Role of Ras, ERK, and Akt in glucocorticoid-induced differentiation of embryonic rat somatotropes in vitro

Molecular and Cellular Biochemistry

Volumn 391, Issue 1-2, 2014, Pages 67-75

  Lv, Wen Ming ^a   Zhao, Yan ^a   Yang, Guang ^a   Dong, Shi Yun ^a   Zhang, Guang Hui ^b   Zhang, Yu ^a   Li, Guo Zhong ^a   Cheng, Yu ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Liaocheng Dongchangfu People's Hospital   (China)

Author keywords

Dexamethasone; Differentiation; Growth hormone; Kinase; Pituitary

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; ACTIVATED RAS; DEXAMETHASONE; GLUCOCORTICOID; GROWTH HORMONE; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN KINASE B; RAS PROTEIN; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; AMIDE; CHROMONE DERIVATIVE; FIBROBLAST GROWTH FACTOR 2; MORPHOLINE DERIVATIVE; NITRILE; POLYENE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; GROWTH HORMONE RELEASE; GROWTH HORMONE SECRETING CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; RAT; RAT EMBRYO; WESTERN BLOTTING; ANIMAL; ANIMAL EMBRYO; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BUTADIENES; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMONES; DEXAMETHASONE; EMBRYO, MAMMALIAN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; GLUCOCORTICOIDS; GROWTH HORMONE; MORPHOLINES; NITRILES; PHOSPHORYLATION; POLYENES; POLYUNSATURATED ALKAMIDES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; RATS, SPRAGUE-DAWLEY; SOMATOTROPHS;

EID: 84900830921     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-1988-4     Document Type: Article

References (28)

1. Godfrey P, Rahal JO, Beamer WG, Copeland NG, Jenkins NA, Mayo KE (1993) GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 4:227-232 (Pubitemid 23205169)
2. Liu L, Porter TE (2004) Endogenous thyroid hormones modulate pituitary somatotroph differentiation during chicken embryonic development. J Endocrinol 180:45-53 (Pubitemid 38180756)
3. Cheng K-H, Ponte JF, Thiagalingam S (2004) Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display. Cancer Res 64:1639-1646 (Pubitemid 38428684)
4. Cintra A, Solfrini V, Bunnemann B, Okret S, Bortolotti F, Gustafsson JA, Fuxe K (1993) Prenatal development of glucocorticoid receptor gene expression and immunoreactivity in the rat brain and pituitary gland: a combined in situ hybridization and immunocytochemical analysis. Neuroendocrinology 57:1133-1147 (Pubitemid 23260792)
5. Bossis I, Porter TE (2003) Evaluation of glucocorticoid-induced growth hormone gene expression in chicken embryonic pituitary cells using a novel in situ mRNA quantitation method. Mol Cell Endocrinol 201:13-23 (Pubitemid 36434277)
6. Cheng Y, Xiang Y, Lin Y, Fu S, Jia W, Zhang G, Lv W, Mi S, Zhao Q (2011) Retinoic acid and dexamethasone induce differentiation and maturation of somatotroph cells at different stages in vitro. Endocr J 58:177-184
7. Cook SA, Clerk A, Sugden PH (2009) Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? J Mol Cell Cardiol 46:118-129
8. Rich T, Allen RL, Wyllie AH (2000) Defying death after DNA damage. Nature 407:777-783
9. Uhlirova M, Jasper H, Bohmann D (2005) Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci USA 102:13123-13128 (Pubitemid 41324989)
10. Bhat NR, Zhang P, Lee JC, Hogan EL (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18:1633-1641 (Pubitemid 28103071)
11. Xue L, Fletcher GC, Tolkovsky AM (1999) Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol Cell Neurosci 14:180-198 (Pubitemid 29449222)
12. Kaminska B (2005) MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta 1754:253-262. doi:10.1016/j.bbapap.2005.08.017
13. Mitra SK, Hanson DA, Schlaepfer DD (2005) Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6:56-68 (Pubitemid 40064899)
14. Schlaepfer DD, Mitra SK (2004) Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev 14:92-9101
15. Tafolla E, Wang S, Wong B, Leong J, Kapila YL (2005) JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem 280:19992-19999 (Pubitemid 41379528)
16. Kimura A, Ohmichi M, Tasaka K, Kanda Y, Ikegami H, Hayakawa J, Hisamoto K, Morishige K, Hinuma S, Kurachi H, Murata Y (2000) Prolactin-releasing peptide activation of the prolactin promoter is differentially mediated by extracellular signal-regulated protein kinase and c-Jun N-terminal protein kinase. J Biol Chem 275:3667-3674 (Pubitemid 30083078)
17. Boudouresque F, Guillaume V, Grino M, Strbak V, Chautard T, Conte-Devolx B, Oliver C (1988) Maturation of the pituitary-adrenal function in rat fetuses. Neuroendocrinology 48:417-422
18. Mogi C, Goda H, Mogi K, Takaki A, Yokoyama K, Tomida M, Inoue K (2005) Multistep differentiation of GH-producing cells from their immature cells. J Endocrinol 184:41-50 (Pubitemid 40207559)
19. Nogami H, Inoue K, Kawamura K (1997) Involvement of glucocorticoid- induced factor(s) in the stimulation of growth hormone expression in the fetal rat pituitary gland in vitro. Endocrinology 138:1810-1815 (Pubitemid 27180793)
20. Buday L, Downward J (2008) Many faces of Ras activation. Biochim Biophys Acta 1786:178-187
21. Pan J, Chen B, Su C-H, Zhao R, Xu Z-X, Sun L, Lee M-H, Yeung S-CJ (2008) Autophagy induced by farnesyltransferase inhibitors in cancer cells. Cancer Biol Ther 7:1679-1684
22. Scully KM, Rosenfeld MG (2002) Pituitary development: regulatory codes in mammalian organogenesis. Science 295:2231-2235 (Pubitemid 34258830)
23. Kumar V, Zhang M-X, Swank MW, Kunz J, Wu G-Y (2005) Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways. J Neurosci 25:11288-11299 (Pubitemid 43083703)
24. Petersenn S, Maaser C, Schulte HM (1997) Transcriptional activation of the human growth hormone gene by Ras oncogene. Mol Cell Endocrinol 129:47-54 (Pubitemid 27229216)
25. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101. doi:10.1126/science.1106148 (Pubitemid 40262113)
26. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7:261-269 (Pubitemid 27176852)
27. Pombo CM, Zalvide J, Gaylinn BD, Dieguez C (2000) Growth hormone-releasing hormone stimulates mitogen-activated protein kinase. Endocrinology 141:2113-2119 (Pubitemid 32274364)
28. Sun C, He M, Ko WK, Wong AO (2013) Mechanisms for luteinizing hormone induction of growth hormone gene transcription in fish model: crosstalk of the cAMP/PKA pathway with MAPK-and PI3K-dependent cascades. Mol Cell Endocrinol 382:835-850. doi:10.1016/j.mce.2013.10.017