Mechanisms regulating human trophoblast fusion

Cell Fusions: Regulation and Control

Volumn , Issue , 2011, Pages 203-217

  Huppertz, Berthold ^a   Gauster, Martin ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

caspase 8; fusion; Placenta; trophoblast

Indexed keywords

EID: 84900102247     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-9772-9_9     Document Type: Chapter

References (73)

1. Adler RR, Ng AK, Rote NS (1995) Monoclonal antiphosphatidylserine antibody inhibits intercellular fusion of the choriocarcinoma line, JAR. Biol Reprod 53:905-910
2. Al-Nasiry S, Vercruysse L, Hanssens M et al (2009) Interstitial trophoblastic cell fusion and E-cadherin immunostaining in the placental bed of normal and hypertensive pregnancies. Placenta 30:719-725
3. Baczyk D, Satkunaratnam A, Nait-Oumesmar B et al (2004) Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta. Placenta 25: 553-559
4. Barnoy S, Glaser T, Kosower NS (1998) The calpain-calpastatin system and protein Degradation in fusing myoblasts. Biochim Biophys Acta 1402:52-60
5. Barnoy S, Maki M, Kosower NS (2005) Overexpression of calpastatin inhibits L8 myoblast fusion. Biochem Biophys Res Commun 332:697-701
6. Bartoli M, Richard I (2005) Calpains in muscle wasting. Int J Biochem Cell Biol 37:2115-2133
7. Benirschke K, Kaufmann P, Baergen R (2006) Pathology of the human placenta, 5th edn. Springer, New York, NY
8. Bevers EM, Comfurius P, Zwaal RF (1996) Regulatory mechanisms in maintenance and modulation of transmembrane lipid asymmetry: Pathophysiological implications. Lupus 5:480-487
9. Black S, Kadyrov M, Kaufmann P et al (2004) Syncytial fusion of human trophoblast depends on caspase 8. Cell Death Differ 11:90-98
10. Blond JL, Lavillette D, Cheynet V et al (2000) An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J Virol 74:3321-3329
11. Butler TM, Elustondo PA, Hannigan GE et al (2009) Integrin-linked kinase can facilitate syncytialization and hormonal differentiation of the human trophoblast-derived BeWo cell line. Reprod Biol Endocrinol 7:51
12. Chen CP, Chen LF, Yang SR et al (2008) Functional characterization of the human placental fusogenic membrane protein syncytin 2. Biol Reprod 79:815-823
13. Chen EH, Olson EN (2004) Towards a molecular pathway for myoblast fusion in Drosophila. Trends Cell Biol 14:452-460
14. Chen EH, Olson EN (2005) Unveiling the mechanisms of cell-cell fusion. Science 308:369-373
15. Crocker IP, Strachan BK, Lash GE et al (2001) Vascular endothelial growth factor but not placental growth factor promotes trophoblast syncytialization in vitro. J Soc Gynecol Investig 8:341-346
16. Dalton P, Christian HC, Redman CW et al (2007) Membrane trafficking of CD98 and its ligand galectin 3 in BeWo cells-implication for placental cell fusion. FEBS J 274:2715-2727
17. Daoud G, Amyot M, Rassart E et al (2005) ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta. J Physiol 566:409-423
18. Decout A, Labeur C, Goethals M et al (1998) Enhanced efficiency of a targeted fusogenic peptide. Biochim Biophys Acta 1372:102-116
19. De Falco M, Fedele V, Cobellis L et al (2004) Immunohistochemical distribution of proteins belonging to the receptor-mediated and the mitochondrial apoptotic pathways in human placenta during gestation. Cell Tissue Res 318:599-608
20. de Parseval N, Lazar V, Casella JF et al (2003) Survey of human genes of retroviral origin: Identification and transcriptome of the genes with coding capacity for complete envelope proteins. J Virol 77:10414-10422
21. Eskelinen S, Lehto VP (1994) Induction of cell fusion in cultured fibroblasts and epithelial cells by microinjection of EGTA, GTP gamma S and antifodrin antibodies. FEBS Lett 339:129-133
22. Esnault C, Priet S, Ribet D et al (2008) A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2. Proc Natl Acad Sci USA 105:17532-17537
23. Fong PY, Xue WC, Ngan HY et al (2006) Caspase activity is downregulated in choriocarcinoma:a cDNA array differential expression study. J Clin Pathol 59:179-183
24. Frendo JL, Cronier L, Bertin G et al (2003) Involvement of connexin 43 in human trophoblast cell fusion and differentiation. J Cell Sci 116:3413-3421
25. Frendo JL, Olivier D, Cheynet V et al (2003) Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 23:3566-3574
26. Garcia-Lloret MI, Morrish DW, Wegmann TG et al (1994) Demonstration of functional cytokineplacental interactions:CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion. Exp Cell Res 214:46-54
27. Gauster M, Siwetz M, Huppertz B (2009a) Fusion of villous trophoblast can be visualized by localizing active caspase 8. Placenta 30:547-550
28. Gauster M, Siwetz M, Orendi K et al (2009b) Caspases rather than calpains mediate remodelling of the fodrin skeleton During human placental trophoblast fusion. Cell Death Differ. doi:10.1038/cdd.2009.133
29. Guilbert LJ, Winkler-Lowen B, Sherburne R et al (2002) Preparation and functional characterization of villous cytotrophoblasts free of syncytial fragments. Placenta 23:175-183
30. Huppertz B, Bartz C, Kokozidou M (2006) Trophoblast fusion: Fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion. Micron 37:509-517
31. Huppertz B, Frank HG, Kingdom JC et al (1998) Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol 110:495-508
32. Huppertz B, Frank HG, Reister F et al (1999) Apoptosis cascade progresses during turnover of human trophoblast:analysis of villous cytotrophoblast and syncytial fragments in vitro. Lab Invest 79:1687-1702
33. Huppertz B, Kaufmann P, Kingdom JCP (2002) Trophoblast turnover in health and disease. Fetal Maternal Med Rev 13:17-32
34. Huppertz B, Kingdom JC (2004) Apoptosis in the trophoblast - role of apoptosis in placental morphogenesis. J Soc Gynecol Investig 11:353-362
35. Jansson T (2001) Amino acid transporters in the human placenta. Pediatr Res 49:141-147
36. Jiang B, Kamat A, Mendelson CR (2000) Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture:potential inhibitory role of the hypoxia-inducible transcription factor Mash-2 (mammalian achaete-scute homologous protein-2). Mol Endocrinol 14:1661-1673
37. Kliman HJ, Nestler JE, Sermasi E et al (1986) Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118:1567-1582
38. Knerr I, Schubert SW,Wich C et al (2005) Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. FEBS Lett 579:3991-3998
39. Kudo Y, Boyd CA (2002) Human placental amino acid transporter genes:expression and function. Reproduction 124:593-600
40. Kudo Y, Boyd CA (2004) RNA interference-induced reduction in CD98 expression suppresses cell fusion During syncytialization of human placental BeWo cells. FEBS Lett 577:473-477
41. Kudo Y, Boyd CA, Millo J et al (2003) Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells. J Physiol 550:3-9
42. Lee X, Keith JC, Jr, Stumm N et al (2001) Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia. Placenta 22:808-812
43. Leisser C, Saleh L, Haider S et al (2006) Tumour necrosis factor-Alpha impairs chorionic gonadotrophin beta-subunit expression and cell fusion of human villous cytotrophoblast. Mol Hum Reprod 12:601-609
44. Li H, Dakour J, Guilbert LJ et al (2005) PL74, a novel member of the transforming growth factorbeta superfamily, is overexpressed in preeclampsia and causes apoptosis in trophoblast cells. J Clin Endocrinol Metab 90:3045-3053
45. Lin C, Lin M, Chen H (2005) Biochemical characterization of the human placental transcription factor GCMa/1. Biochem Cell Biol 83:188-195
46. Lin L, Xu B, Rote NS (1999) Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast. Placenta 20:109-118
47. Lyden TW, Ng AK, Rote NS (1993) Modulation of phosphatidylserine epitope expression by BeWo cells during forskolin treatment. Placenta 14:177-186
48. Malassine A, Blaise S, Handschuh K et al (2007) Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells. Placenta 28:185-191
49. Malassine A, Frendo JL, Blaise S et al (2008) Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-Affected placenta. Retrovirology 5:6
50. Mandal D, Mazumder A, Das P et al (2005) Fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes. J Biol Chem 280:39460-39467
51. Martens S,McMahon HT (2008) Mechanisms of membrane fusion: Disparate players and common principles. Nat Rev Mol Cell Biol 9:543-556
52. Martin I, Pecheur EI, Ruysschaert JM et al (1999) Membrane fusion induced by a short fusogenic peptide is assessed by its insertion and orientation into target bilayers. Biochemistry 38:9337-9347
53. Mi S, Lee X, Li X et al (2000) Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403:785-789
54. Miehe U, Kadyrov M, Neumaier-Wagner P et al (2006) Expression of the actin stress fiberassociated protein CLP36 in the human placenta. Histochem Cell Biol 126:465-471
55. Midgley AR, Pierce GB, Jr, Deneau GA et al (1963) Morphogenesis of syncytiotrophoblast in vivo: An autoradiographic demonstration. Science 141:349-350
56. Mombers C, Verkleij AJ, de Gier J et al (1979) The interaction of spectrin-Actin and synthetic phospholipids. II. The interaction with phosphatidylserine. Biochim Biophys Acta 551:271-281
57. Morrish DW, Bhardwaj D, Dabbagh LK et al (1987) Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta. J Clin Endocrinol Metab 65:1282-1290
58. Morrish DW, Bhardwaj D, Paras MT (1991) Transforming growth factor beta 1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion. Endocrinology 129:22-26
59. Ohtani T, Hatori M, Ito H et al (2000) Involvement of caspases in 5-FU induced apoptosis in an oral cancer cell line. Anticancer Res 20:3117-3121
60. Oren-Suissa M, Podbilewicz B (2007) Cell fusion During development. Trends Cell Biol 17:537-546
61. Panigel M (1993) The origin and structure of extraembryonic tissues. In: Redman C, Sargent I, Starkey P (eds) The human placenta. Blackwell Scientific Publications, London
62. Potgens AJ, Schmitz U, Bose P et al (2002) Mechanisms of syncytial fusion: A review. Placenta 23 Suppl A:S107-S113
63. Richart R (1961) Studies of placental morphogenesis. I. Radioautographic studies of human placenta utilizing tritiated thymidine. Proc Soc Exp Biol Med 106:829-831
64. Rote NS, Chakrabarti S, Stetzer BP (2004) The role of human endogenous retroviruses in trophoblast differentiation and placental development. Placenta 25:673-683
65. Sato SB, Ohnishi S (1983) Interaction of a peripheral protein of the erythrocyte membrane, band 4.1, with phosphatidylserine-containing liposomes and erythrocyte inside-out vesicles. Eur J Biochem 130:19-25
66. Savill J (1998) Apoptosis. Phagocytic docking without shocking. Nature 392:442-443
67. Shi QJ, Lei ZM, Rao CV et al (1993) Novel role of human chorionic gonadotropin in Differentiation of human cytotrophoblasts. Endocrinology 132:1387-1395
68. Than NG, Romero R, Goodman M et al (2009) A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Proc Natl Acad Sci USA 106:9731-9736
69. van Den Eijnde SM, van Den Hoff MJ, Reutelingsperger CP et al (2001) Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. J Cell Sci 114:3631-3642
70. Vargas A, Moreau J, Landry S et al (2009) Syncytin-2 plays an important role in the fusion of human trophoblast cells. J Mol Biol 392:301-318
71. White L, Dharmarajan A, Charles A (2007) Caspase-14: A new player in cytotrophoblast differentiation. Reprod Biomed Online 14:300-307
72. Yang M, Lei ZM, Rao Ch V (2003) The central role of human chorionic gonadotropin in the formation of human placental syncytium. Endocrinology 144:1108-1120
73. Yu C, Shen K, Lin M et al (2002) GCMa regulates the syncytin-mediated trophoblastic fusion. J Biol Chem 277:50062-50068