Mechanistic insights into the functional role of vascular endothelial growth factor and its signalling partner brain-derived neurotrophic factor in angiogenic tube formation

Acta Physiologica

Volumn 211, Issue 2, 2014, Pages 268-270

  Deindl, E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; VASCULOTROPIN; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; P37 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANGIOGENESIS; CAPILLARY ENDOTHELIAL CELL; CELL MIGRATION; CELL PROLIFERATION; EDITORIAL; ENDOTHELIUM CELL; MECHANOTRANSDUCTION; NERVE SPROUTING; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; HUMAN; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BRAIN-DERIVED NEUROTROPHIC FACTOR; ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; OXIDATIVE STRESS; RECEPTOR, TRKB;

EID: 84900564651     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12299     Document Type: Editorial

References (22)

1. Acheson, A., Conover, J.C., Fandl, J.P., DeChiara, T.M., Russell, M., Thadani, A., Squinto, S.P., Yancopoulos, G.D. & Lindsay, R.M. 1995. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374, 450-453.
2. Au, C.W., Siu, M.K., Liao, X., Wong, E.S., Ngan, H.Y., Tam, K.F., Chan, D.C., Chan, Q.K. & Cheung, A.N. 2009. Tyrosine kinase B receptor and BDNF expression in ovarian cancers - effect on cell migration, angiogenesis and clinical outcome. Cancer Lett 281, 151-161.
3. Carmeliet, P. & Jain, R.K. 2011. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298-307.
4. Carmeliet, P. & Ruiz de Almodovar, C. 2013. VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration. Cell Mol Life Sci 70, 1763-1778.
5. Chen, J., Zhang, Z.G., Li, Y., Wang, Y., Wang, L., Jiang, H., Zhang, C., Lu, M., Katakowski, M., Feldkamp, C.S. & Chopp, M. 2003. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 53, 743-751.
6. Chen, J., Zhang, C., Jiang, H., Li, Y., Zhang, L., Robin, A., Katakowski, M., Lu, M. & Chopp, M. 2005. Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 25, 281-290.
7. Donovan, M.J., Lin, M.I., Wiegn, P., Ringstedt, T., Kraemer, R., Hahn, R., Wang, S., Ibanez, C.F., Rafii, S. & Hempstead, B.L. 2000. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 127, 4531-4540.
8. Fritzsch, B., Tessarollo, L., Coppola, E. & Reichardt, L.F. 2004. Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance. Prog Brain Res 146, 265-278.
9. Gliki, G., Wheeler-Jones, C. & Zachary, I. 2002. Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesis. Cell Biol Int 26, 751-759.
10. Hu, Y., Wang, Y.D., Guo, T., Wei, W.N., Sun, C.Y., Zhang, L. & Huang, J. 2007. Identification of brain-derived neurotrophic factor as a novel angiogenic protein in multiple myeloma. Cancer Genet Cytogenet 178, 1-10.
11. Huang, E.J. & Reichardt, L.F. 2001. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24, 677-736.
12. Ikeda, S., Yamaoka-Tojo, M., Hilenski, L., Patrushev, N.A., Anwar, G.M., Quinn, M.T. & Ushio-Fukai, M. 2005. IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2. Arterioscler Thromb Vasc Biol 25, 2295-2300.
13. Katare, R.G., Kakinuma, Y., Arikawa, M., Yamasaki, F. & Sato, T. 2009. Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway. J Mol Cell Cardiol 46, 405-412.
14. Kermani, P., Rafii, D., Jin, D.K., Whitlock, P., Schaffer, W., Chiang, A., Vincent, L., Friedrich, M., Shido, K., Hackett, N.R., Crystal, R.G., Rafii, S. & Hempstead, B.L. 2005. Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest 115, 653-663.
15. Kim, H., Li, Q., Hempstead, B.L. & Madri, J.A. 2004. Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. J Biol Chem 279, 33538-33546.
16. Lessmann, V., Gottmann, K. & Malcangio, M. 2003. Neurotrophin secretion: current facts and future prospects. Prog Neurobiol 69, 341-374.
17. Long, B.L., Rekhi, R., Abrego, A., Jung, J. & Qutub, A.A. 2013. Cells as state machines: cell behavior patterns arise during capillary formation as a function of BDNF and VEGF. J Theor Biol 326, 43-57.
18. Lu, B., Nagappan, G. & Lu, Y. 2014. BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol 220, 223-250.
19. Skaper, S.D. 2008. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol Disord Drug Targets 7, 46-62.
20. Ushio-Fukai, M. 2007. VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 9, 731-739.
21. Usui, T., Naruo, A., Okada, M., Hayabe, Y. & Yamawaki, H. 2014. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. Acta Physiol (Oxf) 211, 385-394.
22. Wu, H., Lu, D., Jiang, H., Xiong, Y., Qu, C., Li, B., Mahmood, A., Zhou, D. & Chopp, M. 2008. Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury. J Neurotrauma 25, 130-139.