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Volumn 256, Issue , 2014, Pages 133-143

Modeling Parkinson's disease in monkeys for translational studies, a critical analysis

Author keywords

Dyskinesia; Model; MPTP; Non human primate; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; LEVODOPA;

EID: 84900826387     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.09.014     Document Type: Review
Times cited : (57)

References (58)
  • 1
    • 0023254201 scopus 로고
    • Peripheral effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its main metabolite 1-methyl-4-phenylpyridinium ion (MPP+) in the rat
    • Algeri S., Ambrosio S., Garofalo P., Gerli P. Peripheral effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its main metabolite 1-methyl-4-phenylpyridinium ion (MPP+) in the rat. Eur. J. Pharmacol. 1987, 141:309-312.
    • (1987) Eur. J. Pharmacol. , vol.141 , pp. 309-312
    • Algeri, S.1    Ambrosio, S.2    Garofalo, P.3    Gerli, P.4
  • 2
    • 0023772213 scopus 로고
    • Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines in heart, adrenal gland, retina and caudate nucleus of the cat
    • Ambrosio S., Blesa R., Mintenig G.M., Palacios-Araus L., Mahy N., Gual A. Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines in heart, adrenal gland, retina and caudate nucleus of the cat. Toxicol. Lett. 1988, 44:1-6.
    • (1988) Toxicol. Lett. , vol.44 , pp. 1-6
    • Ambrosio, S.1    Blesa, R.2    Mintenig, G.M.3    Palacios-Araus, L.4    Mahy, N.5    Gual, A.6
  • 3
    • 80055002811 scopus 로고    scopus 로고
    • Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease
    • Armentero M.T., Pinna A., Ferre S., Lanciego J.L., Muller C.E., Franco R. Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. Pharmacol. Ther. 2011, 132(3):280-299.
    • (2011) Pharmacol. Ther. , vol.132 , Issue.3 , pp. 280-299
    • Armentero, M.T.1    Pinna, A.2    Ferre, S.3    Lanciego, J.L.4    Muller, C.E.5    Franco, R.6
  • 4
    • 0022589131 scopus 로고
    • Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Bankiewicz K.S., Oldfield E.H., Chiueh C.C., Doppman J.L., Jacobowitz D.M., Kopin I.J. Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci. 1986, 39:7-16.
    • (1986) Life Sci. , vol.39 , pp. 7-16
    • Bankiewicz, K.S.1    Oldfield, E.H.2    Chiueh, C.C.3    Doppman, J.L.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 6
    • 79957608284 scopus 로고    scopus 로고
    • A tale on animal models of Parkinson's disease
    • Bezard E., Przedborski S. A tale on animal models of Parkinson's disease. Mov. Disord. 2011, 26:993-1002.
    • (2011) Mov. Disord. , vol.26 , pp. 993-1002
    • Bezard, E.1    Przedborski, S.2
  • 7
    • 0035449393 scopus 로고    scopus 로고
    • Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
    • Bezard E., Dovero S., Prunier C., Ravenscroft P., Chalon S., Guilloteau D., Crossman A.R., Bioulac B., Brotchie J.M., Gross C.E. Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J. Neurosci. 2001, 21:6853-6861.
    • (2001) J. Neurosci. , vol.21 , pp. 6853-6861
    • Bezard, E.1    Dovero, S.2    Prunier, C.3    Ravenscroft, P.4    Chalon, S.5    Guilloteau, D.6    Crossman, A.R.7    Bioulac, B.8    Brotchie, J.M.9    Gross, C.E.10
  • 8
    • 13444273340 scopus 로고    scopus 로고
    • Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates
    • Bibbiani F., Costantini L.C., Patel R., Chase T.N. Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates. Exp. Neurol. 2005, 192:73-78.
    • (2005) Exp. Neurol. , vol.192 , pp. 73-78
    • Bibbiani, F.1    Costantini, L.C.2    Patel, R.3    Chase, T.N.4
  • 10
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., Kopin I.J. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. U. S. A. 1983, 80:4546-4550.
    • (1983) Proc. Natl. Acad. Sci. U. S. A. , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 11
    • 41049095853 scopus 로고    scopus 로고
    • Contributions of non-human primates to neuroscience research
    • Capitanio J.P., Emborg M.E. Contributions of non-human primates to neuroscience research. Lancet 2008, 371:1126-1135.
    • (2008) Lancet , vol.371 , pp. 1126-1135
    • Capitanio, J.P.1    Emborg, M.E.2
  • 12
    • 0031925945 scopus 로고    scopus 로고
    • L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    • Cenci M.A., Lee C.S., Bjorklund A. L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA. Eur. J. Neurosci. 1998, 10:2694-2706.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2694-2706
    • Cenci, M.A.1    Lee, C.S.2    Bjorklund, A.3
  • 15
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: mechanisms and models
    • Dauer W., Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003, 39:889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 16
    • 80052533576 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease
    • Duty S., Jenner P. Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease. Br. J. Pharmacol. 2011, 164(4):1357-1391.
    • (2011) Br. J. Pharmacol. , vol.164 , Issue.4 , pp. 1357-1391
    • Duty, S.1    Jenner, P.2
  • 18
    • 0022511809 scopus 로고
    • Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys
    • Eidelberg E., Brooks B.A., Morgan W.W., Walden J.G., Kokemoor R.H. Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys. Neuroscience 1986, 18:817-822.
    • (1986) Neuroscience , vol.18 , pp. 817-822
    • Eidelberg, E.1    Brooks, B.A.2    Morgan, W.W.3    Walden, J.G.4    Kokemoor, R.H.5
  • 19
    • 0032738101 scopus 로고    scopus 로고
    • Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment
    • Elsworth J.D., Taylor J.R., Sladek J.R., Collier T.J., Redmond D.E., Roth R.H. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment. Neuroscience 2000, 95:399-408.
    • (2000) Neuroscience , vol.95 , pp. 399-408
    • Elsworth, J.D.1    Taylor, J.R.2    Sladek, J.R.3    Collier, T.J.4    Redmond, D.E.5    Roth, R.H.6
  • 20
    • 36048948687 scopus 로고    scopus 로고
    • Nonhuman primate models of Parkinson's disease
    • Emborg M.E. Nonhuman primate models of Parkinson's disease. ILAR J. 2007, 48:339-355.
    • (2007) ILAR J. , vol.48 , pp. 339-355
    • Emborg, M.E.1
  • 24
    • 0027343340 scopus 로고
    • Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease. Neuropathologic considerations
    • Forno L.S., DeLanney L.E., Irwin I., Langston J.W. Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease. Neuropathologic considerations. Adv. Neurol. 1993, 60:600-608.
    • (1993) Adv. Neurol. , vol.60 , pp. 600-608
    • Forno, L.S.1    DeLanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 25
    • 77955402231 scopus 로고    scopus 로고
    • The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future
    • Fox S.H., Brotchie J.M. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future. Prog. Brain Res. 2010, 184:133-157.
    • (2010) Prog. Brain Res. , vol.184 , pp. 133-157
    • Fox, S.H.1    Brotchie, J.M.2
  • 26
    • 0024497157 scopus 로고
    • The evolution and distribution of morphological changes in the nervous system of the common marmoset following the acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Gibb W.R., Terruli M., Lees A.J., Jenner P., Marsden C.D. The evolution and distribution of morphological changes in the nervous system of the common marmoset following the acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Mov. Disord. 1989, 4:53-74.
    • (1989) Mov. Disord. , vol.4 , pp. 53-74
    • Gibb, W.R.1    Terruli, M.2    Lees, A.J.3    Jenner, P.4    Marsden, C.D.5
  • 27
    • 0035793308 scopus 로고    scopus 로고
    • Effects of acute and repeated treatment with a novel dopamine D2 receptor ligand on L-DOPA-induced dyskinesias in MPTP monkeys
    • Hadj Tahar A., Ekesbo A., Gregoire L., Bangassoro E., Svensson K.A., Tedroff J., Bedard P.J. Effects of acute and repeated treatment with a novel dopamine D2 receptor ligand on L-DOPA-induced dyskinesias in MPTP monkeys. Eur. J. Pharmacol. 2001, 412:247-254.
    • (2001) Eur. J. Pharmacol. , vol.412 , pp. 247-254
    • Hadj Tahar, A.1    Ekesbo, A.2    Gregoire, L.3    Bangassoro, E.4    Svensson, K.A.5    Tedroff, J.6    Bedard, P.J.7
  • 28
    • 84855193194 scopus 로고    scopus 로고
    • Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation
    • Iravani M.M., Jenner P. Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation. J. Neural Transm. 2011, 118:1661-1690.
    • (2011) J. Neural Transm. , vol.118 , pp. 1661-1690
    • Iravani, M.M.1    Jenner, P.2
  • 29
    • 9344235042 scopus 로고    scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of Parkinson's disease, with emphasis on mice and nonhuman primates
    • Jakowec M.W., Petzinger G.M. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of Parkinson's disease, with emphasis on mice and nonhuman primates. Comp. Med. 2004, 54:497-513.
    • (2004) Comp. Med. , vol.54 , pp. 497-513
    • Jakowec, M.W.1    Petzinger, G.M.2
  • 30
    • 0034032141 scopus 로고    scopus 로고
    • Factors influencing the onset and persistence of dyskinesia in MPTP-treated primates
    • Jenner P. Factors influencing the onset and persistence of dyskinesia in MPTP-treated primates. Ann. Neurol. 2000, 47:S90-S104.
    • (2000) Ann. Neurol. , vol.47
    • Jenner, P.1
  • 31
    • 0141856260 scopus 로고    scopus 로고
    • The MPTP-treated primate as a model of motor complications in PD: primate model of motor complications
    • Jenner P. The MPTP-treated primate as a model of motor complications in PD: primate model of motor complications. Neurology 2003, 61:S4-S11.
    • (2003) Neurology , vol.61
    • Jenner, P.1
  • 32
    • 50049087567 scopus 로고    scopus 로고
    • Molecular mechanisms of L-DOPA-induced dyskinesia
    • Jenner P. Molecular mechanisms of L-DOPA-induced dyskinesia. Nat. Rev. Neurosci. 2008, 9:665-677.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 665-677
    • Jenner, P.1
  • 33
    • 0021893796 scopus 로고
    • Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects
    • Johannessen J.N., Chiueh C.C., Burns R.S., Markey S.P. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects. Life Sci. 1985, 36:219-224.
    • (1985) Life Sci. , vol.36 , pp. 219-224
    • Johannessen, J.N.1    Chiueh, C.C.2    Burns, R.S.3    Markey, S.P.4
  • 34
    • 77952382801 scopus 로고    scopus 로고
    • Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
    • Johnston T.H., Fox S.H., McIldowie M.J., Piggott M.J., Brotchie J.M. Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. J. Pharmacol. Exp. Ther. 2010, 333:865-873.
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 865-873
    • Johnston, T.H.1    Fox, S.H.2    McIldowie, M.J.3    Piggott, M.J.4    Brotchie, J.M.5
  • 37
    • 50549097894 scopus 로고    scopus 로고
    • Inversion of dopamine responses in striatal medium spiny neurons and involuntary movements
    • Liang L., DeLong M.R., Papa S.M. Inversion of dopamine responses in striatal medium spiny neurons and involuntary movements. J. Neurosci. 2008, 28:7537-7547.
    • (2008) J. Neurosci. , vol.28 , pp. 7537-7547
    • Liang, L.1    DeLong, M.R.2    Papa, S.M.3
  • 38
    • 0026600262 scopus 로고
    • Selective D2 receptor stimulation induces dyskinesia in parkinsonian monkeys
    • Luquin M.R., Laguna J., Obeso J.A. Selective D2 receptor stimulation induces dyskinesia in parkinsonian monkeys. Ann. Neurol. 1992, 31:551-554.
    • (1992) Ann. Neurol. , vol.31 , pp. 551-554
    • Luquin, M.R.1    Laguna, J.2    Obeso, J.A.3
  • 39
    • 0342308802 scopus 로고    scopus 로고
    • Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen
    • Luquin M.R., Montoro R.J., Guillen J., Saldise L., Insausti R., Del Rio J., Lopez-Barneo J. Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Neuron 1999, 22:743-750.
    • (1999) Neuron , vol.22 , pp. 743-750
    • Luquin, M.R.1    Montoro, R.J.2    Guillen, J.3    Saldise, L.4    Insausti, R.5    Del Rio, J.6    Lopez-Barneo, J.7
  • 40
    • 30444460587 scopus 로고    scopus 로고
    • Motor complications in Parkinson's disease and the clinical significance of rotational behavior in the rat: have we wasted our time?
    • Marin C., Rodriguez-Oroz M.C., Obeso J.A. Motor complications in Parkinson's disease and the clinical significance of rotational behavior in the rat: have we wasted our time?. Exp. Neurol. 2006, 197:269-274.
    • (2006) Exp. Neurol. , vol.197 , pp. 269-274
    • Marin, C.1    Rodriguez-Oroz, M.C.2    Obeso, J.A.3
  • 41
    • 84900820438 scopus 로고    scopus 로고
    • Modeling dyskinesia in animal models of Parkinson disease
    • Morin N., Jourdain V.A., Di Paolo T. Modeling dyskinesia in animal models of Parkinson disease. Exp. Neurol. 2013, 256:105-116.
    • (2013) Exp. Neurol. , vol.256 , pp. 105-116
    • Morin, N.1    Jourdain, V.A.2    Di Paolo, T.3
  • 43
    • 70449371718 scopus 로고    scopus 로고
    • Modeling Parkinson's disease
    • Olanow C.W., Kordower J.H. Modeling Parkinson's disease. Ann. Neurol. 2009, 66:432-436.
    • (2009) Ann. Neurol. , vol.66 , pp. 432-436
    • Olanow, C.W.1    Kordower, J.H.2
  • 44
    • 0037096359 scopus 로고    scopus 로고
    • Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration
    • Palfi S., Leventhal L., Chu Y., Ma S.Y., Emborg M., Bakay R., Deglon N., Hantraye P., Aebischer P., Kordower J.H. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J. Neurosci. 2002, 22:4942-4954.
    • (2002) J. Neurosci. , vol.22 , pp. 4942-4954
    • Palfi, S.1    Leventhal, L.2    Chu, Y.3    Ma, S.Y.4    Emborg, M.5    Bakay, R.6    Deglon, N.7    Hantraye, P.8    Aebischer, P.9    Kordower, J.H.10
  • 45
    • 0029665122 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys
    • Papa S.M., Chase T.N. Levodopa-induced dyskinesias improved by a glutamate antagonist in parkinsonian monkeys. Ann. Neurol. 1996, 39:574-578.
    • (1996) Ann. Neurol. , vol.39 , pp. 574-578
    • Papa, S.M.1    Chase, T.N.2
  • 46
    • 0028046229 scopus 로고
    • Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration
    • Papa S.M., Engber T.M., Kask A.M., Chase T.N. Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration. Brain Res. 1994, 662:69-74.
    • (1994) Brain Res. , vol.662 , pp. 69-74
    • Papa, S.M.1    Engber, T.M.2    Kask, A.M.3    Chase, T.N.4
  • 47
    • 0035091767 scopus 로고    scopus 로고
    • The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety
    • Przedborski S., Jackson-Lewis V., Naini A.B., Jakowec M., Petzinger G., Miller R., Akram M. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J. Neurochem. 2001, 76:1265-1274.
    • (2001) J. Neurochem. , vol.76 , pp. 1265-1274
    • Przedborski, S.1    Jackson-Lewis, V.2    Naini, A.B.3    Jakowec, M.4    Petzinger, G.5    Miller, R.6    Akram, M.7
  • 50
    • 0027207709 scopus 로고
    • Delayed matching-to-sample, object retrieval, and discrimination reversal deficits in chronic low dose MPTP-treated monkeys
    • Schneider J.S., Roeltgen D.P. Delayed matching-to-sample, object retrieval, and discrimination reversal deficits in chronic low dose MPTP-treated monkeys. Brain Res. 1993, 615:351-354.
    • (1993) Brain Res. , vol.615 , pp. 351-354
    • Schneider, J.S.1    Roeltgen, D.P.2
  • 51
    • 0032808086 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys
    • Schneider J.S., Tinker J.P., Van Velson M., Menzaghi F., Lloyd G.K. Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys. J. Pharmacol. Exp. Ther. 1999, 290:731-739.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 731-739
    • Schneider, J.S.1    Tinker, J.P.2    Van Velson, M.3    Menzaghi, F.4    Lloyd, G.K.5
  • 52
    • 77952430842 scopus 로고    scopus 로고
    • Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism
    • Schneider J.S., Tinker J.P., Decamp E. Clonidine improves attentional and memory components of delayed response performance in a model of early Parkinsonism. Behav. Brain Res. 2010, 211:236-239.
    • (2010) Behav. Brain Res. , vol.211 , pp. 236-239
    • Schneider, J.S.1    Tinker, J.P.2    Decamp, E.3
  • 53
    • 0034235742 scopus 로고    scopus 로고
    • Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting
    • Song D.D., Haber S.N. Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting. J. Neurosci. 2000, 20:5102-5114.
    • (2000) J. Neurosci. , vol.20 , pp. 5102-5114
    • Song, D.D.1    Haber, S.N.2
  • 55
    • 0031587263 scopus 로고    scopus 로고
    • Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (Cercopithecus aethiops sabaeus)
    • Taylor J.R., Elsworth J.D., Roth R.H., Sladek J.R., Redmond D.E. Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (Cercopithecus aethiops sabaeus). Neuroscience 1997, 81:745-755.
    • (1997) Neuroscience , vol.81 , pp. 745-755
    • Taylor, J.R.1    Elsworth, J.D.2    Roth, R.H.3    Sladek, J.R.4    Redmond, D.E.5
  • 57
    • 0023550354 scopus 로고
    • An immunohistochemical study of the acute and long-term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the marmoset
    • Waters C.M., Hunt S.P., Jenner P., Marsden C.D. An immunohistochemical study of the acute and long-term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the marmoset. Neuroscience 1987, 23:1025-1039.
    • (1987) Neuroscience , vol.23 , pp. 1025-1039
    • Waters, C.M.1    Hunt, S.P.2    Jenner, P.3    Marsden, C.D.4
  • 58
    • 0036070538 scopus 로고    scopus 로고
    • L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of Parkinson's disease: relation to motor and cellular parameters of nigrostriatal function
    • Winkler C., Kirik D., Bjorklund A., Cenci M.A. L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of Parkinson's disease: relation to motor and cellular parameters of nigrostriatal function. Neurobiol. Dis. 2002, 10:165-186.
    • (2002) Neurobiol. Dis. , vol.10 , pp. 165-186
    • Winkler, C.1    Kirik, D.2    Bjorklund, A.3    Cenci, M.A.4


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