A sustained increase in the endogenous level of cAMP reduces the retinoid concentration required for APL cell maturation to near physiological levels

Leukemia

Volumn 12, Issue 11, 1998, Pages 1829-1833

  Quenech'Du, N ^a   Ruchaud, S ^a   Khelef, N ^b   Guiso, N ^b   Lanotte, M ^a  

^a INSERM   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

cAMPp; Differentiation; Leukemia; Retinoids

Indexed keywords

ADENYLATE CYCLASE; BACTERIAL ENZYME; CYCLIC AMP; RETINOID;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BORDETELLA PERTUSSIS; CELL MATURATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

EID: 0031752849     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401171     Document Type: Article

References (4)

1. Huang ME, Ye CY, Chen SR, Chai JC, Lu JX, Zhoa L, Gu LG, Wang Z. Use of all-trans retinoic acid in the treatment of acute promyelocyic leukemia. Blood 1988; 72: 567-572.
2. Grignani F, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo Cocco F, Grignani F, Pelicci PG. Acute promyelocytic leukemia: from genetics to treatment. Blood 1994; 83: 1025.
3. Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L. All trans-retinoic acid as a differentiation therapy for acute promyelocytic leukemia: I. Clinical results. Blood 1990; 76: 1704-1709.
4. Warrell RP. Retinoid resistance in acute promyelocytic leukemia, new mechanisms, strategies and implications. Blood 1993; 82: 1949-1953.