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Angewandte Chemie - International Edition

Volumn 53, Issue 20, 2014, Pages 5102-5106

Phenotypic screening to identify small-molecule enhancers for glucose uptake: Target identification and rational optimization of their efficacy

(8) Koh, Minseob a Park, Jongmin a Koo, Ja Young a Lim, Donghyun a Cha, Mi Young a Jo, Ala a Choi, Jang Hyun b Park, Seung Bum a

a Seoul National University (South Korea)

b Ulsan National Institute of Science and Technology (South Korea)

Author keywords

drug discovery; glucose uptake; phenotypic screening; PPAR ; target identification

Indexed keywords

BINDING ENERGY; CHIRALITY; CYTOLOGY; LEAD COMPOUNDS; LIGANDS; MOLECULES; OPTIMIZATION; STEREOCHEMISTRY;

CYCLIN-DEPENDENT KINASE; DRUG DISCOVERY; GLUCOSE UPTAKE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PHENOTYPIC SCREENING; RATIONAL OPTIMIZATION; TARGET IDENTIFICATION; TRANSCRIPTIONAL ACTIVITY;

GLUCOSE;

GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

3T3 CELL LINE; ANIMAL; GENETICS; METABOLISM; MOUSE; TRANSCRIPTION INITIATION;

3T3-L1 CELLS; ANIMALS; GLUCOSE; MICE; PPAR GAMMA; TRANSCRIPTIONAL ACTIVATION;

EID: 84900006899 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201310618 Document Type: Article

Times cited : (25)

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