Adenovirus purification by two-column, size-exclusion, simulated countercurrent chromatography

Journal of Chromatography A

Volumn 1347, Issue , 2014, Pages 111-121

  Nestola, Piergiuseppe ^a,b   Silva, Ricardo J S ^a   Peixoto, Cristina ^a   Alves, Paula M ^a,b   Carrondo, Manuel J T ^a,b,c   Mota, José P B ^a,d  

^a INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d DEPARTAMENTO DE QUÍMICA   (Portugal)

Author keywords

Adenovirus; Downstream processing; Simulating moving bed; Size exclusion chromatography; Two column chromatography; Virus purification

Indexed keywords

EFFLUENTS; LIQUID CHROMATOGRAPHY; PRODUCTIVITY; PURIFICATION; SIZE EXCLUSION CHROMATOGRAPHY; VIRUSES;

ADENOVIRUS; ADENOVIRUS PURIFICATION; BATCH CHROMATOGRAPHY; COUNTERCURRENT CHROMATOGRAPHY; DOWNSTREAM-PROCESSING; MOVING BED; OPEN-LOOP CONFIGURATION; VIRUS PURIFICATION;

COLUMN CHROMATOGRAPHY;

CELL PROTEIN; DNA; RESIN;

ARTICLE; CLEARANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; EFFLUENT; ELUTION; EMBRYO; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN ADENOVIRUS 5; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SIMULATION; VALIDATION STUDY; VIRAL CONTAMINATION; VIRUS PURIFICATION; WASTE;

ADENOVIRIDAE;

ADENOVIRUS; DOWNSTREAM PROCESSING; SIMULATING MOVING BED; SIZE EXCLUSION CHROMATOGRAPHY; TWO-COLUMN CHROMATOGRAPHY; VIRUS PURIFICATION;

ADENOVIRIDAE; CHROMATOGRAPHY, GEL; COUNTERCURRENT DISTRIBUTION; DNA, VIRAL; HEK293 CELLS; HUMANS; VIRION;

EID: 84901014122     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.04.079     Document Type: Article

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