Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI 3-kinase-dependent manner

Cardiovascular Research

Volumn 68, Issue 2, 2005, Pages 299-306

  George, Jacob ^a   Goldstein, Emil ^a   Abashidze, Anastasia ^a   Wexler, Dov ^a   Hamed, Saher ^a   Shmilovich, Haim ^a   Deutsch, Varda ^a   Miller, Hylton ^a   Keren, Gad ^a   Roth, Arie ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Angiogenesis; CHF; EPC; Epo; Stem cell; VEGF

Indexed keywords

CD133 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; ERYTHROPOIETIN; FIBRONECTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN RECEPTOR 2;

AGED; ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ERYTHROCYTE ADHESIVENESS; FEMALE; HEART CELL CULTURE; HEMATOPOIETIC CELL; HUMAN; MALE; PRIORITY JOURNAL; SAMPLE SIZE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGED; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; ERYTHROPOIETIN; FEMALE; FIBROBLASTS; FIBRONECTINS; HEART FAILURE, CONGESTIVE; HUMANS; MALE; MYOCYTES, CARDIAC; STEM CELLS; STIMULATION, CHEMICAL;

EID: 26444488135     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2005.06.022     Document Type: Article

References (35)

1. P. Ghezzi, and M. Brines Erythropoietin as an antiapoptotic, tissue-protective cytokine Cell Death Differ 11 2004 S37 S44
2. F.H. Bahlmann, K. de Groot, H. Haller, and D. Fliser Erythropoietin: is it more than correcting anaemia? Nephrol Dial Transplant 19 2004 20 22
3. K.J. Smith, A.J. Bleyer, W.C. Little, and D.C. Sane The cardiovascular effects of erythropoietin Cardiovasc Res 59 2003 538 548
4. D. Ribatti, M. Presta, A. Vacca, R. Ria, R. Giuliani, and P. Dell'Era Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo Blood 93 1999 2627 2636
5. C. Heeschen, A. Aicher, R. Lehmann, S. Fichtlscherer, M. Vasa, and C. Urbich Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization Blood 102 2003 1340 1346
6. S. Rafii, and D. Lyden Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration Nat Med 9 2003 702 712
7. C. Urbich, and S. Dimmeler Endothelial progenitor cells: characterization and role in vascular biology Circ Res 95 2004 343 353
8. T. Asahara, T. Murohara, A. Sullivan, M. Silver, R. van der Zee, and T. Li Isolation of putative progenitor endothelial cells for angiogenesis Science 275 1997 964 967
9. M. Vasa, S. Fichtlscherer, A. Aicher, K. Adler, C. Urbich, and H. Martin Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease Circ Res 89 2001 E1 E7
10. J.M. Hill, G. Zalos, J.P. Halcox, W.H. Schenke, M.A. Waclawiw, and A.A. Quyyumi Circulating endothelial progenitor cells, vascular function, and cardiovascular risk N Engl J Med 348 2003 593 600
11. O.M. Tepper, R.D. Galiano, and J.M. Capla Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures Circulation 106 26 2002 2781 2786
12. D. Simper, S. Wang, A. Deb, D. Holmes, C. McGregor, and R. Frantz Endothelial progenitor cells are decreased in blood of cardiac allograft patients with vasculopathy and endothelial cells of noncardiac origin are enriched in transplant atherosclerosis Circulation 108 2003 143 149
13. S. Shintani, T. Murohara, and H. Ikeda Mobilization of endothelial progenitor cells in patients with acute myocardial infarction Circulation 103 2001 2776 2779
14. J. George, E. Goldstein, S. Abashidze, V. Deutsch, H. Shmilovich, and A. Finkelstein Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation Eur Heart J 25 2004 1003 1008
15. B. Assmus, V. Schachinger, C. Teupe, M. Britten, R. Lehmann, and N. Dobert Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI) Circulation 106 2002 3009 3017
16. K.C. Wollert, G.P. Meyer, J. Lotz, S. Ringes-Lichtenberg, P. Lippolt, and C. Breidenbach Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial Lancet 364 2004 141 148
17. F.H. Bahlmann, K. DeGroot, T. Duckert, E. Niemczyk, E. Bahlmann, and S.M. Boehm Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin Kidney Int 64 2003 1648 1652
18. F.H. Bahlmann, K. DeGroot, J.M. Spandau, A.L. Landry, B. Hertel, and T. Duckert Erythropoietin regulates endothelial progenitor cells Blood 103 2004 921 926
19. M. Jessup, and S. Brozena Heart failure N Engl J Med 348 2003 2007 2018
20. D.S. Silverberg, D. Wexler, D. Sheps, M. Blum, G. Keren, and R. Baruch The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study J Am Coll Cardiol 37 2001 1775 1780
21. D.M. Mancini, S.D. Katz, C.C. Lang, J. LaManca, A. Hudaihed, and A.S. Androne Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure Circulation 107 2003 294 299
22. J. George, I. Herz, E. Goldstein, S. Abashidze, V. Deutch, and A. Finkelstein Number and adhesive properties of circulating endothelial progenitor cells in patients with in-stent restenosis Arterioscler Thromb Vasc Biol 23 2003 e57 e60
23. K. Yamamoto, Q.N. Dang, and S.P. Kennedy Induction of tenascin-C in cardiac myocytes by mechanical deformation: role of reactive oxygen species J Biol Chem 274 1999 21840 21846
24. J.H. Choi, K.L. Kim, W. Huh, B. Kim, J. Byun, and W. Suh Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure Arterioscler Thromb Vasc Biol 24 2004 1246 1252
25. P. van der Meer, A.A. Voors, E. Lipsic, W.H. van Gilst, and D.J. van Veldhuisen Erythropoietin in cardiovascular diseases Eur Heart J 25 2004 285 291
26. Z. Cai, D.J. Manalo, G. Wei, E.R. Rodriguez, K. Fox-Talbot, and H. Lu Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury Circulation 108 2003 79 85
27. L. Calvillo, R. Latini, J. Kajstura, A. Leri, P. Anversa, and P. Ghezzi Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling Proc Natl Acad Sci U S A 100 2003 4802 4806
28. C.J. Parsa, A. Matsumoto, J. Kim, R.U. Riel, L.S. Pascal, and G.B. Walton A novel protective effect of erythropoietin in the infarcted heart J Clin Invest 112 2003 999 1007
29. M. Valgimigli, G.M. Rigolin, A. Fucili, M.D. Porta, O. Soukhomovskaia, and P. Malagutti CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure Circulation 110 2004 1209 1212
30. E. Dernbach, C. Urbich, R.P. Brandes, W.K. Hofmann, A.M. Zeiher, and S. Dimmeler Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress Blood 104 2004 3591 3597
31. T. Asahara, T. Takahashi, H. Masuda, C. Kalka, D. Chen, and H. Iwaguro VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells EMBO J 18 1999 3964 3972
32. N. Kertesz, J. Wu, T.H. Chen, H.M. Sucov, and H. Wu The role of erythropoietin in regulating angiogenesis Dev Biol 276 2004 101 110
33. L. Wang, Z. Zhang, Y. Wang, R. Zhang, and M. Chopp Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats Stroke 35 2004 1732 1737
34. R. Möhle, D. Green, M.A.S. Moore, R.L. Nachman, and S. Rafii Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets Proc Natl Acad Sci U S A 94 1997 663 668
35. Z.Z. Chong, J.Q. Kang, and K. Maiese Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases Circulation 106 2002 2973 2979