Serum ghrelin and leptin levels in patients with depression and the effects of treatment

Psychiatry Investigation

Volumn 11, Issue 2, 2014, Pages 167-172

  Ozsoy, Saliha ^a   Besirli, Asli ^b   Abdulrezzak, Ummuhan ^a   Basturk, Mustafa ^a  

^a ERCIYES UNIVERSITY MEDICAL FACULTY   (Turkey)

^b Mus State Hospital   (Turkey)

Author keywords

Depression; Ghrelin; Leptin; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; ESCITALOPRAM; GHRELIN; LEPTIN; MIRTAZAPINE; PAROXETINE; SERTRALINE; VENLAFAXINE;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE SEVERITY; ELECTROCONVULSIVE THERAPY; FEMALE; HAMILTON SCALE; HUMAN; LOSS OF APPETITE; MALE; MIDDLE AGED; RADIOIMMUNOASSAY; STRESS; SYMPTOMATOLOGY;

EID: 84900302792     PISSN: 17383684     EISSN: 19763026     Source Type: Journal    
DOI: 10.4306/pi.2014.11.2.167     Document Type: Article

References (32)

1. Friedman JM. Leptin at 14 y of age: an ongoing story. Am J Clin Nutr 2009;89:973S-979S.
2. Lu XY, Kim CS, Frazer A, Zhang W. Leptin: a potential novel antidepressant. Proc Natl Acad Sci U S A 2006;103:1593-1598.
3. Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmacher T. Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology 2001;73:243-247.
4. Jow GM, Yang TT, Chen CL. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. J Affect Disord 2006;90:21-27.
5. Deuschle M, Blum WF, Englaro P, Schweiger U, Weber B, Pflaum CD, et al. Plasma leptin in depressed patients and healthy controls. Horm Metab Res 1996;28:714-717.
6. Esel E, Ozsoy S, Tutus A, Sofuoglu S, Kartalci S, Bayram F, et al. Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:565-570.
7. Cizza G, Nguyen VT, Eskandari F, Duan Z, Wright EC, Reynolds JC, et al. Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia/ Osteoporosis, Women, Alendronate, Depression (POWER) study. J Clin Psychiatry 2010;71:1079-1087.
8. Milaneschi Y, Simonsick EM, Vogelzangs N, Strotmeyer ES, Yaffe K, Harris TB, et al. Leptin, abdominal obesity, and onset of depression in older men and women. J Clin Psychiatry 2012;73:1205-1211.
9. Yamada N, Katsuura G, Ochi Y, Ebihara K, Kusakabe T, Hosoda K, et al. Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 2011;152:2634-2643.
10. Lu XY. The leptin hypothesis of depression: a potential link between mood disorders and obesity? Curr Opin Pharmacol 2007;7:648-652.
11. Moosa MY, Panz VR, Jeenah FY, Joffe BI. African women with depression: the effect of imipramine and fluoxetine on body mass index and leptin secretion. J Clin Psychopharmacol 2003;23:549-552.
12. Schilling C, Gilles M, Blum WF, Daseking E, Colla M, Weber-Hamann B, et al. Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity? J Clin Psychopharmacol 2013;33:99-103.
13. Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D, Pollmacher T. Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine. Pharmacopsychiatry 2002;35:220-225.
14. Kurt E, Guler O, Serteser M, Cansel N, Ozbulut O, Altinbas K, et al. The effects of electroconvulsive therapy on ghrelin, leptin and cholesterol levels in patients with mood disorders. Neurosci Lett 2007;426:49-53.
15. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001;50:707-709.
16. Kristenssson E, Sundqvist M, Astin M, Kjerling M, Mattsson H, Dornonville de la Cour C, et al. Acute psychological stress raises plasma ghrelin in the rat. Regul Pept 2006;134:114-117.
17. Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, et al. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 2008;11:752-753.
18. Hansson C, Haage D, Taube M, Egecioglu E, Salome N, Dickson SL. Central administration of ghrelin alters emotional responses in rats: behavioural, electrophysiological and molecular evidence. Neuroscience 2011;180:201-211.
19. Kluge M, Schussler P, Dresler M, Schmidt D, Yassouridis A, Uhr M, et al. Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression. J Psychiatr Res 2011;45:421-426.
20. Barim AO, Aydin S, Colak R, Dag E, Deniz O, Sahin I. Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment. Clin Biochem 2009;42:1076-1081.
21. Schanze A, Reulbach U, Scheuchenzuber M, Groschl M, Kornhuber J, Kraus T. Ghrelin and eating disturbances in psychiatric disorders. Neuropsychobiology 2008;57:126-130.
22. Kluge M, Schussler P, Schmid D, Uhr M, Kleyer S, Yassouridis A, et al. Ghrelin plasma levels are not altered in major depression. Neuropsychobiology 2009;59:199-204.
23. Matsuo K, Nakano M, Nakashima M, Watanuki T, Egashira K, Matsubara T, et al. Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder. Brain Res 2012;1473:185-192.
24. Gecici O, Serteser M, Emul M, Demirel R. Serum ghrelin and leptin levels in major depressive disorders. Neurol Psychiatry Brain Res 2005; 12:47-52.
25. Schmid DA, Wichniak A, Uhr M, Ising M, Brunner H, Held K, et al. Changes of sleep architecture, spectral composition of sleep EEG, the nocturnal secretion of cortisol, ACTH, GH, prolactin, melatonin, ghrelin, and leptin, and the DEX-CRH test in depressed patients during treatment with mirtazapine. Neuropsychopharmacology 2006;31: 832-844.
26. Pinar M, Gulsun M, Tasci I, Erdil A, Bolu E, Acikel C, et al. Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:135-139.
27. Zigman JM, Elmquist JK. Minireview: From anorexia to obesity--the yin and yang of body weight control. Endocrinology 2003;144:3749-3756.
28. Schmid DA, Held K, Ising M, Uhr M, Weikel JC, Steiger A. Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology 2005;30:1187-1192.
29. Kageyama K, Kumata Y, Akimoto K, Takayasu S, Tamasawa N, Suda T. Ghrelin stimulates corticotropin-releasing factor and vasopressin gene expression in rat hypothalamic 4B cells. Stress 2011;14:520-529.
30. Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman AT, Penninx BW. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry 2013;18:692-699.
31. Kageyama K, Akimoto K, Yamagata S, Sugiyama A, Murasawa S, Watanuki Y, et al. Dexamethasone stimulates the expression of ghrelin and its receptor in rat hypothalamic 4B cells. Regul Pept 2012;174:12-17.
32. Hinze-Selch D, Schuld A, Kraus T, Kuhn M, Uhr M, Haack M, et al. Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine. Neuropsychopharmacology 2000;23:13-19.