메뉴 건너뛰기




Volumn 12, Issue 2, 2014, Pages

The time of prenatal androgen exposure affects development of polycystic ovary syndrome-like phenotype in adulthood in female rats

Author keywords

Androgens; Exposure time; Fetus; Polycystic ovary syndrome; Rats

Indexed keywords

ESTROGEN; MUELLERIAN INHIBITING FACTOR; TESTOSTERONE;

EID: 84900306819     PISSN: 1726913X     EISSN: 17269148     Source Type: Journal    
DOI: 10.5812/ijem.16502     Document Type: Article
Times cited : (40)

References (42)
  • 1
    • 0141844618 scopus 로고    scopus 로고
    • Assessment and management of anovulatory infertility in polycystic ovary syndrome
    • Franks S. Assessment and management of anovulatory infertility in polycystic ovary syndrome. Endocrinol Metab Clin North Am. 2003;32(3):639-51.
    • (2003) Endocrinol Metab Clin North Am. , vol.32 , Issue.3 , pp. 639-651
    • Franks, S.1
  • 2
    • 77953647358 scopus 로고    scopus 로고
    • Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats
    • Wu XY, Li ZL, Wu CY, Liu YM, Lin H, Wang SH, et al. Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats. Endocr J. 2010;57(3):201-9.
    • (2010) Endocr J. , vol.57 , Issue.3 , pp. 201-209
    • Wu, X.Y.1    Li, Z.L.2    Wu, C.Y.3    Liu, Y.M.4    Lin, H.5    Wang, S.H.6
  • 3
    • 84861369568 scopus 로고    scopus 로고
    • Prenatal hyperandrogenization induces metabolic and endocrine alterations which depend on the levels of testosterone exposure
    • AmalfiS, Velez LM, Heber MF, Vighi S, Ferreira SR, Orozco AV, et al. Prenatal hyperandrogenization induces metabolic and endocrine alterations which depend on the levels of testosterone exposure. PLoS One. 2012;7(5).
    • (2012) PLoS One. , vol.7 , Issue.5
    • Amalfi, S.1    Velez, L.M.2    Heber, M.F.3    Vighi, S.4    Ferreira, S.R.5    Orozco, A.V.6
  • 5
    • 21244500111 scopus 로고    scopus 로고
    • Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
    • Abbott DH, Barnett DK, Bruns CM, Dumesic DA. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome? Hum Reprod Update. 2005;11(4):357-74.
    • (2005) Hum Reprod Update. , vol.11 , Issue.4 , pp. 357-374
    • Abbott, D.H.1    Barnett, D.K.2    Bruns, C.M.3    Dumesic, D.A.4
  • 6
    • 38849106857 scopus 로고    scopus 로고
    • Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome
    • Li Z, Huang H. Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome. Med Hypotheses. 2008;70(3):638-42.
    • (2008) Med Hypotheses. , vol.70 , Issue.3 , pp. 638-642
    • Li, Z.1    Huang, H.2
  • 8
    • 0034503112 scopus 로고    scopus 로고
    • Premature adrenarche-- normal variant or forerunner of adult disease?
    • Ibanez L, Dimartino-Nardi J, Potau N, Saenger P. Premature adrenarche-- normal variant or forerunner of adult disease? Endocr Rev. 2000;21(6):671-96.
    • (2000) Endocr Rev. , vol.21 , Issue.6 , pp. 671-696
    • Ibanez, L.1    Dimartino-Nardi, J.2    Potau, N.3    Saenger, P.4
  • 9
    • 33846999319 scopus 로고    scopus 로고
    • Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls
    • McCartney CR, Blank SK, Prendergast KA, Chhabra S, Eagleson CA, Helm KD, et al. Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. J Clin Endocrinol Metab. 2007;92(2):430-6.
    • (2007) J Clin Endocrinol Metab. , vol.92 , Issue.2 , pp. 430-436
    • McCartney, C.R.1    Blank, S.K.2    Prendergast, K.A.3    Chhabra, S.4    Eagleson, C.A.5    Helm, K.D.6
  • 10
    • 2342539599 scopus 로고    scopus 로고
    • Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder
    • Sullivan SD, Moenter SM. Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder. Proc Natl Acad Sci U S A. 2004;101(18):7129-34.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , Issue.18 , pp. 7129-7134
    • Sullivan, S.D.1    Moenter, S.M.2
  • 11
    • 27144489633 scopus 로고    scopus 로고
    • Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone
    • Recabarren SE, Padmanabhan V, Codner E, Lobos A, Duran C, Vidal M, et al. Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone. Am J Physiol Endocrinol Metab. 2005;289(5):E801-6.
    • (2005) Am J Physiol Endocrinol Metab. , vol.289 , Issue.5
    • Recabarren, S.E.1    Padmanabhan, V.2    Codner, E.3    Lobos, A.4    Duran, C.5    Vidal, M.6
  • 12
    • 0002455381 scopus 로고
    • The "Early-Androgen" Syndrome; Differences in Response to Pre-Natal and Post-Natal Administration of Various Doses of Testosterone Propionate in Female and Male Rats
    • Swanson HE, Werfftenbosch JJ. The "Early-Androgen" Syndrome; Differences in Response to Pre-Natal and Post-Natal Administration of Various Doses of Testosterone Propionate in Female and Male Rats. Acta Endocrinol (Copenh). 1964;47:37-50.
    • (1964) Acta Endocrinol (Copenh). , vol.47 , pp. 37-50
    • Swanson, H.E.1    Werfftenbosch, J.J.2
  • 13
    • 33947245423 scopus 로고    scopus 로고
    • Prenatal testosterone exposure permanently masculinizes anogenital distance, nipple development, and reproductive tract morphology in female Sprague-Dawley rats
    • Hotchkiss AK, Lambright CS, Ostby JS, Parks-Saldutti L, Vandenbergh JG, Gray LE, Jr. Prenatal testosterone exposure permanently masculinizes anogenital distance, nipple development, and reproductive tract morphology in female Sprague-Dawley rats. Toxicol Sci. 2007;96(2):335-45.
    • (2007) Toxicol Sci. , vol.96 , Issue.2 , pp. 335-345
    • Hotchkiss, A.K.1    Lambright, C.S.2    Ostby, J.S.3    Parks-Saldutti, L.4    Vandenbergh, J.G.5    Gray Jr., L.E.6
  • 14
    • 0036149750 scopus 로고    scopus 로고
    • Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study
    • Wolf CJ, Hotchkiss A, Ostby JS, LeBlanc GA, Gray LE, Jr. Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study. Toxicol Sci. 2002;65(1):71-86.
    • (2002) Toxicol Sci. , vol.65 , Issue.1 , pp. 71-86
    • Wolf, C.J.1    Hotchkiss, A.2    Ostby, J.S.3    LeBlanc, G.A.4    Gray Jr., L.E.5
  • 15
    • 84863416250 scopus 로고    scopus 로고
    • The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats
    • Dean A, Smith LB, Macpherson S, Sharpe RM. The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats. Int J Androl. 2012;35(3):330-9.
    • (2012) Int J Androl. , vol.35 , Issue.3 , pp. 330-339
    • Dean, A.1    Smith, L.B.2    Macpherson, S.3    Sharpe, R.M.4
  • 16
    • 0025936537 scopus 로고
    • Control of gonadotropin secretion in the ovine fetus. IV. Male-specific entrainment of the hypothalamic control of luteinizing hormone secretion by testosterone in the female ovine fetus
    • Matwijiw I, Faiman C. Control of gonadotropin secretion in the ovine fetus. IV. Male-specific entrainment of the hypothalamic control of luteinizing hormone secretion by testosterone in the female ovine fetus. Endocrinology. 1991;129(3):1447-51.
    • (1991) Endocrinology. , vol.129 , Issue.3 , pp. 1447-1451
    • Matwijiw, I.1    Faiman, C.2
  • 17
    • 0031028152 scopus 로고    scopus 로고
    • Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood
    • Dumesic DA, Abbott DH, Eisner JR, Goy RW. Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood. Fertil Steril. 1997;67(1):155-63.
    • (1997) Fertil Steril. , vol.67 , Issue.1 , pp. 155-163
    • Dumesic, D.A.1    Abbott, D.H.2    Eisner, J.R.3    Goy, R.W.4
  • 18
    • 0032780179 scopus 로고    scopus 로고
    • Prenatal testosterone masculinizes synaptic input to gonadotropin-releasing hormone neurons in sheep
    • Kim SJ, Foster DL, Wood RI. Prenatal testosterone masculinizes synaptic input to gonadotropin-releasing hormone neurons in sheep. Biol Reprod. 1999;61(3):599-605.
    • (1999) Biol Reprod. , vol.61 , Issue.3 , pp. 599-605
    • Kim, S.J.1    Foster, D.L.2    Wood, R.I.3
  • 19
    • 0017160742 scopus 로고
    • Sexual differentiation and feedback control of luteinizing hormone secretion in the rhesus monkey
    • Steiner RA, Clifton DK, Spies HG, Resko JA. Sexual differentiation and feedback control of luteinizing hormone secretion in the rhesus monkey. Biol Reprod. 1976;15(2):206-12.
    • (1976) Biol Reprod. , vol.15 , Issue.2 , pp. 206-212
    • Steiner, R.A.1    Clifton, D.K.2    Spies, H.G.3    Resko, J.A.4
  • 21
    • 0030735282 scopus 로고    scopus 로고
    • Resistance of gonadotropin releasing hormone drive to sex steroid-induced suppression in hyperandrogenic anovulation
    • Daniels TL, Berga SL. Resistance of gonadotropin releasing hormone drive to sex steroid-induced suppression in hyperandrogenic anovulation. J Clin Endocrinol Metab. 1997;82(12):4179-83.
    • (1997) J Clin Endocrinol Metab. , vol.82 , Issue.12 , pp. 4179-4183
    • Daniels, T.L.1    Berga, S.L.2
  • 22
    • 0034523425 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone
    • Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, et al. Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab. 2000;85(11):4047-52.
    • (2000) J Clin Endocrinol Metab. , vol.85 , Issue.11 , pp. 4047-4052
    • Eagleson, C.A.1    Gingrich, M.B.2    Pastor, C.L.3    Arora, T.K.4    Burt, C.M.5    Evans, W.S.6
  • 23
    • 78049388028 scopus 로고    scopus 로고
    • Prenatal androgen exposure programs metabolic dysfunction in female mice
    • Roland AV, Nunemaker CS, Keller SR, Moenter SM. Prenatal androgen exposure programs metabolic dysfunction in female mice. J Endocrinol. 2010;207(2):213-23.
    • (2010) J Endocrinol. , vol.207 , Issue.2 , pp. 213-223
    • Roland, A.V.1    Nunemaker, C.S.2    Keller, S.R.3    Moenter, S.M.4
  • 24
    • 84861321357 scopus 로고    scopus 로고
    • Rodent models for human polycystic ovary syndrome
    • Walters KA, Allan CM, Handelsman DJ. Rodent models for human polycystic ovary syndrome. Biol Reprod. 2012;86(5):149-12.
    • (2012) Biol Reprod. , vol.86 , Issue.5 , pp. 112-149
    • Walters, K.A.1    Allan, C.M.2    Handelsman, D.J.3
  • 25
    • 34547138420 scopus 로고    scopus 로고
    • A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome
    • Manneras L, Cajander S, Holmang A, Seleskovic Z, Lystig T, Lonn M, et al. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology. 2007;148(8):3781-91.
    • (2007) Endocrinology. , vol.148 , Issue.8 , pp. 3781-3791
    • Manneras, L.1    Cajander, S.2    Holmang, A.3    Seleskovic, Z.4    Lystig, T.5    Lonn, M.6
  • 26
    • 76549204430 scopus 로고
    • A 24-hour periodicity in the "LH-release apparatus" of female rats, disclosed by barbiturate sedation
    • Everett JW, Sawyer CH. A 24-hour periodicity in the "LH-release apparatus" of female rats, disclosed by barbiturate sedation. Endocrinology. 1950;47(3):198-218.
    • (1950) Endocrinology. , vol.47 , Issue.3 , pp. 198-218
    • Everett, J.W.1    Sawyer, C.H.2
  • 27
    • 0031059168 scopus 로고    scopus 로고
    • New concepts of the neuroendocrine regulation of gonadotropin surges in rats
    • Levine JE. New concepts of the neuroendocrine regulation of gonadotropin surges in rats. Biol Reprod. 1997;56(2):293-302.
    • (1997) Biol Reprod. , vol.56 , Issue.2 , pp. 293-302
    • Levine, J.E.1
  • 28
    • 0034457485 scopus 로고    scopus 로고
    • Stimulation of gonadotropin-releasing hormone surges by estroge. II. Role of cyclic adenosine 3'5'-monophosphate
    • Chappell PE, Lee J, Levine JE. Stimulation of gonadotropin-releasing hormone surges by estrogen. II. Role of cyclic adenosine 3'5'-monophosphate. Endocrinology. 2000;141(4):1486-92.
    • (2000) Endocrinology. , vol.141 , Issue.4 , pp. 1486-1492
    • Chappell, P.E.1    Lee, J.2    Levine, J.E.3
  • 29
    • 0033305055 scopus 로고    scopus 로고
    • Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice
    • Chappell PE, Schneider JS, Kim P, Xu M, Lydon JP, O'Malley BW, et al. Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology. 1999;140(8):3653-8.
    • (1999) Endocrinology. , vol.140 , Issue.8 , pp. 3653-3658
    • Chappell, P.E.1    Schneider, J.S.2    Kim, P.3    Xu, M.4    Lydon, J.P.5    O'Malley, B.W.6
  • 30
    • 0034457255 scopus 로고    scopus 로고
    • Stimulation of gonadotropin-releasing hormone surges by estrogen. I. Role of hypothalamic progesterone receptors
    • Chappell PE, Levine JE. Stimulation of gonadotropin-releasing hormone surges by estrogen. I. Role of hypothalamic progesterone receptors. Endocrinology. 2000;141(4):1477-85.
    • (2000) Endocrinology. , vol.141 , Issue.4 , pp. 1477-1485
    • Chappell, P.E.1    Levine, J.E.2
  • 31
    • 0022977510 scopus 로고
    • Blockade of the spontaneous midcycle gonadotropin surge in monkeys by RU 486: a progesterone antagonist or agonist?
    • Collins RL, Hodgen GD. Blockade of the spontaneous midcycle gonadotropin surge in monkeys by RU 486: a progesterone antagonist or agonist? J Clin Endocrinol Metab. 1986;63(6):1270-6.
    • (1986) J Clin Endocrinol Metab. , vol.63 , Issue.6 , pp. 1270-1276
    • Collins, R.L.1    Hodgen, G.D.2
  • 32
    • 0027139752 scopus 로고
    • RU486 administration blocks neuropeptide Y potentiation of luteinizing hormone (LH)-releasing hormone-induced LH surges in proestrous rats
    • Bauer-Dantoin AC, Tabesh B, Norgle JR, Levine JE. RU486 administration blocks neuropeptide Y potentiation of luteinizing hormone (LH)-releasing hormone-induced LH surges in proestrous rats. Endocrinology. 1993;133(6):2418-23.
    • (1993) Endocrinology. , vol.133 , Issue.6 , pp. 2418-2423
    • Bauer-Dantoin, A.C.1    Tabesh, B.2    Norgle, J.R.3    Levine, J.E.4
  • 33
    • 0028361063 scopus 로고
    • The antiprogestin RU486 delays the midcycle gonadotropin surge and ovulation in gonadotropin-releasing hormone-induced cycles
    • Batista MC, Cartledge TP, Zellmer AW, Nieman LK, Loriaux DL, Merriam GR. The antiprogestin RU486 delays the midcycle gonadotropin surge and ovulation in gonadotropin-releasing hormone-induced cycles. Fertil Steril. 1994;62(1):28-34.
    • (1994) Fertil Steril. , vol.62 , Issue.1 , pp. 28-34
    • Batista, M.C.1    Cartledge, T.P.2    Zellmer, A.W.3    Nieman, L.K.4    Loriaux, D.L.5    Merriam, G.R.6
  • 34
    • 0030021334 scopus 로고    scopus 로고
    • Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge
    • Szabo M, Knox KL, Ringstrom SJ, Perlyn CA, Sutandi S, Schwartz NB. Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge. Endocrinology. 1996;137(1):85-9.
    • (1996) Endocrinology. , vol.137 , Issue.1 , pp. 85-89
    • Szabo, M.1    Knox, K.L.2    Ringstrom, S.J.3    Perlyn, C.A.4    Sutandi, S.5    Schwartz, N.B.6
  • 35
    • 0032887141 scopus 로고    scopus 로고
    • Antiprogestins RU486 and ZK299 suppress basal and LHRH-stimulated FSH and LH secretion at pituitary level in the rat in an oestrous cycle stage-dependent manner
    • Bellido C, Gonzalez D, Aguilar R, Sanchez-Criado JE. Antiprogestins RU486 and ZK299 suppress basal and LHRH-stimulated FSH and LH secretion at pituitary level in the rat in an oestrous cycle stage-dependent manner. J Endocrinol. 1999;163(1):79-85.
    • (1999) J Endocrinol. , vol.163 , Issue.1 , pp. 79-85
    • Bellido, C.1    Gonzalez, D.2    Aguilar, R.3    Sanchez-Criado, J.E.4
  • 36
    • 18844378644 scopus 로고    scopus 로고
    • Neuroendocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator
    • Foecking EM, Szabo M, Schwartz NB, Levine JE. Neuroendocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator. Biol Reprod. 2005;72(6):1475-83.
    • (2005) Biol Reprod. , vol.72 , Issue.6 , pp. 1475-1483
    • Foecking, E.M.1    Szabo, M.2    Schwartz, N.B.3    Levine, J.E.4
  • 37
    • 0029775865 scopus 로고    scopus 로고
    • Sexual differentiation of the surge mode of gonadotropin secretion: prenatal androgens abolish the gonadotropin-releasing hormone surge in the sheep
    • Herbosa CG, Dahl GE, Evans NP, Pelt J, Wood RI, Foster DL. Sexual differentiation of the surge mode of gonadotropin secretion: prenatal androgens abolish the gonadotropin-releasing hormone surge in the sheep. J Neuroendocrinol. 1996;8(8):627-33.
    • (1996) J Neuroendocrinol. , vol.8 , Issue.8 , pp. 627-633
    • Herbosa, C.G.1    Dahl, G.E.2    Evans, N.P.3    Pelt, J.4    Wood, R.I.5    Foster, D.L.6
  • 38
    • 0033304755 scopus 로고    scopus 로고
    • Prenatal dihydrotestosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in sheep
    • Masek KS, Wood RI, Foster DL. Prenatal dihydrotestosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in sheep. Endocrinology. 1999;140(8):3459-66.
    • (1999) Endocrinology. , vol.140 , Issue.8 , pp. 3459-3466
    • Masek, K.S.1    Wood, R.I.2    Foster, D.L.3
  • 39
    • 0036480684 scopus 로고    scopus 로고
    • Prenatal exposure of the ovine fetus to androgens sexually differentiates the steroid feedback mechanisms that control gonadotropin releasing hormone secretion and disrupts ovarian cycles
    • Robinson JE, Birch RA, Foster DL, Padmanabhan V. Prenatal exposure of the ovine fetus to androgens sexually differentiates the steroid feedback mechanisms that control gonadotropin releasing hormone secretion and disrupts ovarian cycles. Arch Sex Behav. 2002;31(1):35-41.
    • (2002) Arch Sex Behav. , vol.31 , Issue.1 , pp. 35-41
    • Robinson, J.E.1    Birch, R.A.2    Foster, D.L.3    Padmanabhan, V.4
  • 40
    • 0036198971 scopus 로고    scopus 로고
    • Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep
    • Sharma TP, Herkimer C, West C, Ye W, Birch R, Robinson JE, et al. Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep. Biol Reprod. 2002;66(4):924-33.
    • (2002) Biol Reprod. , vol.66 , Issue.4 , pp. 924-933
    • Sharma, T.P.1    Herkimer, C.2    West, C.3    Ye, W.4    Birch, R.5    Robinson, J.E.6
  • 41
    • 1442303311 scopus 로고    scopus 로고
    • Administration of dihydrotestosterone to rhesus monkeys inhibits gonadotropinstimulated ovarian steroidogenesis
    • Zeleznik AJ, Little-Ihrig L, Ramasawamy S. Administration of dihydrotestosterone to rhesus monkeys inhibits gonadotropinstimulated ovarian steroidogenesis. J Clin Endocrinol Metab. 2004;89(2):860-6.
    • (2004) J Clin Endocrinol Metab. , vol.89 , Issue.2 , pp. 860-866
    • Zeleznik, A.J.1    Little-Ihrig, L.2    Ramasawamy, S.3
  • 42
    • 84857782237 scopus 로고    scopus 로고
    • Developmental programming: prenatal testosterone excess disrupts anti-Mullerian hormone expression in preantral and antral follicles
    • Veiga-Lopez A, Ye W, Padmanabhan V. Developmental programming: prenatal testosterone excess disrupts anti-Mullerian hormone expression in preantral and antral follicles. Fertil Steril. 2012;97(3):748-56.
    • (2012) Fertil Steril. , vol.97 , Issue.3 , pp. 748-756
    • Veiga-Lopez, A.1    Ye, W.2    Padmanabhan, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.