Thrombomodulin administration attenuates ischemia-reperfusion injury of the remnant liver after 70% hepatectomy in rats: Simulated model of small-for-size graft in living donor liver transplantation

Transplantation Proceedings

Volumn 46, Issue 4, 2014, Pages 1107-1111

  Tanemura, A ^a   Kuriyama, N ^a   Azumi, Y ^a   Ohsawa, I ^a   Kishiwada, M ^a   Mizuno, S ^a   Usui, M ^a   Sakurai, H ^a   Tabata, M ^a   Isaji, S ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLINE; RECOMBINANT THROMBOMODULIN; BIOLOGICAL MARKER; PROTECTIVE AGENT; RECOMBINANT PROTEIN; THBD PROTEIN, HUMAN; THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER INJURY; LIVER ISCHEMIA; LIVER RESECTION; LIVER TRANSPLANTATION; LIVER WEIGHT; LIVING DONOR; LIVING DONOR LIVER TRANSPLANTATION; MACROPHAGE; MALE; MONOCYTE; NICK END LABELING; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; ANIMAL; BLOOD; CELL PROTECTION; DISEASE MODEL; DRUG EFFECTS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER; LIVER REGENERATION; ORGAN SIZE; PATHOLOGY; PROCEDURES; TIME; VASCULARIZATION; WISTAR RAT;

ADMINISTRATION, INTRAVENOUS; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL PROLIFERATION; CYTOPROTECTION; DISEASE MODELS, ANIMAL; HEPATECTOMY; HUMANS; LIVER; LIVER REGENERATION; LIVER TRANSPLANTATION; LIVING DONORS; MALE; ORGAN SIZE; PROTECTIVE AGENTS; RATS, WISTAR; RECOMBINANT PROTEINS; REPERFUSION INJURY; THROMBOMODULIN; TIME FACTORS;

EID: 84900315272     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2013.11.128     Document Type: Conference Paper

References (23)

1. Y. Zhai, H. Petrowsky, and J.C. Hong et al. Ischaemia-reperfusion injury in liver transplantation - from bench to bedside Nat Rev Gastroenterol Hepatol 10 2013 79 89
2. Y. Yamaguchi, N. Hisama, and K. Okajima et al. Pretreatment with activated protein C or active human urinary thrombomodulin attenuates the production of cytokine-induced neutrophil chemoattractant following ischemia/reperfusion in rat liver Hepatology 25 1997 1136 1140
3. N. Yoshimura, Y. Kobayashi, and K. Nakamura et al. The effect of tissue factor pathway inhibitor on hepatic ischemic reperfusion injury of the rat Transplantation 67 1999 45 53
4. K. Abeyama, D.M. Stern, and Y. Ito et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism J Clin Invest 115 2005 1267 1274
5. A. Tsung, R. Sahai, and H. Tanaka et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion J Exp Med 201 2005 1135 1143
6. G.M. Higgins, and R.M. Anderson Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal Arch Pathol 12 1931 186 202
7. M. Selzner, and P.A. Clavien Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway Hepatology 31 2000 35 42
8. M. Kume, T. Hayashi, and H. Yuasa et al. Bacterial lipopolysaccharide decreases thrombomodulin expression in the sinusoidal endothelial cells of rats - a possible mechanism of intrasinusoidal microthrombus formation and liver dysfunction J Hepatol 38 2003 9 17
9. T. Kaido, A. Yoshikawa, and S. Seto et al. Pretreatment with soluble thrombomodulin prevents intrasinusoidal coagulation and liver dysfunction following extensive hepatectomy in cirrhotic rats Thromb Haemost 82 1999 1302 1306
10. S. Mochida, M. Arai, and A. Ohno et al. Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats Hepatology 29 1999 1532 1540
11. M. Nagato, K. Okamoto, and Y. Abe et al. Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia Crit Care Med 37 2009 2181 2186
12. T. Iba, E. Nakarai, and T. Takayama et al. Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model Crit Care 13 2009 R203
13. T. Kashiwadate, S. Miyagi, and Y. Hara et al. Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors Transplant Proc 44 2012 369 372
14. Y. Uchida, B. Ke, and M.C. Freitas et al. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse Hepatology 51 2010 1363 1372
15. M. Arai, S. Mochida, and A. Ohno et al. Sinusoidal endothelial cell damage by activated macrophages in rat liver necrosis Gastroenterology 104 1993 1466 1471
16. V. Kohli, M. Selzner, and J.F. Madden et al. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver Transplantation 67 1999 1099 1105
17. N. Schuster, and K. Krieglstein Mechanisms of TGF-beta-mediated apoptosis Cell Tissue Res 307 2002 1 14
18. T.A. Wynn, and L. Barron Macrophages: master regulators of inflammation and fibrosis Semin Liver Dis 30 2010 245 257
19. Y. Zhang, H. Ji, and X. Shen et al. Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation Am J Transplant 13 2013 56 66
20. N. Kuriyama, S. Isaji, and T. Hamada et al. Activated protein C prevents hepatic ischaemia-reperfusion injury in rats Liver Int 29 2009 299 307
21. N. Kuriyama, S. Isaji, and T. Hamada et al. The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats Liver Transpl 16 2010 1 11
22. N. Selzner, M. Selzner, and Y. Tian et al. Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: a TNF-alpha/IL-6-dependent mechanism Hepatology 36 2002 812 818
23. R. Yang, S. Zhang, and A. Cotoia et al. High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity BMC Gastroenterol 12 2012 45