Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression

Psychiatry Research

Volumn 217, Issue 1-2, 2014, Pages 34-38

  Rudolf, Sebastian ^a   Greggersen, Wiebke ^a   Kahl, Kai Gustav ^b   Hüppe, Michael ^a   Schweiger, Ulrich ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cytokines; Metabolic syndrome; Mood disorder; Neuroimmunomodulation

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN A1C; INSULIN; INTERLEUKIN 6; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; ATYPICAL DEPRESSION; BODY MASS; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DSM-IV; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE CLAMP TECHNIQUE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLISM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TYPICAL DEPRESSION; WAIST CIRCUMFERENCE; BLOOD; CASE CONTROL STUDY; CLASSIFICATION; COMPLICATION; DRINKING BEHAVIOR; FEMALE; MAJOR DEPRESSION; METABOLIC SYNDROME X;

ADULT; ALCOHOL DRINKING; BODY MASS INDEX; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GLUCOSE CLAMP TECHNIQUE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INTERLEUKIN-6; MALE; METABOLIC SYNDROME X;

EID: 84899954108     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2014.02.016     Document Type: Article

References (54)

1. Bob P., Raboch J., Maes M., Susta M., Pavlat J., Jasova D., Vevera J., Uhrova J., Benakova H., Zima T. Depression, traumatic stress and interleukin-6. Journal of Affective Disorders 2009, 120:231-234.
2. Capuron L., Su S., Miller A.H., Bremner J.D., Goldberg J., Vogt G.J., Maisano C., Jones L., Murrah N.V., Vaccarino V. Depressive symptoms and metabolic syndrome: is inflammation the underlying link?. Biological Psychiatry 2008, 64:896-900.
3. Cizza G., Ravn P., Chrousos G.P., Gold P.W. Depression: a major, unrecognized risk factor for osteoporosis?. Trends in Endocrinology and Metabolism 2001, 12:198-203.
4. Dantzer R., Kelley K.W. Twenty years of research on cytokine-induced sickness behavior. Brain, Behavior and Immunity 2007, 21:153-160.
5. Davidson K.W., Schwartz J.E., Kirkland S.A., Mostofsky E., Fink D., Guernsey D., Shimbo D. Relation of inflammation to depression and incident coronary heart disease (from the Canadian Nova Scotia Health Survey [NSHS95] Prospective Population Study). American Journal of Cardiology 2009, 103:755-761.
6. Deuschle M., Schweiger U., Weber B., Gotthardt U., Korner A., Schmider J., Standhardt H., Lammers C.H., Heuser I. Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. Journal of Clinical Endocrinolology and Metabolism 1997, 82:234-238.
7. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., Lanctot K.L. A meta-analysis of cytokines in major depression. Biological Psychiatry 2009, 67:446-457.
8. Duivis H.E., de Jonge P., Penninx B.W., Na B.Y., Cohen B.E., Whooley M.A. Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. American Journal of Psychiatry 2011, 168:913-920.
9. Dunjic-Kostic B., Ivkovic M., Radonjic N.V., Petronijevic N.D., Pantovic M., Damjanovic A., Poznanovic S.T., Jovanovic A., Nikolic T., Jasovic-Gasic M. Melancholic and atypical major depression-connection between cytokines, psychopathology and treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2012, 43:1-6.
10. Einvik G., Vistnes M., Hrubos-Strom H., Randby A., Namtvedt S.K., Nordhus I.H., Somers V.K., Dammen T., Omland T. Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort. General Hospital Psychiatry 2012, 34:262-267.
11. Empana J.P., Sykes D.H., Luc G., Juhan-Vague I., Arveiler D., Ferrieres J., Amouyel P., Bingham A., Montaye M., Ruidavets J.B., Haas B., Evans A., Jouven X., Ducimetiere P. Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation 2005, 111:2299-2305.
12. Eskandari F., Martinez P.E., Torvik S., Phillips T.M., Sternberg E.M., Mistry S., Ronsaville D., Wesley R., Toomey C., Sebring N.G., Reynolds J.C., Blackman M.R., Calis K.A., Gold P.W., Cizza G. Low bone mass in premenopausal women with depression. Archives of Internal Medicine 2007, 167:2329-2336.
13. Gimeno D., Kivimaki M., Brunner E.J., Elovainio M., De Vogli R., Steptoe A., Kumari M., Lowe G.D., Rumley A., Marmot M.G., Ferrie J.E. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychological Medicine 2009, 39:413-423.
14. Gold P.W., Chrousos G.P. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Molecular Psychiatry 2002, 7:254-275.
15. Goldbacher E.M., Bromberger J., Matthews K.A. Lifetime history of major depression predicts the development of the metabolic syndrome in middle-aged women. Psychosomatic Medicine 2009, 71:266-272.
16. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosomatic Medicine 2009, 71:171-186.
17. Humphreys D., Schlesinger L., Lopez M., Araya A.V. Interleukin-6 production and deregulation of the hypothalamic-pituitary-adrenal axis in patients with major depressive disorders. Endocrine 2006, 30:371-376.
18. Jakovljevic M., Crncevic Z., Ljubicic D., Babic D., Topic R., Saric M. Mental disorders and metabolic syndrome: a fatamorgana or warning reality?. Psychiatria Danubina 2007, 19:76-86.
19. Kahl K.G., Bester M., Greggersen W., Rudolf S., Dibbelt L., Stoeckelhuber B.M., Gehl H.B., Sipos V., Hohagen F., Schweiger U. Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder. Psychosomatic Medicine 2005, 67:407-412.
20. Karlovic D., Serretti A., Vrkic N., Martinac M., Marcinko D. Serum concentrations of CRP, IL-6, TNF-alpha and cortisol in major depressive disorder with melancholic or atypical features. Psychiatry Research 2012, 198:74-80.
21. Kinder L.S., Carnethon M.R., Palaniappan L.P., King A.C., Fortmann S.P. Depression and the metabolic syndrome in young adults: findings from the Third National Health and Nutrition Examination Survey. Psychosomatic Medicine 2004, 66:316-322.
22. Kop W.J., Stein P.K., Tracy R.P., Barzilay J.I., Schulz R., Gottdiener J.S. Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosomatic Medicine 2010, 72:626-635.
23. Lamers F., Burstein M., He J.P., Avenevoli S., Angst J., Merikangas K.R. Structure of major depressive disorder in adolescents and adults in the US general population. British Journal of Psychiatry 2012, 201:143-150.
24. Lamers F., de Jonge P., Nolen W.A., Smit J.H., Zitman F.G., Beekman A.T., Penninx B.W. Identifying depressive subtypes in a large cohort study: results from the Netherlands Study of Depression and Anxiety (NESDA). Journal of Clinical Psychiatry 2010, 71:1582-1589.
25. Lamers F., Vogelzangs N., Merikangas K.R., de Jonge P., Beekman A.T., Penninx B.W. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Molecular Psychiatry 2012, 18:692-699.
26. Maes M., Berk M., Goehler L., Song C., Anderson G., Galecki P., Leonard B. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Medicine 2012, 10:66.
27. Maes M., Scharpe S., Meltzer H.Y., Bosmans E., Suy E., Calabrese J., Cosyns P. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Research 1993, 49:11-27.
28. Martinez Cantarin M.P., Keith S.W., Deloach S., Huan Y., Falkner B. Relationship of adipokines with insulin sensitivity in African Americans. American Journal of the Medical Sciences 2011, 342:192-197.
29. Mastorakos G., Chrousos G.P., Weber J.S. Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans. Journal of Clinical Endocrinology and Metabolism 1993, 77:1690-1694.
30. Matza L.S., Revicki D.A., Davidson J.R., Stewart J.W. Depression with atypical features in the National Comorbidity Survey: classification, description, and consequences. Archives of General Psychiatry 2003, 60:817-826.
31. Mezuk B., Eaton W.W., Albrecht S., Golden S.H. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 2008, 31:2383-2390.
32. Mohamed-Ali V., Goodrick S., Rawesh A., Katz D.R., Miles J.M., Yudkin J.S., Klein S., Coppack S.W. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. Journal of Clinical Endocrinology and Metabolism 1997, 82:4196-4200.
33. Motivala S.J., Sarfatti A., Olmos L., Irwin M.R. Inflammatory markers and sleep disturbance in major depression. Psychosomatic Medicine 2005, 67:187-194.
34. Murphy J.M., Burke J.D., Monson R.R., Horton N.J., Laird N.M., Lesage A., Sobol A.M., Leighton A.H. Mortality associated with depression: a forty-year perspective from the Stirling County Study. Social Psychiatry and Psychiatric Epidemiology 2008, 43:594-601.
35. Murphy J.M., Gilman S.E., Lesage A., Horton N.J., Rasic D., Trinh N.H., Alamiri B., Sobol A.M., Fava M., Smoller J.W. Time trends in mortality associated with depression: findings from the Stirling County study. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 2010, 55:776-783.
36. Mykletun A., Bjerkeset O., Overland S., Prince M., Dewey M., Stewart R. Levels of anxiety and depression as predictors of mortality: the HUNT study. British Journal of Psychiatry 2009, 195:118-125.
37. Papanicolaou D.A., Wilder R.L., Manolagas S.C., Chrousos G.P. The pathophysiologic roles of interleukin-6 in human disease. Annals of Internal Medicine 1998, 128:127-137.
38. Raison C.L., Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. American Journal of Psychiatry 2003, 160:1554-1565.
39. Raison C.L., Miller A.H. Is depression an inflammatory disorder?. Current Psychiatry Reports 2011, 13:467-475.
40. Renn B.N., Feliciano L., Segal D.L. The bidirectional relationship of depression and diabetes: a systematic review. Clinical Psychology Review 2011, 31:1239-1246.
41. Rush A.J. The varied clinical presentations of major depressive disorder. Journal of Clinical Psychiatry 2007, 68(Suppl. 8):S4-S10.
42. Schweiger U., Greggersen W., Rudolf S., Pusch M., Menzel T., Winn S., Hassfurth J., Fassbinder E., Kahl K.G., Oltmanns K.M., Hohagen F., Peters A. Disturbed glucose disposal in patients with major depression; application of the glucose clamp technique. Psychosomatic Medicine 2008, 70:170-176.
43. Silic A., Karlovic D., Serretti A. Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome. Journal of Affective Disorders 2012, 141:72-78.
44. Skilton M.R., Moulin P., Terra J.L., Bonnet F. Associations between anxiety, depression, and the metabolic syndrome. Biological Psychiatry 2007, 62:1251-1257.
45. Thase M.E. Recognition and diagnosis of atypical depression. Journal of Clinical Psychiatry 2007, 68(Suppl. 8):S11-S16.
46. Tichomirowa M.A., Keck M.E., Schneider H.J., Paez-Pereda M., Renner U., Holsboer F., Stalla G.K. Endocrine disturbances in depression. Journal Endocrinological Investigations 2005, 28:89-99.
47. Vaccarino V., Johnson B.D., Sheps D.S., Reis S.E., Kelsey S.F., Bittner V., Rutledge T., Shaw L.J., Sopko G., Bairey Merz C.N. Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia: the National Heart, Lung, and Blood Institute-sponsored WISE study. Journal of the American College of Cardiology 2007, 50:2044-2050.
48. Vaccarino V., McClure C., Johnson B.D., Sheps D.S., Bittner V., Rutledge T., Shaw L.J., Sopko G., Olson M.B., Krantz D.S., Parashar S., Marroquin O.C., Merz C.N. Depression, the metabolic syndrome and cardiovascular risk. Psychosomatic Medicine 2008, 70:40-48.
49. Vogelzangs N., Kritchevsky S.B., Beekman A.T., Brenes G.A., Newman A.B., Satterfield S., Yaffe K., Harris T.B., Penninx B.W. Obesity and onset of significant depressive symptoms: results from a prospective community-based cohort study of older men and women. Journal of Clinical Psychiatry 2010, 71:391-399.
50. Vogelzangs N., Seldenrijk A., Beekman A.T., van Hout H.P., de Jonge P., Penninx B.W. Cardiovascular disease in persons with depressive and anxiety disorders. Journal of Affective Disorders 2010, 125:241-248.
51. Whooley M.A., Caska C.M., Hendrickson B.E., Rourke M.A., Ho J., Ali S. Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study. Biological Psychiatry 2007, 62:314-320.
52. Yoon H.K., Kim Y.K., Lee H.J., Kwon D.Y., Kim L. Role of cytokines in atypical depression. Nordic Journal of Psychiatry 2012, 66:183-188.
53. Yudkin J.S., Kumari M., Humphries S.E., Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis 2000, 148:209-214.
54. Zeugmann S., Quante A., Heuser I., Schwarzer R., Anghelescu I. Inflammatory biomarkers in 70 depressed inpatients with and without the metabolic syndrome. Journal of Clinical Psychiatry 2010, 71:1007-1016.