Accelerated repair and reduced mutagenicity of DNA damage induced by cigarette smoke in human bronchial cells transfected with E.coli formamidopyrimidine DNA glycosylase

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Foresta, Mara ^a,b   Izzotti, Alberto ^a,b   La Maestra, Sebastiano ^a   Micale, Rosanna ^a   Poggi, Alessandro ^b   Vecchio, Donatella ^b   Frosina, Guido ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CIGARETTE SMOKE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; ENHANCED GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PLASMID VECTOR;

ARTICLE; BRONCHUS CELL; CARCINOMA CELL LINE; CELL CYCLE; CLONOGENESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; ESCHERICHIA COLI; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; LUNG NON SMALL CELL CANCER; MUTAGENICITY; MUTANT; NCI H727 CELL LINE; TOXICITY;

BRONCHI; CELL LINE, TUMOR; DNA DAMAGE; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FEMALE; HUMANS; MIDDLE AGED; RECOMBINANT PROTEINS; TOBACCO SMOKE POLLUTION; TRANSFECTION;

EID: 84900444945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087984     Document Type: Article

References (40)

1. De Flora S, Izzotti A, Randerath K, Randerath E, Bartsch H, et al. (1996) DNA adducts and chronic degenerative disease. pathogenetic relevance and implications in preventive medicine. Mutat Res 366: 197-238. (Pubitemid 27051417)
2. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2012) Personal habits and indoor combustions. volume 100 E. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum 100: 1-538.
3. DeMarini DM (2004) Genotoxicity of tobacco smoke and tobacco smoke condensate: A review. Mutat Res 567: 447-474.
4. Kim KC, Lee IK, Kang KA, Cha JW, Cho SJ, et al. (2013) 7,8-dihydroxyflavone suppresses oxidative stress-induced base modification in DNA via induction of the repair enzyme 8-oxoguanine DNA glycosylase-1. Biomed Res Int 2013: 863720.
5. Coste F, Ober M, Carell T, Boiteux S, Zelwer C, et al. (2004) Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5- formamidopyrimidine) by formamidopyrimidine-DNA glycosylase. J Biol Chem 279: 44074-44083. (Pubitemid 39390717)
6. Coste F, Ober M, Le Bihan YV, Izquierdo MA, Hervouet N, et al. (2008) Bacterial base excision repair enzyme fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding mode. Chem Biol 15: 706-717. (Pubitemid 351965501)
7. Tudek B, Van Zeeland AA, Kusmierek JT, Laval J (1998) Activity of escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives. Mutat Res 407: 169-176. (Pubitemid 28241558)
8. Boiteux S, Bichara M, Fuchs RP, Laval J (1989) Excision of the imidazole ring-opened form of N-2-aminofluorene-C(8)-guanine adduct in poly(dG-dC) by escherichia coli formamidopyrimidine-DNA glycosylase. Carcinogenesis 10: 1905-1909. (Pubitemid 19244868)
9. Li Q, Laval J, Ludlum DB (1997) Fpg protein releases a ring-opened N-7 guanine adduct from DNA that has been modified by sulfur mustard. Carcinogenesis 18: 1035-1038. (Pubitemid 28132351)
10. Frosina G (2006) Prophylaxis of oxidative DNA damage by formamidopyrimidine-DNA glycosylase. Int J Cancer 119: 1-7.
11. Ropolo M, Geroldi A, Degan P, Andreotti V, Zupo S, et al. (2006) Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein. Int J Cancer 118: 1628-1634. (Pubitemid 43376425)
12. Zharkov DO, Rieger RA, Iden CR, Grollman AP (1997) NH2-terminal proline acts as a nucleophile in the glycosylase/AP-lyase reaction catalyzed by escherichia coli formamidopyrimidine-DNA glycosylase (fpg) protein. J Biol Chem 272: 5335-5341. (Pubitemid 27090098)
13. Sidorkina OM, Laval J (2000) Role of the N-terminal proline residue in the catalytic activities of the escherichia coli fpg protein. J Biol Chem 275: 9924-9929. (Pubitemid 30202037)
14. Foresta M, Ropolo M, Degan P, Pettinati I, Kow YW, et al. (2010) Defective repair of 5-hydroxy-29-deoxycytidine in cockayne syndrome cells and its complementation by escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III. Free Radic Biol Med 48: 681-690.
15. Biade S, Sobol RW, Wilson SH, Matsumoto Y (1998) Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. J Biol Chem 273: 898-902. (Pubitemid 28049182)
16. Glaab WE, Tindall KR (1997) Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects. Carcinogenesis 18: 1-8. (Pubitemid 28134609)
17. De Flora S, Camoirano A, Cartiglia C, Ferguson L (1997) Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism. Mutagenesis 12: 431-435. (Pubitemid 27503897)
18. Izzotti A, Bagnasco M, D'Agostini F, Cartiglia C, Lubet RA, et al. (1999) Formation and persistence of nucleotide alterations in rats exposed whole-body to environmental cigarette smoke. Carcinogenesis 20: 1499-1505. (Pubitemid 29385436)
19. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191.
20. Asagoshi K, Yamada T, Terato H, Ohyama Y, Monden Y, et al. (2000) Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine. J Biol Chem 275: 4956-4964. (Pubitemid 30108891)
21. Ropolo M, Degan P, Foresta M, D'Errico M, Lasiglie D, et al. (2007) Complementation of the oxidatively damaged DNA repair defect in cockayne syndrome A and B cells by escherichia coli formamidopyrimidine DNA glycosylase. Free Radic Biol Med 42: 1807-1817. (Pubitemid 46754757)
22. Foresta M, Frosina G, Sacca SC, Cartiglia C, Longobardi M, et al. (2011) Increased resistance to oxidative DNA damage of trabecular meshwork cells by E. coli FPG gene transfection. Free Radic Res 45: 751-758.
23. Migliaccio AR, Bengra C, Ling J, Pi W, Li C, et al. (2000) Stable and unstable transgene integration sites in the human genome: Extinction of the green fluorescent protein transgene in K562 cells. Gene 256: 197-214.
24. Kobune M, Xu Y, Baum C, Kelley MR, Williams DA (2001) Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N′,N″-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo. Cancer Res 61: 5116-5125. (Pubitemid 32681543)
25. Paul S, Gros L, Laval J, Sutherland BM (2006) Expression of the E. coli fpg protein in CHO cells lowers endogenous oxypurine clustered damage levels and decreases accumulation of endogenous hprt mutations. Environ Mol Mutagen 47: 311-319. (Pubitemid 43900283)
26. Gill RD, Cussac C, Souhami RL, Laval F (1996) Increased resistance to N,N′,N″ -triethylenethiophosphoramide (thiotepa) in cells expressing the escherichia coli formamidopyrimidine-DNA glycosylase. Cancer Res 56: 3721-3724. (Pubitemid 26272019)
27. Xu Y, Hansen WK, Rosenquist TA, Williams DA, Limp-Foster M, et al. (2001) Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N′-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes fpg and alpha-hOgg1: Implications for protective gene therapy applications. J Pharmacol Exp Ther 296: 825-831. (Pubitemid 32187354)
28. Seibel NM, Eljouni J, Nalaskowski MM, Hampe W (2007) Nuclear localization of enhanced green fluorescent protein homomultimers. Anal Biochem 368: 95-99. (Pubitemid 47058434)
29. Hemminki K, Forsti A, Mustonen R, Savela K (1986) DNA adducts in experimental cancer research. J Cancer Res Clin Oncol 112: 181-188. (Pubitemid 17043656)
30. Boiteux S, Belleney J, Roques BP, Laval J (1984) Two rotameric forms of open ring 7-methylguanine are present in alkylated polynucleotides. Nucleic Acids Res 12: 5429-5439.
31. Phillips DH, Farmer PB, Beland FA, Nath RG, Poirier MC, et al. (2000) Methods of DNA adduct determination and their application to testing compounds for genotoxicity. Environ Mol Mutagen 35: 222-233. (Pubitemid 30196666)
32. Basu AK, Wood ML, Niedernhofer LJ, Ramos LA, Essigmann JM (1993) Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole. Biochemistry 32: 12793-12801. (Pubitemid 24005879)
33. Speina E, Ciesla JM, Wojcik J, Bajek M, Kusmierek JT, et al. (2001) The pyrimidine ring-opened derivative of 1,N6-ethenoadenine is excised from DNA by the escherichia coli fpg and nth proteins. J Biol Chem 276: 21821-21827.
34. Izzotti A, Balansky R, Scatolini L, Rovida A, De Flora S (1995) Inhibition by N-acetylcysteine of carcinogen-DNA adducts in the tracheal epithelium of rats exposed to cigarette smoke. Carcinogenesis 16: 669-672.
35. Cortes-Sempere M, Chattopadhyay S, Rovira A, Rodriguez-Fanjul V, Belda-Iniesta C, et al. (2009) MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer. Cancer Lett 286: 206-216.
36. Pitt SC, Chen H, Kunnimalaiyaan M (2009) Phosphatidylinositol 3-kinase-akt signaling in pulmonary carcinoid cells. J Am Coll Surg 209: 82-88.
37. Lundin A, Driscoll B (2013) Lung cancer stem cells: Progress and prospects. Cancer Lett 338: 89-93.
38. Coquerelle T, Dosch J, Kaina B (1995) Overexpression of N-methylpurine-DNA glycosylase in chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents-a case of imbalanced DNA repair. Mutat Res 336: 9-17.
39. Canitrot Y, Frechet M, Servant L, Cazaux C, Hoffmann JS (1999) Overexpression of DNA polymerase beta: A genomic instability enhancer process. FASEB J 13: 1107-1111. (Pubitemid 29249737)
40. Laval F (1994) Expression of the E. coli fpg gene in mammalian cells reduces the mutagenicity of gamma-rays. Nucleic Acids Res 22: 4943-4946.