Increased resistance to oxidative DNA damage of trabecular meshwork cells by E. coli FPG gene transfection

Free Radical Research

Volumn 45, Issue 7, 2011, Pages 751-758

  Foresta, M ^a,b   Frosina, G ^a   Sacca, S C ^a   Cartiglia, C ^b   Longobardi, M ^b   Izzotti, A ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

cell transfection; DNA repair; gene therapy; glaucoma; Oxidative DNA damage

Indexed keywords

DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE;

ARTICLE; BACTERIAL GENE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENDOTHELIUM CELL; ENZYME ACTIVITY; ESCHERICHIA COLI; EXPRESSION VECTOR; GENETIC TRANSFECTION; GLAUCOMA; HUMAN; HUMAN CELL; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; TRABECULAR MESHWORK;

CELL LINE, TUMOR; DEOXYGUANOSINE; DNA DAMAGE; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ENDOTHELIAL CELLS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION; GENE THERAPY; GLAUCOMA; HUMANS; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; TRABECULAR MESHWORK; TRANSFECTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 79957885201     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2011.579122     Document Type: Article

References (34)

1. Izzotti A. Gene-environment interactions in non-cancer degenerative diseases. Mutat Res 2009;667:1-3.
2. De Flora S, Izzotti A, Randerath K, Randerath E, Bartsch H, Nair J, et al. DNA adducts and chronic degenerative disease. pathogenetic relevance and implications in preventive medi-cine. Mutat Res 1996;366:197-238. (Pubitemid 27051417)
3. Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res 2006;612:105-114. (Pubitemid 43222096)
4. Izzotti A, Sacca SC, Cartiglia C, De Flora S. Oxidative deox-yribonucleic acid damage in the eyes of glaucoma patients. Am J Med 2003;114:638-646. (Pubitemid 36703232)
5. Hernandez MR. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res 2000; 19:297-321. (Pubitemid 30122725)
6. Yucel Y H, Zhang Q, Weinreb RN, Kaufman PL, Gupta N. Effects of retinal ganglion cell loss on magno-, parvo-, konio-cellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res 2003;22:465-481. (Pubitemid 36556145)
7. Sacca SC, Izzotti A. Oxidative stress and glaucoma: injury in the anterior segment of the eye. Prog Brain Res 2008;173: 385-407.
8. Izzotti A, Sacca SC, Di Marco B, Penco S, Bassi AM. Anti-oxidant activity of timolol on endothelial cells and its rele-vance for glaucoma course. Eye (Lond) 2008;22:445-453. (Pubitemid 351404474)
9. Sacca SC, Izzotti A, Rossi P, Traverso C Glaucomatous outflow pathway and oxidative stress. Exp Eye Res 2007;84:389-399. (Pubitemid 46210055)
10. Alvarado JA, Alvarado RG, Yeh RF, Franse-Carman L, Mar-cellino GR, Brownstein MJ. A new insight into the cellular regulation of aqueous outflow: how trabecular meshwork endo thelial cells drive a mechanism that regulates the perme-ability of schlemm's canal endothelial cells. Br J Ophthalmol 2005;89:1500-1505. (Pubitemid 41527390)
11. Sacca SC, Bolognesi C, Battistella A, Bagnis A, Izzotti A. Gene-environment interactions in ocular diseases. Mutat Res 2009;667:98-117.
12. Luna C, Li G, Liton PB, Epstein DL, Gonzalez P. Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. Mol Vis 2009;15:534-544.
13. Izzotti A, Sacca SC, Longobardi M, Cartiglia C Mitochon-drial damage in the trabecular meshwork of patients with glaucoma. Arch Ophthalmol 2010;128:724-730.
14. Alvarado J, Murphy C, Juster R. Trabecular meshwork cel-lularity in primary open-angle glaucoma and nonglaucoma-tous normals. Ophthalmology 1984;91:564-579. (Pubitemid 14120061)
15. Izzotti A, Sacca SC, Longobardi M, Cartiglia C Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma. Invest Ophthal-mol Vis Sci 2009;50:5251-5258.
16. Sacca SC, La Maestra S, Micale RT, Larghero P, Travaini G, Baluce B, Izzotti A. Ability of dorzolamide hydrochloride and timolol maleate to target mitochondria in glaucoma therapy. Arch Ophthalmol 2011;129:48-55.
17. Yu AL, Fuchshofer R, Kampik A, Welge-Lussen U. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues. Invest Ophthalmol Vis Sci 2008; 49:4872-4880.
18. Dizdaroglu M, Kirkali G, Jaruga P. Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects. Free Radic Biol Med 2008; 45:1610-1621
19. Asagoshi K, Yamada T, Terato H, Ohyama Y, Monden Y, Arai T, et al. Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine. J Biol Chem 2000;275:4956-4964. (Pubitemid 30108891)
20. Coste F, Ober M, Carell T, Boiteux S, Zelwer C, Castaing B. Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5- formamidopyrimidine) by forma-midopyrimidine-DNA glycosylase. J Biol Chem 2004;279: 44074-44083. (Pubitemid 39390717)
21. Frosina G. Prophylaxis of oxidative DNA damage by formami-dopyrimidine- DNA glycosylase. Int J Cancer 2006;119:1-7.
22. Ropolo M, Geroldi A, Degan P, Andreotti V Zupo S, Poggi A, et al. Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein. Int J Cancer 2006;118:1628-1634. (Pubitemid 43376425)
23. Izzotti A, Cartiglia C, Taningher M, De Flora S, Balansky R. Age-related increases of 8-hydroxy-2 '-deoxyguanosine and DNA-protein crosslinks in mouse organs. Mutat Res 1999; 446:215-223.
24. Ropolo M, Degan P, Foresta M, D'Errico M, Lasiglie D, Dog-liotti E, Casartelli G, et al. Complementation of the oxida-tively damaged DNA repair defect in cockayne syndrome A and B cells by escherichia coli formamidopyrimidine DNA glycosylase. Free Radic Biol Med 2007;42:1807-1817. (Pubitemid 46754757)
25. Foresta M, Ropolo M, Degan P, Pettinati I, Kow YW, Damonte G, et al. Defective repair of 5-hydroxy-2 '-deoxycytidine in cockayne syndrome cells and its complementation by escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III. Free Radic Biol Med 2010;48:681-690.
26. Kubo K, Ide H, Wallace SS, Kow YW. A novel, sensitive, and specifi c assay for abasic sites, the most commonly produced DNA lesion. Biochemistry 1992;31:3703-3708.
27. Atamna H, Cheung I, Ames BN. A method for detecting aba-sic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci USA 2000;97:686-691. (Pubitemid 30070370)
28. Frosina G. Gene prophylaxis by a DNA repair function. Mol Aspects Med 2007;28:323-344. (Pubitemid 47331608)
29. Boiteux S, Gajewski E, Laval J, Dizdaroglu M. Substrate spe-cifi city of the escherichia coli fpg protein (formamidopyrimi-dine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Bio-chemistry 1992;31:106-110.
30. Zharkov DO, Rieger RA, Iden CR, Grollman AP. NH2-ter-minal proline acts as a nucleophile in the glycosylase/AP-lyase reaction catalyzed by escherichia coli formamidopyrimidine-DNA glycosylase (fpg) protein. J Biol Chem 1997;272: 5335-5341. (Pubitemid 27090098)
31. Hoffman EA, Conley SM, Stamer WD, McKay BS. Barriers to productive transfection of trabecular meshwork cells. Mol Vis 2005;11:869-875. (Pubitemid 41601354)
32. Rohen JW, van der Zypen E. The phagocytic activity of the trabecular meshwork endothelium. An electron-microscopic study of the vervet (cercopithecus aethiops). Albrecht Von Graefes. Arch Klin Exp Ophthalmol 1968;175:143-160.
33. Polansky JR, Wood IS, Maglio MT, Alvarado JA. Trabecular meshwork cell culture in glaucoma research: evaluation of biological activity and structural properties of human trabec-ular cells in vitro. Ophthalmology 1984;91:580-595. (Pubitemid 14120062)
34. Hogg P, Calthorpe M, Batterbury M, Grierson I. Aqueous humor stimulates the migration of human trabecular mesh-work cells in vitro. Invest Ophthalmol Vis Sci 2000;41: 1091-1098. (Pubitemid 30187546)