Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia

Leukemia Research

Volumn 34, Issue 8, 2010, Pages 1023-1026

  Kapoor, Gauri ^a   Sinha, Rupal ^a   Naithani, Rahul ^a   Chandgothia, Meenal ^b  

^a RAJIV GANDHI CANCER INSTITUTE AND RESEARCH CENTRE   (India)

^b Acton Biotech India Pvt Ltd   (India)

Author keywords

6 Mercaptopurine; Childhood acute lymphoblastic leukemia; Gene polymorphism; Pharmacogenetics; Thiopurine S methyltransferase

Indexed keywords

ANTIBIOTIC AGENT; MERCAPTOPURINE; METHOTREXATE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CHILD; DIARRHEA; DRUG EFFICACY; EVENING DOSAGE; EVENT FREE SURVIVAL; FEMALE; FEVER; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HUMAN; INDIA; INFANT; INFECTION; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SIDE EFFECT; TREATMENT DURATION; VOMITING;

6-MERCAPTOPURINE; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENOTYPE; HUMANS; INDIA; INFANT; MALE; METHYLTRANSFERASES; POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 77953591482     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.01.029     Document Type: Article

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