New compounds from acid hydrolyzed products of the fruits of Momordica charantia L. and their inhibitory activity against protein tyrosine phosphatas 1B

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 176-180

  Zeng, Ke ^a   He, Yan Ni ^a   Yang, Di ^a   Cao, Jia Qing ^a   Xia, Xi Chun ^b   Zhang, Shi Jun ^b   Bi, Xiu Li ^b   Zhao, Yu Qing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY   (China)

Author keywords

Cucurbitane type triterpene sapogenins; Momordica charantia L.; PTP1B; X ray techniques

Indexed keywords

3BETA,7BETA,25 TRIHYDROXY CUCURBITA DIENE 19 AL; 5BETA,19 EPOXY 19 METHOXY CUCURBITA 6,23 DIEN 3BETA,25 DIOL; 5BETA,19 EPOXY 19 METHOXY CUCURBITA 6,23,25 TRIEN 3BETA O L; 5BETA,19 EPOXY 19,25 DIMETHOXYCUCURBITA 6,23 DIEN 3BETA OL; 5BETA,19 EPOXY CUCURBITA 6,23,25 TRIEN 3BETA 19DIOL; ANTIDIABETIC AGENT; KUGUACIN E; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; STIGMASTA 7,25(27)DIEN 3BETAOL; UNCLASSIFIED DRUG; ACID; ENZYME INHIBITOR;

ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; FRUIT; HYDROLYSIS; MASS SPECTROMETRY; MOMORDICA CHARANTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; ISOLATION AND PURIFICATION; METABOLISM;

ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FRUIT; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOMORDICA CHARANTIA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84900838033     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.066     Document Type: Article

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