Effects of wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal parameters in healthy preadolescent children

Journal of Pediatric Gastroenterology and Nutrition

Volumn 58, Issue 5, 2014, Pages 647-653

  François, Isabelle E J A ^a   Lescroart, Olivier ^a   Veraverbeke, Wim S ^a   Marzorati, Massimo ^b   Possemiers, Sam ^b   Hamer, Henrike ^c   Windey, Karen ^c   Welling, Gjalt W ^d   Delcour, Jan A ^e   Courtin, Christophe M ^e   Verbeke, Kristin ^c   Broekaert, Willem F ^a  

^a Fugeia NV   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e LEUVEN FOOD SCIENCE AND NUTRITION RESEARCH CENTRE LFORCE   (Belgium)

Author keywords

arabinoxylan oligosaccharides; children; prebiotic; protein fermentation reduction; wheat bran extract

Indexed keywords

ARABINOXYLAN; ISOBUTYRIC ACID; ISOVALERIC ACID; PREBIOTIC AGENT; UNCLASSIFIED DRUG; WHEAT BRAN EXTRACT; AMMONIA; FATTY ACID; OLIGOSACCHARIDE; PLACEBO; PLANT EXTRACT; VOLATILE FATTY ACID; XYLAN;

ABDOMINAL CRAMP; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEFECATION HABIT; DISEASE SEVERITY; DISTRESS SYNDROME; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FECES ANALYSIS; FECES MICROFLORA; FLATULENCE; GASTROINTESTINAL SYMPTOM; HUMAN; PATIENT COMPLIANCE; PH; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WHEAT BRAN; ABDOMINAL PAIN; ANALYSIS; BIFIDOBACTERIUM; CHEMICALLY INDUCED; CHEMISTRY; CHILD; DIETARY FIBER; DRUG EFFECTS; FECES; FEMALE; GASTROINTESTINAL TRACT; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; MICROFLORA;

ABDOMINAL PAIN; AMMONIA; BIFIDOBACTERIUM; CHILD; CROSS-OVER STUDIES; DIETARY FIBER; DOUBLE-BLIND METHOD; FATTY ACIDS; FATTY ACIDS, VOLATILE; FECES; FEMALE; FLATULENCE; GASTROINTESTINAL TRACT; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MICROBIOTA; OLIGOSACCHARIDES; PATIENT COMPLIANCE; PLACEBOS; PLANT EXTRACTS; PREBIOTICS; XYLANS;

EID: 84900451978     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000285     Document Type: Article

References (49)

1. Broekaert WF, Courtin CM, Verbeke K, et al. Prebiotic and other health-related effects of cereal-derived arabinoxylans, arabinoxylan-oligosac- charides and xylo-oligosaccharides. Crit Rev Food Sci Nutr 2011;51:178-94.
2. Femia AP, Salvadori M, Broekaert WF, et al. Arabinoxylan oligosac-charides (AXOS) reduce preneoplastic lesions in the colon of rats treated with 1, 2-dimethylhydrazine (DMH). Eur J Nutr 2010;49: 127-32.
3. Yamada H, Itoh K, Morishita Y, et al. Structure and properties of oligosaccharides from wheat bran. Cereal Food World 1993;38:490-2.
4. Courtin CM, Swennen K, Broekaert WF, et al. Dietary inclusion of wheat bran arabinoxylooligosaccharides has beneficial nutritional effects on chickens. Cereal Chem 2008;85:607-13.
5. Courtin CM, Swennen K, Broekaert WF, et al. Effects of dietary inclusion of xylooligosaccharides, arabinoxylooligosaccharides and soluble arabinoxylan on the microbial composition of caecal contents of chickens. J Sci Food Agric 2008;88:2517-22.
6. Van Craeyveld V, Swennen K, Dornez E, et al. Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats. J Nutr 2008;138:2348-55.
7. Cloetens L, Broekaert WF, Delaedt Y, et al. Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study. Br J Nutr 2010;103: 703-13.
8. François IEJA, Lescroart O, Veraverbeke WS, et al. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomized, placebo-controlled, crossover trial. Br J Nutr 2012;108:2229-42.
9. Maki KC, Gibson GR, Dickmann RS, et al. Digestive and physiological effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal. Nutrition 2012;28:1115-21.
10. Hamer HM, De Preter V, Cloetens L, et al. A dietary intervention with arabinoxylan oligosaccharides reduces colonic protein fermentation in healthy subjects: results from faecal metabolite fingerprint analysis. Gastroenterology 2010;138 (S1):616.
11. Hughes R, Magee EA, Bingham S. Protein degradation in the large intestine: relevance to colorectal cancer. Curr Issues Intest Microbiol 2000;1:51-8.
12. Bammens B, Evenepoel P, Keuleers H, et al. Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int 2006;69:1081-7.
13. Bone E, Tamm A, Hill M. Production of urinary phenols by gut bacteria and their possible role in causation of large bowel cancer. Am J Clin Nutr 1976;29:1448-54.
14. De Graaf AA, Venema K. Gaining insight into microbial physiology in the large intestine: a special role for stable isotopes. Adv Microb Physiol 2008;53:73-168.
15. Attene-Ramos MS, Wagner ED, Plewa MJ, et al. Evidence that hydrogen sulfide is a genotoxic agent. Mol Cancer Res 2006;4:9-14.
16. Bartram HP, Scheppach W, Schmid H, et al. Proliferation of human colonic mucosa as an intermediate biomarker of carcinogenesis: effects of butyrate, deoxycholate, calcium, ammonia, and pH. Cancer Res 1993;53:3283-8.
17. Leschelle X, Robert V, Delpal S, et al. Isolation of pig crypts for cytotoxic assay of luminal compounds: effects of hydrogen sulfide, ammonia, and deoxycholic acid. Cell Biol Toxicol 2002;18:193-203.
18. Andriamihaja M, Davila AM, Eklou-Lawson M, et al. Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet. Am J Physiol Gastrointest Liver Physiol 2010;299:G1030-7.
19. Toden S, Bird AR, Topping DL, et al. Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats. Nutr Cancer 2005;51:45-51.
20. Paliy O, Kenche H, Abernathy F, et al. High throughput quantitative analysis of the human intestinal microbiota with a phylogenetic micro-array. Appl Environ Microb 2009;75:3572-9.
21. Agans R, Rigsbee L, Kenche H, et al. Distal gut microbiota of adolescent children is different from that of adults. FEMS Microbiol Ecol 2011;77:404-12.
22. Swennen K, Courtin CM, Lindemans GCJE, et al. Large scale production and characterisation of wheat bran arabinoxylooligosaccharides. J Sci Food Agric 2006;86:1722-31.
23. Van de Wiele T, Boon N, Possemiers S, et al. Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem. FEMS Microbiol Ecol 2004;51:143-53.
24. Yap WKW, Mohamed S, Jamal MH, et al. Changes in infants faecal characteristics and microbiota by inulin supplementation. J Clin Bio-chem Nutr 2008;43:159-66.
25. Bremner JM, Keeney RD. Steam distillation methods for determination of ammonium, nitrate and nitrite. Anal Chem Acta 1965;32:485-95.
26. Riegler G, Esposito I. Bristol scale stool form. A still valid help in medical practice and clinical research. Techn Coloproct 2001;5:163-4.
27. Maki KC, Carson ML, Miller MP, et al. Hydroxypropylmethylcellulose lowers cholesterol in statin-treated men and women with primary hypercholesterolemia. Eur J Clin Nutr 2009;63:1001-7.
28. Pinheiro JC, Bates DM. Mixed-Effects Models in S and S-PLUS. New York: Springer-Verlag; 2004
29. Shapiro SS, Wilk MB. An analysis of variance test for normality [complete samples]. Biometrika 1965;52:591-611.
30. Conover WJ, Iman RL. Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat 1981;35:124-9.
31. Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biometrical J 2008;50:346-63.
32. Sidak Z. Rectangular confidence region for the means of multivariate normal distributions. J Am Stat Assoc 1967;62:626-33.
33. Molenberghs G, Verbeke G. Models for Discrete Longitudinal Data. New York: Springer; 2005.
34. Cloetens L. In Vivo Evaluation of the Gastrointestinal Effects of Arabinoxylan-Oligosaccharides in Healthy Subjects [PhD thesis]. Leu-ven, Belgium: University of Leuven; 2009.
35. Taipale T, Pienihäkkinen K, Isolauri E, et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr 2011;105:409-16.
36. O'Mahony L, McCarthy J, Kelly P, et al. Lactobacillus and bifidobac-terium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005;128:541-51.
37. Guglielmetti S, Mora D, Gschwender M, et al. Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life-a double-blind, placebo-controlled study. Aliment Pharmacol Ther 2011; 33:1123-32.
38. Bermudez-Brito M, Plaza-D́iaz J, Muñoz-Quezada S, et al. Probiotic mechanisms of action. Ann Nutr Metab 2012;61:160-74.
39. Smith EA, Macfarlane GT. Dissimilatory amino acid metabolism in human colonic bacteria. Anaerobe 1997;3:327-37.
40. Geypens B, Claus D, Evenepoel P, et al. Influence of dietary protein supplements on the fermentation of bacterial metabolites in the colon. Gut 1997;41:70-6.
41. Cloetens L, De Preter V, Swennen K, et al. Dose-response effect of arabinoxylooligosaccharides on gastrointestinal motility and on colonic bacterial metabolism in healthy volunteers. J Am Col Nutr 2008;27: 512-8.
42. De Preter V, Falony G, Windey K, et al. The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis. Mol Nutr Food Res 2010;54:1791-801.
43. Belenguer A, Duncan S, Holtrop G, et al. Quantitative analysis of microbial metabolism in the human large intestine. Curr Nutr Food Sci 2008;4:109-26.
44. Grabitske HA, Slavin JL. Gastrointestinal effects of low-digestible carbohydrates. Crit Rev Food Sci Nutr 2009;49:327-60.
45. Slavin J, Feirtag J. Chicoryinul in does not increases tool weight or speed up intestinal transit time in healthy male subjects. Food Funct 2011;2:72-6.
46. Kruse HP, Kleessen B, Blaut M. Effects of inulin on faecal bifidobac-teria in human subjects. Br J Nutr 1999;82:375-82.
47. Bouhnik Y, Raskine L, Champion K, et al. Prolonged administration of low-dose inulin stimulates the growth of bifidobacteria in humans. Nutr Res 2007;27:187-93.
48. Bonnema AL, Kolberg LW, Thomas W, et al. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110:865-8.
49. Wilson TA, Adolph AL, Butte NF. Nutrient adequacy and diet quality in non-overweight and overweight Hispanic children of low socioeco-nomic status: the Viva la Familia Study. J Am Diet Assoc 2009;109: 1012-21.