneous cervical cordotomy: a review of 181 operations on 146 patients with a study on the location of "pain fibers" in the C-2 spinal cord segment of 29 cases. J.Neurosurg. 1994, 80:975-985.
122. Leem J.W., Willis W.D., Chung J.M. Cutaneous sensory receptors in the rat foot. J.Neurophysiol. 1993, 69:1684-1699.
123. Leonard J.A., Berkowitz T., Shusterman A. The effect of friendly touch on delay-of-gratification in preschool children. Q.J. Exp. Psychol. 2014, Published online April 22, 2014. 10.1080/17470218.2014.907325.
124. Li L., Rutlin M., Abraira V.E., Cassidy C., Kus L., Gong S., Jankowski M.P., Luo W., Heintz N., Koerber H.R., et al. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell 2011, 147:1615-1627.
125. Liedloff J. The Continuum Concept: In Search of Happiness Lost 1985, Perseus Books, Cambridge.
126. Light A.R., Perl E.R. Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers. J.Comp. Neurol. 1979, 186:133-150.
127. Liljencrantz J., Björnsdotter M., Morrison I., Bergstrand S., Ceko M., Seminowicz D.A., Cole J., Bushnell M.C., Olausson H. Altered C-tactile processing in human dynamic tactile allodynia. Pain 2013, 154:227-234.
128. Liu D., Diorio J., Tannenbaum B., Caldji C., Francis D., Freedman A., Sharma S., Pearson D., Plotsky P.M., Meaney M.J. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenalresponses to stress. Science 1997, 277:1659-1662.
129. Liu Q., Vrontou S., Rice F.L., Zylka M.J., Dong X., Anderson D.J. Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nat. Neurosci. 2007, 10:946-948.
130. Liu J., Dietz K., DeLoyht J.M., Pedre X., Kelkar D., Kaur J., Vialou V., Lobo M.K., Dietz D.M., Nestler E.J., et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat. Neurosci. 2012, 15:1621-1623.
131. Lloyd D.M., Gillis V., Lewis E., Farrell M.J., Morrison I. Pleasant touch moderates the subjective but not objective aspects of body perception. Front Behav Neurosci 2013, 7:207. 10.3389/fnbeh.2013.00207.
132. Löken L.S., Wessberg J., Morrison I., McGlone F., Olausson H. Coding of pleasant touch by unmyelinated afferents in humans. Nat. Neurosci. 2009, 12:547-548.
133. Lou S., Duan B., Vong L., Lowell B.B., Ma Q. Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. J.Neurosci. 2013, 33:870-882.
134. Lovero K.L., Simmons A.N., Aron J.L., Paulus M.P. Anterior insular cortex anticipates impending stimulus significance. Neuroimage 2009, 45:976-983.
135. Lu Y., Perl E.R. Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II). J.Neurosci. 2005, 25:3900-3907.
136. Lyons D.M., Buckmaster P.S., Lee A.G., Wu C., Mitra R., Duffey L.M., Buckmaster C.L., Her S., Patel P.D., Schatzberg A.F. Stress coping stimulates hippocampal neurogenesis in adult monkeys. Proc. Natl. Acad. Sci. USA 2010, 107:14823-14827.
137. Main M., Hesse E. Parents' unresolved traumatic experiences are related to infant disorganized attachment status: Is frightened and/or frightening parental behavior the linking mechanism?. Attachment in the Preschool Years: Theory, Research, and Intervention 1990, 161-182. University of Chicago Press, Chicago. M.T. Greenberg, D. Cicchetti, M.E. Cummings (Eds.).
138. Makinodan M., Rosen K.M., Ito S., Corfas G. A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science 2012, 337:1357-1360.
139. Marshall K.L., Lumpkin E.A. The molecular basis of mechanosensory transduction. Adv. Exp. Med. Biol. 2012, 739:142-155.
140. Maxwell D.J., Belle M.D., Cheunsuang O., Stewart A., Morris R. Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn. J.Physiol. 2007, 584:521-533.
141. McCabe C., Rolls E.T., Bilderbeck A., McGlone F. Cognitive influences on the affective representation of touch and the sight of touch in the human brain. Soc. Cogn. Affect. Neurosci. 2008, 3:97-108.
142. McGlone F., Reilly D. The cutaneous sensory system. Neurosci. Biobehav. Rev. 2010, 34:148-159.
143. McGlone F., Kelly E.F., Trulsson M., Francis S.T., Westling G., Bowtell R. Functional neuroimaging studies of human somatosensory cortex. Behav. Brain Res. 2002, 135:147-158.
144. McGlone F., Vallbo A.B., Olausson H., Loken L., Wessberg J. Discriminative touch and emotional touch. Can. J. Exp. Psychol. 2007, 61:173-183.
145. McGlone F., Olausson H., Boyle J.A., Jones-Gotman M., Dancer C., Guest S., Essick G. Touching and feeling: differences in pleasant touch processing between glabrous and hairy skin in humans. Eur. J. Neurosci. 2012, 35:1782-1788.
146. Meaney M.J., Szyf M. Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin. Neurosci. 2005, 7:103-123.
147. Meaney M.J., Diorio J., Francis D., Widdowson J., LaPlante P., Caldji C., Sharma S., Seckl J.R., Plotsky P.M. Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev. Neurosci. 1996, 18:49-72.
148. Meaney M.J., Szyf M., Seckl J.R. Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol. Med. 2007, 13:269-277.
149. Menard J.L., Champagne D.L., Meaney M.J. Variations of maternal care differentially influence 'fear' reactivity and regional patterns of cFos immunoreactivity in response to the shock-probe burying test. Neuroscience 2004, 129:297-308.
150. Miles R., Cowan F., Glover V., Stevenson J., Modi N. A controlled trial of skin-to-skin contact in extremely preterm infants. Early Hum. Dev. 2006, 82:447-455.
151. Molenberghs P., Cunnington R., Mattingley J.B. Brain regions with mirror properties: a meta-analysis of 125 human fMRI studies. Neurosci. Biobehav. Rev. 2012, 36:341-349.
152. Moles A., Kieffer B.L., D'Amato F.R. Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science 2004, 304:1983-1986.
153. Montagu A. Touching: On the Human Significance of Skin 1978, Harper, New York.
154. Morrison I., Löken L.S., Olausson H. The skin as a social organ. Exp. Brain Res. 2010, 204:305-314.
155. Morrison I., Löken L.S., Minde J., Wessberg J., Perini I., Nennesmo I., Olausson H. Reduced C-afferent fibre density affects perceived pleasantness and empathy for touch. Brain 2011, 134:1116-1126.
156. Morrison I., Björnsdotter M., Olausson H. Vicarious responses to social touch in posterior insular cortex are tuned to pleasant caressing speeds. J.Neurosci. 2011, 31:9554-9562.
157. Mountcastle V.B. The Sensory Hand 2005, Harvard University Press, Cambridge.
158. Naber F.B., Swinkels S.H., Buitelaar J.K., Bakermans-Kranenburg M.J., van IJzendoorn M.H., Dietz C., van Daalen E., van Engeland H. Attachment in toddlers with autism and other developmental disorders. J.Autism Dev. Disord. 2007, 37:1123-1138.
159. Nagi S.S., Rubin T.K., Chelvanayagam D.K., Macefield V.G., Mahns D.A. Allodynia mediated by C-tactile afferents in human hairy skin. J.Physiol. 2011, 589:4065-4075.
160. Nagy Z., Westerberg H., Klingberg T. Maturation of white matter is associated with the development of cognitive functions during childhood. J.Cogn. Neurosci. 2004, 16:1227-1233.
161. Nelson E.E., Panksepp J. Brain substrates of infant-mother attachment: contributions of opioids, oxytocin, and norepinephrine. Neurosci. Biobehav. Rev. 1998, 22:437-452.
162. Nelson R.J., Trainor B.C. Neural mechanisms of aggression. Nat. Rev. Neurosci. 2007, 8:536-546.
163. Nichols D.E., Marona-Lewicka D., Huang X., Johnson M.P. Novel serotonergic agents. Drug Des. Discov. 1993, 9:299-312.
164. Nordin M. Low-threshold mechanoreceptive and nociceptive units with unmyelinated (C) fibres in the human supraorbital nerve. J.Physiol. 1990, 426:229-240.
165. Ochoa J., Torebjörk E. Sensations evoked by intraneural microstimulation of single mechanoreceptor units innervating the human hand. J.Physiol. 1983, 342:633-654.
166. Olausson H., Lamarre Y., Backlund H., Morin C., Wallin B.G., Starck G., Ekholm S., Strigo I., Worsley K., Vallbo A.B., Bushnell M.C. Unmyelinated tactile afferents signal touch and project to insular cortex. Nat. Neurosci. 2002, 5:900-904.
167. Olausson H., Cole J., Rylander K., McGlone F., Lamarre Y., Wallin B.G., Krämer H., Wessberg J., Elam M., Bushnell M.C., Vallbo A. Functional role of unmyelinated tactile afferents in human hairy skin: sympathetic response and perceptual localization. Exp. Brain Res. 2008, 184:135-140.
168. Panksepp J. A neurochemical theory of autism. Trends Neurosci. 1989, 2:174-177.
169. Panksepp J. Emotional endophenotypes in evolutionary psychiatry. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30:774-784.
170. Panksepp J. Cross-species affective neuroscience decoding of the primal affective experiences of humans and related animals. PLoS ONE 2011, 6:e21236. 10.1371/journal.pone.0021236.
171. Peciña S., Smith K.S., Berridge K.C. Hedonic hot spots in the brain. Neuroscientist 2006, 12:500-511.
172. Petrides M. Lateral prefrontal cortex: architectonic and functional organization. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2005, 360:781-795.
173. Pine D.S., Coplan J.D., Wasserman G.A., Miller L.S., Fried J.E., Davies M., Cooper T.B., Greenhill L., Shaffer D., Parsons B. Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing. Arch. Gen. Psychiatry 1997, 54:839-846.
174. Prescott J.W. Deprivation of physical affection as a primary process in the development of physical violence. Child Abuse and Violence 1979, 66-137. AMS Press, New York. D.G. Gil (Ed.).
175. Raleigh M.J., Brammer G.L., Yuwiler A., Flannery J.W., McGuire M.T., Geller E. Serotonergic influences on the social behavior of vervet monkeys (Cercopithecus aethiops sabaeus). Exp. Neurol. 1980, 68:322-334.
176. Raleigh M.J., McGuire M.T., Brammer G.L., Pollack D.B., Yuwiler A. Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res. 1991, 559:181-190.
177. Reilly D.M., Ferdinando D., Johnston C., Shaw C., Buchanan K.D., Green M.R. The epidermal nerve fibre network: characterization of nerve fibres in human skin by confocal microscopy and assessment of racial variations. Br. J. Dermatol. 1997, 137:163-170.
178. Rogers S.J., Hepburn S.L., Stackhouse T., Wehner E. Imitation performance in toddlers with autism and those with other developmental disorders. J.Child Psychol. Psychiatry 2003, 44:763-781.
179. Rolls E.T. The functions of the orbitofrontal cortex. Brain Cogn. 2004, 55:11-29.
180. Rolls E.T., O'Doherty J., Kringelbach M.L., Francis S., Bowtell R., McGlone F. Representations of pleasant and painful touch in the human orbitofrontal and cingulate cortices. Cereb. Cortex 2003, 13:308-317.
181. Rosenblum L.A., Coplan J.D., Friedman S., Bassoff T., Gorman J.M., Andrews M.W. Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates. Biol. Psychiatry 1994, 35:221-227.
182. Seal R.P., Wang X., Guan Y., Raja S.N., Woodbury C.J., Basbaum A.I., Edwards R.H. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature 2009, 462:651-655.
183. Sewards T.V., Sewards M. Separate, parallel sensory and hedonic pathways in the mammalian somatosensory system. Brain Res. Bull. 2002, 58:243-260.
184. Sharp H., Pickles A., Meany M., Marshall K., Tibu F., Hill J. Frequency of infant stroking reported by mothers moderates the effect of prenatatl depression on infant behavioural and physiological outcomes. PLoS ONE 2012, 7:e45446.
185. Silk J.B. Using the 'F'-word in primatology. Behaviour 2002, 139:421-446.
186. Soares M.C., Oliveira R.F., Ros A.F., Grutter A.S., Bshary R. Tactile stimulation lowers stress in fish. Nat. Commun. 2011, 2:534. 10.1038/ncomms1547.
187. Spitz R.A. Hospitalism. The Psychoanalytic Study of the Child 1945, VolumeI:53-74. International Universities Press, New York. R.S. Eissler (Ed.).
188. Spitz R.A. Hospitalism: A follow-up report. The Psychoanalytic Study of the Child 1946, Volume II:113-117. International UniversitiesPress, New York. R.S. Eissler (Ed.).
189. Stack D.M., Muir D.W. Tactile stimulation as a component of social interchange - new interpretations for the still-face effect. Br. J. Dev. Psychol. 1990, 8:131-145.
190. Stack D.M., Muir D.W. Adult tactile stimulation during face-to-face interactions modulates five-month-olds' affect and attention. Child Dev. 1992, 63:1509-1525.
191. Starr M.A., Page M.E., Waterhouse B.D. MDMA (3,4-methylenedioxymethamphetamine)-mediated distortion of somatosensory signal transmission and neurotransmitter efflux in the ventral posterior medial thalamus. J.Pharmacol. Exp. Ther. 2008, 327:20-31.
192. Stenneken P., Prinz W., Cole J., Paillard J., Aschersleben G. The effect of sensory feedback on the timing of movements: evidence from deafferented patients. Brain Res. 2006, 1084:123-131.
193. Sterman A.B., Schaumburg H.H., Asbury A.K. The acute sensory neuronopathy syndrome: a distinct clinical entity. Ann. Neurol. 1980, 7:354-358.
194. Strumia R. Dermatologic signs in patients with eating disorders. Am. J. Clin. Dermatol. 2005, 6:165-173.
195. Sugiura Y. Spinal organization of C-fiber afferents related with nociception or non-nociception. Prog. Brain Res. 1996, 113:320-339.
196. Suomi S.J. Risk, resilience, and gene-environment interplay in primates. J.Can. Acad. Child Adolesc. Psychiatry 2011, 20:289-297.
197. Thayer S. Touch: fronteir of intimacy. J.Nonverbal Behav. 1986, 10:7-11.
198. Thompson M.R., Callaghan P.D., Hunt G.E., Cornish J.L., McGregor I.S. A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience 2007, 146:509-514.
199. Todd A.J. Neuronal circuitry for pain processing in the dorsal horn. Nat. Rev. Neurosci. 2010, 11:823-836.
200. Trulsson M., Francis S.T., Kelly E.F., Westling G., Bowtell R., McGlone F. Cortical responses to single mechanoreceptive afferent microstimulation revealed with fMRI. Neuroimage 2001, 13:613-622.
201. Tzschentke T.M. Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade. Addict. Biol. 2007, 12:227-462.
202. Uvänas-Moberg K., Arn I., Magnusson D. The psychobiology of emotion: the role of the oxytocinergic system. Int. J. Behav. Med. 2005, 12:59-65.
203. Uvnäs-Moberg K. Oxytocin linked antistress effects-the relaxation and growth response. Acta Physiol. Scand. Suppl. 1997, 640:38-42.
204. Vallbo A.B., Johansson R.S. Properties of cutaneous mechanoreceptors in the human hand related to touch sensation. Hum. Neurobiol. 1984, 3:3-14.
205. Vallbo A.B., Olsson K.A., Westberg K.G., Clark F.J. Microstimulation of single tactile afferents from the human hand. Sensory attributes related to unit type and properties of receptive fields. Brain 1984, 107:727-749.
206. Vallbo A.B., Olausson H., Wessberg J., Norrsell U. A system of unmyelinated afferents for innocuous mechanoreception in the human skin. Brain Res. 1993, 628:301-304.
207. Vallbo A.B., Olausson H., Wessberg J., Kakuda N. Receptive field characteristics of tactile units with myelinated afferents in hairy skin of human subjects. J.Physiol. 1995, 483:783-795.
208. Vallbo A.B., Olausson H., Wessberg J. Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin. J.Neurophysiol. 1999, 81:2753-2763.
209. van Stralen H.E., van Zandvoort M.J.E., Hoppenbrouwers S.S., Vissers L.M.G., Kappelle L.J., Dijkerman H.C. Affective touch modulates the rubber hand illusion. Cognition 2014, 131:147-158.
210. Veenema A.H., Neumann I.D. Central vasopressin and oxytocin release: regulation of complex social behaviours. Prog. Brain Res. 2008, 170:261-276.
211. Verrillo R.T. Effects of contactor area on the vibrotactile threshold. J.Acoust. Soc. Am. 1963, 35:1962-1966.
212. Verrillo R.T. A duplex mechanism of mechanoreception. The Skin Senses 1968, 135-159. Thomas, Springfield. D.R. Kensalo (Ed.).
213. Voos A.C., Pelphrey K.A., Kaiser M.D. Autistic traits are associated with diminished neural response to affective touch. Soc. Cogn. Affect. Neurosci. 2013, 8:378-386.
214. Vrontou S., Wong A.M., Rau K.K., Koerber H.R., Anderson D.J. Genetic identification of C fibres that detect massage-like stroking of hairy skin invivo. Nature 2013, 493:669-673.
215. Walker S.C., McGlone F.P. The social brain: neurobiological basis of affiliative behaviours and psychological well-being. Neuropeptides 2013, 47:379-393.
216. Weaver I.C., Cervoni N., Champagne F.A., D'Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., Meaney M.J. Epigenetic programming by maternal behavior. Nat. Neurosci. 2004, 7:847-854.
217. Wessberg J., Olausson H., Fernström K.W., Vallbo A.B. Receptive field properties of unmyelinated tactile afferents in the human skin. J.Neurophysiol. 2003, 89:1567-1575.
218. Whitcher S.J., Fisher J.D. Multidimensional reaction to therapeutic touch in a hospital setting. J.Pers. Soc. Psychol. 1979, 37:87-96.
219. Willis W.D., Coggeshall R.E. Sensory Mechanisms of the Spinal Cord 1978, Springer Science+Business Media, Plenum.
220. Yoshida M., Takayanagi Y., Inoue K., Kimura T., Young L.J., Onaka T., Nishimori K. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J.Neurosci. 2009, 29:2259-2271.
221. Zotterman Y. Touch, pain and tickling: an electro-physiological investigation on cutaneous sensory nerves. J.Physiol. 1939, 95:1-28.
222. Zylka M.J., Dong X., Southwell A.L., Anderson D.J. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Proc. Natl. Acad. Sci. USA 2003, 100:10043-10048.