Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b

Journal of Cellular Biochemistry

Volumn 115, Issue 7, 2014, Pages 1277-1289

  Adapala, Naga Suresh ^a   Barbe, Mary F ^b   Tsygankov, Alexander Y ^b   Lorenzo, Joseph A ^a   Sanjay, Archana ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AKT; Cbl b; GSK; RANKL; SURVIVAL

Indexed keywords

CBL B PROTEIN; CBL PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P21; RAS PROTEIN; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CBL PROTEIN, MOUSE; CBLB PROTEIN, MOUSE; CHROMONE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN BINDING; PROTEIN KINASE B; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE REMODELING; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; MOLECULAR INTERACTION; MOUSE; MUTATION; NONHUMAN; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BONE DENSITY; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE DENSITY; BONE REMODELING; BONE RESORPTION; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CHROMONES; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; GLYCOGEN SYNTHASE KINASE 3; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; MUTATION; OSTEOCLASTS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS P21(RAS); RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 84900005994     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24779     Document Type: Article

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