QUERCETIN: A POTENTIAL NATURAL DRUG FOR ADJUVANT TREATMENT OF RHEUMATOID ARTHRITIS

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 10, Issue 3, 2013, Pages 418-421

  Ji, Jian Jun ^a   Lin, Yuan ^a   Huang, Shan Shan ^a   Zhang, Hou Li ^a   Diao, Yun Peng ^a   Li, Kun ^b  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b LIAONING NORMAL UNIVERSITY   (China)

Author keywords

natural drug; quercetin; rheumatoid arthritis

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; AUTACOID; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT; QUERCETIN;

ANIMAL; ARTHRITIS, RHEUMATOID; ARTICLE; DRUG EFFECT; DRUG EFFECTS; HUMAN; INFLAMMATION; METABOLISM; NATURAL DRUG; NEOVASCULARIZATION (PATHOLOGY); NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PHYTOTHERAPY; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM;

NATURAL DRUG; QUERCETIN; RHEUMATOID ARTHRITIS;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ARTHRITIS, RHEUMATOID; CYTOKINES; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PHYTOTHERAPY; PLANT EXTRACTS; QUERCETIN; SYNOVIAL MEMBRANE; SYNOVITIS;

EID: 84900740331     PISSN: None     EISSN: 25050044     Source Type: Journal    
DOI: 10.4314/ajtcam.v10i3.5     Document Type: Article

References (23)

1. Cho S, Park S, Kwon M, Jeong T, Bok S, Choi W, et al.(2003). Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kB pathway in lipolysaccharide-stimulated macrophage. Mol Cell Biochem,243,153-60.
2. Choy EH, Panayi GS.(2001).Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med,344,907-916.
3. Cooles FA, Isaacs JD.(2011).Pathophysiology of rheumatoid arthritis. Curr Opin Rheumatol,23,233-40.
4. Ferry DR, Smith A, Malkhandi J, Fyfe DW, deTakats PG, Anderson D, et al.(1996). Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res,2,659-68.
5. Firestein GS.(2003).Evolving concepts of rheumatoid arthritis. Nature,423,356-361.
6. GarcI′a-Roma′n R, Salazar-Gonza′ lez D, Osas S, Arellanes-Robledo J, Beltra′n-RamI′rez O, Fattel-Fazenda S, et al.(2008).The differential NF-kB modulation by Sadenosyl-L-methionine. N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free Radic Res,42,331-43.
7. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC.(2007). A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol,45,2179-205.
8. Hertog MG, Kromhout D, Aravanis C, Blackburn H, Buzina R, Fidanza F, et al.(1995). Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med,155,381-6.
9. Hollman P C, Katan M B.(1999).Dietary flavonoids:intake,health effect and bioavailability. Food Chem Toxicol,37(9-10),937-942.
10. Kumar A, Takada Y, Boriek AM, Aggarwal BB.(2004). Nuclear factor-κB: its role in health and disease. J Mol Med,82,434-448.
11. Lamson DW, Brignall MS.(2000).Antioxidants and cancer, part 3: quercetin.Altern Med Rev,5,196-208.
12. Li ZG, Zhang FC, Bao CD.(2009)Rheumatoid Arthritis [M]. Beijing: People’s Medical Publishing House, 56.
13. Mamani-Matsuda M, Kauss T, Al-Kharrat A, Rambert J, Fawaz F, Thiolat D, Moynet D, Coves S, Malvy D, Mossalayi MD.(2006).Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol,72,1304-1310.
14. MartI′nez-Flo′ rez S, Gutie′rez S, Gutie′ rrez-Ferna′ndez B, Sa′nchez-Campos S, Gonza′ lez-Gallego J, Tun˜o′n M.(2005).Quercetin attenuates nuclear factor-kB activation and nitric oxide production in interleukin-1-b-activated rat hepatocytes. J Nutr,135,1359-65.
15. Miyasaka N, Hirata Y.(1997). Nitric oxide and inflammation arthritides. Life Sci,61,2073-81.
16. Pfander D,Kortje D,Zimmermann R,et al.(2001).Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints.Ann Rheum Dis, 60,1070-1073.
17. Sano H, Hla T, Maier JA, Crofford LJ, Case JP, Maciag T, et al.(1992). In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J Clin Invest,89,97-108.
18. Sen R, Baltimore D.(1986).Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell,46,705-716.
19. Sylwia B, Magdalena C, Teresa W, et al.(2012). In vitro effect of quercetin on human gastric carcinoma: Targeting cancer cells death and MDR. Food Chem Toxicol,50(9),3375-3383.
20. Tan W, Lin L, Li M,et al.(2003).Quercetin,a dietary-derived flavonoid,possesses antiangiogenic potential.Eur J Pharmacol,459,255-262.
21. Teresita Guardia, Alejandra Ester Rotelli, Americo Osvaldo Juarez, Lilian Eugenia Pelzer.(2001).Anti-inflammatory properties of plant flavonoids.Effects of rutin,quercetin and hesperidin on adjuvant arthritis in rat. Il Farmaco,56(9),683-687.
22. Verma RP,Hansch C.(2007).Matrixmetalloproteinases (MMPs): chemical-biological functions and (Q)SARs.BioorgMed Chem,15(6),2223-2268.
23. Yamada T, Sawatsubashi M,Yakushiji H,et al. (1998).Localization of vascular endothelial growth factor in synovial membrance mast cell:examination with“multi-labelling subtraction immunostaining”.Virchows Arch,433,567-570.