Oncogenic BRAF inhibitor UAI-201 induces cell cycle arrest and autophagy in BRAF mutant glioma cells

Life Sciences

Volumn 104, Issue 1-2, 2014, Pages 38-46

  Ahn, Jun Ho ^a   Lee, Yong Woo ^b   Ahn, Soon Kil ^a,c   Lee, Michael ^a  

^a SolarLight Ltd   (South Korea)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c YOUAI Co Ltd   (South Korea)

Author keywords

Autophagy; BRAF inhibitor; Cell cycle arrest; Glioma; UAI 201

Indexed keywords

AUTOPHAGY PROTEIN 5; B RAF KINASE INHIBITOR; BECLIN 1; CRYSTAL VIOLET; MULTIDRUG RESISTANCE PROTEIN; SMALL INTERFERING RNA; UAI 201; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; BRAIN TUMOR; CELL CYCLE; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; GENOTYPE; GLIOMA CELL; GLIOMA CELL LINE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

AUTOPHAGY; BRAF INHIBITOR; CELL CYCLE ARREST; GLIOMA; UAI-201;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BRAIN NEOPLASMS; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, MULTIPLE; GLIOMA; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF; PURINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFONAMIDES;

EID: 84900516324     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.03.026     Document Type: Article

References (41)

1. J.-H. Ahn, S.K. Ahn, and M. Lee The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts Biochem Biophys Res Commun 417 2012 857 863
2. D. Basto, V. Trovisco, J.M. Lopes, A. Martins, F. Pardal, and P. Soares et al. Mutation analysis of B-RAF gene in human gliomas Acta Neuropathol 109 2005 207 210 (Pubitemid 40468390)
3. M.V. Blagosklonny Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events Cell Cycle 6 2007 70 74 (Pubitemid 46178022)
4. S.M. Chang, N.A. Butowski, P.K. Sneed, and I.V. Garner Standard treatment and experimental targeted drug therapy for recurrent glioblastoma multiforme Neurosurg Focus 20 2006 E4
5. P.B. Chapman, A. Hauschild, C. Robert, J.B. Haanen, P. Ascierto, and J. Larkin et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation N Engl J Med 364 2011 2507 2516
6. H. Davies, G. Bignell, C. Cox, P. Stephens, S. Edkins, and S. Clegg et al. Mutations of the B-Raf gene in human cancer Nature 417 2002 949 954 (Pubitemid 34716871)
7. J. Debnath, E.H. Baehrecke, and G. Kroemer Does autophagy contribute to cell death? Autophagy 1 2005 e10 e18
8. X. Declèves, A. Fajac, J. Lehmann-Che, M. Tardy, C. Mercier, and I. Hurbain et al. Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines Int J Cancer 98 2002 173 180 (Pubitemid 34150798)
9. D. Dias-Santagata, Q. Lam, K. Vernovsky, N. Vena, J.K. Lennerz, and D.R. Borger et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications PLoS One 6 2011 e17948
10. S.M. Dombrowski, S.Y. Desai, M. Marroni, L. Cucullo, K. Goodrich, and W. Bingaman et al. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy Epilepsia 42 2001 1501 1506 (Pubitemid 34020086)
11. M.J. Dougherty, M. Santi, M.S. Brose, C. Ma, A.C. Resnick, and A.J. Sievert et al. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas Neuro Oncol 12 2010 621 630
12. T. Eisen, T. Ahmad, K.T. Flaherty, M. Gore, S. Kaye, and R. Marais et al. Sorafenib in advanced melanoma: a phase II randomised discontinuation trial analysis Br J Cancer 95 2006 581 586 (Pubitemid 44325897)
13. K.-H. Eum, and M. Lee Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras transformed NIH3T3 cells Mol Cells 31 2010 231 238
14. K.-H. Eum, and M. Lee Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts Mol Cell Biochem 348 2011 61 68
15. K.T. Flaherty, I. Puzanov, K.B. Kim, A. Ribas, G.A. McArthur, and J.A. Sosman et al. Inhibition of mutated, activated BRAF in metastatic melanoma N Engl J Med 363 2010 809 819
16. S.J. Heidorn, C. Milagre, S. Whittaker, A. Nourry, I. Niculescu-Duvas, and N. Dhomen et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 2010 209 221
17. D.T.W. Jones, S. Kocialkowski, L. Liu, D.M. Pearson, L.M. Bäcklund, and K. Ichimura et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas Cancer Res 68 2008 8673 8677
18. C. Kang, and L. Avery To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation Autophagy 4 2008 82 84
19. M. Karbowniczek, T. Cash, M. Cheung, G.P. Robertson, A. Astrinidis, and E.P. Henske Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent J Biol Chem 279 2004 29930 29937 (Pubitemid 38937912)
20. B.K. Kleinschmidt-DeMasters, D.L. Aisner, D.K. Birks, and N.K. Foreman Epithelioid GBMs show a high percentage of BRAF V600E mutation Am J Surg Pathol 37 2013 685 698
21. G. Lama, A. Mangiola, C. Anile, G. Sabatino, P. De Bonis, and L. Lauriola et al. Activated ERK1/2 expression in glioblastoma multiforme and in peritumor tissue Int J Oncol 30 2007 1333 1342
22. B. Levine, and J. Yuan Autophagy in cell death: an innocent convict? J Clin Invest 115 2005 2679 2688 (Pubitemid 41434392)
23. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408 (Pubitemid 34164012)
24. N. Maddodi, W. Huang, T. Havighurst, K. Kim, B.J. Longley, and V. Setaluri Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF J Invest Dermatol 130 2010 1657 1667
25. M.C. Maiuri, E. Zalckvar, A. Kimchi, and G. Kroemer Self-eating and self-killing: crosstalk between autophagy and apoptosis Nat Rev Mol Cell Biol 8 2007 714 752
26. A.I. Marcus, U. Peters, S.L. Thomas, S. Garrett, A. Zelnak, and T.M. Kapoor et al. Mitotic kinesin inhibitors induce mitotic arrest and cell death in taxol-resistant and -sensitive cancer cells J Biol Chem 280 2005 11569 11577 (Pubitemid 40418469)
27. C. Mawrin, S. Diete, T. Treuheit, S. Kropf, C.K. Vorwerk, and C. Boltze et al. Prognostic relevance of MAPK expression in glioblastoma multiforme Int J Oncol 23 2003 641 648
28. A.J. Meijer, and P. Codogno Autophagy: regulation and role in disease Crit Rev Clin Lab Sci 46 2009 210 240
29. R.K. Mittapalli, S. Vaidhyanathan, R. Sane, and W.F. Elmquist Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032) J Pharmacol Exp Ther 342 2012 33 40
30. N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075 (Pubitemid 351317450)
31. T.P. Nicolaides, H. Li, D.A. Solomon, S. Hariono, R. Hashizume, and K. Barkovich et al. Targeted therapy for BRAFV600E malignant astrocytoma Clin Cancer Res 17 2011 7595 7604
32. B. Pollo Pathological classification of brain tumors Q J Nucl Med Mol Imaging 56 2012 103 111
33. P.I. Poulikakos, C. Zhang, G. Bollag, K.M. Shokat, and N. Rosen RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 2010 427 430
34. A. Ribas, and K.T. Flaherty BRAF targeted therapy changes the treatment paradigm in melanoma Nat Rev Clin Oncol 8 2011 426 432
35. G. Schindler, D. Capper, J. Meyer, W. Janzarik, H. Omran, and C. Herold-Mende et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma Acta Neuropathol 121 2011 397 405
36. T. Schmelzle, and M.N. Hall TOR, a central controller of cell growth Cell 103 2000 253 262
37. D.B. Solit, L.A. Garraway, C.A. Pratilas, A. Sawai, G. Getz, and A. Basso et al. BRAF mutation predicts sensitivity to MEK inhibition Nature 439 2006 358 362 (Pubitemid 43128863)
38. Q. Sun, W. Fan, and Q. Zhong Regulation of Beclin 1 in autophagy Autophagy 5 2009 713 716
39. J. Tsai, J.T. Lee, W. Wang, J. Zhang, H. Cho, and S. Mamo et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc Natl Acad Sci U S A 105 2008 3041 3046 (Pubitemid 351723664)
40. P.Y. Wen, and S. Kesari Malignant gliomas in adults N Engl J Med 359 2008 492 507
41. S.M. Wilhelm, C. Carter, L. Tang, D. Wilkie, A. McNabola, and H. Rong et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis Cancer Res 64 2004 7099 7109 (Pubitemid 39331023)