Late-stage C-H coupling enables rapid identification of HDAC inhibitors: Synthesis and evaluation of NCH-31 analogues

ACS Medicinal Chemistry Letters

Volumn 5, Issue 5, 2014, Pages 582-586

  Sekizawa, Hiromi ^a   Amaike, Kazuma ^a   Itoh, Yukihiro ^b   Suzuki, Takayoshi ^b,c   Itami, Kenichiro ^a   Yamaguchi, Junichiro ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

C H coupling; HDAC6; Histone deacetylase; inhibitor

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 9; HISTONE DEACETYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; C H COUPLING; CHEMICAL REACTION; DRUG BINDING; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; IC 50; PRIORITY JOURNAL;

EID: 84900392663     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500024s     Document Type: Article

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