Diagnostic and prognostic utilities of multimarkers approach using procalcitonin, B-type natriuretic peptide, and neutrophil gelatinase-associated lipocalin in critically ill patients with suspected sepsis

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Hur, Mina ^a   Kim, Hanah ^a   Lee, Seungho ^b   Cristofano, Flavia ^c   Magrini, Laura ^c   Marino, Rossella ^c   Gori, Chiara S ^c   Bongiovanni, Cristina ^c   Zancla, Benedetta ^c   Cardelli, Patrizia ^c   Di Somma, Salvatore ^c  

^a Konkuk University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

B type natriuretic peptide; Diagnosis; Neutrophil gelatinase associated lipocalin; Procalcitonin; Prognosis; Sepsis

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROCALCITONIN; BIOLOGICAL MARKER; CALCITONIN; LIPOCALIN; PROTEIN PRECURSOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEWBORN; OBSERVATIONAL STUDY; ORGAN DYSFUNCTION SCORE; OUTCOME ASSESSMENT; PROGNOSIS; PROSPECTIVE STUDY; SEPSIS; SURVIVAL PREDICTION; BLOOD; CRITICAL ILLNESS; MIDDLE AGED; PREDICTIVE VALUE; PRESCHOOL CHILD; VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CALCITONIN; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LIPOCALINS; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTEIN PRECURSORS; SEPSIS;

EID: 84899989605     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-14-224     Document Type: Article

References (26)

1. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013, 39:165-228. 10.1007/s00134-012-2769-8, 23361625.
2. Winters BD, Eberlein M, Leung J, Needham DM, Pronovost PJ, Sevransky JE. Long-term mortality and quality of life in sepsis: a systematic review. Crit Care Med 2010, 38:1276-1283.
3. Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, Dodek P, Wood G, Kumar A, Simon D, Peters C, Ahsan M, Chateau D. Cooperative antimicrobial therapy of septic shock database research group: initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009, 136:1237-1248.
4. Schuetz P, Maurer P, Punjabi V, Desai A, Amin DN, Gluck E. Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit Care 2013, 17:R115. 10.1186/cc12787, 23787145.
5. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the European society of intensive care medicine. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239.
6. Reinhart K, Meisner M. Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin 2011, 27:253-263. 10.1016/j.ccc.2011.01.002, 21440200.
7. Kopterides P, Tsangaris I. Procalcitonin and sepsis: recent data on diagnostic utility prognostic potential and therapeutic implications in critically ill patients. Minerva Anestesiol 2012, 78:823-835.
8. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 2013, 13:426-435. 10.1016/S1473-3099(12)70323-7, 23375419.
9. Maisel A, Hollander JE, Guss D, McCullough P, Nowak R, Green G, Saltzberg M, Ellison SR, Bhalla MA, Bhalla V, Clopton P, Jesse R. Rapid Emergency Department Heart Failure Outpatient Trial investigators: primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT). A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath. J Am Coll Cardiol 2004, 44:1328-1333. 10.1016/j.jacc.2004.06.015, 15364340.
10. Gopal DJ, Iqbal MN, Maisel A. Updating the role of natriuretic peptide levels in cardiovascular disease. Postgrad Med 2011, 123:102-113. 10.3810/pgm.2011.11.2500, 22104459.
11. Maisel A, Mueller C, Adams K, Anker SD, Aspromonte N, Cleland JG, Cohen-Solal A, Dahlstrom U, DeMaria A, Di Somma S, Filippatos GS, Fonarow GC, Jourdain P, Komajda M, Liu PP, McDonagh T, McDonald K, Mebazaa A, Nieminen MS, Peacock WF, Tubaro M, Valle R, Vanderhyden M, Yancy CW, Zannad F, Braunwald E. State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail 2008, 10:824-839. 10.1016/j.ejheart.2008.07.014, 18760965.
12. Soni SS, Pophale R, Ronco C. New biomarkers for acute renal injury. Clin Chem Lab Med 2011, 49:1257-1263.
13. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A. NGAL Meta-analysis Investigator Group. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 2009, 54:1012-1024. 10.1053/j.ajkd.2009.07.020, 19850388.
14. Clerico A, Galli C, Fortunato A, Ronco C. Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences. Clin Chem Lab Med 2012, 50:1505-1517.
15. Maisel AS, Mueller C, Fitzgerald R, Brikhan R, Hiestand BC, Iqbal N, Clopton P, van Veldhuisen DJ. Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial. Eur J Heart Fail 2011, 13:846-851. 10.1093/eurjhf/hfr087, 3143832, 21791540.
16. Kim H, Hur M, Cruz DN, Moon HW, Yun YM. Plasma neutrophil gelatinase-associated lipocalin as a biomarker for acute kidney injury in critically ill patients with suspected sepsis. Clin Biochem 2013, 46:1414-1418. 10.1016/j.clinbiochem.2013.05.069, 23747960.
17. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. SCCM/ESICM/ACCP/ATS/SIS: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003, 31:1250-1256. 10.1097/01.CCM.0000050454.01978.3B, 12682500.
18. Ronco C, Cruz D, Noland BW. Neutrophil gelatinase-associated lipocalin curve and neutrophil gelatinase-associated lipocalin extended-range assay: a new biomarker approach in the early diagnosis of acute kidney injury and cardio-renal syndrome. Semin Nephrol 2012, 32:121-128. 10.1016/j.semnephrol.2011.11.015, 22365170.
19. Hur M, Moon HW, Yun YM, Kim KH, Kim HS, Lee KM. Comparison of diagnostic utility between procalcitonin and C-reactive protein for the patients with blood culture-positive sepsis. Korean J Lab Med 2009, 29:529-535. 10.3343/kjlm.2009.29.6.529, 20046084.
20. Di Somma S, Magrini L, Travaglino F, Lalle I, Fiotti N, Cervellin G, Avanzi GC, Lupia E, Maisel A, Hein F, Wagner F, Lippi G. Opinion paper on innovative approach of biomarkers for infectious diseases and sepsis management in the emergency department. Clin Chem Lab Med 2013, 51:1167-1175.
21. Schuetz P, Haubitz S, Mueller B. Do sepsis biomarkers in the emergency room allow transition from bundled sepsis care to personalized patient care?. Curr Opin Crit Care 2012, 18:341-349. 10.1097/MCC.0b013e328354b2c8, 22610364.
22. Riedel S, Carroll KC. Laboratory detection of sepsis. Biomarkers and molecular approaches. Clin Lab Med 2013, 33:413-437. 10.1016/j.cll.2013.03.006, 23931833.
23. Mueller F, Christ-Crain M, Bregenzer T, Krause M, Zimmerli W, Mueller B, Schuetz P. ProHOSP Study Group: procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest 2010, 138:121-129. 10.1378/chest.09-2920, 20299634.
24. Schuetz P, Mueller B, Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci. Infection 2007, 35:352-355. 10.1007/s15010-007-7065-0, 17882355.
25. Magrini L, Travaglino F, Marino R, Ferri E, De Berardinis B, Cardelli P, Salerno G, Di Somma S. Procalcitonin variations after Emergency Department admission are highly predictive of hospital mortality in patients with acute infectious diseases. Eur Rev Med Pharmacol Sci 2013, 17(Suppl 1):133-142.
26. Di Somma S, Magrini L, De Berardinis B, Marino R, Ferri E, Moscatelli P, Ballarino P, Carpinteri G, Noto P, Gliozzo B, Paladino L, Di Stasio E. Additive value of blood neutrophil gelatinase-associated lipocalin to clinical judgement in acute kidney injury diagnosis and mortality prediction in patients hospitalized from the emergency department. Crit Care 2013, 17:R29. 10.1186/cc12510, 23402494.