Blunting of the HPA-axis underlies the lack of preventive efficacy of early post-stressor single-dose Delta-9-tetrahydrocannabinol (THC)

Pharmacology Biochemistry and Behavior

Volumn 122, Issue , 2014, Pages 307-318

  Mayer, Tzur Alexander ^a   Matar, Michael Alex ^a   Kaplan, Zeev ^a   Zohar, Joseph ^b   Cohen, Hagit ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Animal model; CB1 antagonist inverse agonist; Delta 9 tetrahydrocannabinol ( 9 THC); Early drug intervention; Posttraumatic stress disorder; Secondary prevention

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CORTICOSTERONE; DRONABINOL;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL STRESS; CORTICOSTERONE BLOOD LEVEL; DRUG EFFICACY; FREEZING; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; SECONDARY PREVENTION; SINGLE DRUG DOSE; STARTLE REFLEX; TRANQUILIZING ACTIVITY; ANIMAL; DRUG EFFECTS; DRUG THERAPY; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MENTAL STRESS; METABOLISM; PREVENTION AND CONTROL; SPRAGUE DAWLEY RAT; TIME; TREATMENT OUTCOME;

ANIMALS; DRONABINOL; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL; TIME FACTORS; TREATMENT OUTCOME;

EID: 84901001657     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.04.014     Document Type: Article

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