메뉴 건너뛰기




Volumn 12, Issue 5, 2014, Pages 775-783

Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; FRAGILE HISTIDINE TRIAD PROTEIN; GEFITINIB; GELATINASE B; PROTEIN KINASE P60; TRANSCRIPTION FACTOR SLUG; VIMENTIN; ACID ANHYDRIDE HYDROLASE; EGFR PROTEIN, HUMAN; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

EID: 84900384733     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-13-0386-T     Document Type: Article
Times cited : (40)

References (44)
  • 1
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 3
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • Nieto MA, Cano A. The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Semin Cancer Biol 2012;22:361-8.
    • (2012) Semin Cancer Biol , vol.22 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 4
    • 34250705693 scopus 로고    scopus 로고
    • β-Catenin and ZO-1: Shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes
    • Polette M, Mestdagt M, Bindels S, Nawrocki-Raby B, Hunziker W, Foidart JM, et al. β-Catenin and ZO-1: shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes. Cells Tissues Organs 2007;185:61-5.
    • (2007) Cells Tissues Organs , vol.185 , pp. 61-65
    • Polette, M.1    Mestdagt, M.2    Bindels, S.3    Nawrocki-Raby, B.4    Hunziker, W.5    Foidart, J.M.6
  • 5
    • 42749091317 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and the invasive potential of tumors
    • Gavert N, Ben-Ze'ev A. Epithelial-mesenchymal transition and the invasive potential of tumors. Trends Mol Med 2008;14:199-209.
    • (2008) Trends Mol Med , vol.14 , pp. 199-209
    • Gavert, N.1    Ben-Ze'Ev, A.2
  • 7
    • 42649137241 scopus 로고    scopus 로고
    • Mechanisms of disease: Epithelial-mesenchymal transition-does cellular plasticity fuel neoplastic progression?
    • Turley EA, Veiseh M, Radisky DC, Bissell MJ. Mechanisms of disease: epithelial-mesenchymal transition-does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol 2008;5:280-90.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 280-290
    • Turley, E.A.1    Veiseh, M.2    Radisky, D.C.3    Bissell, M.J.4
  • 8
    • 70449732503 scopus 로고    scopus 로고
    • Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
    • Roy R, Yang J, Moses MA. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol 2009;27:5287-97.
    • (2009) J Clin Oncol , vol.27 , pp. 5287-5297
    • Roy, R.1    Yang, J.2    Moses, M.A.3
  • 10
    • 84866652772 scopus 로고    scopus 로고
    • Emerging evidence of epithelial-tomesenchymal transition in lung carcinogenesis
    • Sato M, Shames DS, Hasegawa Y. Emerging evidence of epithelial- tomesenchymal transition in lung carcinogenesis. Respirology 2012;17: 1048-59.
    • (2012) Respirology , vol.17 , pp. 1048-1059
    • Sato, M.1    Shames, D.S.2    Hasegawa, Y.3
  • 11
    • 84879080694 scopus 로고    scopus 로고
    • Vimentin expression predicts the occurrence of metastases in non-small cell lung carcinomas
    • Dauphin M, Barbe C, Lemaire S, Nawrocki-Raby B, Lagonotte E, Delepine G, et al. Vimentin expression predicts the occurrence of metastases in non-small cell lung carcinomas. Lung Cancer 2013; 81:117-22.
    • (2013) Lung Cancer , vol.81 , pp. 117-122
    • Dauphin, M.1    Barbe, C.2    Lemaire, S.3    Nawrocki-Raby, B.4    Lagonotte, E.5    Delepine, G.6
  • 12
    • 29344465338 scopus 로고    scopus 로고
    • Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
    • Yauch RL, Januario T, Eberhard DA, Cavet G, Zhu W, Fu L, et al. Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res 2005;11:8686-98.
    • (2005) Clin Cancer Res , vol.11 , pp. 8686-8698
    • Yauch, R.L.1    Januario, T.2    Eberhard, D.A.3    Cavet, G.4    Zhu, W.5    Fu, L.6
  • 13
    • 80052403945 scopus 로고    scopus 로고
    • The EMT regulator Slug and lung carcinogenesis
    • Shih JY, Yang PC. The EMT regulator Slug and lung carcinogenesis. Carcinogenesis 2011;32:1299-304.
    • (2011) Carcinogenesis , vol.32 , pp. 1299-1304
    • Shih, J.Y.1    Yang, P.C.2
  • 14
    • 13344279424 scopus 로고    scopus 로고
    • The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    • Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996;84:587-97.
    • (1996) Cell , vol.84 , pp. 587-597
    • Ohta, M.1    Inoue, H.2    Cotticelli, M.G.3    Kastury, K.4    Baffa, R.5    Palazzo, J.6
  • 15
    • 77950407493 scopus 로고    scopus 로고
    • Pathology and biology associated with the fragile FHIT gene and gene product
    • Saldivar JC, Shibata H, Huebner K. Pathology and biology associated with the fragile FHIT gene and gene product. J Cell Biochem 2010;109:858-65.
    • (2010) J Cell Biochem , vol.109 , pp. 858-865
    • Saldivar, J.C.1    Shibata, H.2    Huebner, K.3
  • 17
    • 77955858320 scopus 로고    scopus 로고
    • FHIT: Doubts are clear now
    • Wali A. FHIT: doubts are clear now. Sci World J 2010;10:1142-51.
    • (2010) Sci World J , vol.10 , pp. 1142-1151
    • Wali, A.1
  • 20
    • 24744470324 scopus 로고    scopus 로고
    • Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells
    • Polette M, Gilles C, Nawrocki-Raby B, Lohi J, Hunziker W, Foidart JM, et al. Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells. Cancer Res 2005;65:7691-8.
    • (2005) Cancer Res , vol.65 , pp. 7691-7698
    • Polette, M.1    Gilles, C.2    Nawrocki-Raby, B.3    Lohi, J.4    Hunziker, W.5    Foidart, J.M.6
  • 22
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 23
    • 77954854837 scopus 로고    scopus 로고
    • Snail family regulation and epithelial mesenchymal transitions in breast cancer progression
    • de Herreros AG, Peiro S, Nassour M, Savagner P. Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia 2010;15:135-47.
    • (2010) J Mammary Gland Biol Neoplasia , vol.15 , pp. 135-147
    • De Herreros, A.G.1    Peiro, S.2    Nassour, M.3    Savagner, P.4
  • 24
    • 79952075985 scopus 로고    scopus 로고
    • Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling
    • Zhang K, Chen D, Jiao X, Zhang S, Liu X, Cao J, et al. Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling. Lab Invest 2011;91:426-38.
    • (2011) Lab Invest , vol.91 , pp. 426-438
    • Zhang, K.1    Chen, D.2    Jiao, X.3    Zhang, S.4    Liu, X.5    Cao, J.6
  • 25
    • 70350143237 scopus 로고    scopus 로고
    • Slug is a downstream mediator of transforming growth factor-β1- induced matrix metalloproteinase-9 expression and invasion of oral cancer cells
    • Joseph MJ, Dangi-Garimella S, Shields MA, Diamond ME, Sun L, Koblinski JE, et al. Slug is a downstream mediator of transforming growth factor-β1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells. J Cell Biochem 2009;108:726-36.
    • (2009) J Cell Biochem , vol.108 , pp. 726-736
    • Joseph, M.J.1    Dangi-Garimella, S.2    Shields, M.A.3    Diamond, M.E.4    Sun, L.5    Koblinski, J.E.6
  • 26
    • 79953060389 scopus 로고    scopus 로고
    • Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
    • Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi JP, Nevo J, Gjerdrum C, et al. Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene 2011;30:1436-48.
    • (2011) Oncogene , vol.30 , pp. 1436-1448
    • Vuoriluoto, K.1    Haugen, H.2    Kiviluoto, S.3    Mpindi, J.P.4    Nevo, J.5    Gjerdrum, C.6
  • 27
    • 78149302129 scopus 로고    scopus 로고
    • Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of Slug
    • Yang J, Eddy JA, Pan Y, Hategan A, Tabus I, Wang Y, et al. Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of Slug. Mol Cell Proteomics 2010;9:2405-13.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 2405-2413
    • Yang, J.1    Eddy, J.A.2    Pan, Y.3    Hategan, A.4    Tabus, I.5    Wang, Y.6
  • 29
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of E-cadherin expression by cadherincadherin interactions: The roles of β-catenin signaling, Slug, and MAPK
    • Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A. Autoregulation of E-cadherin expression by cadherincadherin interactions: the roles of β-catenin signaling, Slug, and MAPK. J Cell Biol 2003;163:847-57.
    • (2003) J Cell Biol , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1    Simcha, I.2    Ben-Yedidia, T.3    Blechman, J.4    Savagner, P.5    Ben-Ze'Ev, A.6
  • 30
    • 73649124286 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining Slug expression
    • Chen H, Zhu G, Li Y, Padia RN, Dong Z, Pan ZK, et al. Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining Slug expression. Cancer Res 2009;69: 9228-35.
    • (2009) Cancer Res , vol.69 , pp. 9228-9235
    • Chen, H.1    Zhu, G.2    Li, Y.3    Padia, R.N.4    Dong, Z.5    Pan, Z.K.6
  • 31
    • 60549108144 scopus 로고    scopus 로고
    • Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway
    • Chou TY, Chen WC, Lee AC, Hung SM, Shih NY, Chen MY. Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway. Cell Signal 2009;21:704-11.
    • (2009) Cell Signal , vol.21 , pp. 704-711
    • Chou, T.Y.1    Chen, W.C.2    Lee, A.C.3    Hung, S.M.4    Shih, N.Y.5    Chen, M.Y.6
  • 32
    • 84855224166 scopus 로고    scopus 로고
    • C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway
    • Zhang L, Teng Y, Zhang Y, Liu J, Xu L, Qu J, et al. C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway. Oncol Lett 2012;3:395-400.
    • (2012) Oncol Lett , vol.3 , pp. 395-400
    • Zhang, L.1    Teng, Y.2    Zhang, Y.3    Liu, J.4    Xu, L.5    Qu, J.6
  • 33
    • 56049123161 scopus 로고    scopus 로고
    • Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation
    • Sun CK, Man K, Ng KT, Ho JW, Lim ZX, Cheng Q, et al. Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation. Carcinogenesis 2008;29:2096-105.
    • (2008) Carcinogenesis , vol.29 , pp. 2096-2105
    • Sun, C.K.1    Man, K.2    Ng, K.T.3    Ho, J.W.4    Lim, Z.X.5    Cheng, Q.6
  • 34
    • 84871961245 scopus 로고    scopus 로고
    • Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion
    • Ferguson J, Arozarena I, Ehrhardt M, Wellbrock C. Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion. Oncogene 2013;32:86-96.
    • (2013) Oncogene , vol.32 , pp. 86-96
    • Ferguson, J.1    Arozarena, I.2    Ehrhardt, M.3    Wellbrock, C.4
  • 35
    • 75749103348 scopus 로고    scopus 로고
    • Src signaling in cancer invasion
    • Guarino M. Src signaling in cancer invasion. J Cell Physiol 2010;223: 14-26.
    • (2010) J Cell Physiol , vol.223 , pp. 14-26
    • Guarino, M.1
  • 36
    • 67650588774 scopus 로고    scopus 로고
    • Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
    • Meng XN, Jin Y, Yu Y, Bai J, Liu GY, Zhu J, et al. Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer 2009;101:327-34.
    • (2009) Br J Cancer , vol.101 , pp. 327-334
    • Meng, X.N.1    Jin, Y.2    Yu, Y.3    Bai, J.4    Liu, G.Y.5    Zhu, J.6
  • 37
    • 85047696594 scopus 로고    scopus 로고
    • Src kinase contributes to the metastatic spread of carcinoma cells
    • Boyer B, Bourgeois Y, Poupon MF. Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene 2002;21:2347-56.
    • (2002) Oncogene , vol.21 , pp. 2347-2356
    • Boyer, B.1    Bourgeois, Y.2    Poupon, M.F.3
  • 38
    • 40549085666 scopus 로고    scopus 로고
    • Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation
    • Wei J, Xu G, Wu M, Zhang Y, Li Q, Liu P, et al. Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation. Anticancer Res 2008;28:327-34.
    • (2008) Anticancer Res , vol.28 , pp. 327-334
    • Wei, J.1    Xu, G.2    Wu, M.3    Zhang, Y.4    Li, Q.5    Liu, P.6
  • 39
    • 47549092230 scopus 로고    scopus 로고
    • Bypassing cellular EGF receptor dependence through epithelialto- mesenchymal-like transitions
    • Barr S, Thomson S, Buck E, Russo S, Petti F, Sujka-Kwok I, et al. Bypassing cellular EGF receptor dependence through epithelialto-mesenchymal-like transitions. Clin Exp Metastasis 2008;25: 685-93.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 685-693
    • Barr, S.1    Thomson, S.2    Buck, E.3    Russo, S.4    Petti, F.5    Sujka-Kwok, I.6
  • 40
    • 34249979835 scopus 로고    scopus 로고
    • Epidermal growth factor and transforming growth factor-b1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway
    • Tian YC, Chen YC, Chang CT, Hung CC, Wu MS, Phillips A, et al. Epidermal growth factor and transforming growth factor-b1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Exp Cell Res 2007;313:2367-77.
    • (2007) Exp Cell Res , vol.313 , pp. 2367-2377
    • Tian, Y.C.1    Chen, Y.C.2    Chang, C.T.3    Hung, C.C.4    Wu, M.S.5    Phillips, A.6
  • 41
    • 84860389234 scopus 로고    scopus 로고
    • Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin
    • Zuo JH, Zhu W, Li MY, Li XH, Yi H, Zeng GQ, et al. Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin. J Cell Biochem 2011;112:2508-17.
    • (2011) J Cell Biochem , vol.112 , pp. 2508-2517
    • Zuo, J.H.1    Zhu, W.2    Li, M.Y.3    Li, X.H.4    Yi, H.5    Zeng, G.Q.6
  • 42
    • 34047197438 scopus 로고    scopus 로고
    • FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
    • Bianchi F, Magnifico A, Olgiati C, Zanesi N, Pekarsky Y, Tagliabue E, et al. FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells. Proc Natl Acad Sci U S A 2006;103:18981-6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18981-18986
    • Bianchi, F.1    Magnifico, A.2    Olgiati, C.3    Zanesi, N.4    Pekarsky, Y.5    Tagliabue, E.6
  • 43
    • 44649115694 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer
    • Egloff AM, Grandis JR. Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer. Semin Oncol. 2008;35: 286-97.
    • (2008) Semin Oncol. , vol.35 , pp. 286-297
    • Egloff, A.M.1    Grandis, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.