Combination of antithrombin and recombinant thrombomodulin attenuates leukocyte-endothelial interaction and suppresses the increase of intrinsic damage-associated molecular patterns in endotoxemic rats

Journal of Surgical Research

Volumn 187, Issue 2, 2014, Pages 581-586

  Iba, Toshiaki ^a   Miki, Takahiro ^a   Hashiguchi, Naoyuki ^a   Yamada, Atsushi ^a   Nagaoka, Isao ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Antithrombin concentrate; High mobility group box 1; Neutrophil extracellular traps; Nucleosome; Recombinant thrombomodulin

Indexed keywords

ANTITHROMBIN; HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE; PLACEBO; RECOMBINANT THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BLOOD CLOTTING; BLOOD FLOW; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; EXPERIMENTAL ENDOTOXEMIA; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE; LEUKOCYTE ADHERENCE; MICROCIRCULATION; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; RAT; VENULE;

ANTITHROMBIN CONCENTRATE; HIGH-MOBILITY GROUP BOX 1; NEUTROPHIL EXTRACELLULAR TRAPS; NUCLEOSOME; RECOMBINANT THROMBOMODULIN;

ANIMALS; ANTITHROMBINS; CELL ADHESION; CELL COMMUNICATION; DRUG THERAPY, COMBINATION; ENDOTHELIAL CELLS; ENDOTOXEMIA; HMGB1 PROTEIN; LIPOPOLYSACCHARIDES; NEUTROPHILS; NUCLEOSOMES; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SEPSIS; THROMBOMODULIN; THROMBOSIS;

EID: 84900525998     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.10.058     Document Type: Article

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