Preparation of nanobubbles carrying androgen receptor siRNA and their inhibitory effects on androgen-independent prostate cancer when combined with ultrasonic irradiation

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Wang, Luofu ^a   Zhang, Miao ^b   Tan, Kaibin ^b   Guo, Yanli ^b   Tong, Haipeng ^b   Fan, Xiaozhou ^b   Fang, Kejing ^b   Li, Rui ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; MESSENGER RNA; NANOBUBBLE; POLYLYSINE; SMALL INTERFERING RNA; SONOVUE; AR PROTEIN, HUMAN; NANOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CELL COUNT; CONTROLLED STUDY; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATIC ELECTRICITY; TUMOR XENOGRAFT; ULTRASOUND THERAPY; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; GENE THERAPY; GENE VECTOR; GENETICS; METABOLISM; PATHOLOGY; PROCEDURES; PROSTATIC NEOPLASMS; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GENETIC THERAPY; GENETIC VECTORS; HETEROGRAFTS; HUMANS; MALE; MICE; NANOSTRUCTURES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; ULTRASONIC THERAPY;

EID: 84900458413     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096586     Document Type: Article

References (27)

1. Hong MY, Seeram NP, Heber D (2008) Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. The Journal of nutritional biochemistry 19: 848-855.
2. Devlin H-L, Mudryj M (2009) Progression of prostate cancer: multiple pathways to androgen independence. Cancer letters 274: 177-186.
3. Akaza H (2011) Combined androgen blockade for prostate cancer: Review of efficacy, safety and cost-effectiveness. Cancer science 102: 51-56.
4. Shiota M, Yokomizo A, Naito S (2011) Increased androgen receptor transcription: a cause of castration-resistant prostate cancer and a possible therapeutic target. Journal of molecular endocrinology 47: R25-R41.
5. Hååg P, Bektic J, Bartsch G, Klocker H, Eder IE (2005) Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. The Journal of steroid biochemistry and molecular biology 96: 251-258. (Pubitemid 41080506)
6. Miao Z, Yanli G, Luofu W, Yan L, Rui L (2011) Screening and evaluation of a newly designed siRNA targeting androgen receptor [J]. Journal of Third Military Medical University 23.
7. Watanabe Y, Aoi A, Horie S, Tomita N, Mori S, et al. (2008) Low-intensity ultrasound and microbubbles enhance the antitumor effect of cisplatin. Cancer science 99: 2525-2531.
8. Vandenbroucke RE, Lentacker I, Demeester J, De Smedt SC, Sanders NN (2008) Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles. Journal of controlled release 126: 265-273.
9. Endo-Takahashi Y, Negishi Y, Kato Y, Suzuki R, Maruyama K, et al. (2012) Efficient siRNA delivery using novel siRNA-loaded Bubble liposomes and ultrasound. International journal of pharmaceutics 422: 504-509.
10. Yin T, Wang P, Zheng R, Zheng B, Cheng D, et al. (2012) Nanobubbles for enhanced ultrasound imaging of tumors. Int J Nanomedicine 7: 895-904.
11. Wang D, Yang K, Gao Y-H, Tan K-B, Liu Z (2010) Preparation and characterization of a nanoscale ultrasound contrast agent. Clinical imaging 34: 288-292.
12. Li H, Zheng X, Wang H, Li F, Wu Y, et al. (2009) Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo. Gene therapy 16: 1146-1153.
13. Rahim A, Taylor SL, Bush NL, Ter Haar GR, Bamber JC, et al. (2006) Physical parameters affecting ultrasound/microbubble-mediated gene delivery efficiency in vitro. Ultrasound in medicine & biology 32: 1269-1279. (Pubitemid 44093795)
14. Hernot S, Klibanov AL (2008) Microbubbles in ultrasound-triggered drug and gene delivery. Advanced drug delivery reviews 60: 1153-1166.
15. Díaz-López R, Tsapis N, Santin M, Bridal SL, Nicolas V, et al. (2010) The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent. Biomaterials 31: 1723-1731.
16. Oeffinger BE, Wheatley MA (2004) Development and characterization of a nano-scale contrast agent. Ultrasonics 42: 343-347.
17. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, et al. (1998) Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proceedings of the National Academy of Sciences 95: 4607-4612. (Pubitemid 28207960)
18. Hughes MS, Marsh JN, Hall CS, Fuhrhop RW, Lacy EK, et al. (2005) Acoustic characterization in whole blood and plasma of site-targeted nanoparticle ultrasound contrast agent for molecular imaging. The Journal of the Acoustical Society of America 117: 964-972. (Pubitemid 40223454)
19. Pan D, Lanza GM, Wickline SA, Caruthers SD (2009) Nanomedicine: perspective and promises with ligand-directed molecular imaging. European journal of radiology 70: 274-285.
20. Zhang M, Guo Y, Tan K, Li R, Huo X, Ding J (2011) Physical characteristics and tumors model contrast imaging of a self-made nano-scale microbubble contrast agent. Chinese journal of Ultrasonograpy 20: 894-897
21. Kornmann LM, Reesink KD, Reneman RS, Hoeks AP (2010) Critical appraisal of targeted ultrasound contrast agents for molecular imaging in large arteries. Ultrasound in medicine & biology 36: 181-191.
22. Ferrante E, Pickard J, Rychak J, Klibanov A, Ley K (2009) Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. Journal of controlled release 140: 100-107.
23. Wang Z-X, Wang Z-G, Xu C-S, Ren J-L (2009) Experimental study on preparation of lipid ultrasound microbubbles loaded gene and polylysine. Chinese Journal of Ultrasound in Medicine 25: 101-104.
24. Chen W-S, Lu X, Liu Y, Zhong P (2004) The effect of surface agitation on ultrasound-mediated gene transfer in vitro. The Journal of the Acoustical Society of America 116: 2440-2450. (Pubitemid 39391646)
25. Haag P, Frauscher F, Gradl J, Seitz A, Schäfer G, et al. (2006) Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours. The Journal of steroid biochemistry and molecular biology 102: 103-113. (Pubitemid 44750646)
26. Böhmer MR, Klibanov AL, Tiemann K, Hall CS, Gruell H, et al. (2009) Ultrasound triggered image-guided drug delivery. European journal of radiology 70: 242-253.
27. Zhou YF (2011) High intensity focused ultrasound in clinical tumor ablation. World J Clin Oncol 2: 8-27