SiRNA delivery targeting to the lung via agglutination-induced accumulation and clearance of cationic tetraamino fullerene

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Minami, Kosuke ^a,b   Okamoto, Koji ^a   Doi, Kent ^a   Harano, Koji ^a   Noiri, Eisei ^a   Nakamura, Eiichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE FOR MATERIALS SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FULLERENE DERIVATIVE; NANOCONJUGATE; SMALL INTERFERING RNA; TETRAAMINO FULLERENE; TOLL LIKE RECEPTOR 4;

ANIMAL; ANTIGEN ANTIBODY REACTION; CHEMISTRY; GENE TRANSFER; GENETICS; LUNG; METABOLISM; MOUSE; MUTATION; NEUTROPHIL; RNA INTERFERENCE; TIME; TISSUE DISTRIBUTION;

AGGLUTINATION; ANIMALS; FULLERENES; GENE TRANSFER TECHNIQUES; LUNG; MICE; MUTATION; NANOCONJUGATES; NEUTROPHILS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS; TISSUE DISTRIBUTION; TOLL-LIKE RECEPTOR 4;

EID: 84900419623     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04916     Document Type: Article

References (36)

1. Peer, D. et al. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2, 751-760 (2007). (Pubitemid 350223348)
2. Zhang, G. et al. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat. Med. 18, 307-314 (2012).
3. Merkel, O. M. & Kissel, T. Nonviral pulmonary delivery of siRNA. Acc. Chem. Res. 7, 961-970 (2012).
4. Kitamura, H. et al. Inhalation of inorganic particles as a risk factor for idiopathic pulmonary fibrosis-elemental microanalysis of pulmonary lymph nodes obtained at autopsy cases. Pathol. Res. Pract. 203, 575-585 (2007). (Pubitemid 47163498)
5. Klonne, D. R., Dodd, D. E., Losco, P. E., Troup, C. M. & Tyler, T. R. Pulmonary fibrosis produced in F-344 rats by subchronic inhalation of aerosols of a 4000 molecular weight ethylene oxide/propylene oxide polymer. Fundam. Appl. Toxicol. 10, 682-690 (1998).
6. Dokka, S., Toledo, D., Shi, X., Castranova, V. & Rojanasakul, Y. Oxygen radicalmediated pulmonary toxicity induced by some cationic liposomes. Pharm. Res. 17, 521-525 (2000). (Pubitemid 30416388)
7. Eldem, T., Speiser, P. & Hincal, A. Optimization of spray-dried and -congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy. Pharm. Res. 8, 47-54 (1991).
8. Saralidze, K., Van Hooy-Corstjens, C. S., Koole, L. H. & Knetsch, M. L. New acrylic microspheres for arterial embolization: combining radiopacity for precise localization with immobilized thrombin to trigger local blood coagulation. Biomaterials 28, 2457-2464 (2007). (Pubitemid 46365912)
9. Yang, R. et al. Lung-specific delivery of paclitaxel by chitosan-modified PLGA nanoparticles via transient formation of microaggregates. J. Pharm. Sci. 98, 970-984 (2009).
10. 141Ce-Labeled Microspheres from Blood and Distribution in Specific Organs following Intravenous and Intraarterial Administration in Beagle Dogs. J. Pharm. Sci. 69, 755-762 (1980). (Pubitemid 11237850)
11. Doerschuk, C. M., Beyers, N., Coxson, H. O., Wiggs, B. & Hogg, J. C. Comparison of neutrophil and capillary diameters and their relation to neutrophil sequestration in the lung. J. Appl. Physiol. 74, 3040-3045 (1993). (Pubitemid 23201341)
12. Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986). (Pubitemid 17221789)
13. Kearney, C. J. & Mooney, D. J. Macroscale delivery systems for molecular and cellular payloads. Nat. Mater. 12, 1004-1017 (2013).
14. Nakamura, E. & Isobe, H. In vitro and in vivo gene delivery with tailor-designed aminofullerenes. Chem. Rec. 10, 260-270 (2010).
15. Nakamura, E. et al. Functionalized fullerene as a new artificial vector for transfection. Angew. Chem. Int. Ed. 39, 4254-4257 (2000).
16. Maeda-Mamiya, R. et al. in vivo gene delivery by cationic tetraamino fullerene. Proc. Natl. Acad. Sci. USA 107, 5339-5344 (2010).
17. 60 as a multifunctional systemfor drug and gene delivery. Nanoscale 3, 4035-4041 (2011).
18. Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998). (Pubitemid 28099681)
19. Kanasty, R., Dorkin, J. R., Vegas, A. & Anderson, D. Delivery materials for siRNA therapeutics. Nat. Mater. 12, 967-977 (2013).
20. Isobe, H. et al. Gene delivery by aminofullerenes: structural requirements for efficient transfection. Chem. Asian J. 1, 167-175 (2006). (Pubitemid 44384639)
21. Burnett, J. C., Rossi, J. J. & Tiemann, K. Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol. J. 6, 1130-1146 (2011).
22. Kesharwani, P., Gajbhiye, V. & Jain, N. K. A review of nanocarriers for the delivery of small interfering RNA. Biomaterials 33, 7138-7150 (2012).
23. Buyens, K. et al. Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design. J. Control. Release 158, 362-370 (2012).
24. Isobe, H., Sugiyama, S., Fukui, K., Iwasawa, Y. & Nakamura, E. Atomic force microscope studies on condensation of plasmid DNA with functionalized fullerene. Angew. Chem. Int. Ed. 40, 3364-3367 (2001). (Pubitemid 32916600)
25. Isobe, H. et al. Nonviral gene delivery by tetraamino fullerene. Mol. Pharmaceutics 3, 124-134 (2006). (Pubitemid 43672248)
26. 14C labeling, absorption, distribution, excretion and acute toxicity. Chem. Biol. 2, 385-389 (1995).
27. 3+ ions for photodynamic therapy. J. Control. Release 117, 104-110 (2007). (Pubitemid 46164862)
28. Sakurai, F., Nishioka, T., Yamashita, F., Takakura, Y. & Hashida, M. Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system. Eur. J. Pharm. Biopharm. 52, 165-172 (2001). (Pubitemid 32755895)
29. Homma, T., Harano, K., Isobe, H. & Nakamura, E. Preparation and properties of vesicles made of nonpolar/polar/nonpolar fullerene amphiphiles. J. Am. Chem. Soc. 133, 6364-6370 (2011).
30. 60 (buckminsterfullerene) and newly synthesized fulleropyrrolidine derivatives encapsulated in liposomes. Biotechnol. Appl. Biochem. 51, 135-140 (2008).
31. 60. Science 54, 1183-1185 (1991). (Pubitemid 21917446)
32. Maeda, R. et al. A water-soluble fullerene vesicle alleviates angiotensin II-induced oxidative stress in human umbilical venous endothelial cells. Hypertens. Res. 31, 141-151 (2008). (Pubitemid 351325626)
33. Andonegui, G. et al. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J. Clin. Invest. 111, 1011-1020 (2003). (Pubitemid 36397477)
34. Committee on Care and Use of Laboratory Animals Guide for the Care and Use of Laboratory Animals (Natl. Inst. Health, Bethesda), DHHS Publ No (NIH) 85-23 (1985).
35. Provencher, S. W. A Fourier method for the analysis of exponential decay curves. Biophys. J. 16, 27-41 (1976).
36. Provencher, S. W. A constrained regularization method for inverting data represented by linear algebraic or integral equations. Comp. Phys. Comm. 27, 213-227 (1982).