Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients

Clinical Transplantation

Volumn 19, Issue 5, 2005, Pages 698-703

  Garrean, Sean ^a   Massad, Malek G ^a   Tshibaka, Michael ^a   Hanhan, Ziad ^a   Caines, Amitra E ^a   Benedetti, Enrico ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Interstitial pneumonitis; Lung toxicity; Post transplant; Rapamycin; Sirolimus

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CYCLOSPORIN; IMIPENEM; LIVER ENZYME; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OXYGEN; PREDNISONE; RAPAMYCIN; VANCOMYCIN;

ACIDOSIS; ADULT; ANOREXIA; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CLINICAL FEATURE; COUGHING; DIFFERENTIAL DIAGNOSIS; DRUG DOSE REDUCTION; DRUG FATALITY; DRUG MEGADOSE; DRUG WITHDRAWAL; DYSPNEA; ENZYME DEFECT; FATIGUE; FEMALE; FEVER; FOLLOW UP; HEART LUNG TRANSPLANTATION; HEART TRANSPLANTATION; HEMOPTYSIS; HUMAN; HYPERGLYCEMIA; HYPOXIA; IMMUNOSUPPRESSIVE TREATMENT; INTERSTITIAL PNEUMONIA; JAUNDICE; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LUNG HEMORRHAGE; LUNG INFILTRATE; LUNG TOXICITY; LUNG TRANSPLANTATION; MULTIPLE ORGAN FAILURE; NEPHROTOXICITY; OLIGURIA; PANCREAS ISLET TRANSPLANTATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECIPIENT; RESPIRATORY DISTRESS; RESPIRATORY TRACT DISEASE; RISK FACTOR; SEX DIFFERENCE; SYMPTOMATOLOGY; TACHYPNEA; THORAX RADIOGRAPHY; TREATMENT OUTCOME;

BRONCHOSCOPY; CARDIOMYOPATHY, DILATED; DISEASE PROGRESSION; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUNG DISEASES, INTERSTITIAL; MIDDLE AGED; SIROLIMUS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 25144441807     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2005.00356.x     Document Type: Article

References (16)

1. Manito N, Kaplinsky EJ, Bernat R et al. Fatal interstitial pneurnonitis associated with sirolimus therapy in a heart transplant recipient. J Heart Lung Transplant 2004: 23: 780.
2. Singer SJ, Tiernan R, Sullwan EJ. Interstitial pneumonitis associated with sirolimus therapy in renal transplant recipients. N Engl J Med 2000: 343: 1815.
3. McWilliams TJ, Levvey BJ, Russell PA, Milne DG, Snell GI. Interstitial pneumonitis associated with Sirolimus: a dilemma for lung transplantation. J Heart Lung Transplant 2003: 22: 210.
4. Seethamraju H, Kaleekal TS, Bag R. Pulmonary toxicity of sirolimus in lung transplant patients. Chest 2003: 124: 101S.
5. Brar JS, Ambreen Q, James S. Sirolimus induced interstitial pneumonitis and diffuse alveolar hemorrhage. Chest 2004: 126: 971.
6. Haydar AA, Denton M, West A, Rees J, Goldsmith DJA. Sirolimus-induced pneumonitis: three cases and a review of the literature. Am J Transplant 2004: 4: 137.
7. Nayak SK, Jeloka TK, Sreepada SV. Sirolimus-induced pneumonitis, sinusitis, and macular oedema. Nephrol Dial Transplant 2004: 19: 2931.
8. Pham PTT, Pham PCT, Danovitch GM et al. Sirolimus-associated pulmonary toxicity. Transplantation 2004: 77: 1215.
9. Shefet D, Ben-Dor I. Sirolimus-induced interstitial pneumonitis after renal transplantation. Transplantation 2004: 78: 950.
10. Vlahakis NE, Rickman OB, Morgenthaler T. Sirolimus-associated diffuse alveolar hemorrhage. Mayo Clin Proc 2004: 79: 541.
11. Morelon E, Stern M, Israel-Biet D et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 2001: 72: 787.
12. Mahalati K, Murphy DM. Bronchiolitis obliterans and organizing pneumonia in renal transplant recipients. Transplantation 2000: 69: 1531.
13. Avitzur Y, Jimenez-Rivera C, Fecteau A, Jones N, Ngan BY, Ng VL. Interstitial granulomatous pneumonitis associated with sirolimus in a child after liver transplantation. J Pediatr Gastroenterol Nutr 2003: 37: 91.
14. Lennon A, Finan K, Fitzgerald MX, McCormick PA. Interstitial pneumonitis associated with sirolimus (rapamycin) therapy after liver transplantation. Transplantation 2001: 72: 1166.
15. Digon BJ, Rother KI, Hirshberg B, Harlan DM. Sirolimus-induced interstitial pneumonitis in an islet transplant recipient. Diabetes Care 2003: 26: 3191.
16. Groetzner J, Kur F, Spelsberg F et al. Airway anastomotic complications in de novo lung transplantation with sirolimus-based immuosuppression. J Heart Lung Transplant 2004: 23: 632.