Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Farfan, Mauricio J ^a,b   Salas, Carolina ^b   Canales, Cristina ^a   Silva, Felipe ^b   Villarroel, Milena ^b   Kopp, Katherine ^b   Torres, Juan P ^b   Santolaya, María E ^a,b   Morales, Jorge ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b Hospital Dr Luis Calvo Mackenna   (Chile)

Author keywords

6 Mercaptopurine; Acute lymphoblastic leukemia (ALL); Genetic polymorphism; TPMT

Indexed keywords

DNA; INOSINE TRIPHOSPHATE PYROPHOSPHATASE; MERCAPTOPURINE; METHOTREXATE; NUCLEOSIDE DIPHOSPHATASE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG; INORGANIC PYROPHOSPHATASE; ITPA PROTEIN, HUMAN; METHYLTRANSFERASE;

ALLELE; ARTICLE; CHILD; CHILE; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG EFFECT; GENE FREQUENCY; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN CELL; ITPA GENE; LYMPHATIC LEUKEMIA; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; TPMT GENE; ADOLESCENT; FEMALE; GENETICS; MALE; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRESCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

6-MERCAPTOPURINE; ADOLESCENT; ALLELES; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; MALE; METHYLTRANSFERASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PYROPHOSPHATASES;

EID: 84899975387     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-299     Document Type: Article

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