NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 20, 2014, Pages

  Jaworska, Joanna ^a   Coulombe, François ^a   Downey, Jeffrey ^a   Tzelepis, Fanny ^a   Shalaby, Karim ^a   Tattoli, Ivan ^b   Berube, Julie ^a   Rousseau, Simon ^a   Martin, James G ^a   Girardin, Stephen E ^b   McCullers, Jonathan A ^c,d   Divangahi, Maziar ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR X1; PB1 F2 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H1N1); INFLUENZA VIRUS A H1N1; INNATE IMMUNITY; LEUKOCYTE; LOSS OF FUNCTION MUTATION; LUNG DISEASE; MACROPHAGE; MITOCHONDRION; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS IMMUNITY; VIRUS LOAD; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN;

INNATE IMMUNITY; NOD-LIKE RECEPTOR;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; INFLAMMATION; INFLUENZA A VIRUS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84901002026     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322118111     Document Type: Article

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