A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis

Arthritis and Rheumatism

Volumn 40, Issue 12, 1997, Pages 2187-2198

  Guillevin, Loïc ^a   Cordier, Jean François ^b   Lhote, François ^c   Cohen, Pascal ^a   Jarrousse, Bernard ^a   Royer, Isabelle ^a   Lesavre, Philippe ^d   Jacquot, Christian ^e   Bindi, Pascal ^f   Bielefeld, Philippe ^f   Desson, Jean François ^f   Détrée, Frédérick ^f   Dubois, Alain ^f   Hachulla, Eric ^f   Hoen, Bruno ^f   Jacomy, Dominique ^f   Seigneuric, Christian ^f   Lauque, Dominique ^f   Stern, Marc ^f   Longy Boursier, Maïté ^f  

^a AVICENNE HOSPITAL   (France)

^b LOUIS PRADEL HOSPITAL   (France)

^c DELAFONTAINE HOSPITAL   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e HÔPITAL BROUSSAIS   (France)

^f Fac de Médecine Paris Nord ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; METHYLPREDNISOLONE; PREDNISONE; STEROID;

ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; CORTICOSTEROID THERAPY; DIABETES MELLITUS; DISEASE ACTIVITY; DRUG INDUCED DISEASE; GLAUCOMA; HEMORRHAGIC CYSTITIS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTIOUS COMPLICATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; PRIORITY JOURNAL; RHEUMATIC DISEASE; TREATMENT OUTCOME; WEGENER GRANULOMATOSIS;

EID: 15644362541     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780401213     Document Type: Article

References (37)

1. Wegener F: Über generalisierte septische Gefässerkrankungen. Verh Dtsch Ges Pathol 29:202-210, 1936
2. Van der Woud FJ, Lobatto S, Permin H, van der Giessen M, Rasmussen N, Wilk A: Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet i:425-429, 1985
3. Gross WL, Csernok E: Immunodiagnostic pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis. Curr Opin Rheumatol 7:11-19, 1995
4. Fauci AS, Haynes BF, Katz P, Wolff SM: Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 98:76-85, 1983
5. Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, Rottem M, Fauci AS: Wegener's granulomatosis: an analysis of 158 patients. Ann Intern Med 116:488-498, 1992
6. Bradley JD, Brandt KD, Katz BP: Infectious complications of cyclophosphamide treatment for vasculitis. Arthritis Rheum 32: 45-53, 1989
7. Cohen J, Pinching A, Rees A, Peters D: Infection and immunosuppression. Q J Med 51:1-15, 1982
8. Fauci A, Katz P, Haynes B, Wolff S: Cyclophosphamide therapy of severe necrotizing vasculitis. N Engl J Med 301:235-238, 1979
9. Fort JG, Abruzzo JL: Reversal of progressive necrotizing vasculitis with intravenous pulse cyclophosphamide and methylprednisolone. Arthritis Rheum 31:1194-1198, 1988
10. Amoura Z, Choukroun G, Rover I, Gayraud M, Guillevin L: Traitement des maladies systémiques par bolus de cyclophosphamide: 15 observations. Ann Med Interne (Paris) 141:416-420, 1990
11. Drosos AA, Sakkas LI, Goussia A, Siamopoulos KC, Moutsopoulos HM: Pulse cyclophosphamide therapy in Wegener's granulomatosis: a pilot study. J Intern Med 232:279-282, 1992
12. Haga HJ, d'Cruz D, Asherson R, Hughes GR: Short term effects of intravenous pulses of cyclophosphamide in the treatment of connective tissue disease crisis. Ann Rheum Dis 51:885-888, 1992
13. Lhote F, Guillevin L: Treatment of polyarteritis nodosa and microscopic polyangiitis. Ann Med Interne (Paris) 145:550-565, 1994
14. Luqmani R, Watts R, Scott D, Bacon P: Treatment of vasculitis in rheumatoid arthritis. Ann Med Interne (Paris) 145:566-576, 1994
15. De Vita S, Neri R, Bombardieri S: Cyclophosphamide pulses in the treatment of rheumatic diseases: an update. Clin Exp Rheumatol 9:179-193, 1991
16. Heer A, Schroeder JO, Euler HH: Combination of plasmapheresis with subsequent pulse cyclophosphamide as initial treatment of severe Wegener's granulomatosis. APMIS Suppl 19:66, 1990
17. Hoffman GS, Leavitt RY, Fleisher TA, Minor JR, Fauci AS: Treatment of Wegener's granulomatosis with intermittent high dose intravenous cyclophosphamide. Am J Med 89:403-410, 1990
18. Talar-Williams C, Hijazi YM, Walther MM, Linehan WM, Hallahan CW, Lubensky I, Kerr GS, Hoffman GS, Fauci AS, Sneller MC: Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Ann Intern Med 124:477-484, 1996
19. Guillevin L, Lhote F, Jarrousse B, Fain O: Treatment of polyarteritis nodosa and Churg-Strauss syndrome: a meta-analysis of 3 prospective controlled trials including 182 patients over 12 years. Ann Med Interne (Paris) 143:405-416, 1992
20. Kaplan E, Meier P: Nonparametric estimation for incomplete information. J Am Stat Assoc 53:457-481, 1958
21. Peto R, Pike M, Armitage P: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1-39, 1977
22. Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, Calabrese LH, Fries JF, Lie JT, Lightfoot RW Jr, Masi AT, McShane DJ, Mills JA, Stevens MB, Wallace SL, Zvaifler NJ: The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum 33:1101-1107, 1990
23. Le Thi Huong D, Wechsler B, Cabane J, Piette J-C, Helleman G, Guillevin L, Blétig O, Godeau P: La granulomatose de Wegener: aspects cliniques et problèmes nosologiques; revue de la littérature à propos de 30 cas. Ann Med Interne (Paris) 139:169-182, 1988
24. Briedigkeit L, Ulmer M, Gobel U, Natusch R, Reinhold KE, Gross WL: Treatment of Wegener's granulomatosis. Adv Exp Med Biol 336:491-495, 1993
25. Gross WL: New developments in the treatment of systemic vasculitis. Curr Opin Rheumatol 6:11-19, 1994
26. Hoffman GS: Immunosuppressive therapy for autoimmune diseases. Ann Allergy 70:263-274, 1993
27. Reinhold-Keller E, Kekow J, Schnabel A, Schmitt WH, Heller M, Beigel A, Duncker G, Gross WL: Influence of disease manifestalions and antineutrophil cytoplasmic antibody titer on the response to pulse cyclophosphamide therapy in patients with Wegener's granulomatosis. Arthritis Rheum 37:919-924, 1994
28. Généreau T, Lortholary O, Leclerc P, Grenet D, Tubéry M, Sicard D, Caubarrère I, Guillevin L: Treatment of systemic vasculitis with cyclophosphamide and steroids: daily oral low-dose cyclophosphamide administration after failure of a pulse intravenous high-dose regimen in four patients. Br J Rheumatol 33:959-962, 1994
29. Falk RJ, Hogan S, Carey TS, Jennette JC, The Glomerular Disease Collaborative Network: Clinical course of antineutrophil cytoplasmic antibody-associated glomerulonephritis and systemic vasculitis. Ann Intern Med 113:656-663, 1990
30. Haubitz M, Frei U, Rother U, Brunkhorst R, Koch KM: Cyclophosphamide pulse therapy in Wegener's granulomatosis. Nephrol Dial Transplant 6:531-535, 1991
31. Jarrousse B, Guillevin L, Bindi E, Hachulla E, Leclerc P, Nilson B, Rémy P, Rossert J, Jacquot C: Increased risk of Pneumocystis carinii pneumonia in patients with Wegener's granulomatosis. Clin Exp Rheumatol 11:615-621, 1993
32. Godeau B, Coutant-Perronne V, Le Thi Huong D, Guillevin L, Magadur G, de Bandt M, Dellion S, Rossert J, Rostoker G, Piette J-C, Schaeffer A: Pneumocystis carinii pneumonia in the course of connective tissue disease: report of 34 cases. J Rheumatol 21:246-251, 1994
33. Ognihene FP, Shelhamer JH, Hoffman GS, Kerr OS, Reda D, Fauci AS, Leavitt RY: Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis. Am J Respir Crit Care Med 151:795-799, 1995
34. Stegeman CA, Cohen Tervaert JW, de Jong PE, Kallenberg CGM: Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis. N Engl J Med 335:16-20, 1996
35. Matteson EL, Gold KN, Bloch DA, Hunder GG: Long-term survival of patients with Wegener's granulomatosis from the American College of Rheumatology Wegener' granulomatosis classification criteria cohort. Am J Med 101:129-134, 1996
36. Hoffman GS, Leavitt RY, Kerr GS, Fauci AS: The treatment of Wegener's granulomatosis with glucocorticoids and methotrexate. Arthritis Rheum 35:1322-1329, 1992
37. Sneller MC, Hoffman GS, Talar-Williams C, Kerr GS, Hallahan CW, Fauci AS: An analysis of forty-two Wegener's granulomatosis patients treated with methotrexate and prednisone. Arthritis Rheum 38:608-613, 1995