A mutation in TRPC6 channels abolishes their activation by hypoosmotic stretch but does not affect activation by diacylglycerol or G protein signaling cascades

American Journal of Physiology - Renal Physiology

Volumn 306, Issue 9, 2014, Pages

  Wilson, Cory ^a   Dryer, Stuart E ^a,b  

^a University of Houston   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Focal and segmental glomerulosclerosis; Glomerular filtration; Mechanosensitive channels; Podocyte; TRP channel

Indexed keywords

DIACYLGLYCEROL; GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRPC6 N143S CHANNEL; UNCLASSIFIED DRUG;

ALLELE; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL SURFACE; CONTROLLED STUDY; FOCAL GLOMERULOSCLEROSIS; GENE ACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOOSMOTIC STRETCH; OSMOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS; GLOMERULAR FILTRATION; MECHANOSENSITIVE CHANNELS; PODOCYTE; TRP CHANNEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIGLYCERIDES; GENOTYPE; HUMANS; ION CHANNEL GATING; MECHANOTRANSDUCTION, CELLULAR; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OSMOSIS; PHENOTYPE; RECEPTORS, PURINERGIC P2Y2; TRANSFECTION; TRPC CATION CHANNELS;

EID: 84900564971     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00662.2013     Document Type: Article

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