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Volumn 53, Issue 6, 2014, Pages 975-987

Is immunosuppressive therapy the anchor treatment to achieve remission in systemic sclerosis?

Author keywords

Azathioprine; Cyclophosphamide; Hematopoietic stem cell transplantation; Methotrexate; Mycophenolate mofetil; Rituximab; Systemic sclerosis

Indexed keywords

ABATACEPT; ALEFACEPT; ALEMTUZUMAB; AZATHIOPRINE; BASILIXIMAB; CORTICOSTEROID; CYCLOPHOSPHAMIDE; ETANERCEPT; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; RITUXIMAB; TOCILIZUMAB;

EID: 84900811420     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ket312     Document Type: Review
Times cited : (18)

References (96)
  • 1
    • 78649502678 scopus 로고    scopus 로고
    • Immunotherapy of systemic sclerosis
    • Manno R, Boin F. Immunotherapy of systemic sclerosis. Immunotherapy 2010;2:863-78.
    • (2010) Immunotherapy , vol.2 , pp. 863-878
    • Manno, R.1    Boin, F.2
  • 2
    • 77956631231 scopus 로고    scopus 로고
    • Evidence-based management of rapidly progressing systemic sclerosis
    • Khanna D, Denton CP. Evidence-based management of rapidly progressing systemic sclerosis. Best Pract Res Clin Rheumatol 2010;24:387-400.
    • (2010) Best Pract Res Clin Rheumatol , vol.24 , pp. 387-400
    • Khanna, D.1    Denton, C.P.2
  • 3
    • 66149100618 scopus 로고    scopus 로고
    • EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)
    • Kowal-Bielecka O, Landewé R, Avouac J et al. EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Ann Rheum Dis 2009;68:620-8.
    • (2009) Ann Rheum Dis , vol.68 , pp. 620-628
    • Kowal-Bielecka, O.1    Landewé, R.2    Avouac, J.3
  • 4
    • 84864095990 scopus 로고    scopus 로고
    • Participating members of the Scleroderma Clinical Trials Consortium (SCTC), Canadian Scleroderma Research Group (CSRG). Treatment of systemic sclerosis complications: what to use when first-line treatment fails-a consensus of systemic sclerosis experts
    • Walker KM, Pope J. Participating members of the Scleroderma Clinical Trials Consortium (SCTC), Canadian Scleroderma Research Group (CSRG). Treatment of systemic sclerosis complications: what to use when first-line treatment fails-a consensus of systemic sclerosis experts. Semin Arthritis Rheum 2012; 42:42-55.
    • (2012) Semin Arthritis Rheum , vol.42 , pp. 42-55
    • Walker, K.M.1    Pope, J.2
  • 5
    • 0029867337 scopus 로고    scopus 로고
    • Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial
    • van den Hoogen FH, Boerbooms AM, Swaak AJ et al. Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial. Br J Rheumatol 1996;35:364-72.
    • (1996) Br J Rheumatol , vol.35 , pp. 364-372
    • van den Hoogen, F.H.1    Boerbooms, A.M.2    Swaak, A.J.3
  • 6
    • 0034970031 scopus 로고    scopus 로고
    • A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma
    • Pope JE, Bellamy N, Seibold JR et al. A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma. Arthritis Rheum 2001;44:1351-8.
    • (2001) Arthritis Rheum , vol.44 , pp. 1351-1358
    • Pope, J.E.1    Bellamy, N.2    Seibold, J.R.3
  • 8
    • 15644362541 scopus 로고    scopus 로고
    • A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis
    • Guillevin L, Cordier JF, Lhote F et al. A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis. Arthritis Rheum 1997;40: 2187-98.
    • (1997) Arthritis Rheum , vol.40 , pp. 2187-2198
    • Guillevin, L.1    Cordier, J.F.2    Lhote, F.3
  • 9
    • 0036225585 scopus 로고    scopus 로고
    • Cyclophosphamide pulse regimen in the treatment of alveolitis in systemic sclerosis
    • Giacomelli R, Valentini G, Salsano F et al. Cyclophosphamide pulse regimen in the treatment of alveolitis in systemic sclerosis. J Rheumatol 2002;29: 731-6.
    • (2002) J Rheumatol , vol.29 , pp. 731-736
    • Giacomelli, R.1    Valentini, G.2    Salsano, F.3
  • 10
    • 33745227399 scopus 로고    scopus 로고
    • Cyclophosphamide versus placebo in scleroderma lung disease
    • Tashkin DP, Elashoff R, Clements PJ et al. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 2006;354:2655-66.
    • (2006) N Engl J Med , vol.354 , pp. 2655-2666
    • Tashkin, D.P.1    Elashoff, R.2    Clements, P.J.3
  • 11
    • 36249001195 scopus 로고    scopus 로고
    • Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    • Tashkin DP, Elashoff R, Clements PJ et al. Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med 2007;76:1026-34.
    • (2007) Am J Respir Crit Care Med , vol.76 , pp. 1026-1034
    • Tashkin, D.P.1    Elashoff, R.2    Clements, P.J.3
  • 12
    • 33845643063 scopus 로고    scopus 로고
    • A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma
    • Hoyles RK, Ellis RW, Wellsbury J et al. A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum 2006;54:3962-70.
    • (2006) Arthritis Rheum , vol.54 , pp. 3962-3970
    • Hoyles, R.K.1    Ellis, R.W.2    Wellsbury, J.3
  • 13
    • 33644870428 scopus 로고    scopus 로고
    • A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis
    • Nadashkevich O, Davis P, Fritzler M et al. A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis. Clin Rheum 2006; 25:205-12.
    • (2006) Clin Rheum , vol.25 , pp. 205-212
    • Nadashkevich, O.1    Davis, P.2    Fritzler, M.3
  • 14
    • 55749093240 scopus 로고    scopus 로고
    • Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies
    • Nannini C, West CP, Erwin PJ et al. Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies. Arthritis Res Ther 2008;10:R124.
    • (2008) Arthritis Res Ther , vol.10
    • Nannini, C.1    West, C.P.2    Erwin, P.J.3
  • 15
    • 45149125661 scopus 로고    scopus 로고
    • High-dose cyclophosphamide without stem cell rescue in scleroderma
    • Tehlirian CV, Hummers LK, White B et al. High-dose cyclophosphamide without stem cell rescue in scleroderma. Ann Rheum Dis 2008;67:775-81.
    • (2008) Ann Rheum Dis , vol.67 , pp. 775-781
    • Tehlirian, C.V.1    Hummers, L.K.2    White, B.3
  • 16
    • 64849103964 scopus 로고    scopus 로고
    • Shifting our thinking about uncommon disease trials: the case of methotrexate in scleroderma
    • Johnson SR, Feldman BM, Pope JE et al. Shifting our thinking about uncommon disease trials: the case of methotrexate in scleroderma. J Rheumatol 2009;36: 323-9.
    • (2009) J Rheumatol , vol.36 , pp. 323-329
    • Johnson, S.R.1    Feldman, B.M.2    Pope, J.E.3
  • 17
    • 34248137269 scopus 로고    scopus 로고
    • A pilot study of mycophenolate mofetil combined to intravenous methylprednisolone pulses and oral low-dose glucocorticoids in severe early systemic sclerosis
    • Vanthuyne M, Blockmans D, Westhovens R et al. A pilot study of mycophenolate mofetil combined to intravenous methylprednisolone pulses and oral low-dose glucocorticoids in severe early systemic sclerosis. Clin Exp Rheumatol 2007;25:287-92.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 287-292
    • Vanthuyne, M.1    Blockmans, D.2    Westhovens, R.3
  • 18
    • 75649109604 scopus 로고    scopus 로고
    • A prospective open-label study of mycophenolate mofetil for the treatment of diffuse systemic sclerosis
    • Derk CT, Grace E, Shenin M et al. A prospective open-label study of mycophenolate mofetil for the treatment of diffuse systemic sclerosis. Rheumatology 2009;48:1595-9.
    • (2009) Rheumatology , vol.48 , pp. 1595-1599
    • Derk, C.T.1    Grace, E.2    Shenin, M.3
  • 19
    • 73649119523 scopus 로고    scopus 로고
    • Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis
    • Herrick AL, Lunt M, Whidby N et al. Observational study of treatment outcome in early diffuse cutaneous systemic sclerosis. J Rheumatol 2010;37:116-24.
    • (2010) J Rheumatol , vol.37 , pp. 116-124
    • Herrick, A.L.1    Lunt, M.2    Whidby, N.3
  • 20
    • 79955788963 scopus 로고    scopus 로고
    • Long-term experience of mycophenolate mofetil for treatment of diffuse cutaneous systemic sclerosis
    • Le EN, Wigely FM, Shah AA et al. Long-term experience of mycophenolate mofetil for treatment of diffuse cutaneous systemic sclerosis. Ann Rheum Dis 2011;70:1104-7.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1104-1107
    • Le, E.N.1    Wigely, F.M.2    Shah, A.A.3
  • 21
    • 33847394965 scopus 로고    scopus 로고
    • Mycophenolate mofetil in diffuse cutaneous systemic sclerosis-a retrospective analysis
    • Nihtyanova SI, Brough GM, Black CM et al. Mycophenolate mofetil in diffuse cutaneous systemic sclerosis-a retrospective analysis. Rheumatology 2007; 46:442-5.
    • (2007) Rheumatology , vol.46 , pp. 442-445
    • Nihtyanova, S.I.1    Brough, G.M.2    Black, C.M.3
  • 22
    • 79952109158 scopus 로고    scopus 로고
    • Mycophenolate mofetil in systemic sclerosis-associated interstitial lung disease
    • Koutroumpas A, Ziogas A, Alexiou L et al. Mycophenolate mofetil in systemic sclerosis-associated interstitial lung disease. Clin Rheumatol 2010;29:1167-8.
    • (2010) Clin Rheumatol , vol.29 , pp. 1167-1168
    • Koutroumpas, A.1    Ziogas, A.2    Alexiou, L.3
  • 23
    • 33746437403 scopus 로고    scopus 로고
    • Mycophenolate mofetil as first-line treatment improves clinically evident early scleroderma lung disease
    • Liossis SNC, Bounas A, Anonopoulos AP. Mycophenolate mofetil as first-line treatment improves clinically evident early scleroderma lung disease. Rheumatology 2006;45: 1005-8.
    • (2006) Rheumatology , vol.45 , pp. 1005-1008
    • Liossis, S.N.C.1    Bounas, A.2    Anonopoulos, A.P.3
  • 24
    • 39449103902 scopus 로고    scopus 로고
    • Effect of mycophenolate mofetil on pulmonary function in scleroderma-associated interstitial lung disease
    • Gerbino AJ, Goss CH, Molitor JA. Effect of mycophenolate mofetil on pulmonary function in scleroderma-associated interstitial lung disease. Chest 2008;133:455-60.
    • (2008) Chest , vol.133 , pp. 455-460
    • Gerbino, A.J.1    Goss, C.H.2    Molitor, J.A.3
  • 25
    • 36349014858 scopus 로고    scopus 로고
    • Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease
    • Zamora AC, Wolters PJ, Collard HR et al. Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease. Respir Med 2008;102:150-5.
    • (2008) Respir Med , vol.102 , pp. 150-155
    • Zamora, A.C.1    Wolters, P.J.2    Collard, H.R.3
  • 26
    • 33746372441 scopus 로고    scopus 로고
    • Mycophenolate mofetil is safe, well tolerated, and preserves lung function in patients with connective tissue disease-related interstitial lung disease
    • Swigris JJ, Olson AL, Fischer A et al. Mycophenolate mofetil is safe, well tolerated, and preserves lung function in patients with connective tissue disease-related interstitial lung disease. Chest 2006;130:30-6.
    • (2006) Chest , vol.130 , pp. 30-36
    • Swigris, J.J.1    Olson, A.L.2    Fischer, A.3
  • 27
    • 80755163187 scopus 로고    scopus 로고
    • Effect of mycophenolate sodium in scleroderma-related interstitial lung disease
    • Simeón-Aznar CP, Fonollosa-Plá V, Tolosa-Vilella C et al. Effect of mycophenolate sodium in scleroderma-related interstitial lung disease. Clin Rheumatol 2011;30:1393-8.
    • (2011) Clin Rheumatol , vol.30 , pp. 1393-1398
    • Simeón-Aznar, C.P.1    Fonollosa-Plá, V.2    Tolosa-Vilella, C.3
  • 28
    • 84878676906 scopus 로고    scopus 로고
    • Enteric-coated mycophenolate sodium for progressive systemic sclerosis-a prospective open-label study with CT histography for monitoring of pulmonary fibrosis
    • Henes JC, Horger M, Amberger C et al. Enteric-coated mycophenolate sodium for progressive systemic sclerosis-a prospective open-label study with CT histography for monitoring of pulmonary fibrosis. Clin Rheumatol 2013;32:673-8.
    • (2013) Clin Rheumatol , vol.32 , pp. 673-678
    • Henes, J.C.1    Horger, M.2    Amberger, C.3
  • 29
    • 4444379671 scopus 로고    scopus 로고
    • Experience with azathioprine in systemic sclerosis associated with interstitial lung disease
    • Dheda K, Laloo UG, Cassim B et al. Experience with azathioprine in systemic sclerosis associated with interstitial lung disease. Clin Rheumatol 2004;23:306-9.
    • (2004) Clin Rheumatol , vol.23 , pp. 306-309
    • Dheda, K.1    Laloo, U.G.2    Cassim, B.3
  • 30
    • 0018581154 scopus 로고
    • Progressive systemic sclerosis-long-term treatment with azathioprine
    • Mass D, Schramm A, Jaeckle B et al. Progressive systemic sclerosis-long-term treatment with azathioprine. Immun Infekt 1979;7:165-9.
    • (1979) Immun Infekt , vol.7 , pp. 165-169
    • Mass, D.1    Schramm, A.2    Jaeckle, B.3
  • 31
    • 34648822788 scopus 로고    scopus 로고
    • Twelve-month azathioprine as maintenance therapy in early diffuse systemic sclerosis patients treated for 1-year with low dose cyclophosphamide pulse therapy
    • Paone C, Chiarolanza I, Cuomo G et al. Twelve-month azathioprine as maintenance therapy in early diffuse systemic sclerosis patients treated for 1-year with low dose cyclophosphamide pulse therapy. Clin Exp Rheumatol 2007;25:613-6.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 613-616
    • Paone, C.1    Chiarolanza, I.2    Cuomo, G.3
  • 33
    • 6544229063 scopus 로고    scopus 로고
    • Cyclosporin A and iloprost treatment of systemic sclerosis: clinical results and interleukin-6 serum changes after 12 months of therapy
    • Filaci G, Cutolo M, Scudeletti M et al. Cyclosporin A and iloprost treatment of systemic sclerosis: clinical results and interleukin-6 serum changes after 12 months of therapy. Rheumatology 1999;38:992-6.
    • (1999) Rheumatology , vol.38 , pp. 992-996
    • Filaci, G.1    Cutolo, M.2    Scudeletti, M.3
  • 34
    • 0033836975 scopus 로고    scopus 로고
    • Cyclosporin and tacrolimus: their use in a routine clinical setting for scleroderma
    • Morton SJ, Powell RJ. Cyclosporin and tacrolimus: their use in a routine clinical setting for scleroderma. Rheumatology 2000;39:865-9.
    • (2000) Rheumatology , vol.39 , pp. 865-869
    • Morton, S.J.1    Powell, R.J.2
  • 35
    • 73249139173 scopus 로고    scopus 로고
    • Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study
    • Su TI, Khanna D, Furst DE et al. Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study. Arthritis Rheum 2009;60:3821-30.
    • (2009) Arthritis Rheum , vol.60 , pp. 3821-3830
    • Su, T.I.1    Khanna, D.2    Furst, D.E.3
  • 37
    • 25144441807 scopus 로고    scopus 로고
    • Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients
    • Garrean S, Massad MG, Tashibaka M et al. Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients. Clin Transplant 2005;19: 698-703.
    • (2005) Clin Transplant , vol.19 , pp. 698-703
    • Garrean, S.1    Massad, M.G.2    Tashibaka, M.3
  • 38
    • 0029899152 scopus 로고    scopus 로고
    • Pilot study of antithymocyte globulin in systemic sclerosis
    • Matteson EL, Sheeb MI, McCarthy TG et al. Pilot study of antithymocyte globulin in systemic sclerosis. Arthritis Rheum 1996;39:1132-7.
    • (1996) Arthritis Rheum , vol.39 , pp. 1132-1137
    • Matteson, E.L.1    Sheeb, M.I.2    McCarthy, T.G.3
  • 39
    • 0035144259 scopus 로고    scopus 로고
    • Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma
    • Stratton RJ, Wilson H, Black CM. Pilot study of anti-thymocyte globulin plus mycophenolate mofetil in recent-onset diffuse scleroderma. Rheumatology 2001; 40:84-8.
    • (2001) Rheumatology , vol.40 , pp. 84-88
    • Stratton, R.J.1    Wilson, H.2    Black, C.M.3
  • 40
    • 0022759549 scopus 로고
    • Factors involved in the control of fibroblast proliferation by glucocorticoids: a review
    • Durant S, Duval D, Homo-Delarche F. Factors involved in the control of fibroblast proliferation by glucocorticoids: a review. Endocr Rev 1986;7:254-69.
    • (1986) Endocr Rev , vol.7 , pp. 254-269
    • Durant, S.1    Duval, D.2    Homo-Delarche, F.3
  • 41
    • 0036843172 scopus 로고    scopus 로고
    • Systemic sclerosis and interstitial lung disease: a pilot study using pulse intravenous methylprednisolone and cyclophosphamide to assess the effect on high resolution computed tomography scan and lung function
    • Griffiths B, Miles S, Moss H et al. Systemic sclerosis and interstitial lung disease: a pilot study using pulse intravenous methylprednisolone and cyclophosphamide to assess the effect on high resolution computed tomography scan and lung function. J Rheumatol 2002;29: 2371-8.
    • (2002) J Rheumatol , vol.29 , pp. 2371-2378
    • Griffiths, B.1    Miles, S.2    Moss, H.3
  • 42
    • 33846333911 scopus 로고    scopus 로고
    • Combination of intravenous pulses of cyclophosphamide and methylprednisolone in patients with systemic sclerosis and interstitial lung disease
    • Yiannopoulos G, Pastromas V, Antonopoulos I et al. Combination of intravenous pulses of cyclophosphamide and methylprednisolone in patients with systemic sclerosis and interstitial lung disease. Rheumatol Int 2007; 27:357-61.
    • (2007) Rheumatol Int , vol.27 , pp. 357-361
    • Yiannopoulos, G.1    Pastromas, V.2    Antonopoulos, I.3
  • 43
    • 0031684342 scopus 로고    scopus 로고
    • Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis
    • Steen VD, Medsger TA Jr. Case-control study of corticosteroids and other drugs that either precipitate or protect from the development of scleroderma renal crisis. Arthritis Rheum 1998;41:1613-9.
    • (1998) Arthritis Rheum , vol.41 , pp. 1613-1619
    • Steen, V.D.1    Medsger Jr., T.A.2
  • 44
    • 84868947099 scopus 로고    scopus 로고
    • Scleroderma renal crisis: presentation, outcome and risk factors based on retrospective multicenter study of 50 patients
    • Teixeira L, Mouthon L, Mahr A et al. Scleroderma renal crisis: presentation, outcome and risk factors based on retrospective multicenter study of 50 patients. Ann Rheum Dis 2006;54(Suppl):S743.
    • (2006) Ann Rheum Dis , vol.54 , Issue.SUPPL.
    • Teixeira, L.1    Mouthon, L.2    Mahr, A.3
  • 45
    • 0036845156 scopus 로고    scopus 로고
    • Predictors and outcomes of scleroderma renal crisis: the high dose versus low dose of penicillamine in early diffuse systemic sclerosis trial
    • DeMarco PJ, Weisman MH, Seibold JR et al. Predictors and outcomes of scleroderma renal crisis: the high dose versus low dose of penicillamine in early diffuse systemic sclerosis trial. Arthritis Rheum 2002;46:2983-9.
    • (2002) Arthritis Rheum , vol.46 , pp. 2983-2989
    • DeMarco, P.J.1    Weisman, M.H.2    Seibold, J.R.3
  • 46
    • 0024465792 scopus 로고
    • Normotensive renal failure in systemic sclerosis
    • Helfrich DJ, Banner B, Steen VD et al. Normotensive renal failure in systemic sclerosis. Arthritis Rheum 1989;32: 1128-34.
    • (1989) Arthritis Rheum , vol.32 , pp. 1128-1134
    • Helfrich, D.J.1    Banner, B.2    Steen, V.D.3
  • 47
    • 67649639520 scopus 로고    scopus 로고
    • Renal complications and scleroderma renal crisis
    • Denton CP, Lapadula G, Mouthon L et al. Renal complications and scleroderma renal crisis. Rheumatology 2009;48(Suppl):iii32-5.
    • (2009) Rheumatology , vol.48 , Issue.SUPPL.
    • Denton, C.P.1    Lapadula, G.2    Mouthon, L.3
  • 48
    • 77956992383 scopus 로고    scopus 로고
    • B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial
    • Bosello S, De Santis M, Lama G et al. B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial. Arthritis Res Ther 2010; 12:R50.
    • (2010) Arthritis Res Ther , vol.12
    • Bosello, S.1    De Santis, M.2    Lama, G.3
  • 49
    • 73449095775 scopus 로고    scopus 로고
    • Rituximab in diffuse cutaneous systemic sclerosis: an open label clinical and histopathological study
    • Smith V, Van Praet JT, Vandooren B et al. Rituximab in diffuse cutaneous systemic sclerosis: an open label clinical and histopathological study. Ann Rheum Dis 2010;69: 193-7.
    • (2010) Ann Rheum Dis , vol.69 , pp. 193-197
    • Smith, V.1    Van Praet, J.T.2    Vandooren, B.3
  • 50
    • 59649109772 scopus 로고    scopus 로고
    • B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis
    • Layaftis R, Kissin E, York M et al. B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum 2009;60:578-83.
    • (2009) Arthritis Rheum , vol.60 , pp. 578-583
    • Layaftis, R.1    Kissin, E.2    York, M.3
  • 51
    • 77950443096 scopus 로고    scopus 로고
    • Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study
    • Daoussis D, Liossis SN, Tsamandas AC et al. Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study. Rheumatology 2010;49:271-80.
    • (2010) Rheumatology , vol.49 , pp. 271-280
    • Daoussis, D.1    Liossis, S.N.2    Tsamandas, A.C.3
  • 52
    • 84867383069 scopus 로고    scopus 로고
    • Effect of long-term treatment with rituximab on pulmonary function and skin fibrosis in patients with diffuse systemic sclerosis
    • Daoussis D, Liossis SN, Tsamandas AC et al. Effect of long-term treatment with rituximab on pulmonary function and skin fibrosis in patients with diffuse systemic sclerosis. Clin Exp Rheumatol 2012;30:17-22.
    • (2012) Clin Exp Rheumatol , vol.30 , pp. 17-22
    • Daoussis, D.1    Liossis, S.N.2    Tsamandas, A.C.3
  • 53
    • 83155162394 scopus 로고    scopus 로고
    • Rheumatoid arthritis. Treatment and assessment
    • Klippel JH, ed, New York: Springer
    • Oliver AM, Clair EWS. Rheumatoid arthritis. Treatment and assessment. In: Klippel JH, ed. Primer on the rheumatic diseases. New York: Springer, 2008:139.
    • (2008) Primer on the rheumatic diseases , pp. 139
    • Oliver, A.M.1    Clair, E.W.S.2
  • 54
    • 84878404903 scopus 로고    scopus 로고
    • Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study
    • Elhai M, Meunier M, Matucci-Cerinic M et al. Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study. Ann Rheum Dis 2013;72: 1217-20.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1217-1220
    • Elhai, M.1    Meunier, M.2    Matucci-Cerinic, M.3
  • 55
    • 78649507951 scopus 로고    scopus 로고
    • Selective T-cell reduction in scleroderma lung disease using LFA-3/IgG1 human fusion protein (alefacept)
    • White B, Choi J, Wigley F et al. Selective T-cell reduction in scleroderma lung disease using LFA-3/IgG1 human fusion protein (alefacept). Arthritis Rheum 2002;46:202.
    • (2002) Arthritis Rheum , vol.46 , pp. 202
    • White, B.1    Choi, J.2    Wigley, F.3
  • 56
    • 79957663518 scopus 로고    scopus 로고
    • The monoclonal anti-CD25 antibody basiliximab for the treatment of progressive systemic sclerosis: an open label study
    • Becker MO, Brückner C, Scherer HU et al. The monoclonal anti-CD25 antibody basiliximab for the treatment of progressive systemic sclerosis: an open label study. Ann Rheum Dis 2011;70:1340-1.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1340-1341
    • Becker, M.O.1    Brückner, C.2    Scherer, H.U.3
  • 57
    • 0023785977 scopus 로고
    • Tumor necrosis factor inhibits collagen and fibronectin synthesis in human dermal fibroblasts
    • Mauviel A, Daireaux M, Rédini F et al. Tumor necrosis factor inhibits collagen and fibronectin synthesis in human dermal fibroblasts. FEBS Lett 1988;236:47-52.
    • (1988) FEBS Lett , vol.236 , pp. 47-52
    • Mauviel, A.1    Daireaux, M.2    Rédini, F.3
  • 58
    • 0026027772 scopus 로고
    • Comparative effects of interleukin-1 and tumor necrosis factor-a on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts
    • Mauviel A, Heino J, Kähäri VM et al. Comparative effects of interleukin-1 and tumor necrosis factor-a on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts. J Invest Dermatol 1991;96: 243-9.
    • (1991) J Invest Dermatol , vol.96 , pp. 243-249
    • Mauviel, A.1    Heino, J.2    Kähäri, V.M.3
  • 59
    • 0022296893 scopus 로고
    • Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts
    • Dayer JM, Beutler B, Cerami AJ. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. Exp Med 1985;162:2163-8.
    • (1985) Exp Med , vol.162 , pp. 2163-2168
    • Dayer, J.M.1    Beutler, B.2    Cerami, A.J.3
  • 60
    • 0024661765 scopus 로고
    • Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases
    • Meikle MC, Atkinson SJ, Ward RV et al. Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases. J Periodontal Res 1989;24:207-13.
    • (1989) J Periodontal Res , vol.24 , pp. 207-213
    • Meikle, M.C.1    Atkinson, S.J.2    Ward, R.V.3
  • 61
    • 0025211892 scopus 로고
    • Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis
    • Piguet PF, Collart MA, Grau GE et al. Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature 1990;344:245-7.
    • (1990) Nature , vol.344 , pp. 245-247
    • Piguet, P.F.1    Collart, M.A.2    Grau, G.E.3
  • 62
    • 0028286946 scopus 로고
    • Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice
    • Piguet PF, Vesin C. Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J 1994;7:515-8.
    • (1994) Eur Respir J , vol.7 , pp. 515-518
    • Piguet, P.F.1    Vesin, C.2
  • 63
    • 34447503592 scopus 로고    scopus 로고
    • Efficacy and safety of etanercept in the treatment of scleroderma-associated joint disease
    • Lam GK, Hummers LK, Woods A et al. Efficacy and safety of etanercept in the treatment of scleroderma-associated joint disease. J Rheumatol 2007;34:1636-7.
    • (2007) J Rheumatol , vol.34 , pp. 1636-1637
    • Lam, G.K.1    Hummers, L.K.2    Woods, A.3
  • 65
    • 69949138488 scopus 로고    scopus 로고
    • An open label pilot study of infliximab in diffuse cutaneous systemic sclerosis
    • Denton CP, Engelhart M, Tvede N et al. An open label pilot study of infliximab in diffuse cutaneous systemic sclerosis. Ann Rheum Dis 2009;68:1433-9.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1433-1439
    • Denton, C.P.1    Engelhart, M.2    Tvede, N.3
  • 66
    • 33644878626 scopus 로고    scopus 로고
    • Tumor necrosis factor-a inhibitor therapy in erosive polyarthritis secondary to systemic sclerosis
    • Bosello S, De Santis M, Tolusso B et al. Tumor necrosis factor-a inhibitor therapy in erosive polyarthritis secondary to systemic sclerosis. Ann Intern Med 2005; 143:918-20.
    • (2005) Ann Intern Med , vol.143 , pp. 918-920
    • Bosello, S.1    De Santis, M.2    Tolusso, B.3
  • 68
    • 79551704329 scopus 로고    scopus 로고
    • Biologic therapy for systemic sclerosis: a systemic review
    • Phumethum V, Jamal S, Johnson SR. Biologic therapy for systemic sclerosis: a systemic review. J Rheumatol 2011; 38:289-96.
    • (2011) J Rheumatol , vol.38 , pp. 289-296
    • Phumethum, V.1    Jamal, S.2    Johnson, S.R.3
  • 69
    • 84867368217 scopus 로고    scopus 로고
    • Long-term safety and effectiveness of tumor necrosis factor inhibitors in systemic sclerosis patients with inflammatory arthritis
    • Omair MA, Phumethum V, Johnson SR. Long-term safety and effectiveness of tumor necrosis factor inhibitors in systemic sclerosis patients with inflammatory arthritis. Clin Exp Rheumatol 2012;30(Suppl 71):55-9.
    • (2012) Clin Exp Rheumatol , vol.30 , Issue.SUPPL. 71 , pp. 55-59
    • Omair, M.A.1    Phumethum, V.2    Johnson, S.R.3
  • 70
    • 0031911610 scopus 로고    scopus 로고
    • Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis
    • Hasegawa M, Sato S, Fujimoto M et al. Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis. J Rheumatol 1998;25:308-13.
    • (1998) J Rheumatol , vol.25 , pp. 308-313
    • Hasegawa, M.1    Sato, S.2    Fujimoto, M.3
  • 71
    • 81555209757 scopus 로고    scopus 로고
    • The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis
    • 721608. doi: 10.1155/2011/721608
    • Barnes TC, Anderson ME, Moots RJ. The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis. Int J Rheumatol 2011;2011:721608. doi: 10.1155/2011/721608.
    • (2011) Int J Rheumatol , vol.2011
    • Barnes, T.C.1    Anderson, M.E.2    Moots, R.J.3
  • 73
    • 78049421175 scopus 로고    scopus 로고
    • The skin of patients with systemic sclerosis softened during the treatment with anti-IL6 receptor antibody tocilizumab
    • Shima Y, Kuwahara Y, Murota H et al. The skin of patients with systemic sclerosis softened during the treatment with anti-IL6 receptor antibody tocilizumab. Rheumatology 2010;49:2408-12.
    • (2010) Rheumatology , vol.49 , pp. 2408-2412
    • Shima, Y.1    Kuwahara, Y.2    Murota, H.3
  • 74
    • 0029934535 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H
    • Isaacs JD, Hazleman BL, Chakravarty K et al. Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H. J Rheumatol 1996;23:1103-6.
    • (1996) J Rheumatol , vol.23 , pp. 1103-1106
    • Isaacs, J.D.1    Hazleman, B.L.2    Chakravarty, K.3
  • 75
    • 0036721372 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes
    • McSweeney PA, Nash RA, Sullivan KM et al. High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes. Blood 2002;100:1602-10.
    • (2002) Blood , vol.100 , pp. 1602-1610
    • McSweeney, P.A.1    Nash, R.A.2    Sullivan, K.M.3
  • 76
    • 54149083949 scopus 로고    scopus 로고
    • Stem cell transplantation for rheumatic autoimmune diseases
    • Hügle T, van Laar JM. Stem cell transplantation for rheumatic autoimmune diseases. Arthritis Res Ther 2008; 10:217.
    • (2008) Arthritis Res Ther , vol.10 , pp. 217
    • Hügle, T.1    van Laar, J.M.2
  • 77
    • 0142023807 scopus 로고    scopus 로고
    • Haematopoietic stem cell transplantation for the treatment of systemic sclerosis and other autoimmune disorders
    • Tyndall A, Matucci-Cerinic M. Haematopoietic stem cell transplantation for the treatment of systemic sclerosis and other autoimmune disorders. Expert Opin Biol Ther 2003; 3:1041-9.
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 1041-1049
    • Tyndall, A.1    Matucci-Cerinic, M.2
  • 78
    • 0035017415 scopus 로고    scopus 로고
    • Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease
    • Binks M, Passweg JR, Furst D et al. Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease. Ann Rheum Dis 2001;60:577-84.
    • (2001) Ann Rheum Dis , vol.60 , pp. 577-584
    • Binks, M.1    Passweg, J.R.2    Furst, D.3
  • 79
    • 3242658935 scopus 로고    scopus 로고
    • Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry
    • Farge D, Passweg J, van Laar JM et al. Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry. Ann Rheum Dis 2004;63:974-81.
    • (2004) Ann Rheum Dis , vol.63 , pp. 974-981
    • Farge, D.1    Passweg, J.2    van Laar, J.M.3
  • 80
    • 34548013337 scopus 로고    scopus 로고
    • High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study
    • Nash RA, McSweeney PA, Crofford LJ et al. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Blood 2007;110:1388-96.
    • (2007) Blood , vol.110 , pp. 1388-1396
    • Nash, R.A.1    McSweeney, P.A.2    Crofford, L.J.3
  • 81
    • 84875236160 scopus 로고    scopus 로고
    • The ASTIS trial: autologous stem cell transplantation versus IV pulse cyclophosphamide in poor prognosis systemic sclerosis, first results [abstract]
    • van Laar JM, Farge D, Sont JK et al. The ASTIS trial: autologous stem cell transplantation versus IV pulse cyclophosphamide in poor prognosis systemic sclerosis, first results [abstract]. Ann Rheum Dis 2012; 71(Suppl 3):151.
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 151
    • van Laar, J.M.1    Farge, D.2    Sont, J.K.3
  • 82
    • 84861475814 scopus 로고    scopus 로고
    • Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies
    • Elhai M, Meune C, Avouac J et al. Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies. Rheumatology 2012;51:1017-26.
    • (2012) Rheumatology , vol.51 , pp. 1017-1026
    • Elhai, M.1    Meune, C.2    Avouac, J.3
  • 83
    • 44449152061 scopus 로고    scopus 로고
    • Interstitial lung disease in systemic sclerosis: a simple staging system
    • Goh NS, Desai SR, Veeraraghavan S et al. Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med 2008;177:1248-54.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 1248-1254
    • Goh, N.S.1    Desai, S.R.2    Veeraraghavan, S.3
  • 84
    • 0030866707 scopus 로고    scopus 로고
    • Predictors of survival in 171 patients with systemic sclerosis (scleroderma)
    • Nagy Z, Czirják L. Predictors of survival in 171 patients with systemic sclerosis (scleroderma). Clin Rheumatol 1997;16:454-60.
    • (1997) Clin Rheumatol , vol.16 , pp. 454-460
    • Nagy, Z.1    Czirják, L.2
  • 85
    • 0026100542 scopus 로고
    • Clinical pharmacokinetics of cyclophosphamide
    • Moore MJ. Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet 1991;20:194-208.
    • (1991) Clin Pharmacokinet , vol.20 , pp. 194-208
    • Moore, M.J.1
  • 86
    • 0004469552 scopus 로고    scopus 로고
    • Immunosuppressives
    • Klippel JH, Dieppe PA, eds, 2nd edn. London: Mosby, 9.1-9.10
    • Furst DE, Clements PJ. Immunosuppressives. In: Klippel JH, Dieppe PA, eds. Rheumatology. 2nd edn. London: Mosby, 1998:9.1-9.10.
    • (1998) Rheumatology
    • Furst, D.E.1    Clements, P.J.2
  • 87
    • 0030000725 scopus 로고    scopus 로고
    • Guidelines for monitoring drug therapy in rheumatoid arthritis. American College of Rheumatology Ad Hoc Committee on Clinical Guidelines
    • Guidelines for monitoring drug therapy in rheumatoid arthritis. American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. Arthritis Rheum 1996; 79:723-31.
    • (1996) Arthritis Rheum , vol.79 , pp. 723-731
  • 88
    • 0002500095 scopus 로고    scopus 로고
    • Methotrexate
    • Ruddy S, Harris ED Jr, Sledge CB, eds, 6th edn. Philadelphia: W.B. Saunders
    • Weinblatt ME. Methotrexate. In: Ruddy S, Harris ED Jr, Sledge CB, eds. Kelley's textbook of rheumatology. 6th edn. Philadelphia: W.B. Saunders, 2001:841-50.
    • (2001) Kelley's textbook of rheumatology , pp. 841-850
    • Weinblatt, M.E.1
  • 89
    • 33847773940 scopus 로고    scopus 로고
    • Immunomodulatory agents
    • Koopman WJ, Moreland LW, eds, 5th edn., Philadelphia: Lippincott Williams & Wilkins
    • Sawitzke AD, Canon GW. Immunomodulatory agents. In: Koopman WJ, Moreland LW, eds. Arthritis and allied conditions. 5th edn. Philadelphia: Lippincott Williams & Wilkins, 2005:885-913.
    • (2005) Arthritis and allied conditions , pp. 885-913
    • Sawitzke, A.D.1    Canon, G.W.2
  • 90
    • 44949095328 scopus 로고    scopus 로고
    • The safety of mycophenolate mofetil in pregnancy
    • Pisoni CN, D'Cruz DP. The safety of mycophenolate mofetil in pregnancy. Expert Opin Drug Saf 2008;7: 219-22.
    • (2008) Expert Opin Drug Saf , vol.7 , pp. 219-222
    • Pisoni, C.N.1    D'Cruz, D.P.2
  • 91
    • 84900799053 scopus 로고    scopus 로고
    • Immunoregulatory drugs
    • Ruddy S, Harris ED Jr, Sledge CB, eds. . 6th edn. Philadelphia: W.B. Saunders
    • Stein CM. Immunoregulatory drugs. In: Ruddy S, Harris ED Jr, Sledge CB, eds. Kelley's textbook of rheumatology. 6th edn. Philadelphia: W.B. Saunders, 2001:884-6.
    • (2001) , pp. 884-886
    • Stein, C.M.1
  • 92
    • 34249780137 scopus 로고    scopus 로고
    • Intravenous cyclophosphamide for interstitial lung disease associated to systemic sclerosis: results with an 18-month long protocol including a maintenance phase
    • Airò P, Danieli E, Rossi M et al. Intravenous cyclophosphamide for interstitial lung disease associated to systemic sclerosis: results with an 18-month long protocol including a maintenance phase. Clin Exp Rheumatol 2007;25:293-6.
    • (2007) Clin Exp Rheumatol , vol.25 , pp. 293-296
    • Airò, P.1    Danieli, E.2    Rossi, M.3
  • 93
    • 33845867399 scopus 로고    scopus 로고
    • Oral cyclophosphamide improves pulmonary function in scleroderma patients with fibrosing alveolitis: experience in one centre
    • Beretta L, Caronni M, Raimondi M et al. Oral cyclophosphamide improves pulmonary function in scleroderma patients with fibrosing alveolitis: experience in one centre. Clin Rheumatol 2007;26: 168-72.
    • (2007) Clin Rheumatol , vol.26 , pp. 168-172
    • Beretta, L.1    Caronni, M.2    Raimondi, M.3
  • 94
    • 0033398663 scopus 로고    scopus 로고
    • Intravenous cyclophosphamide pulse therapy for the treatment of lung disease associated with scleroderma
    • Davas EM, Peppas C, Maragou M et al. Intravenous cyclophosphamide pulse therapy for the treatment of lung disease associated with scleroderma. Clin Rheumatol 1999;18:455-61.
    • (1999) Clin Rheumatol , vol.18 , pp. 455-461
    • Davas, E.M.1    Peppas, C.2    Maragou, M.3
  • 95
    • 0027314630 scopus 로고
    • Cyclophosphamide and low-dose prednisone therapy in patients with systemic sclerosis (scleroderma) with interstitial lung disease
    • Silver RM, Warrick JH, Kinsella MB et al. Cyclophosphamide and low-dose prednisone therapy in patients with systemic sclerosis (scleroderma) with interstitial lung disease. J Rheumatol 1993;20: 838-44.
    • (1993) J Rheumatol , vol.20 , pp. 838-844
    • Silver, R.M.1    Warrick, J.H.2    Kinsella, M.B.3
  • 96
    • 79955742433 scopus 로고    scopus 로고
    • Efficacy of cyclophosphamide in the treatment of interstitial lung disease associated with systemic sclerosis
    • Espinosa G, Simeón CP, Plasín MÁ et al. Efficacy of cyclophosphamide in the treatment of interstitial lung disease associated with systemic sclerosis. Arch Bronconeumol 2011;47:239-45.
    • (2011) Arch Bronconeumol , vol.47 , pp. 239-245
    • Espinosa, G.1    Simeón, C.P.2    Plasín, M.Á.3


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