KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine

Annals of Neurology

Volumn 75, Issue 4, 2014, Pages 581-590

  Milligan, Carol J ^a   Li, Melody ^a   Gazina, Elena V ^a   Heron, Sarah E ^b   Nair, Umesh ^a   Trager, Chantel ^a   Reid, Christopher A ^a   Venkat, Anu ^c,d   Younkin, Donald P ^d   Dlugos, Dennis J ^c,d   Petrovski, Slavé ^e,f   Goldstein, David B ^e   Dibbens, Leanne M ^b   Scheffer, Ingrid E ^a,f   Berkovic, Samuel F ^f   Petrou, Steven ^a,f  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; POTASSIUM CHANNEL KCNT1; QUINIDINE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; BENIGN CHILDHOOD EPILEPSY; BRAIN ELECTROPHYSIOLOGY; DRUG EFFECT; EPILEPSY; FRONTAL LOBE EPILEPSY; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; OOCYTE; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICROINJECTIONS; MUTATION; NERVE TISSUE PROTEINS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; QUINIDINE; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS; XENOPUS LAEVIS;

EID: 84899952041     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24128     Document Type: Article

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