Activity of Pemetrexed on brain metastases from Non-Small Cell Lung Cancer

Lung Cancer

Volumn 68, Issue 2, 2010, Pages 264-268

  Bearz, Alessandra ^a   Garassino, Isabella ^b   Tiseo, Marcello ^c   Caffo, Orazio ^d   Soto Parra, Hector ^e   Boccalon, Massimo ^f   Talamini, Renato ^a   Santoro, Armando ^b   Bartolotti, Marco ^c   Murgia, Viviana ^d   Berretta, Massimiliano ^a   Tirelli, Umberto ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c GENERAL HOSPITAL   (Italy)

^d General Hospital   (Italy)

^e GARIBALDI HOSPITAL   (Italy)

^f General Hospital   (Italy)

Author keywords

Brain localization; Chemotherapy; Metastases; Non Small Cell Lung Cancer; Pemetrexed; Second line treatment

Indexed keywords

PEMETREXED;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN METASTASIS; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE COURSE; DRUG TOLERABILITY; FEMALE; HUMAN; LUNG NON SMALL CELL CANCER; MALE; MULTIPLE CYCLE TREATMENT; NEURORADIOLOGY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; TREATMENT OUTCOME; TUMOR LOCALIZATION;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; FEMALE; GLUTAMATES; GUANINE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; RADIOTHERAPY, ADJUVANT; SURVIVAL ANALYSIS;

EID: 77950457810     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2009.06.018     Document Type: Article

References (26)

1. Schiller J.H., Harrington D., Belani C.P., Langer C., Sandler A., Krook J., et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med 2002, 346:92-98.
2. Shepherd F.A., Dancey J., Ramlau R., Mattson K., Gralla R., O'Rourke M., et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non small cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000, 18:2095-2103.
3. Hanna N., Shepherd F.A., Fossella F.V., Pereira J.R., De Marinis F., von Pawel J., et al. Randomized phase III trial of Pemetrexed versus docetaxel in patients with non small cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004, 22:1589-1596.
4. Shepherd F.A., Rodrigues Pereira J., Ciuleanu T., Tan E.H., Hirsh V., Thongprasert S., et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005, 353:123-132.
5. Scagliotti G.V., Parikh P., von Pawel J., Biesma B., Vansteenkiste J., Manegold C., et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:3543-3551.
6. Peterson P., Park P., Fossella F., Gatzmeier F., Ulrich J., Scagliotti G. Is Pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non small cell lung cancer. J Thoracic Oncol 2007, 2(SUPP1. 4):S851. WCLC 2007.
7. Cairncross J.G., Kim J.H., Poster J.B. Radiation therapy for brain metastases. Ann Neurol 1980, 7:529-541.
8. Delattre J.Y., Krol G., Thaler H.T., Posner J.B. Distribution of brain metastases. Arch Neurol 1988, 45:741-744.
9. Patchell R.A. Brain metastases. Neurol Clin 1991, 9:817-824.
10. Hazuka M.B., Burleson W.D., Stround D.N., Leonard C.E., Lillehei K.O., Kinzie J.J. Multiple brain metastases are associated with poor survival in patients treated with surgery and radiotherapy. J Clin Oncol 1993, 11:369-373.
11. Nussbaum E.S., Djalilian H.R., Cho K.H., Hall W.A. Brain metastases. Cancer 1996, 78:1781-1788.
12. Cortes J., Rodriguez J., Aramendia J.M., Salgado E., Gurpide A., Garcia-Foncillas J., et al. Frontline paclitaxel/cisplatin-based chemotherapy in brain metastases from non small cell lung cancer. Oncology 2003, 64:28-35.
13. Minotti V., Crino' L., Meacci M.L., Corgna E., Darwish S., Palladino M.A., et al. Chemotherapy with cisplatin and teniposide for cerebral metastases in non small cell lung cancer. Lung Cancer 1998, 20:93-98.
14. Fujita A., Fukuoka S., Takabatake H., Tagaki S., Sekine K. Combination chemotherapy of cisplatin, ifosfamide and irinotecan with rh-GCSF support in patient with brain metastases from non small cell lung cancer. Oncology 2000, 59:291-295.
15. Dziadziusko R., Ardizzoni A., Postmus P.E., Smit E.F., Price A., Debruyne C., et al. Temozolamide in patients with advanced non small cell lung cancer with and without brain metastases: a phase II study of the EORTC lung Cancer Group (08965). Eur J Cancer 2003, 39:2271-2276.
16. Omlin A., D'Addario G., Gillessen S., Cerny T., von Hessling A., Früh M Activity of Pemetrexed against brain metastases in a patient with adenocarcinoma of the lung. Lung Cancer 2009, (April). [Epub ahead of print].
17. Data on file, Lilly research Laboratories.
18. Dai H., Chen Y., Elmquist W.F. Distribution of the novel antifolate pemetrexed to the brain. J Pharmacol Exp Ther 2005, 315:222-229.
19. Chay S.H., Herman J.L., Pohland R.C., Shih C. Quantitative whole body autoradiographic (QWBA) disposition of [14C]LY231514 (MTA) in male CD-1 mice after a single IV 20mg/kg dose. Proc Am Assoc Cancer Res 1998, 39:524-525.
20. Stapleton S.L., Reid J.M., Thompson P.A., et al. Plasma and cerebrospinal fluid pharmacokinetics of pemetrexed after intravenous administration in non-human primates. Cancer Chemother Pharmacol 2007, 59:461-466.
21. Therasse P., Arbuck S.G., Eisenhauer E.A., Wanders J., Kaplan R.S., Rubinstein L., et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000, 92:205-216.
22. Kaplan E.L., Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
23. Ruderman N.B., Hall T.C. Use of glucocorticoids in the palliative treatment of metastaic brain tumors. Cancer 1965, 18:298-306.
24. Kurtz J.M., Gelber R., Brady L.W., Carella R.J., Cooper J.S. The palliation of brain metastases in a favourable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981, 7:891-895.
25. Zimm S., Wampler G.L., Stablein D., Hazra T., Young H.F. Intracerebral metastases in solid-tumor patients: natural history and results of treatment. Cancer 1981, 48:384-394.
26. Bearz A., Garassino I., Cavina R., Favaretto A., Boccalon M., Talamini R., et al. Pemetrexed single agent in previously treated non-small cell lung cancer: a multi-institutional observational study. Lung Cancer 2008, 60:240-245.