-
1
-
-
51949118437
-
Antipsychotic drug mechanisms: Links between therapeutic effects, metabolic side effects and the insulin signaling pathway
-
Girgis RR, Javitch JA, Lieberman JA. Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway. Mol Psychiatry 2008;13:918-929.
-
(2008)
Mol Psychiatry
, vol.13
, pp. 918-929
-
-
Girgis, R.R.1
Javitch, J.A.2
Lieberman, J.A.3
-
2
-
-
34247626414
-
Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia
-
Spelman LM, Walsh PI, Sharifi N, Collins P, Thakore JH. Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia. Diabet Med 2007;24:481-485.
-
(2007)
Diabet Med
, vol.24
, pp. 481-485
-
-
Spelman, L.M.1
Walsh, P.I.2
Sharifi, N.3
Collins, P.4
Thakore, J.H.5
-
3
-
-
7544236299
-
Clinical constructs and therapeutic discovery
-
Carpenter WT Jr. Clinical constructs and therapeutic discovery. Schizophr Res 2004;72:69-73.
-
(2004)
Schizophr Res
, vol.72
, pp. 69-73
-
-
Carpenter Jr., W.T.1
-
4
-
-
0033521616
-
Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials
-
Leucht S, Pitschel-Walz G, Abraham D, Kissling W. Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials. Schizophr Res 1999;35:51-68.
-
(1999)
Schizophr Res
, vol.35
, pp. 51-68
-
-
Leucht, S.1
Pitschel-Walz, G.2
Abraham, D.3
Kissling, W.4
-
5
-
-
1942518840
-
PPARs and the complex journey to obesity
-
Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 2004;10:355-361.
-
(2004)
Nat Med
, vol.10
, pp. 355-361
-
-
Evans, R.M.1
Barish, G.D.2
Wang, Y.X.3
-
6
-
-
0026517010
-
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
-
Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992;68:879-887.
-
(1992)
Cell
, vol.68
, pp. 879-887
-
-
Dreyer, C.1
Krey, G.2
Keller, H.3
Givel, F.4
Helftenbein, G.5
Wahli, W.6
-
7
-
-
0028865305
-
Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes
-
Jones PS, Savory R, Barratt P, Bell AR, Gray TJ, Jenkins NA, et al. Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes. Eur J Biochem 1995;233:219-226.
-
(1995)
Eur J Biochem
, vol.233
, pp. 219-226
-
-
Jones, P.S.1
Savory, R.2
Barratt, P.3
Bell, A.R.4
Gray, T.J.5
Jenkins, N.A.6
-
8
-
-
0029731662
-
Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
-
Lemberger T, Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 1996;12:335-363.
-
(1996)
Annu Rev Cell Dev Biol
, vol.12
, pp. 335-363
-
-
Lemberger, T.1
Desvergne, B.2
Wahli, W.3
-
9
-
-
9144229185
-
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
-
He W, Barak Y, Hevener A, Olson P, Liao D, Le J, et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 2003;100:15712-15717.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener, A.3
Olson, P.4
Liao, D.5
Le, J.6
-
10
-
-
0344630205
-
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice
-
Koutnikova H, Cock TA, Watanabe M, Houten SM, Champy MF, Dierich A, et al. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A 2003;100:14457-14462.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14457-14462
-
-
Koutnikova, H.1
Cock, T.A.2
Watanabe, M.3
Houten, S.M.4
Champy, M.F.5
Dierich, A.6
-
11
-
-
78650931873
-
Gender differences in the effects of peroxisome proliferator-activated receptor γ2 gene polymorphisms on metabolic adversity in patients with schizophrenia or schizoaffective disorder
-
Chen CH, Lu ML, Kuo PH, Chen PY, Chiu CC, Kao CF, et al. Gender differences in the effects of peroxisome proliferator-activated receptor γ2 gene polymorphisms on metabolic adversity in patients with schizophrenia or schizoaffective disorder. Prog Neuropsychopharmacol Biol Psychiatry 2011;5:239-245.
-
(2011)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.5
, pp. 239-245
-
-
Chen, C.H.1
Lu, M.L.2
Kuo, P.H.3
Chen, P.Y.4
Chiu, C.C.5
Kao, C.F.6
-
12
-
-
34249888775
-
Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research
-
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, et al. Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-1336.
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
de Bakker, P.I.5
-
13
-
-
0036779687
-
Emerging roles of PPARs in inflammation and immunity
-
Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2002;2:748-759.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 748-759
-
-
Daynes, R.A.1
Jones, D.C.2
-
14
-
-
0030818756
-
Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element
-
Ijpenberg A, Jeannin E, Wahli W, Desvergne B. Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem 1997;272:20108-20117.
-
(1997)
J Biol Chem
, vol.272
, pp. 20108-20117
-
-
Ijpenberg, A.1
Jeannin, E.2
Wahli, W.3
Desvergne, B.4
-
15
-
-
0026705751
-
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
-
Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 1992;358:771-774.
-
(1992)
Nature
, vol.358
, pp. 771-774
-
-
Kliewer, S.A.1
Umesono, K.2
Noonan, D.J.3
Heyman, R.A.4
Evans, R.M.5
-
16
-
-
0032560480
-
Three independent lines of evidence suggest retinoids as causal to schizophrenia
-
Goodman AB. Three independent lines of evidence suggest retinoids as causal to schizophrenia. Proc Natl Acad Sci U S A 1998;95:7240-7244.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 7240-7244
-
-
Goodman, A.B.1
-
17
-
-
0028796740
-
Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR heterodimers to confer ligand-dependent activation of hRAR beta 2/RARE (DR5)
-
Xiao JH, Durand B, Chambon P, Voorhees JJ. Endogenous retinoic acid receptor (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR heterodimers to confer ligand-dependent activation of hRAR beta 2/RARE (DR5). J Biol Chem 1995;270:3001-3011.
-
(1995)
J Biol Chem
, vol.270
, pp. 3001-3011
-
-
Xiao, J.H.1
Durand, B.2
Chambon, P.3
Voorhees, J.J.4
-
18
-
-
0001340336
-
Positive and negative syndrome scale (PANSS): Establishment and reliability study of a mandarin Chinese language version
-
Cheng JJ, Ho H, Chang CJ, Lane HY, Hu HG. Positive and negative syndrome scale (PANSS): Establishment and reliability study of a mandarin Chinese language version. Chin Psychiaty 1996;10:251-258.
-
(1996)
Chin Psychiaty
, vol.10
, pp. 251-258
-
-
Cheng, J.J.1
Ho, H.2
Chang, C.J.3
Lane, H.Y.4
Hu, H.G.5
-
19
-
-
0029152375
-
Isolation of the human peroxisome proliferator activated receptor gamma cDNA: Expression in hematopoietic cells and chromosomal mapping
-
Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, et al. Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr 1995;4:281-299.
-
(1995)
Gene Expr
, vol.4
, pp. 281-299
-
-
Greene, M.E.1
Blumberg, B.2
McBride, O.W.3
Yi, H.F.4
Kronquist, K.5
Kwan, K.6
-
20
-
-
73549099359
-
Regulation of translational efficiency by disparate 5' UTRs of PPARgamma splice variants
-
McClelland S, Shrivastava R, Medh JD. Regulation of translational efficiency by disparate 5' UTRs of PPARgamma splice variants. PPAR Res 2009;2009:193413.
-
(2009)
PPAR Res
, vol.2009
, pp. 193413
-
-
McClelland, S.1
Shrivastava, R.2
Medh, J.D.3
-
21
-
-
0030835678
-
The organization, promoter analysis, and expression of the human PPARgamma gene
-
Fajas L, Auboeuf D, Raspé E, Schoonjans K, Lefebvre AM, Saladin R, et al. The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 1997;272:18779-18789.
-
(1997)
J Biol Chem
, vol.272
, pp. 18779-18789
-
-
Fajas, L.1
Auboeuf, D.2
Raspé, E.3
Schoonjans, K.4
Lefebvre, A.M.5
Saladin, R.6
-
22
-
-
77953121307
-
Powerful SNP-set analysis for case-control genome-wide association studies
-
Wu MC, Kraft P, Epstein MP, Taylor DM, Chanock SJ, Hunter DJ, et al. Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet 2010;86:929-942.
-
(2010)
Am J Hum Genet
, vol.86
, pp. 929-942
-
-
Wu, M.C.1
Kraft, P.2
Epstein, M.P.3
Taylor, D.M.4
Chanock, S.J.5
Hunter, D.J.6
-
23
-
-
0033624575
-
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000;26:76-80.
-
(2000)
Nat Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
Lindgren, C.M.4
Vohl, M.C.5
Nemesh, J.6
-
24
-
-
33845472305
-
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: Meta-analysis of 57 studies on nondiabetic individuals
-
Tonjes A, Scholz M, Loeffler M, Stumvoll M. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 2006;29:2489-2497.
-
(2006)
Diabetes Care
, vol.29
, pp. 2489-2497
-
-
Tonjes, A.1
Scholz, M.2
Loeffler, M.3
Stumvoll, M.4
-
25
-
-
46249104490
-
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: The SzGene database
-
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008; 40:827-834.
-
(2008)
Nat Genet
, vol.40
, pp. 827-834
-
-
Allen, N.C.1
Bagade, S.2
McQueen, M.B.3
Ioannidis, J.P.4
Kavvoura, F.K.5
Khoury, M.J.6
-
26
-
-
33646534632
-
Meta-analysis of association between ApoE epsilon4 allele and schizophrenia
-
Xu MQ, St Clair D, He L. Meta-analysis of association between ApoE epsilon4 allele and schizophrenia. Schizophr Res 2006;84:228-235.
-
(2006)
Schizophr Res
, vol.84
, pp. 228-235
-
-
Xu, M.Q.1
St. Clair, D.2
He, L.3
-
27
-
-
77953026034
-
Apolipoprotein E polymorphisms and type 2 diabetes: A meta-analysis of 30 studies including 5423 cases and 8197 controls
-
Anthopoulos PG, Hamodrakas SJ, Bagos PG. Apolipoprotein E polymorphisms and type 2 diabetes: a meta-analysis of 30 studies including 5423 cases and 8197 controls. Mol Genet Metab 2010;100:283-291.
-
(2010)
Mol Genet Metab
, vol.100
, pp. 283-291
-
-
Anthopoulos, P.G.1
Hamodrakas, S.J.2
Bagos, P.G.3
-
28
-
-
17744376173
-
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
-
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, et al. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001;7:161-171.
-
(2001)
Mol Cell
, vol.7
, pp. 161-171
-
-
Chawla, A.1
Boisvert, W.A.2
Lee, C.H.3
Laffitte, B.A.4
Barak, Y.5
Joseph, S.B.6
-
30
-
-
84865519631
-
Impact of metabolic syndrome on cognition and brain: A selected review of the literature
-
Yates KF, Sweat V, Yau PL, Turchiano MM, Convit A. Impact of metabolic syndrome on cognition and brain: a selected review of the literature. Arterioscler Thromb Vasc Biol 2012;32:2060-2067.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 2060-2067
-
-
Yates, K.F.1
Sweat, V.2
Yau, P.L.3
Turchiano, M.M.4
Convit, A.5
|