메뉴 건너뛰기




Volumn 40, Issue 6, 2014, Pages 716-722

Indications and limitations of chemotherapy and targeted agents in non-small cell lung cancer brain metastases

Author keywords

Brain metastasis; Driver oncogenes; Non small cell lung cancer (NSCLC); Stereotactic radiotherapy; Targeted treatment

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CISPLATIN; CRIZOTINIB; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; METHOTREXATE; NAVELBINE; PACLITAXEL; PEMETREXED; TEMOZOLOMIDE; TOPOTECAN;

EID: 84899972290     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2014.03.005     Document Type: Review
Times cited : (138)

References (99)
  • 1
    • 0025615213 scopus 로고
    • Lung cancer with a single brain metastasis: therapeutic options
    • Rizzi A., et al. Lung cancer with a single brain metastasis: therapeutic options. Tumori 1990, 76(6):579-581.
    • (1990) Tumori , vol.76 , Issue.6 , pp. 579-581
    • Rizzi, A.1
  • 2
    • 2142813718 scopus 로고    scopus 로고
    • Temporal and gender-related trends in brain metastases from lung and breast cancer
    • Yawn B.P., et al. Temporal and gender-related trends in brain metastases from lung and breast cancer. Minn Med 2003, 86(12):32-37.
    • (2003) Minn Med , vol.86 , Issue.12 , pp. 32-37
    • Yawn, B.P.1
  • 3
    • 0023885240 scopus 로고
    • Distribution of brain metastases
    • Delattre J.Y., et al. Distribution of brain metastases. Arch Neurol 1988, 45(7):741-744.
    • (1988) Arch Neurol , vol.45 , Issue.7 , pp. 741-744
    • Delattre, J.Y.1
  • 4
    • 84867494866 scopus 로고    scopus 로고
    • Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data
    • Davis F.G., et al. Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data. Neuro Oncol 2012, 14(9):1171-1177.
    • (2012) Neuro Oncol , vol.14 , Issue.9 , pp. 1171-1177
    • Davis, F.G.1
  • 5
    • 70649098235 scopus 로고    scopus 로고
    • Brain metastases admissions in Sweden between 1987 and 2006
    • Smedby K.E., et al. Brain metastases admissions in Sweden between 1987 and 2006. Br J Cancer 2009, 101(11):1919-1924.
    • (2009) Br J Cancer , vol.101 , Issue.11 , pp. 1919-1924
    • Smedby, K.E.1
  • 6
    • 84863020427 scopus 로고    scopus 로고
    • Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
    • Sperduto P.W., et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 2012, 30(4):419-425.
    • (2012) J Clin Oncol , vol.30 , Issue.4 , pp. 419-425
    • Sperduto, P.W.1
  • 7
    • 78249268287 scopus 로고    scopus 로고
    • Prognostic relevance of the metastatic localisation in patients with stage IV NSCLC - results of a prospective epidemiological study
    • Blankenburg T., et al. Prognostic relevance of the metastatic localisation in patients with stage IV NSCLC - results of a prospective epidemiological study. Pneumologie 2010, 64(11):679-685.
    • (2010) Pneumologie , vol.64 , Issue.11 , pp. 679-685
    • Blankenburg, T.1
  • 8
    • 84866597083 scopus 로고    scopus 로고
    • Metastatic non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Peters S., et al. Metastatic non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012, 23(Suppl. 7):vii56-vii64.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 7 , pp. 756-764
    • Peters, S.1
  • 9
    • 0025189608 scopus 로고
    • A randomized trial of surgery in the treatment of single metastases to the brain
    • Patchell R.A., et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990, 322(8):494-500.
    • (1990) N Engl J Med , vol.322 , Issue.8 , pp. 494-500
    • Patchell, R.A.1
  • 10
    • 0027217452 scopus 로고
    • Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?
    • Vecht C.J., et al. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery?. Ann Neurol 1993, 33(6):583-590.
    • (1993) Ann Neurol , vol.33 , Issue.6 , pp. 583-590
    • Vecht, C.J.1
  • 11
    • 2442713678 scopus 로고    scopus 로고
    • Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    • Andrews D.W., et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 2004, 363(9422):1665-1672.
    • (2004) Lancet , vol.363 , Issue.9422 , pp. 1665-1672
    • Andrews, D.W.1
  • 12
    • 2542590281 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients
    • Ostermann S., et al. Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients. Clin Cancer Res 2004, 10(11):3728-3736.
    • (2004) Clin Cancer Res , vol.10 , Issue.11 , pp. 3728-3736
    • Ostermann, S.1
  • 13
    • 0016803892 scopus 로고
    • Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections
    • Shapiro W.R., Young D.F., Mehta B.M. Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. N Engl J Med 1975, 293(4):161-166.
    • (1975) N Engl J Med , vol.293 , Issue.4 , pp. 161-166
    • Shapiro, W.R.1    Young, D.F.2    Mehta, B.M.3
  • 14
    • 0027940704 scopus 로고
    • A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid
    • Sung C., et al. A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid. Cancer Res 1994, 54(19):5118-5122.
    • (1994) Cancer Res , vol.54 , Issue.19 , pp. 5118-5122
    • Sung, C.1
  • 15
    • 70449529433 scopus 로고    scopus 로고
    • Structure and function of the blood-brain barrier
    • Abbott N.J., et al. Structure and function of the blood-brain barrier. Neurobiol Dis 2010, 37(1):13-25.
    • (2010) Neurobiol Dis , vol.37 , Issue.1 , pp. 13-25
    • Abbott, N.J.1
  • 16
    • 34547632714 scopus 로고    scopus 로고
    • Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development
    • Ohtsuki S., Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res 2007, 24(9):1745-1758.
    • (2007) Pharm Res , vol.24 , Issue.9 , pp. 1745-1758
    • Ohtsuki, S.1    Terasaki, T.2
  • 17
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J., et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999, 284(5422):1994-1998.
    • (1999) Science , vol.284 , Issue.5422 , pp. 1994-1998
    • Holash, J.1
  • 18
    • 0036161382 scopus 로고    scopus 로고
    • The seed and soil hypothesis: vascularisation and brain metastases
    • Fidler I.J., et al. The seed and soil hypothesis: vascularisation and brain metastases. Lancet Oncol 2002, 3(1):53-57.
    • (2002) Lancet Oncol , vol.3 , Issue.1 , pp. 53-57
    • Fidler, I.J.1
  • 19
    • 18744393078 scopus 로고    scopus 로고
    • Front-line paclitaxel/cisplatin-based chemotherapy in brain metastases from non-small-cell lung cancer
    • Cortes J., et al. Front-line paclitaxel/cisplatin-based chemotherapy in brain metastases from non-small-cell lung cancer. Oncology 2003, 64(1):28-35.
    • (2003) Oncology , vol.64 , Issue.1 , pp. 28-35
    • Cortes, J.1
  • 20
    • 0032080147 scopus 로고    scopus 로고
    • Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer
    • Minotti V., et al. Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer. Lung Cancer 1998, 20(2):93-98.
    • (1998) Lung Cancer , vol.20 , Issue.2 , pp. 93-98
    • Minotti, V.1
  • 21
    • 0033668063 scopus 로고    scopus 로고
    • Combination chemotherapy of cisplatin, ifosfamide, and irinotecan with rhG-CSF support in patients with brain metastases from non-small cell lung cancer
    • Fujita A., et al. Combination chemotherapy of cisplatin, ifosfamide, and irinotecan with rhG-CSF support in patients with brain metastases from non-small cell lung cancer. Oncology 2000, 59(4):291-295.
    • (2000) Oncology , vol.59 , Issue.4 , pp. 291-295
    • Fujita, A.1
  • 22
    • 0033120802 scopus 로고    scopus 로고
    • Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma: a prospective study
    • Franciosi V., et al. Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma: a prospective study. Cancer 1999, 85(7):1599-1605.
    • (1999) Cancer , vol.85 , Issue.7 , pp. 1599-1605
    • Franciosi, V.1
  • 23
    • 0001318359 scopus 로고    scopus 로고
    • A phase II trial of fotemustine and cisplatin in central nervous system metastases from non-small cell lung cancer
    • Cotto C., et al. A phase II trial of fotemustine and cisplatin in central nervous system metastases from non-small cell lung cancer. Eur J Cancer 1996, 32A(1):69-71.
    • (1996) Eur J Cancer , vol.32 A , Issue.1 , pp. 69-71
    • Cotto, C.1
  • 24
    • 0036252666 scopus 로고    scopus 로고
    • First-line chemotherapy with vinorelbine, gemcitabine, and carboplatin in the treatment of brain metastases from non-small-cell lung cancer: a phase II study
    • Bernardo G., et al. First-line chemotherapy with vinorelbine, gemcitabine, and carboplatin in the treatment of brain metastases from non-small-cell lung cancer: a phase II study. Cancer Invest 2002, 20(3):293-302.
    • (2002) Cancer Invest , vol.20 , Issue.3 , pp. 293-302
    • Bernardo, G.1
  • 25
    • 0035137984 scopus 로고    scopus 로고
    • Results of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Groupe Francais de Pneumo-Cancerologie (GFPC) Protocol 95-1
    • Robinet G., et al. Results of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Groupe Francais de Pneumo-Cancerologie (GFPC) Protocol 95-1. Ann Oncol 2001, 12(1):59-67.
    • (2001) Ann Oncol , vol.12 , Issue.1 , pp. 59-67
    • Robinet, G.1
  • 26
    • 80155136933 scopus 로고    scopus 로고
    • Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: a multicenter phase II trial (GFPC 07-01)
    • Barlesi F., et al. Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: a multicenter phase II trial (GFPC 07-01). Ann Oncol 2011, 22(11):2466-2470.
    • (2011) Ann Oncol , vol.22 , Issue.11 , pp. 2466-2470
    • Barlesi, F.1
  • 27
    • 84859535445 scopus 로고    scopus 로고
    • Upfront association of carboplatin plus pemetrexed in patients with brain metastases of lung adenocarcinoma
    • Bailon O., et al. Upfront association of carboplatin plus pemetrexed in patients with brain metastases of lung adenocarcinoma. Neuro Oncol 2012, 14(4):491-495.
    • (2012) Neuro Oncol , vol.14 , Issue.4 , pp. 491-495
    • Bailon, O.1
  • 28
    • 77950457810 scopus 로고    scopus 로고
    • Activity of pemetrexed on brain metastases from non-small cell lung cancer
    • Bearz A., et al. Activity of pemetrexed on brain metastases from non-small cell lung cancer. Lung Cancer 2010, 68(2):264-268.
    • (2010) Lung Cancer , vol.68 , Issue.2 , pp. 264-268
    • Bearz, A.1
  • 29
    • 0034763862 scopus 로고    scopus 로고
    • A phase II trial of temozolomide for patients with recurrent or progressive brain metastases
    • Abrey L.E., et al. A phase II trial of temozolomide for patients with recurrent or progressive brain metastases. J Neurooncol 2001, 53(3):259-265.
    • (2001) J Neurooncol , vol.53 , Issue.3 , pp. 259-265
    • Abrey, L.E.1
  • 30
    • 0035100919 scopus 로고    scopus 로고
    • Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases
    • Christodoulou C., et al. Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases. Ann Oncol 2001, 12(2):249-254.
    • (2001) Ann Oncol , vol.12 , Issue.2 , pp. 249-254
    • Christodoulou, C.1
  • 31
    • 0037903423 scopus 로고    scopus 로고
    • Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases. a phase II study of the EORTC lung cancer group (08965)
    • Dziadziuszko R., et al. Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases. a phase II study of the EORTC lung cancer group (08965). Eur J Cancer 2003, 39(9):1271-1276.
    • (2003) Eur J Cancer , vol.39 , Issue.9 , pp. 1271-1276
    • Dziadziuszko, R.1
  • 32
    • 11144350196 scopus 로고    scopus 로고
    • Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial
    • Verger E., et al. Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial. Int J Radiat Oncol Biol Phys 2005, 61(1):185-191.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , Issue.1 , pp. 185-191
    • Verger, E.1
  • 33
    • 0036731532 scopus 로고    scopus 로고
    • Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases
    • Antonadou D., et al. Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J Clin Oncol 2002, 20(17):3644-3650.
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3644-3650
    • Antonadou, D.1
  • 34
    • 77952497156 scopus 로고    scopus 로고
    • Whole-brain radiation therapy plus concomitant temozolomide for the treatment of brain metastases from non-small-cell lung cancer: a randomized, open-label phase II study
    • Chua D., et al. Whole-brain radiation therapy plus concomitant temozolomide for the treatment of brain metastases from non-small-cell lung cancer: a randomized, open-label phase II study. Clin Lung Cancer 2010, 11(3):176-181.
    • (2010) Clin Lung Cancer , vol.11 , Issue.3 , pp. 176-181
    • Chua, D.1
  • 35
    • 1842564740 scopus 로고    scopus 로고
    • A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung
    • Guerrieri M., et al. A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung. Lung Cancer 2004, 46(1):107-111.
    • (2004) Lung Cancer , vol.46 , Issue.1 , pp. 107-111
    • Guerrieri, M.1
  • 36
    • 58749092817 scopus 로고    scopus 로고
    • A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer
    • Neuhaus T., et al. A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer. Br J Cancer 2009, 100(2):291-297.
    • (2009) Br J Cancer , vol.100 , Issue.2 , pp. 291-297
    • Neuhaus, T.1
  • 37
    • 70350596516 scopus 로고    scopus 로고
    • CNS complications of radiotherapy and chemotherapy
    • Soussain C., et al. CNS complications of radiotherapy and chemotherapy. Lancet 2009, 374(9701):1639-1651.
    • (2009) Lancet , vol.374 , Issue.9701 , pp. 1639-1651
    • Soussain, C.1
  • 38
    • 85040908336 scopus 로고    scopus 로고
    • Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases
    • Tsao M.N., et al. Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev 2012, 4:CD00869.
    • (2012) Cochrane Database Syst Rev , vol.4
    • Tsao, M.N.1
  • 39
    • 47149093012 scopus 로고    scopus 로고
    • Primary chemotherapy for newly diagnosed nonsmall cell lung cancer patients with synchronous brain metastases compared with whole-brain radiotherapy administered first: result of a randomized pilot study
    • Lee D.H., et al. Primary chemotherapy for newly diagnosed nonsmall cell lung cancer patients with synchronous brain metastases compared with whole-brain radiotherapy administered first: result of a randomized pilot study. Cancer 2008, 113(1):143-149.
    • (2008) Cancer , vol.113 , Issue.1 , pp. 143-149
    • Lee, D.H.1
  • 40
    • 84861448166 scopus 로고    scopus 로고
    • Neurocognitive function impairment after whole brain radiotherapy for brain metastases: actual assessment
    • Tallet A.V., et al. Neurocognitive function impairment after whole brain radiotherapy for brain metastases: actual assessment. Radiat Oncol 2012, 7:77.
    • (2012) Radiat Oncol , vol.7 , pp. 77
    • Tallet, A.V.1
  • 41
    • 78649675456 scopus 로고    scopus 로고
    • Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve
    • Ahles T.A., et al. Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol 2010, 28(29):4434-4440.
    • (2010) J Clin Oncol , vol.28 , Issue.29 , pp. 4434-4440
    • Ahles, T.A.1
  • 42
    • 79960131410 scopus 로고    scopus 로고
    • Cerebral hyporesponsiveness and cognitive impairment 10years after chemotherapy for breast cancer
    • de Ruiter M.B., et al. Cerebral hyporesponsiveness and cognitive impairment 10years after chemotherapy for breast cancer. Hum Brain Mapp 2011, 32(8):1206-1219.
    • (2011) Hum Brain Mapp , vol.32 , Issue.8 , pp. 1206-1219
    • de Ruiter, M.B.1
  • 43
    • 84863752197 scopus 로고    scopus 로고
    • Neuropsychological performance in survivors of breast cancer more than 20years after adjuvant chemotherapy
    • Koppelmans V., et al. Neuropsychological performance in survivors of breast cancer more than 20years after adjuvant chemotherapy. J Clin Oncol 2012, 30(10):1080-1086.
    • (2012) J Clin Oncol , vol.30 , Issue.10 , pp. 1080-1086
    • Koppelmans, V.1
  • 44
    • 9644289272 scopus 로고    scopus 로고
    • Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen
    • Castellon S.A., et al. Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. J Clin Exp Neuropsychol 2004, 26(7):955-969.
    • (2004) J Clin Exp Neuropsychol , vol.26 , Issue.7 , pp. 955-969
    • Castellon, S.A.1
  • 45
    • 33744954692 scopus 로고    scopus 로고
    • Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial
    • Aoyama H., et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 2006, 295(21):2483-2491.
    • (2006) JAMA , vol.295 , Issue.21 , pp. 2483-2491
    • Aoyama, H.1
  • 46
    • 79951966253 scopus 로고    scopus 로고
    • Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
    • Kocher M., et al. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 2011, 29(2):134-141.
    • (2011) J Clin Oncol , vol.29 , Issue.2 , pp. 134-141
    • Kocher, M.1
  • 47
    • 71249157772 scopus 로고    scopus 로고
    • Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial
    • Chang E.L., et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 2009, 10(11):1037-1044.
    • (2009) Lancet Oncol , vol.10 , Issue.11 , pp. 1037-1044
    • Chang, E.L.1
  • 48
    • 84899951160 scopus 로고    scopus 로고
    • Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole brain radiation therapy (WBRT) versus WBRT plus stereotactic radiosurgery (SRS) in patients with 1-3 brain metastases poststratified by the graded prognostic assessment (GPA)
    • [2S:S51 (abstr. 123)]
    • Sperduto P., Shanley R., Luo X. Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole brain radiation therapy (WBRT) versus WBRT plus stereotactic radiosurgery (SRS) in patients with 1-3 brain metastases poststratified by the graded prognostic assessment (GPA). Int J Radiat Oncol Biol Phys 2013, 87. [2S:S51 (abstr. 123)].
    • (2013) Int J Radiat Oncol Biol Phys , vol.87
    • Sperduto, P.1    Shanley, R.2    Luo, X.3
  • 49
    • 68649083031 scopus 로고    scopus 로고
    • Whole-brain radiotherapy with simultaneous integrated boost to multiple brain metastases using volumetric modulated arc therapy
    • Lagerwaard F.J., et al. Whole-brain radiotherapy with simultaneous integrated boost to multiple brain metastases using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 2009, 75(1):253-259.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.1 , pp. 253-259
    • Lagerwaard, F.J.1
  • 50
    • 79952258470 scopus 로고    scopus 로고
    • Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastases
    • Rodrigues G., et al. Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastases. Int J Radiat Oncol Biol Phys 2011, 80(4):1128-1133.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , Issue.4 , pp. 1128-1133
    • Rodrigues, G.1
  • 51
    • 78651483077 scopus 로고    scopus 로고
    • Why avoid the hippocampus? A comprehensive review
    • Gondi V., Tome W.A., Mehta M.P. Why avoid the hippocampus? A comprehensive review. Radiother Oncol 2010, 97(3):370-376.
    • (2010) Radiother Oncol , vol.97 , Issue.3 , pp. 370-376
    • Gondi, V.1    Tome, W.A.2    Mehta, M.P.3
  • 52
    • 77952585016 scopus 로고    scopus 로고
    • Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933
    • Gondi V., et al. Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933. Radiother Oncol 2010, 95(3):327-331.
    • (2010) Radiother Oncol , vol.95 , Issue.3 , pp. 327-331
    • Gondi, V.1
  • 53
    • 84874914437 scopus 로고    scopus 로고
    • Implications for preserving neural stem cells in whole brain radiotherapy and prophylactic cranial irradiation: a review of 2270 metastases in 488 patients
    • Wan J.F., et al. Implications for preserving neural stem cells in whole brain radiotherapy and prophylactic cranial irradiation: a review of 2270 metastases in 488 patients. J Radiat Res 2013, 54(2):285-291.
    • (2013) J Radiat Res , vol.54 , Issue.2 , pp. 285-291
    • Wan, J.F.1
  • 54
    • 84871366289 scopus 로고    scopus 로고
    • Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases: a planning study on treatment concepts
    • Prokic V., et al. Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases: a planning study on treatment concepts. Int J Radiat Oncol Biol Phys 2013, 85(1):264-270.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.1 , pp. 264-270
    • Prokic, V.1
  • 55
    • 84884999605 scopus 로고    scopus 로고
    • Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial
    • Brown P.D., et al. Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro Oncol 2013, 15(10):1429-1437.
    • (2013) Neuro Oncol , vol.15 , Issue.10 , pp. 1429-1437
    • Brown, P.D.1
  • 56
    • 84890805332 scopus 로고    scopus 로고
    • Treatment of brain metastases in lung cancer: strategies to avoid/reduce late complications of whole brain radiation therapy
    • Shaw M.G., Ball D.L. Treatment of brain metastases in lung cancer: strategies to avoid/reduce late complications of whole brain radiation therapy. Curr Treat Options Oncol 2013, 14(4):553-567.
    • (2013) Curr Treat Options Oncol , vol.14 , Issue.4 , pp. 553-567
    • Shaw, M.G.1    Ball, D.L.2
  • 57
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok T.S., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009, 361(10):947-957.
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1
  • 58
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
    • Rosell R., et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012, 13(3):239-246.
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1
  • 59
    • 82355191818 scopus 로고    scopus 로고
    • Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
    • Sequist L.V., et al. Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol 2011, 22(12):2616-2624.
    • (2011) Ann Oncol , vol.22 , Issue.12 , pp. 2616-2624
    • Sequist, L.V.1
  • 60
    • 84899908262 scopus 로고    scopus 로고
    • EGFR, KRAS, BRAF, and HER-2 molecular status in brain metastases from 77 NSCLC patients
    • Villalva C., et al. EGFR, KRAS, BRAF, and HER-2 molecular status in brain metastases from 77 NSCLC patients. Cancer Med 2013, 2(3):296-304.
    • (2013) Cancer Med , vol.2 , Issue.3 , pp. 296-304
    • Villalva, C.1
  • 61
    • 68049147562 scopus 로고    scopus 로고
    • HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors
    • Sun M., et al. HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res 2009, 15(15):4829-4837.
    • (2009) Clin Cancer Res , vol.15 , Issue.15 , pp. 4829-4837
    • Sun, M.1
  • 62
    • 77952822151 scopus 로고    scopus 로고
    • KRAS mutation status in primary nonsmall cell lung cancer and matched metastases
    • Cortot A.B., et al. KRAS mutation status in primary nonsmall cell lung cancer and matched metastases. Cancer 2010, 116(11):2682-2687.
    • (2010) Cancer , vol.116 , Issue.11 , pp. 2682-2687
    • Cortot, A.B.1
  • 63
    • 0038166890 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC)
    • Cappuzzo F., et al. Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC). Lung Cancer 2003, 41(2):227-231.
    • (2003) Lung Cancer , vol.41 , Issue.2 , pp. 227-231
    • Cappuzzo, F.1
  • 64
    • 7444234824 scopus 로고    scopus 로고
    • Gefitinib in patients with brain metastases from non-small-cell lung cancer: review of 15 clinical cases
    • Namba Y., et al. Gefitinib in patients with brain metastases from non-small-cell lung cancer: review of 15 clinical cases. Clin Lung Cancer 2004, 6(2):123-128.
    • (2004) Clin Lung Cancer , vol.6 , Issue.2 , pp. 123-128
    • Namba, Y.1
  • 65
    • 79952268212 scopus 로고    scopus 로고
    • Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation
    • Porta R., et al. Brain metastases from lung cancer responding to erlotinib: the importance of EGFR mutation. Eur Respir J 2011, 37(3):624-631.
    • (2011) Eur Respir J , vol.37 , Issue.3 , pp. 624-631
    • Porta, R.1
  • 66
    • 84865197331 scopus 로고    scopus 로고
    • Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation
    • Park S.J., et al. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation. Lung Cancer 2012, 77(3):556-560.
    • (2012) Lung Cancer , vol.77 , Issue.3 , pp. 556-560
    • Park, S.J.1
  • 67
    • 67849103953 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors as a first-line therapy for never-smokers with adenocarcinoma of the lung having asymptomatic synchronous brain metastasis
    • Kim J.E., et al. Epidermal growth factor receptor tyrosine kinase inhibitors as a first-line therapy for never-smokers with adenocarcinoma of the lung having asymptomatic synchronous brain metastasis. Lung Cancer 2009, 65(3):351-354.
    • (2009) Lung Cancer , vol.65 , Issue.3 , pp. 351-354
    • Kim, J.E.1
  • 68
    • 84857088535 scopus 로고    scopus 로고
    • The retrospective analysis of the frequency of EGFR mutations and the efficacy of gefitinib in NSCLC patients with brain metastasis
    • [abstr. e18065]
    • Li Z. The retrospective analysis of the frequency of EGFR mutations and the efficacy of gefitinib in NSCLC patients with brain metastasis. J Clin Oncol 2011, 29(Suppl.). [abstr. e18065].
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Li, Z.1
  • 69
    • 78650127780 scopus 로고    scopus 로고
    • EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer
    • Eichler A.F., et al. EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol 2010, 12(11):1193-1199.
    • (2010) Neuro Oncol , vol.12 , Issue.11 , pp. 1193-1199
    • Eichler, A.F.1
  • 70
    • 70449584901 scopus 로고    scopus 로고
    • Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib
    • Katayama T., et al. Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib. J Thorac Oncol 2009, 4(11):1415-1419.
    • (2009) J Thorac Oncol , vol.4 , Issue.11 , pp. 1415-1419
    • Katayama, T.1
  • 71
    • 84866364723 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer
    • Togashi Y., et al. Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer. Cancer Chemother Pharmacol 2012, 70(3):399-405.
    • (2012) Cancer Chemother Pharmacol , vol.70 , Issue.3 , pp. 399-405
    • Togashi, Y.1
  • 72
    • 84861726185 scopus 로고    scopus 로고
    • Cerebral penetration of gefitinib in patients with lung adenocarcinoma
    • [abstr. 7608]
    • Wang M. Cerebral penetration of gefitinib in patients with lung adenocarcinoma. J Clin Oncol 2011, 29(Suppl.). [abstr. 7608].
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Wang, M.1
  • 73
    • 84880923423 scopus 로고    scopus 로고
    • Erlotinib versus gefitinib for control of leptomeningeal carcinomatosis in non-small-cell lung cancer
    • Lee E., et al. Erlotinib versus gefitinib for control of leptomeningeal carcinomatosis in non-small-cell lung cancer. J Thorac Oncol 2013, 8(8):1069-1074.
    • (2013) J Thorac Oncol , vol.8 , Issue.8 , pp. 1069-1074
    • Lee, E.1
  • 74
    • 77956060394 scopus 로고    scopus 로고
    • High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer
    • Clarke J.L., et al. High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer. J Neurooncol 2010, 99(2):283-286.
    • (2010) J Neurooncol , vol.99 , Issue.2 , pp. 283-286
    • Clarke, J.L.1
  • 75
    • 84856304068 scopus 로고    scopus 로고
    • "Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer
    • Grommes C., et al. "Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer. Neuro Oncol 2011, 13(12):1364-1369.
    • (2011) Neuro Oncol , vol.13 , Issue.12 , pp. 1364-1369
    • Grommes, C.1
  • 76
    • 80054730405 scopus 로고    scopus 로고
    • Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation
    • Togashi Y., et al. Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation. Cancer Chemother Pharmacol 2011, 68(4):1089-1092.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.4 , pp. 1089-1092
    • Togashi, Y.1
  • 77
    • 59649105302 scopus 로고    scopus 로고
    • EGFR-TKI and lung adenocarcinoma with CNS relapse: interest of molecular follow-up
    • Ruppert A.M., et al. EGFR-TKI and lung adenocarcinoma with CNS relapse: interest of molecular follow-up. Eur Respir J 2009, 33(2):436-440.
    • (2009) Eur Respir J , vol.33 , Issue.2 , pp. 436-440
    • Ruppert, A.M.1
  • 78
    • 84875720245 scopus 로고    scopus 로고
    • Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer
    • Welsh J.W., et al. Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer. J Clin Oncol 2013, 31(7):895-902.
    • (2013) J Clin Oncol , vol.31 , Issue.7 , pp. 895-902
    • Welsh, J.W.1
  • 79
    • 84875239644 scopus 로고    scopus 로고
    • A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: radiation therapy oncology group 0320
    • Sperduto P.W., et al. A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: radiation therapy oncology group 0320. Int J Radiat Oncol Biol Phys 2013, 85(5):1312-1318.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.5 , pp. 1312-1318
    • Sperduto, P.W.1
  • 80
    • 84887023536 scopus 로고    scopus 로고
    • Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma
    • Iuchi T., et al. Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma. Lung Cancer 2013, 82(2):282-287.
    • (2013) Lung Cancer , vol.82 , Issue.2 , pp. 282-287
    • Iuchi, T.1
  • 81
    • 84875385880 scopus 로고    scopus 로고
    • Rapid response of brain metastasis to crizotinib in a patient with ALK rearrangement-positive non-small-cell lung cancer
    • Kaneda H., Okamoto I., Nakagawa K. Rapid response of brain metastasis to crizotinib in a patient with ALK rearrangement-positive non-small-cell lung cancer. J Thorac Oncol 2013, 8(4):e32-e33.
    • (2013) J Thorac Oncol , vol.8 , Issue.4
    • Kaneda, H.1    Okamoto, I.2    Nakagawa, K.3
  • 82
    • 84875393191 scopus 로고    scopus 로고
    • Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement
    • Maillet D., et al. Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement. J Thorac Oncol 2013, 8(4):e30-e31.
    • (2013) J Thorac Oncol , vol.8 , Issue.4
    • Maillet, D.1
  • 83
    • 84899941554 scopus 로고    scopus 로고
    • Clinical experience with crizotinib in patients (pts) with advanced ALK+ non-small cell lung cancer (NSCLC) and brain metastases ECCO Meeting
    • Crino, L. Clinical experience with crizotinib in patients (pts) with advanced ALK+ non-small cell lung cancer (NSCLC) and brain metastases ECCO Meeting, 2013.
    • (2013)
    • Crino, L.1
  • 84
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw A.T., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013, 368(25):2385-2394.
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1
  • 85
    • 80052492099 scopus 로고    scopus 로고
    • Progression-free survival (PFS) from a phase I study of crizotinib (PF02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC)
    • Camidge R. Progression-free survival (PFS) from a phase I study of crizotinib (PF02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol 2011, 29(Suppl.):a2501.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Camidge, R.1
  • 86
    • 80052492099 scopus 로고    scopus 로고
    • Progression-free survival (PFS) from a phase I study of crizotinib (PF02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC)
    • Camidge R. Progression-free survival (PFS) from a phase I study of crizotinib (PF02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol 2011, 29(Suppl.):a2501.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Camidge, R.1
  • 87
    • 84866655837 scopus 로고    scopus 로고
    • Clinical characteristics of ALK+ NSCLC patients (pts) treated with crizotinib beyond disease progression (PD): potential implications for management
    • [abstr. 7600]
    • Otterson G.A. Clinical characteristics of ALK+ NSCLC patients (pts) treated with crizotinib beyond disease progression (PD): potential implications for management. J Clin Oncol 2012, 30(Suppl.). [abstr. 7600].
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Otterson, G.A.1
  • 88
    • 79957487193 scopus 로고    scopus 로고
    • CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib
    • Costa D.B., et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol 2011, 29(15):e443-e445.
    • (2011) J Clin Oncol , vol.29 , Issue.15
    • Costa, D.B.1
  • 89
    • 84883390161 scopus 로고    scopus 로고
    • High-dose crizotinib for brain metastases refractory to standard-dose crizotinib
    • Kim Y.H., et al. High-dose crizotinib for brain metastases refractory to standard-dose crizotinib. J Thorac Oncol 2013, 8(9):e85-e86.
    • (2013) J Thorac Oncol , vol.8 , Issue.9
    • Kim, Y.H.1
  • 90
    • 84876354373 scopus 로고    scopus 로고
    • Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement
    • Takeda M., Okamoto I., Nakagawa K. Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement. J Thorac Oncol 2013, 8(5):654-657.
    • (2013) J Thorac Oncol , vol.8 , Issue.5 , pp. 654-657
    • Takeda, M.1    Okamoto, I.2    Nakagawa, K.3
  • 91
    • 84884268356 scopus 로고    scopus 로고
    • First-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies: updated results
    • [abstr. 8031]
    • Camidge R. First-in-human dose-finding study of the ALK/EGFR inhibitor AP26113 in patients with advanced malignancies: updated results. J Clin Oncol 2013, 31(Suppl.). [abstr. 8031].
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Camidge, R.1
  • 92
    • 84884993118 scopus 로고    scopus 로고
    • Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC
    • [abstr. 8010]
    • Shaw A.T. Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC. J Clin Oncol 2013, 31(Suppl.). [abstr. 8010].
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Shaw, A.T.1
  • 93
    • 84887413723 scopus 로고    scopus 로고
    • A phase I/II study with a highly selective ALK inhibitor CH5424802 in ALK-positive non-small cell lung cancer (NSCLC) patients: updated safety and efficacy results from AF-001JP
    • [abstr. 8033]
    • Nakagawa K. A phase I/II study with a highly selective ALK inhibitor CH5424802 in ALK-positive non-small cell lung cancer (NSCLC) patients: updated safety and efficacy results from AF-001JP. J Clin Oncol 2013, 31(Suppl.). [abstr. 8033].
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Nakagawa, K.1
  • 94
    • 84899069959 scopus 로고    scopus 로고
    • Miliary Brain Metastases in a Patient with ROS1-Rearranged Lung Adenocarcinoma: A Case Report
    • Dziadziuszko K., Szurowska E., Pienkowska J., Jassem J., Dziadziuszko R. Miliary Brain Metastases in a Patient with ROS1-Rearranged Lung Adenocarcinoma: A Case Report. J Thorac Oncol 2014, 9(5):e34-e36.
    • (2014) J Thorac Oncol , vol.9 , Issue.5
    • Dziadziuszko, K.1    Szurowska, E.2    Pienkowska, J.3    Jassem, J.4    Dziadziuszko, R.5
  • 95
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355(24):2542-2550.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1
  • 96
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
    • Reck M., et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010, 21(9):1804-1809.
    • (2010) Ann Oncol , vol.21 , Issue.9 , pp. 1804-1809
    • Reck, M.1
  • 97
    • 84871538217 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of randomised, phase II/III trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-small-cell lung cancer
    • Soria J.C., et al. Systematic review and meta-analysis of randomised, phase II/III trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients with advanced non-small-cell lung cancer. Ann Oncol 2013, 24(1):20-30.
    • (2013) Ann Oncol , vol.24 , Issue.1 , pp. 20-30
    • Soria, J.C.1
  • 98
    • 70449725036 scopus 로고    scopus 로고
    • Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases
    • Socinski M.A., et al. Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases. J Clin Oncol 2009, 27(31):5255-5261.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5255-5261
    • Socinski, M.A.1
  • 99
    • 84886389665 scopus 로고    scopus 로고
    • Final overall survival (OS) results of a noncomparative phase II study of bevacizumab (B) plus first-line chemotherapy or second-line erlotinib (E) in nonsquamous NSCLC (ns-NSCLC) patients with asymptomatic untreated brain metastases (BM) (BRAIN)
    • [abstr. 8059]
    • Besse B. Final overall survival (OS) results of a noncomparative phase II study of bevacizumab (B) plus first-line chemotherapy or second-line erlotinib (E) in nonsquamous NSCLC (ns-NSCLC) patients with asymptomatic untreated brain metastases (BM) (BRAIN). J Clin Oncol 2013, 31(Suppl.). [abstr. 8059].
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Besse, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.