MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation

Cell Death and Disease

Volumn 5, Issue 4, 2014, Pages

  Zhuang, L K ^a   Xu, G P ^a   Pan, X R ^a   Lou, Y J ^a   Zou, Q P ^a   Xia, D ^a   Yan, W W ^a   Zhang, Y T ^a   Jia, P M ^a   Tong, J H ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

AC9; APL; cAMP; Cell differentiation; MiR 181a

Indexed keywords

ADENYLATE CYCLASE; BIOLOGICAL MARKER; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MICRORNA; MICRORNA 181A; PROTEIN AC9; RETINOIC ACID; RETINOIC ACID RECEPTOR; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; ADENYLATE CYCLASE 9; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; MESSENGER RNA; MIRN181 MICRORNA, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIAGNOSTIC VALUE; DOWN REGULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKEMOGENESIS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; SECOND MESSENGER; 3' UNTRANSLATED REGION; BIOLOGICAL MODEL; CARCINOGENESIS; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; INTRACELLULAR SPACE; METABOLISM; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ADENYLATE CYCLASE; CARCINOGENESIS; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYCLIC AMP; DOWN-REGULATION; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SPACE; LEUKEMIA, PROMYELOCYTIC, ACUTE; MICRORNAS; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; TRETINOIN;

EID: 84901004214     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.130     Document Type: Article

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