IL-4 induces columnar-like differentiation of esophageal squamous epithelium through JAK/PI3K pathway: Possible role in pathogenesis of Barrett's esophagus

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 306, Issue 8, 2014, Pages

  Shan, Jing ^a,b   Oshima, Tadayuki ^a   Farre, Ricard ^c   Fukui, Hirokazu ^a   Watari, Jiro ^a   Miwa, Hiroto ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b Third People's Hospital of Chengdu   (China)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Barrett's esophagus; Barrier function; Columnar like differentiation; Cytokine; IL 4

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKERATIN 13; CYTOKERATIN 14; CYTOKERATIN 7; CYTOKERATIN 8; EOSIN; HEMATOXYLIN; INTERLEUKIN 1BETA; INTERLEUKIN 4; INVOLUCRIN; JANUS KINASE; JANUS KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BARRETT ESOPHAGUS; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTRIC RESISTANCE; EPITHELIUM CELL; ESOPHAGUS MUCOSA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS EPITHELIUM; TH1 CELL; TH2 CELL; TISSUE DIFFERENTIATION; WESTERN BLOTTING;

BARRETT'S ESOPHAGUS; BARRIER FUNCTION; COLUMNAR-LIKE DIFFERENTIATION; CYTOKINE; IL-4;

BARRETT ESOPHAGUS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; EPITHELIAL CELLS; ESOPHAGUS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; INTERLEUKIN-4; KERATINS; METAPLASIA; PROTEIN PRECURSORS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84900524905     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00386.2013     Document Type: Article

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