Exploration of the design principles of a cell-penetrating bicylic peptide scaffold

Bioconjugate Chemistry

Volumn 25, Issue 5, 2014, Pages 955-964

  Wallbrecher, Rike ^a   Depré, Luc ^a   Verdurmen, Wouter P R ^a   Bovée Geurts, Petra H ^a   Van Duinkerken, Richard H ^b   Zekveld, Mariët J ^b   Timmerman, Peter ^b   Brock, Roland ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Pepscan Therapeutics   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CELL MEMBRANES; EFFICIENCY; LANTHANUM COMPOUNDS; MOLECULAR BIOLOGY; SCAFFOLDS (BIOLOGY);

ARGININE RESIDUE; CELL-PENETRATING PEPTIDE; CHARGED RESIDUES; CONFORMATIONAL CONSTRAINTS; DESIGN PRINCIPLES; NATURALLY OCCURRING; NEGATIVELY CHARGED; PEPTIDE SCAFFOLDS; PEPTIDE TOXIN; STRUCTURE-ACTIVITY RELATIONSHIPS;

PEPTIDES;

ARGININE; CELL PENETRATING PEPTIDE; HISTIDINE; KALLIKREIN INHIBITOR; TRYPTOPHAN; CYCLOPEPTIDE;

ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYCLIZATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; PEPTIDE SYNTHESIS; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; HELA CELL LINE; METABOLISM; SYNTHESIS;

CELL MEMBRANE; CELL-PENETRATING PEPTIDES; DRUG DESIGN; FLOW CYTOMETRY; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC;

EID: 84901015021     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500107f     Document Type: Article

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