-
1
-
-
84861497716
-
The embryonic origins of erythropoiesis in mammals
-
Baron, M. H., Isern, J., and Fraser, S. T. (2012) The embryonic origins of erythropoiesis in mammals. Blood 119, 4828-4837
-
(2012)
Blood
, vol.119
, pp. 4828-4837
-
-
Baron, M.H.1
Isern, J.2
Fraser, S.T.3
-
2
-
-
79954568538
-
Transcriptional regulation of fetal to adult hemoglobin switching: New therapeutic opportunities
-
Wilber, A., Nienhuis, A. W., and Persons, D. A. (2011) Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities. Blood 117, 3945-3953
-
(2011)
Blood
, vol.117
, pp. 3945-3953
-
-
Wilber, A.1
Nienhuis, A.W.2
Persons, D.A.3
-
3
-
-
0035320886
-
Phenotype-genotype relationships in monogenic disease: Lessons from the thalassaemias
-
Weatherall, D. J. (2001) Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat. Rev. Genet. 2, 245-255
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 245-255
-
-
Weatherall, D.J.1
-
4
-
-
77949846880
-
Advances in the understanding of haemoglobin switching
-
Sankaran, V. G., Xu, J., and Orkin, S. H. (2010) Advances in the understanding of haemoglobin switching. Br. J. Haematol. 149, 181-194
-
(2010)
Br. J. Haematol.
, vol.149
, pp. 181-194
-
-
Sankaran, V.G.1
Xu, J.2
Orkin, S.H.3
-
5
-
-
0025329590
-
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
-
Enver, T., Raich, N., Ebens, A. J., Papayannopoulou, T., Costantini, F., and Stamatoyannopoulos, G. (1990) Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature 344, 309-313
-
(1990)
Nature
, vol.344
, pp. 309-313
-
-
Enver, T.1
Raich, N.2
Ebens, A.J.3
Papayannopoulou, T.4
Costantini, F.5
Stamatoyannopoulos, G.6
-
6
-
-
0027367941
-
Developmental regulation of human gamma-globin genes in transgenic mice
-
Stamatoyannopoulos, G., Josephson, B., Zhang, J. W., and Li, Q. (1993) Developmental regulation of human gamma-globin genes in transgenic mice. Mol. Cell. Biol. 13, 7636-7644
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7636-7644
-
-
Stamatoyannopoulos, G.1
Josephson, B.2
Zhang, J.W.3
Li, Q.4
-
7
-
-
0027261194
-
Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes
-
Peterson, K. R., Clegg, C. H., Huxley, C., Josephson, B. M., Haugen, H. S., Furukawa, T., and Stamatoyannopoulos, G. (1993) Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc. Natl. Acad. Sci. U. S. A. 90, 7593-7597
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 7593-7597
-
-
Peterson, K.R.1
Clegg, C.H.2
Huxley, C.3
Josephson, B.M.4
Haugen, H.S.5
Furukawa, T.6
Stamatoyannopoulos, G.7
-
8
-
-
0027443269
-
Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice
-
Gaensler, K. M., Kitamura, M., and Kan, Y. W. (1993) Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 90, 11381-11385
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 11381-11385
-
-
Gaensler, K.M.1
Kitamura, M.2
Kan, Y.W.3
-
9
-
-
0030709312
-
The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice
-
Porcu, S., Kitamura, M., Witkowska, E., Zhang, Z., Mutero, A., Lin, C., Chang, J., and Gaensler, K. M. (1997) The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice. Blood 90, 4602-4609
-
(1997)
Blood
, vol.90
, pp. 4602-4609
-
-
Porcu, S.1
Kitamura, M.2
Witkowska, E.3
Zhang, Z.4
Mutero, A.5
Lin, C.6
Chang, J.7
Gaensler, K.M.8
-
10
-
-
0033231034
-
Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome
-
Kaufman, R. M., Pham, C. T., and Ley, T. J. (1999) Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. Blood 94, 3178-3184
-
(1999)
Blood
, vol.94
, pp. 3178-3184
-
-
Kaufman, R.M.1
Pham, C.T.2
Ley, T.J.3
-
11
-
-
18144377035
-
Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment
-
Vadolas, J., Wardan, H., Bosmans, M., Zaibak, F., Jamsai, D., Voullaire, L., Williamson, R., and Ioannou, P. A. (2005) Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment. Biochim. Biophys. Acta 1728, 150-162
-
(2005)
Biochim. Biophys. Acta
, vol.1728
, pp. 150-162
-
-
Vadolas, J.1
Wardan, H.2
Bosmans, M.3
Zaibak, F.4
Jamsai, D.5
Voullaire, L.6
Williamson, R.7
Ioannou, P.A.8
-
12
-
-
20144373162
-
A humanized mouse model for a common beta0-thalassemia mutation
-
Jamsai, D., Zaibak, F., Khongnium, W., Vadolas, J., Voullaire, L., Fowler, K. J., Gazeas, S., Fucharoen, S., Williamson, R., and Ioannou, P. A. (2005) A humanized mouse model for a common beta0-thalassemia mutation. Genomics 85, 453-461
-
(2005)
Genomics
, vol.85
, pp. 453-461
-
-
Jamsai, D.1
Zaibak, F.2
Khongnium, W.3
Vadolas, J.4
Voullaire, L.5
Fowler, K.J.6
Gazeas, S.7
Fucharoen, S.8
Williamson, R.9
Ioannou, P.A.10
-
13
-
-
33747785548
-
A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia
-
Jamsai, D., Zaibak, F., Vadolas, J., Voullaire, L., Fowler, K. J., Gazeas, S., Peters, H., Fucharoen, S., Williamson, R., and Ioannou, P. A. (2006) A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia. Genomics 88, 309-315
-
(2006)
Genomics
, vol.88
, pp. 309-315
-
-
Jamsai, D.1
Zaibak, F.2
Vadolas, J.3
Voullaire, L.4
Fowler, K.J.5
Gazeas, S.6
Peters, H.7
Fucharoen, S.8
Williamson, R.9
Ioannou, P.A.10
-
14
-
-
33646368694
-
Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation
-
Vadolas, J., Nefedov, M., Wardan, H., Mansooriderakshan, S., Voullaire, L., Jamsai, D., Williamson, R., and Ioannou, P. A. (2006) Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation. J. Biol. Chem. 281, 7399-7405
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 7399-7405
-
-
Vadolas, J.1
Nefedov, M.2
Wardan, H.3
Mansooriderakshan, S.4
Voullaire, L.5
Jamsai, D.6
Williamson, R.7
Ioannou, P.A.8
-
15
-
-
77955906235
-
Fetal globin gene inducers: Novel agents and new potential
-
Perrine, S. P., Castaneda, S. A., Chui, D. H. K., Faller, D. V., Berenson, R. J., Siritanaratku, N., and Fucharoen, S. (2010) Fetal globin gene inducers: novel agents and new potential. Ann. N. Y. Acad. Sci. 1202, 158-164
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1202
, pp. 158-164
-
-
Perrine, S.P.1
Castaneda, S.A.2
Chui, D.H.K.3
Faller, D.V.4
Berenson, R.J.5
Siritanaratku, N.6
Fucharoen, S.7
-
16
-
-
80052651626
-
A pilot study of subcutaneous decitabine in β-thalassemia intermedia
-
Olivieri, N. F., Saunthararajah, Y., Thayalasuthan, V., Kwiatkowski, J., Ware, R. E., Kuypers, F. A., Kim, H.-Y., Trachtenberg, F. L., and Vichinsky, E. P. (2011) A pilot study of subcutaneous decitabine in β-thalassemia intermedia. Blood 118, 2708-2711
-
(2011)
Blood
, vol.118
, pp. 2708-2711
-
-
Olivieri, N.F.1
Saunthararajah, Y.2
Thayalasuthan, V.3
Kwiatkowski, J.4
Ware, R.E.5
Kuypers, F.A.6
Kim, H.-Y.7
Trachtenberg, F.L.8
Vichinsky, E.P.9
-
17
-
-
84876810376
-
A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia
-
Fucharoen, S., Inati, A., Siritanaratku, N., Thein, S. L., Wargin, W. C., Koussa, S., Taher, A., Chaneim, N., Boosalis, M., Berenson, R., and Perrine, S. P. (2013) A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia. Br. J. Haematol. 161, 587-593
-
(2013)
Br. J. Haematol.
, vol.161
, pp. 587-593
-
-
Fucharoen, S.1
Inati, A.2
Siritanaratku, N.3
Thein, S.L.4
Wargin, W.C.5
Koussa, S.6
Taher, A.7
Chaneim, N.8
Boosalis, M.9
Berenson, R.10
Perrine, S.P.11
-
18
-
-
1642433141
-
Cellular genomic reporter assays for screening and evaluation of inducers of fetal hemoglobin
-
Vadolas, J., Wardan, H., Orford, M., Williamson, R., and Ioannou, P. A. (2004) Cellular genomic reporter assays for screening and evaluation of inducers of fetal hemoglobin. Hum. Mol. Genet. 13, 223-233
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 223-233
-
-
Vadolas, J.1
Wardan, H.2
Orford, M.3
Williamson, R.4
Ioannou, P.A.5
-
19
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl, M. W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45
-
(2001)
Nucleic Acids Res.
, vol.29
-
-
Pfaffl, M.W.1
-
20
-
-
0037370698
-
Circulation is established in a stepwise pattern in the mammalian embryo
-
McGrath, K. E., Koniski, A. D., Malik, J., and Palis, J. (2003) Circulation is established in a stepwise pattern in the mammalian embryo. Blood 101, 1669-1676
-
(2003)
Blood
, vol.101
, pp. 1669-1676
-
-
McGrath, K.E.1
Koniski, A.D.2
Malik, J.3
Palis, J.4
-
21
-
-
32644438114
-
Maturational' globin switching in primary primitive erythroid cells
-
Kingsley, P. D., Malik, J., Emerson, R. L., Bushnell, T. P., McGrath, K. E., Bloedorn, L. A., Bulger, M., and Palis, J. (2006) 'Maturational' globin switching in primary primitive erythroid cells. Blood 107, 1665-1672
-
(2006)
Blood
, vol.107
, pp. 1665-1672
-
-
Kingsley, P.D.1
Malik, J.2
Emerson, R.L.3
Bushnell, T.P.4
McGrath, K.E.5
Bloedorn, L.A.6
Bulger, M.7
Palis, J.8
-
22
-
-
34548016809
-
Developmental-and differentiationspecific patterns of human gamma-and beta-globin promoter DNA methylation
-
Mabaera, R., Richardson, C. A., Johnson, K., Hsu, M., Fiering, S., and Lowrey, C. H. (2007) Developmental-and differentiationspecific patterns of human gamma-and beta-globin promoter DNA methylation. Blood 110, 1343-1352
-
(2007)
Blood
, vol.110
, pp. 1343-1352
-
-
Mabaera, R.1
Richardson, C.A.2
Johnson, K.3
Hsu, M.4
Fiering, S.5
Lowrey, C.H.6
-
23
-
-
78649348968
-
Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription
-
Akpan, I., Banzon, V., Ibanez, V., Vaitkus, K., DeSimone, J., and Lavelle, D. (2010) Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription. Exp. Hematol. 38, 989-993.e1
-
(2010)
Exp. Hematol.
, vol.38
-
-
Akpan, I.1
Banzon, V.2
Ibanez, V.3
Vaitkus, K.4
Desimone, J.5
Lavelle, D.6
-
24
-
-
43949136445
-
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
-
Stresemann, C., and Lyko, F. (2008) Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int. J. Cancer 123, 8-13
-
(2008)
Int. J. Cancer
, vol.123
, pp. 8-13
-
-
Stresemann, C.1
Lyko, F.2
-
25
-
-
84867818765
-
Reawakening fetal hemoglobin: Prospects for new therapies for the β-globin disorders
-
Bauer, D. E., Kamran, S. C., and Orkin, S. H. (2012) Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. Blood 120, 2945-2953
-
(2012)
Blood
, vol.120
, pp. 2945-2953
-
-
Bauer, D.E.1
Kamran, S.C.2
Orkin, S.H.3
-
26
-
-
34547450531
-
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
-
Thein, S. L., Menzel, S., Peng, X., Best, S., Jiang, J., Close, J., Silver, N., Gerovasilli, A., Ping, C., Yamaguchi, M., Wahlberg, K., Ulug, P., Spector, T. D., Garner, C., Matsuda, F., Farrall, M., and Lathrop, M. (2007) Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc. Natl. Acad. Sci. U. S. A. 104, 11346-11351
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 11346-11351
-
-
Thein, S.L.1
Menzel, S.2
Peng, X.3
Best, S.4
Jiang, J.5
Close, J.6
Silver, N.7
Gerovasilli, A.8
Ping, C.9
Yamaguchi, M.10
Wahlberg, K.11
Ulug, P.12
Spector, T.D.13
Garner, C.14
Matsuda, F.15
Farrall, M.16
Lathrop, M.17
-
27
-
-
40349092939
-
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia
-
Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W., Usala, G., Busonero, F., Maschio, A., Albai, G., Piras, M. G., Sestu, N., Lai, S., Dei, M., Mulas, A., Crisponi, L., Naitza, S., Asunis, I., Deiana, M., Nagaraja, R., Perseu, L., Satta, S., Cipollina, M. D., Sollaino, C., Moi, P., Hirschhorn, J. N., Orkin, S. H., Abecasis, G. R., Schlessinger, D., and Cao, A. (2008) Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc. Natl. Acad. Sci. U. S. A. 105, 1620-1625
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 1620-1625
-
-
Uda, M.1
Galanello, R.2
Sanna, S.3
Lettre, G.4
Sankaran, V.G.5
Chen, W.6
Usala, G.7
Busonero, F.8
Maschio, A.9
Albai, G.10
Piras, M.G.11
Sestu, N.12
Lai, S.13
Dei, M.14
Mulas, A.15
Crisponi, L.16
Naitza, S.17
Asunis, I.18
Deiana, M.19
Nagaraja, R.20
Perseu, L.21
Satta, S.22
Cipollina, M.D.23
Sollaino, C.24
Moi, P.25
Hirschhorn, J.N.26
Orkin, S.H.27
Abecasis, G.R.28
Schlessinger, D.29
Cao, A.30
more..
-
28
-
-
77956622584
-
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
-
Borg, J., Papadopoulos, P., Georgitsi, M., Gutiérrez, L., Grech, G., Fanis, P., Phylactides, M., Verkerk, A. J. M. H., van der Spek, P. J., Scerri, C. A., Cassar, W., Galdies, R., van Ijcken, W., Ozgür, Z., Gillemans, N., Hou, J., Bugeja, M., Grosveld, F. G., von Lindern, M., Felice, A. E., Patrinos, G. P., and Philipsen, S. (2010) Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat. Genet. 42, 801-805
-
(2010)
Nat. Genet.
, vol.42
, pp. 801-805
-
-
Borg, J.1
Papadopoulos, P.2
Georgitsi, M.3
Gutiérrez, L.4
Grech, G.5
Fanis, P.6
Phylactides, M.7
Verkerk, A.J.M.H.8
Van Der Spek, P.J.9
Scerri, C.A.10
Cassar, W.11
Galdies, R.12
Van Ijcken, W.13
Ozgür, Z.14
Gillemans, N.15
Hou, J.16
Bugeja, M.17
Grosveld, F.G.18
Von Lindern, M.19
Felice, A.E.20
Patrinos, G.P.21
Philipsen, S.22
more..
-
29
-
-
34748864128
-
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
-
Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., Foglio, M., Zelenika, D., Boland, A., Rooks, H., Best, S., Spector, T. D., Farrall, M., Lathrop, M., and Thein, S. L. (2007) A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat. Genet. 39, 1197-1199
-
(2007)
Nat. Genet.
, vol.39
, pp. 1197-1199
-
-
Menzel, S.1
Garner, C.2
Gut, I.3
Matsuda, F.4
Yamaguchi, M.5
Heath, S.6
Foglio, M.7
Zelenika, D.8
Boland, A.9
Rooks, H.10
Best, S.11
Spector, T.D.12
Farrall, M.13
Lathrop, M.14
Thein, S.L.15
-
30
-
-
50149117726
-
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
-
Lettre, G., Sankaran, V. G., Bezerra, M. A. C., Araújo, A. S., Uda, M., Sanna, S., Cao, A., Schlessinger, D., Costa, F. F., Hirschhorn, J. N., and Orkin, S. H. (2008) DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc. Natl. Acad. Sci. U. S. A. 105, 11869-11874
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 11869-11874
-
-
Lettre, G.1
Sankaran, V.G.2
Bezerra, M.A.C.3
Araújo, A.S.4
Uda, M.5
Sanna, S.6
Cao, A.7
Schlessinger, D.8
Costa, F.F.9
Hirschhorn, J.N.10
Orkin, S.H.11
-
31
-
-
53149150933
-
BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies
-
Sedgewick, A. E., Timofeev, N., Sebastiani, P., So, J. C. C., Ma, E. S. K., Chan, L. C., Fucharoen, G., Fucharoen, S., Barbosa, C. G., Vardarajan, B. N., Farrer, L. A., Baldwin, C. T., Steinberg, M. H., and Chui, D. H. (2008) BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies. Blood Cells Mol. Dis. 41, 255-258
-
(2008)
Blood Cells Mol. Dis.
, vol.41
, pp. 255-258
-
-
Sedgewick, A.E.1
Timofeev, N.2
Sebastiani, P.3
So, J.C.C.4
Ma, E.S.K.5
Chan, L.C.6
Fucharoen, G.7
Fucharoen, S.8
Barbosa, C.G.9
Vardarajan, B.N.10
Farrer, L.A.11
Baldwin, C.T.12
Steinberg, M.H.13
Chui, D.H.14
-
32
-
-
33947223723
-
Congenital erythropoietic porphyria due to a mutation in GATA1: The first trans-acting mutation causative for a human porphyria
-
Phillips, J. D., Steensma, D. P., Pulsipher, M. A., Spangrude, G. J., and Kushner, J. P. (2007) Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria. Blood 109, 2618-2621
-
(2007)
Blood
, vol.109
, pp. 2618-2621
-
-
Phillips, J.D.1
Steensma, D.P.2
Pulsipher, M.A.3
Spangrude, G.J.4
Kushner, J.P.5
-
33
-
-
78549244494
-
Fetal globin expression is regulated by Friend of Prmt1
-
Van Dijk, T. B., Gillemans, N., Pourfarzad, F., van Lom, K., von Lindern, M., Grosveld, F., and Philipsen, S. (2010) Fetal globin expression is regulated by Friend of Prmt1. Blood 116, 4349-4352
-
(2010)
Blood
, vol.116
, pp. 4349-4352
-
-
Van Dijk, T.B.1
Gillemans, N.2
Pourfarzad, F.3
Van Lom, K.4
Von Lindern, M.5
Grosveld, F.6
Philipsen, S.7
-
34
-
-
77950930726
-
Transcriptional silencing of β-globin by BCL11A involves long-range interactions and cooperation with SOX6
-
Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., and Orkin, S. H. (2010) Transcriptional silencing of β-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev. 24, 783-798
-
(2010)
Genes Dev.
, vol.24
, pp. 783-798
-
-
Xu, J.1
Sankaran, V.G.2
Ni, M.3
Menne, T.F.4
Puram, R.V.5
Kim, W.6
Orkin, S.H.7
-
35
-
-
34247569022
-
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4
-
Tanabe, O., McPhee, D., Kobayashi, S., Shen, Y., Brandt, W., Jiang, X., Campbell, A. D., Chen, Y.-T., Chang, C., Yamamoto, M., Tanimoto, K., and Engel, J. D. (2007) Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J. 26, 2295-2306
-
(2007)
EMBO J.
, vol.26
, pp. 2295-2306
-
-
Tanabe, O.1
McPhee, D.2
Kobayashi, S.3
Shen, Y.4
Brandt, W.5
Jiang, X.6
Campbell, A.D.7
Chen, Y.-T.8
Chang, C.9
Yamamoto, M.10
Tanimoto, K.11
Engel, J.D.12
-
36
-
-
77955350385
-
Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis
-
Fraser, S. T., Isern, J., and Baron, M. H. (2010) Use of transgenic fluorescent reporter mouse lines to monitor hematopoietic and erythroid development during embryogenesis. Methods Enzymol. 476, 403-427
-
(2010)
Methods Enzymol.
, vol.476
, pp. 403-427
-
-
Fraser, S.T.1
Isern, J.2
Baron, M.H.3
-
37
-
-
0028305957
-
Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis
-
Thorpe, S. J., Thein, S.L., Sampietro, M., Craig, J. E., Mahon, B., and Huehns, E. R. (1994) Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis. Br. J. Haematol. 87, 125-132
-
(1994)
Br. J. Haematol.
, vol.87
, pp. 125-132
-
-
Thorpe, S.J.1
Thein, S.L.2
Sampietro, M.3
Craig, J.E.4
Mahon, B.5
Huehns, E.R.6
-
38
-
-
43249098151
-
Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the-566 GATA site
-
Harju-Baker, S., Costa, F. C., Fedosyuk, H., Neades, R., and Peterson, K. R. (2008) Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the-566 GATA site. Mol. Cell. Biol. 28, 3101-3113
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3101-3113
-
-
Harju-Baker, S.1
Costa, F.C.2
Fedosyuk, H.3
Neades, R.4
Peterson, K.R.5
-
39
-
-
84872022660
-
Mi2β is required for γ-globin gene silencing: Temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in -YAC transgenic mice
-
Costa, F. C., Fedosyuk, H., Chazelle, A. M., Neades, R. Y., and Peterson, K. R. (2012) Mi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in -YAC transgenic mice. PLoS Genet. 8, e1003155
-
(2012)
PLoS Genet
, vol.8
-
-
Costa, F.C.1
Fedosyuk, H.2
Chazelle, A.M.3
Neades, R.Y.4
Peterson, K.R.5
-
40
-
-
84871266959
-
A dual reporter mouse model of the human β-globin locus: Applications and limitations
-
Papadopoulos, P., Gutiérrez, L., van der Linden, R., Kong-ASan, J., Maas, A., Drabek, D., Patrinos, G. P., Philipsen, S., and Grosveld, F. (2012) A dual reporter mouse model of the human β-globin locus: applications and limitations. PLoS ONE 7, e51272
-
(2012)
PLoS ONE
, vol.7
-
-
Papadopoulos, P.1
Gutiérrez, L.2
Van Der Linden, R.3
Kong-Asan, J.4
Maas, A.5
Drabek, D.6
Patrinos, G.P.7
Philipsen, S.8
Grosveld, F.9
-
41
-
-
0020466344
-
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta thalassemia
-
Ley, T. J., DeSimone, J., Anagnou, N. P., Keller, G. H., Humphries, R. K., Turner, P. H., Young, N. S., Keller, P., and Nienhuis, A. W. (1982) 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta thalassemia. N. Engl. J. Med. 307, 1469-1475
-
(1982)
N. Engl. J. Med.
, vol.307
, pp. 1469-1475
-
-
Ley, T.J.1
Desimone, J.2
Anagnou, N.P.3
Keller, G.H.4
Humphries, R.K.5
Turner, P.H.6
Young, N.S.7
Keller, P.8
Nienhuis, A.W.9
-
42
-
-
84875230084
-
Lysinespecific demethylase 1 is a therapeutic target for fetal hemoglobin induction
-
Shi, L., Cui, S., Engel, J. D., and Tanabe, O. (2013) Lysinespecific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat. Med. 19, 291-294
-
(2013)
Nat. Med.
, vol.19
, pp. 291-294
-
-
Shi, L.1
Cui, S.2
Engel, J.D.3
Tanabe, O.4
-
43
-
-
84876239967
-
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A
-
Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., and Orkin, S. H. (2013) Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc. Natl. Acad. Sci. U. S. A. 110, 6518-6523
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 6518-6523
-
-
Xu, J.1
Bauer, D.E.2
Kerenyi, M.A.3
Vo, T.D.4
Hou, S.5
Hsu, Y.-J.6
Yao, H.7
Trowbridge, J.J.8
Mandel, G.9
Orkin, S.H.10
-
44
-
-
84876258481
-
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells
-
Amaya, M., Desai, M., Gnanapragasam, M. N., Wang, S. Z., Zhu, S. Z., Williams, D. C., Jr., and Ginder, G. D. (2013) Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells. Blood 121, 3493-3501
-
(2013)
Blood
, vol.121
, pp. 3493-3501
-
-
Amaya, M.1
Desai, M.2
Gnanapragasam, M.N.3
Wang, S.Z.4
Zhu, S.Z.5
Williams Jr., D.C.6
Ginder, G.D.7
-
45
-
-
0021034956
-
Molecular mechanisms of human hemoglobin switching: Selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts
-
Mavilio, F., Giampaolo, A., Carè, A., Migliaccio, G., Calandrini, M., Russo, G., Pagliardi, G. L., Mastroberardino, G., Marinucci, M., and Peschle, C. (1983) Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts. Proc. Natl. Acad. Sci. U. S. A. 80, 6907-6911
-
(1983)
Proc. Natl. Acad. Sci. U. S. A.
, vol.80
, pp. 6907-6911
-
-
Mavilio, F.1
Giampaolo, A.2
Carè, A.3
Migliaccio, G.4
Calandrini, M.5
Russo, G.6
Pagliardi, G.L.7
Mastroberardino, G.8
Marinucci, M.9
Peschle, C.10
-
46
-
-
33645302131
-
Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis
-
Lavelle, D., Vaitkus, K., Hankewych, M., Singh, M., and DeSimone, J. (2006) Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis. Blood Cells Mol. Dis. 36, 269-278
-
(2006)
Blood Cells Mol. Dis.
, vol.36
, pp. 269-278
-
-
Lavelle, D.1
Vaitkus, K.2
Hankewych, M.3
Singh, M.4
Desimone, J.5
-
47
-
-
78650181399
-
SiDNMT1 increases β-globin expression in chemical inducer of dimerization (CID)-dependent mouse-YAC bone marrow cells and in baboon erythroid progenitor cell cultures
-
Banzon, V., Ibanez, V., Vaitkus, K., Ruiz, M. A., Peterson, K., DeSimone, J., and Lavelle, D. (2011) siDNMT1 increases β-globin expression in chemical inducer of dimerization (CID)-dependent mouse-YAC bone marrow cells and in baboon erythroid progenitor cell cultures. Exp. Hematol. 39, 26-36.e1
-
(2011)
Exp. Hematol.
, vol.39
-
-
Banzon, V.1
Ibanez, V.2
Vaitkus, K.3
Ruiz, M.A.4
Peterson, K.5
Desimone, J.6
Lavelle, D.7
-
48
-
-
79961145533
-
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells
-
Cui, S., Kolodziej, K. E., Obara, N., Amaral-Psarris, A., Demmers, J., Shi, L., Engel, J. D., Grosveld, F., Strouboulis, J., and Tanabe, O. (2011) Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol. Cell. Biol. 31, 3298-3311
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3298-3311
-
-
Cui, S.1
Kolodziej, K.E.2
Obara, N.3
Amaral-Psarris, A.4
Demmers, J.5
Shi, L.6
Engel, J.D.7
Grosveld, F.8
Strouboulis, J.9
Tanabe, O.10
-
49
-
-
0030923438
-
Induction of gamma-globin by histone deacetylase inhibitors
-
McCaffrey, P. G., Newsome, D. A., Fibach, E., Yoshida, M., and Su, M. S. (1997) Induction of gamma-globin by histone deacetylase inhibitors. Blood 90, 2075-2083
-
(1997)
Blood
, vol.90
, pp. 2075-2083
-
-
McCaffrey, P.G.1
Newsome, D.A.2
Fibach, E.3
Yoshida, M.4
Su, M.S.5
-
50
-
-
84856606869
-
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine
-
Lavelle, D., Vaitkus, K., Ling, Y., Ruiz, M. A., Mahfouz, R., Ng, K. P., Negrotto, S., Smith, N., Terse, P., Engelke, K. J., Covey, J., Chan, K. K., Desimone, J., and Saunthararajah, Y. (2012) Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine. Blood 119, 1240-1247
-
(2012)
Blood
, vol.119
, pp. 1240-1247
-
-
Lavelle, D.1
Vaitkus, K.2
Ling, Y.3
Ruiz, M.A.4
Mahfouz, R.5
Ng, K.P.6
Negrotto, S.7
Smith, N.8
Terse, P.9
Engelke, K.J.10
Covey, J.11
Chan, K.K.12
Desimone, J.13
Saunthararajah, Y.14
-
51
-
-
84860893776
-
Generation of a genomic reporter assay system for analysis of γ-And β-globin gene regulation
-
Chan, K. S. K., Xu, J., Wardan, H., McColl, B., Orkin, S., and Vadolas, J. (2012) Generation of a genomic reporter assay system for analysis of γ-and β-globin gene regulation. FASEB J. 26, 1736-1744
-
(2012)
FASEB J.
, vol.26
, pp. 1736-1744
-
-
Chan, K.S.K.1
Xu, J.2
Wardan, H.3
McColl, B.4
Orkin, S.5
Vadolas, J.6
|