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Volumn 97, Issue 1, 2013, Pages 99-112

Translation of molecular pathways into clinical trials of neuroendocrine tumors

Author keywords

Carcinoid; Neuroendocrine tumors; Signaling pathways; Targeted drugs; Targets

Indexed keywords

ALPHA INTERFERON; ANGIOPEPTIN; AXITINIB; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EVEROLIMUS; FIBROBLAST GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GEFITINIB; INTERFERON RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; OCTREOTIDE; PANITUMUMAB; PAZOPANIB; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SOMATOMEDIN C RECEPTOR; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; SORAFENIB; SUNITINIB; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VATALANIB; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; DOPAMINE RECEPTOR; ENZYME; OXALIPLATIN; PASIREOTIDE; PROTEASOME; STAT3 PROTEIN; TELOTRISTAT ETHYL; TEMOZOLOMIDE; TRYPTOPHAN HYDROXYLASE;

EID: 84874111766     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000336089     Document Type: Review
Times cited : (28)

References (97)
  • 1
    • 0025743467 scopus 로고
    • The role of interferons in the management of carcinoid tumors
    • Öberg K, Eriksson B: The role of interferons in the management of carcinoid tumors. Acta Oncol 1991; 30519-522.
    • (1991) Acta Oncol , vol.3 , pp. 0519-0522
    • Öberg K, E.1
  • 2
    • 37349069330 scopus 로고    scopus 로고
    • Consensus guidelines for the management of patients with digestive neuroendocrine tumors-well-differentiated jejunal-ileal tumor/carcinoma
    • Eriksson B, Klöppel G, Krenning E, et al: Consensus guidelines for the management of patients with digestive neuroendocrine tumors-well- differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 2008; 87: 8-19.
    • (2008) Neuroendocrinology , vol.87 , pp. 8-19
    • Eriksson, B.1    Klöppel, G.2    Krenning, E.3
  • 3
    • 72949085528 scopus 로고    scopus 로고
    • Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumors
    • Modlin IM, Pavel ME, Kidd M, Gustafsson B: Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumors. Aliment Pharmacol Ther 2010; 31: 169-188.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 169-188
    • Modlin, I.M.1    Pavel, M.E.2    Kidd, M.3    Gustafsson, B.4
  • 4
    • 70350442637 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumour growth in patients with metastatic neuroen-docrine midgut tumours: A report from the PROMID Study Group
    • Rinke A, Müller H, Schade-Brittinger C, et al: Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumour growth in patients with metastatic neuroen-docrine midgut tumours: a report from the PROMID Study Group. J Clin Oncol 2009; 28:4656-4663.
    • (2009) J Clin Oncol , vol.28 , pp. 4656-4663
    • Rinke, A.1    Müller, H.2    Schade-Brittinger, C.3
  • 5
    • 24644503671 scopus 로고    scopus 로고
    • Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluoroura-cil or dacarbazine in the treatment of advanced carcinoid tumours: Eastern Cooperative Oncology Group Study E1281
    • Sun W, Lipsitz S, Catalano P, et al: Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluoroura-cil or dacarbazine in the treatment of advanced carcinoid tumours: Eastern Cooperative Oncology Group Study E1281. J Clin Oncol 2005; 23: 4897-4904.
    • (2005) J Clin Oncol , vol.23 , pp. 4897-4904
    • Sun, W.1    Lipsitz, S.2    Catalano, P.3
  • 6
    • 34547790801 scopus 로고    scopus 로고
    • Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors
    • Vilar E, Salazar R, Pérez-García J, et al: Chemotherapy and role of the proliferation marker Ki-67 in digestive neuroendocrine tumors. Endocr Relat Cancer 2007; 14: 221-232.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 221-232
    • Vilar, E.1    Salazar, R.2    Pérez-García, J.3
  • 7
    • 0028856096 scopus 로고
    • Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumor-igenesis
    • Christofori G, Naik P, Hanahan D: Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumor-igenesis. Mol Endocrinol 1995; 9: 1760-1770.
    • (1995) Mol Endocrinol , vol.9 , pp. 1760-1770
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 8
    • 0036491615 scopus 로고    scopus 로고
    • VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic fS-cell carcinogenesis
    • Inoue M, Hager JH, Ferrara N, et al: VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic fS-cell carcinogenesis. Cancer Cell 2002; 1: 193-202.
    • (2002) Cancer Cell , vol.1 , pp. 193-202
    • Inoue, M.1    Hager, J.H.2    Ferrara, N.3
  • 9
    • 0037389850 scopus 로고    scopus 로고
    • Expression of molecular targets for tyro-sine kinase receptor antagonists in malignant endocrine pancreatic tumors
    • Fjällskog ML, Lejonklou MH, Oberg KE, et al: Expression of molecular targets for tyro-sine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin Cancer Res 2003; 9: 1469-1473.
    • (2003) Clin Cancer Res , vol.9 , pp. 1469-1473
    • Fjällskog, M.L.1    Lejonklou, M.H.2    Oberg, K.E.3
  • 10
    • 0034662634 scopus 로고    scopus 로고
    • Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells
    • Von Wichert G, Jehle PM, Hoeflich A, et al: Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res 2000; 60:4573-4581.
    • (2000) Cancer Res , vol.60 , pp. 4573-4581
    • Von Wichert, G.1    Jehle, P.M.2    Hoeflich, A.3
  • 11
    • 0344872791 scopus 로고    scopus 로고
    • A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839)
    • Höpfner M, Sutter AP, Gerst B, Zeitz M, Scherübl H: A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839). Br J Cancer 2003; 89:1766-1775.
    • (2003) Br J Cancer , vol.89 , pp. 1766-1775
    • Höpfner, M.1    Sutter, A.P.2    Gerst, B.3    Zeitz, M.4    Scherübl, H.5
  • 12
    • 77954650348 scopus 로고    scopus 로고
    • Differential contribution to neuroendocrine tumorigenesis of parallel egfr signaling in cancer cells and pericytes
    • Nolan-Stevaux O, Truitt MC, Pahler JC, et al: Differential contribution to neuroendocrine tumorigenesis of parallel EGFR signaling in cancer cells and pericytes. Genes Cancer 2010; 1:125-141.
    • (2010) Genes Cancer , vol.1 , pp. 125-141
    • Nolan-Stevaux, O.1    Truitt, M.C.2    Pahler, J.C.3
  • 13
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted metronomic and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K, Hanahan D: A multitargeted, metronomic, and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005; 23: 939-952.
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 14
    • 79951864002 scopus 로고    scopus 로고
    • Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carci-nogenesis
    • Chiu CW, Nozawa H, Hanahan D: Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carci-nogenesis. J Clin Oncol 2010; 28:4425-4433.
    • (2010) J Clin Oncol , vol.28 , pp. 4425-4433
    • Chiu, C.W.1    Nozawa, H.2    Hanahan, D.3
  • 16
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendo-crine tumors
    • Jiao Y, Shi C, Edil BH, et al: DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendo-crine tumors. Science 2011; 331: 1199-1203.
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 17
    • 33644647053 scopus 로고    scopus 로고
    • So-matostatin receptor profiling in hepatic me-tastases from small intestinal and pancreatic neuroendocrine neoplasms: Immunohisto-chemical approach with potential clinical utility
    • Nasir A, Stridsberg M, Strosberg J, et al: So-matostatin receptor profiling in hepatic me-tastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohisto-chemical approach with potential clinical utility. Cancer Control 2006; 13: 52-60.
    • (2006) Cancer Control , vol.13 , pp. 52-60
    • Nasir, A.1    Stridsberg, M.2    Strosberg, J.3
  • 18
    • 19144366483 scopus 로고    scopus 로고
    • Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2
    • John M, Meyerhof W, Richter D, et al: Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. Gut 1996; 38:33-39.
    • (1996) Gut , vol.38 , pp. 33-39
    • John, M.1    Meyerhof, W.2    Richter, D.3
  • 19
    • 0036135375 scopus 로고    scopus 로고
    • Identification of somatostatin receptor subtypes 1,2A,3, and 5 in neuroendocrine tumours with subtype-specific antibodies
    • Kulaksiz H, Eissele R, Rössler D, et al: Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype-specific antibodies. Gut 2002; 50:52-60.
    • (2002) Gut , vol.50 , pp. 52-60
    • Kulaksiz, H.1    Eissele, R.2    Rössler, D.3
  • 20
    • 0030612281 scopus 로고    scopus 로고
    • Molecular pharmacology of so-matostatin receptor subtypes
    • Patel YC: Molecular pharmacology of so-matostatin receptor subtypes. J Endocrinol Invest 1997; 20:348-367.
    • (1997) J Endocrinol Invest , vol.20 , pp. 348-367
    • Patel, Y.C.1
  • 21
    • 0037233574 scopus 로고    scopus 로고
    • Expression of somatostatin receptor subtypes 1-5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors
    • Fjällskog ML, Ludvigsen E, Stridsberg M, Oberg K, Eriksson B, Janson ET: Expression of somatostatin receptor subtypes 1-5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors. Med Oncol 2003; 20: 59-67.
    • (2003) Med Oncol , vol.20 , pp. 59-67
    • Fjällskog, M.L.1    Ludvigsen, E.2    Stridsberg, M.3    Oberg, K.4    Eriksson, B.5    Janson, E.T.6
  • 22
    • 78649719156 scopus 로고    scopus 로고
    • So-matostatin receptor biology in neuroendo-crine and pituitary tumours: Part 1-molecular pathways
    • Cakir M, Dworakowska D, Grossman A: So-matostatin receptor biology in neuroendo-crine and pituitary tumours: part 1-molecular pathways. J Cell Mol Med 2010: 2570-2584.
    • (2010) J Cell Mol Med , pp. 2570-2584
    • Cakir, M.1    Dworakowska, D.2    Grossman, A.3
  • 24
    • 26844494127 scopus 로고    scopus 로고
    • Endocrine tumours of the gastrointestinal tract. Biotherapy for meta-static endocrine tumours
    • Shah T, Caplin M: Endocrine tumours of the gastrointestinal tract. Biotherapy for meta-static endocrine tumours. Best Pract Res Clin Gastroenterol 2005; 19: 617-636.
    • (2005) Best Pract Res Clin Gastroenterol , vol.19 , pp. 617-636
    • Shah, T.1    Caplin, M.2
  • 25
    • 43549111835 scopus 로고    scopus 로고
    • Pasireotide (SOM230): Development, mechanism of action and potential applications
    • Schmid HA: Pasireotide (SOM230): development, mechanism of action and potential applications. Mol Cell Endocrinol 2008; 286: 69-74.
    • (2008) Mol Cell Endocrinol , vol.286 , pp. 69-74
    • Schmid, H.A.1
  • 26
    • 0036111856 scopus 로고    scopus 로고
    • SOM230: A novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor receptor binding and a unique antisecretory profile
    • Bruns C, Lewis I, Briner U, et al: SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor receptor binding and a unique antisecretory profile. Eur J Endocrinol 2002; 146:707-716.
    • (2002) Eur J Endocrinol , vol.146 , pp. 707-716
    • Bruns, C.1    Lewis, I.2    Briner, U.3
  • 27
    • 77952298716 scopus 로고    scopus 로고
    • Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease
    • Feelders RA, de Bruin C, Pereira AM, et al: Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease. N Engl J Med 2010; 362:1846-1848.
    • (2010) N Engl J Med , vol.362 , pp. 1846-1848
    • Feelders, R.A.1    De Bruin, C.2    Pereira, A.M.3
  • 28
    • 65349180440 scopus 로고    scopus 로고
    • The SOM230 Carcinoid Study Group 2006: Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study
    • Kvols L, Wiedenmann B, Oberg K, et al: The SOM230 Carcinoid Study Group 2006: safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: results of a phase II study. J Clin Oncol 2006; 24: 198s.
    • (2006) J Clin Oncol , vol.24
    • Kvols, L.1    Wiedenmann, B.2    Oberg, K.3
  • 29
    • 34249111192 scopus 로고    scopus 로고
    • SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hor-mone/prolactin-secreting pituitary adenomas
    • Fedele M, De Martino I, Pivonello R, et al: SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hor-mone/prolactin- secreting pituitary adenomas. Clin Cancer Res 2007; 13: 2738-2744.
    • (2007) Clin Cancer Res , vol.13 , pp. 2738-2744
    • Fedele, M.1    De Martino, I.2    Pivonello, R.3
  • 30
    • 41149108033 scopus 로고    scopus 로고
    • Inhibition of proliferation of small intestinal and bronchopul-monary neuroendocrine cell lines by using peptide analogs targeting receptors
    • Kidd M, Schally AV, Pfragner R, Malfert-heiner M V, Modlin IM: Inhibition of proliferation of small intestinal and bronchopul-monary neuroendocrine cell lines by using peptide analogs targeting receptors. Cancer 2008; 112:1404-1414.
    • (2008) Cancer , vol.112 , pp. 1404-1414
    • Kidd, M.1    Schally, A.V.2    Pfragner, R.3    Malfert-Heiner, M.V.4    Modlin, I.M.5
  • 31
    • 33750823665 scopus 로고    scopus 로고
    • Radiola-beled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors
    • Ginj M, Zhang H, Waser B, et al: Radiola-beled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors. Proc Natl Acad Sci USA 2006; 103:16436-16441.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16436-16441
    • Ginj, M.1    Zhang, H.2    Waser, B.3
  • 32
    • 67349158003 scopus 로고    scopus 로고
    • Expression of somato-statin and dopamine-2 receptors in neuro-endocrine tumours and the potential role for new biotherapies
    • Srirajaskanthan R, Watkins J, Marelli L, Khan K, Caplin M: Expression of somato-statin and dopamine-2 receptors in neuro-endocrine tumours and the potential role for new biotherapies. Neuroendocrinology 2009; 89:308-314.
    • (2009) Neuroendocrinology , vol.89 , pp. 308-314
    • Srirajaskanthan, R.1    Watkins, J.2    Marelli, L.3    Khan, K.4    Caplin, M.5
  • 33
    • 33845989087 scopus 로고    scopus 로고
    • The a nalysis of qua nt itat ive ex pression of so-matostatin and dopamine receptors in gas-tro-entero-pancreatic tumours opens new therapeutic strategies
    • O'Toole D, Saveanu A, Couvelard A, et al: The a nalysis of qua nt itat ive ex pression of so-matostatin and dopamine receptors in gas-tro-entero- pancreatic tumours opens new therapeutic strategies. Eur J Endocrinol 2006; 155:849-857.
    • (2006) Eur J Endocrinol , vol.155 , pp. 849-857
    • O'Toole, D.1    Saveanu, A.2    Couvelard, A.3
  • 34
    • 33744988373 scopus 로고    scopus 로고
    • BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, versus universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide
    • Jaquet P, Gunz G, Saveanu A, et al: BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, versus universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide. J Endocri-nol Invest. 2005; 28(suppl int):21-27.
    • (2005) J Endocri-nol Invest. , vol.28 , Issue.SUPPL. INT , pp. 21-27
    • Jaquet, P.1    Gunz, G.2    Saveanu, A.3
  • 35
    • 82155172862 scopus 로고    scopus 로고
    • Somatostatin-dopamine chimeras: A novel approach to treatment of neuroendocrine tumors
    • Culler MD: Somatostatin-dopamine chimeras: a novel approach to treatment of neuroendocrine tumors. Horm Metab Res 2011; 43: 854-857.
    • (2011) Horm Metab Res , vol.43 , pp. 854-857
    • Culler, M.D.1
  • 36
    • 50249160709 scopus 로고    scopus 로고
    • Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines
    • Kidd M, Drozdov I, Joseph R, et al: Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. Cancer 2008; 113: 690-700.
    • (2008) Cancer , vol.113 , pp. 690-700
    • Kidd, M.1    Drozdov, I.2    Joseph, R.3
  • 37
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I-and type-II-interferon-mediated signaling
    • Platanias LC: Mechanisms of type-I-and type-II-interferon-mediated signaling. Nat Rev Immunol 2005; 5: 375-386.
    • (2005) Nat Rev Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 38
    • 0033847685 scopus 로고    scopus 로고
    • Interferon in the management of neuroendocrine GEP-tumors: A review
    • Öberg K: Interferon in the management of neuroendocrine GEP-tumors: a review. Digestion 2000; 62(suppl 1):92-97.
    • (2000) Digestion , vol.62 , Issue.SUPPL. 1 , pp. 92-97
    • Öberg, K.1
  • 39
    • 0043132282 scopus 로고    scopus 로고
    • Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancre-atic tumors-the International Lanreotide and Interferon Alfa Study Group
    • Faiss S, Pape U, Böhmig M: Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancre-atic tumors-the International Lanreotide and Interferon Alfa Study Group. J Clin Oncol 2003; 21:2689-2696.
    • (2003) J Clin Oncol , vol.21 , pp. 2689-2696
    • Faiss, S.1    Pape, U.2    Böhmig, M.3
  • 40
    • 72549103551 scopus 로고    scopus 로고
    • Phase III trial of chemotherapy using 5-fluoroura-cil and streptozotocin compared with inter-feron-a for advanced carcinoid tumors: FNCLCC-FFCD 9710
    • Dahan L, Bonnetain F, Rougier P, et al: Phase III trial of chemotherapy using 5-fluoroura-cil and streptozotocin compared with inter-feron-a for advanced carcinoid tumors: FNCLCC-FFCD 9710. Endocr Relat Cancer 2009; 16: 1351-1361.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 1351-1361
    • Dahan, L.1    Bonnetain, F.2    Rougier, P.3
  • 42
    • 34547170883 scopus 로고    scopus 로고
    • Upregulated expression of PDGF receptor p in endocrine pancreatic tumors and metastases compared to normal endocrine pancreas
    • Fjällskog ML, Hessman O, Eriksson B, Janson ET: Upregulated expression of PDGF receptor p in endocrine pancreatic tumors and metastases compared to normal endocrine pancreas. Acta Oncol 2007; 46:741-746.
    • (2007) Acta Oncol , vol.46 , pp. 741-746
    • Fjällskog, M.L.1    Hessman, O.2    Eriksson, B.3    Janson, E.T.4
  • 43
    • 19944434272 scopus 로고    scopus 로고
    • Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: Negative correlation of microvascular density and VEGF expression with tumour progression
    • Couvelard A, O'Toole D, Turley H, et al: Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. Br J Cancer 2005; 92:94-101.
    • (2005) Br J Cancer , vol.92 , pp. 94-101
    • Couvelard, A.1    O'Toole, D.2    Turley, H.3
  • 44
    • 34247162696 scopus 로고    scopus 로고
    • Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    • Zhang J, Jia Z, Li Q, et al: Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer 2007; 109:1478-1486.
    • (2007) Cancer , vol.109 , pp. 1478-1486
    • Zhang, J.1    Jia, Z.2    Li, Q.3
  • 45
    • 0037454239 scopus 로고    scopus 로고
    • Effects of interferon-a on vascular endothelial growth factor gene transcription and tumor angiogenesis
    • Von Marschall Z, Scholz A, Cramer T, et al: Effects of interferon-a on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Nat Cancer Inst 2003; 95: 437-448.
    • (2003) J Nat Cancer Inst , vol.95 , pp. 437-448
    • Von Marschall, Z.1    Scholz, A.2    Cramer, T.3
  • 46
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergs-land E, Hanahan D: Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003; 111:1287-1295.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergs-Land, E.4    Hanahan, D.5
  • 47
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted metronomic and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K, Hanahan D: A multitargeted, metronomic, and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005; 23: 939-952.
    • (2005) J Clin Oncol , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 48
    • 33747072903 scopus 로고    scopus 로고
    • Phase II study of recombinant human end-ostatin in patients with advanced neuroendocrine tumors
    • Kulke MH, Bergsland EK, Ryan DP, et al: Phase II study of recombinant human end-ostatin in patients with advanced neuroendocrine tumors. J Clin Oncol 2006; 24: 3555-3561.
    • (2006) J Clin Oncol , vol.24 , pp. 3555-3561
    • Kulke, M.H.1    Bergsland, E.K.2    Ryan, D.P.3
  • 49
    • 38049008967 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors
    • Varker KA, Campbell J, Shah MH: Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors. Cancer Chemother Pharmacol 2008; 61: 661-668.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 661-668
    • Varker, K.A.1    Campbell, J.2    Shah, M.H.3
  • 50
    • 41649114168 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor in advanced carcinoid tumor: A
    • 2b
    • 2b. J Clin Oncol 2008; 26: 1316-1323.
    • (2008) J Clin Oncol , vol.26 , pp. 1316-1323
    • Yao, J.C.1    Phan, A.2    Hoff, P.M.3
  • 51
    • 34250703190 scopus 로고    scopus 로고
    • A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors. ASCO Annual Meeting Proceedings, Part i
    • abstr 4044
    • Kulke M, Stuart K, Earle C, et al: A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors. ASCO Annual Meeting Proceedings, Part I. J Clin Oncol 2006; 24(suppl):abstr 4044.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Kulke, M.1    Stuart, K.2    Earle, C.3
  • 52
    • 77954779889 scopus 로고    scopus 로고
    • A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors
    • abstr 4104
    • Kunz P, Kuo T, Zahn J, et al: A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors. J Clin Oncol 2010; 28(suppl):abstr 4104.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Kunz, P.1    Kuo, T.2    Zahn, J.3
  • 53
    • 79960201832 scopus 로고    scopus 로고
    • Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumor: A phase II study of the Spanish Neuroendocrine Tumor Group (GETNE0801)
    • abstr 4113
    • Castellano D, Capdevila J, Salazar R, et al: Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumor: a phase II study of the Spanish Neuroendocrine Tumor Group (GETNE0801). J Clin Oncol 2011; 29(suppl):abstr 4113.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Castellano, D.1    Capdevila, J.2    Salazar, R.3
  • 54
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, Raymond E: Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007; 6:734-745.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 55
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: From rational design to clinical efficacy
    • Chow LQ, Eckhardt S: Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007; 25:884-896.
    • (2007) J Clin Oncol , vol.25 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.2
  • 56
    • 49149114782 scopus 로고    scopus 로고
    • Activity of sunitinib in patients with advanced neuroendocrine tumors
    • Kulke MH, Lenz HJ, Meropol NJ, et al: Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 2008; 26: 3403-3410.
    • (2008) J Clin Oncol , vol.26 , pp. 3403-3410
    • Kulke, M.H.1    Lenz, H.J.2    Meropol, N.J.3
  • 57
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • Raymond E, Dahan L, Raoul J-L, et al: Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 2011; 364:501-513.
    • (2011) N Engl J Med , vol.364 , pp. 501-513
    • Raymond, E.1    Dahan, L.2    Raoul, J.-L.3
  • 58
    • 79960228736 scopus 로고    scopus 로고
    • Updated overall survival and progression-free survival by blinded independent central review of sunitinib versus placebo for patients with advanced unresectable pancreatic neuroendocrine tumors
    • abstr 4008
    • Raymond E, Niccoli P, Raoul J, et al: Updated overall survival and progression-free survival by blinded independent central review of sunitinib versus placebo for patients with advanced unresectable pancreatic neuroendocrine tumors. J Clin Oncol 2011; 29(suppl): abstr 4008.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Raymond, E.1    Niccoli, P.2    Raoul, J.3
  • 59
    • 64349123204 scopus 로고    scopus 로고
    • Open-label, non-randomized, multicenter phase II study evaluating the angiogenesis inhibitor PTK787/ZK222584 in patients with advanced neuroendocrine carcinomas
    • abstr 14684
    • Pavel ME, Bartel C, Heuck F, et al: Open-label, non-randomized, multicenter phase II study evaluating the angiogenesis inhibitor PTK787/ZK222584 in patients with advanced neuroendocrine carcinomas. J Clin Oncol 2008; 26(suppl):abstr 14684.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Pavel, M.E.1    Bartel, C.2    Heuck, F.3
  • 60
    • 41349094931 scopus 로고    scopus 로고
    • MCO44h, a phase II trial of sorafenib in patients with metastatic neuroendocrine tumours: A phase II consortium (P2C) study
    • Hobday T, Rubin J, Holen K: MCO44h, a phase II trial of sorafenib in patients with metastatic neuroendocrine tumours: a phase II consortium (P2C) study. J Clin Oncol 2007; 25(suppl):4504.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. , pp. 4504
    • Hobday, T.1    Rubin, J.2    Holen, K.3
  • 61
    • 78049425681 scopus 로고    scopus 로고
    • A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC)
    • abstr 4001
    • Phan A, Yao J, Fogelman D, Hess KR, et al: A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC). J Clin Oncol 2010; 28(suppl):abstr 4001.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Phan, A.1    Yao, J.2    Fogelman, D.3    Hess, K.R.4
  • 62
    • 65549167833 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network for cancer therapy
    • Meric-Bernstam F, Gonzalez-Angulo AM: Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 2009; 27:2278-2287.
    • (2009) J Clin Oncol , vol.27 , pp. 2278-2287
    • Meric-Bernstam, F.1    Gonzalez-Angulo, A.M.2
  • 63
    • 74949122343 scopus 로고    scopus 로고
    • Pancreatic endocrine tumors: Expression profiling evidences a role for AKT-mTOR pathway
    • Missiaglia E, Dalai I, Barbi S, et al: Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol 2010; 28:245-255.
    • (2010) J Clin Oncol , vol.28 , pp. 245-255
    • Missiaglia, E.1    Dalai, I.2    Barbi, S.3
  • 64
    • 79251512978 scopus 로고    scopus 로고
    • MTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours
    • Kasajima A, Pavel M, Darb-Esfahani S, et al: mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours. Endocr Relat Cancer 2011; 18: 181-192.
    • (2011) Endocr Relat Cancer , vol.18 , pp. 181-192
    • Kasajima, A.1    Pavel, M.2    Darb-Esfahani, S.3
  • 65
    • 77953609118 scopus 로고    scopus 로고
    • Compensatory activation of akt in response to mtor and raf inhibitors-a rationale for dual-targeted therapy approaches in neuro-endocrine tumor disease
    • Zitzmann K, Rüden J, Brand S, et al: Compensatory activation of Akt in response to mTOR and Raf inhibitors-a rationale for dual-targeted therapy approaches in neuro-endocrine tumor disease. Cancer Lett 2011; 295:100-109.
    • (2011) Cancer Lett , vol.295 , pp. 100-109
    • Zitzmann, K.1    Rüden, J.2    Brand, S.3
  • 66
    • 80052448870 scopus 로고    scopus 로고
    • Limitations in small intestinal neuroendocrine tumor therapy by mtor kinase inhibition reflect growth factor-mediated pi3k feedback loop activation via erk12 and akt
    • Svejda B, Kidd M, Kazberouk A, et al: Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT. Cancer 2011; 117: 4141-4154.
    • (2011) Cancer , vol.117 , pp. 4141-4154
    • Svejda, B.1    Kidd, M.2    Kazberouk, A.3
  • 67
    • 33750510023 scopus 로고    scopus 로고
    • A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroen-docrine carcinomas
    • Duran I, Kortmansky J, Singh D, et al: A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroen-docrine carcinomas. Br J Cancer 2006; 95: 1148-1154.
    • (2006) Br J Cancer , vol.95 , pp. 1148-1154
    • Duran, I.1    Kortmansky, J.2    Singh, D.3
  • 68
    • 52049125970 scopus 로고    scopus 로고
    • Efficacy of R AD001 (everolimus) and octreotide LAR i n advanced low-to i nter mediate-g rade neu-roendocrine tumors: Results of a phase II study
    • Yao JC, Phan AT, Chang DZ, et al: Efficacy of R AD001 (everolimus) and octreotide LAR i n advanced low-to i nter mediate-g rade neu-roendocrine tumors: results of a phase II study. J Clin Oncol 2008; 26: 4311-4318.
    • (2008) J Clin Oncol , vol.26 , pp. 4311-4318
    • Yao, J.C.1    Phan, A.T.2    Chang, D.Z.3
  • 69
    • 73949088959 scopus 로고    scopus 로고
    • Daily oral everolimus activity in patients wit h metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II tria l
    • Yao JC, Lombard-Bohas C, Baudin E, et al: Daily oral everolimus activity in patients wit h metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II tria l. J Clin Oncol 2010; 28: 69-76.
    • (2010) J Clin Oncol , vol.28 , pp. 69-76
    • Yao, J.C.1    Lombard-Bohas, C.2    Baudin, E.3
  • 70
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • Yao JC, Shah MH, Ito T, et al: Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 2011, 364: 514-523.
    • (2011) N Engl J Med , vol.364 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 71
    • 81255174910 scopus 로고    scopus 로고
    • Effect of everolimus treatment on chromogranin A, neuron-specific enolase, gastrin, and glu-cagon levels in patients with advanced pancreatic neuroendocrine tumors: Phase III RADIANT-3 study results
    • abstr 10624
    • De Vries E, Anthony L, Sideris L, et al: Effect of everolimus treatment on chromogranin A, neuron-specific enolase, gastrin, and glu-cagon levels in patients with advanced pancreatic neuroendocrine tumors: phase III RADIANT-3 study results. J Clin Oncol 2011; 29(suppl);abstr 10624.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • De Vries, E.1    Anthony, L.2    Sideris, L.3
  • 72
    • 58149385408 scopus 로고    scopus 로고
    • Glycemic control in patients wit h insu linoma treated with everolimus
    • Kulke M, Bergsland E, Yao J: Glycemic control in patients wit h insu linoma treated with everolimus. N Engl J Med 2009; 360: 195-197.
    • (2009) N Engl J Med , vol.360 , pp. 195-197
    • Kulke, M.1    Bergsland, E.2    Yao, J.3
  • 73
    • 83255167036 scopus 로고    scopus 로고
    • Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (radiant-2): A randomised placebo-controlled phase 3 study
    • Pavel M, Hainsworth JD, Baudin E, et al: Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet 2011;378:2005-2012.
    • (2011) Lancet , vol.378 , pp. 2005-2012
    • Pavel, M.1    Hainsworth, J.D.2    Baudin, E.3
  • 74
    • 78650242329 scopus 로고    scopus 로고
    • Phase I/II study of everolimus (RAD001) in combination with temozolomide in patients with advanced pancreatic neuroendocrine tumors
    • abstr 223
    • Kulke M, Blaszkowsky L, Zhu A: Phase I/II study of everolimus (RAD001) in combination with temozolomide in patients with advanced pancreatic neuroendocrine tumors. Gastrointestinal Cancers Symposium 2010, abstr 223.
    • (2010) Gastrointestinal Cancers Symposium
    • Kulke, M.1    Blaszkowsky, L.2    Zhu, A.3
  • 75
    • 77954789459 scopus 로고    scopus 로고
    • Randomized run-in study of bevacizumab and evero-limus in low-to intermediate-grade neuro-endocrine tumors using perfusion CT as functional biomarker
    • abstr 4002
    • Yao J, Phan A, Fogleman D, et al: Randomized run-in study of bevacizumab and evero-limus in low-to intermediate-grade neuro-endocrine tumors using perfusion CT as functional biomarker. J Clin Oncol 2010; 28(suppl):abstr 4002.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Yao, J.1    Phan, A.2    Fogleman, D.3
  • 76
    • 0032457716 scopus 로고    scopus 로고
    • Growth factor receptor expression in human gastroenteropancre-atic neuroendocrine tumours
    • Wulbrand U, Wied M, Zöfel P, Göke B, Arnold R, Fehmann H: Growth factor receptor expression in human gastroenteropancre-atic neuroendocrine tumours. Eur J Clin Invest 1998; 28:1038-1049.
    • (1998) Eur J Clin Invest , vol.28 , pp. 1038-1049
    • Wulbrand, U.1    Wied, M.2    Zöfel, P.3    Göke, B.4    Arnold, R.5    Fehmann, H.6
  • 77
    • 0034662634 scopus 로고    scopus 로고
    • Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells
    • Von Wichert G, Jehle PM, Hoeflich A, et al: Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res 2000; 60:4573-4581.
    • (2000) Cancer Res , vol.60 , pp. 4573-4581
    • Von Wichert, G.1    Jehle, P.M.2    Hoeflich, A.3
  • 78
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmaco-dynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher AW, Sarantopoulos J, Patnaik A, et al: Phase I, pharmacokinetic, and pharmaco-dynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009; 27: 5800-5807.
    • (2009) J Clin Oncol , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3
  • 79
    • 84874113803 scopus 로고    scopus 로고
    • A phase II clinical trial of MK-0646, an insulin-like growth factor-1 receptor inhibitor, in patients with metastatic well-differentiated neuroendocrine tumors
    • abstr 4163
    • Reidy DL, Hollywood E, Segal M, Saltz L: A phase II clinical trial of MK-0646, an insulin-like growth factor-1 receptor inhibitor, in patients with metastatic well-differentiated neuroendocrine tumors. J Clin Oncol 2010; 28(suppl):abstr 4163.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Reidy, D.L.1    Hollywood, E.2    Segal, M.3    Saltz, L.4
  • 80
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
    • Ulanet DB, Ludwig DL, Kahn CR, Hanahan D: Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci USA 2010; 107:10791-10798.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 81
    • 0037429725 scopus 로고    scopus 로고
    • The ErbB receptors and their role in cancer progression
    • Holbro T, Civenni G, Hynes NE: The ErbB receptors and their role in cancer progression. Exp Cell Res 2003; 284: 99-110.
    • (2003) Exp Cell Res , vol.284 , pp. 99-110
    • Holbro, T.1    Civenni, G.2    Hynes, N.E.3
  • 83
    • 77956386513 scopus 로고    scopus 로고
    • Molecular markers for novel therapies in neuro-endocrine (carcinoid) tumors
    • Gilbert JA, Adhikari LJ, Lloyd RV, et al: Molecular markers for novel therapies in neuro-endocrine (carcinoid) tumors. Endocr Relat Cancer 2010; 17: 623-636.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 623-636
    • Gilbert, J.A.1    Adhikari, L.J.2    Lloyd, R.V.3
  • 84
    • 25144432015 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas
    • Papouchado B, Erickson LA, Rohlinger AL, et al: Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. Mod Pathol 2005; 18: 1329-1335.
    • (2005) Mod Pathol , vol.18 , pp. 1329-1335
    • Papouchado, B.1    Erickson, L.A.2    Rohlinger, A.L.3
  • 85
    • 60749086869 scopus 로고    scopus 로고
    • Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: Novel chemotherapeutic targets in pancreatic endocrine tumors?
    • Bergmann F, Breinig M, Höpfner M, et al: Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors? Am J Gastroenterol 2009; 104: 171-181.
    • (2009) Am J Gastroenterol , vol.104 , pp. 171-181
    • Bergmann, F.1    Breinig, M.2    Höpfner, M.3
  • 86
    • 77949481258 scopus 로고    scopus 로고
    • Expression of the her-1-4 family of receptor tyrosine kinases in neuroendocrine tumours
    • Srirajaskanthan R, Shah T, Watkins J, Marel-li L, Khan K, Caplin ME: Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours. Oncol Rep 2010; 23: 909-915.
    • (2010) Oncol Rep , vol.23 , pp. 909-915
    • Srirajaskanthan, R.1    Shah, T.2    Watkins, J.3    Marel-Li, L.4    Khan, K.5    Caplin, M.E.6
  • 87
    • 41349094931 scopus 로고    scopus 로고
    • A phase II trial of gefitinib in patients with progressive metastatic neuroendocrine tumors: A phase II consortium (P2C) study
    • abstr 4043
    • Hobday TJ, Holen K, Donehower R, et al: A phase II trial of gefitinib in patients with progressive metastatic neuroendocrine tumors: a phase II consortium (P2C) study. J Clin Oncol 2006; 24(suppl):abstr 4043.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Hobday, T.J.1    Holen, K.2    Donehower, R.3
  • 88
    • 84874117134 scopus 로고    scopus 로고
    • A phase II, multicenter, randomized, double-blind, placebo-controlled, ascending, multi-dose, US study of oral LX1606 (aka LX1032) in patients with refractory symptomatic carcinoid syndrome
    • abstr TPS168
    • Kulke M, O'Dorisio TM, Phan AT, et al: A phase II, multicenter, randomized, double-blind, placebo-controlled, ascending, multi-dose, US study of oral LX1606 (aka LX1032) in patients with refractory symptomatic carcinoid syndrome. J Clin Oncol 2011; 29(suppl):abstr TPS168.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kulke, M.1    O'Dorisio, T.M.2    Phan, A.T.3
  • 89
  • 90
    • 4644248931 scopus 로고    scopus 로고
    • Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendo-crine tumors
    • Shah MH, Young D, Kindler HL, Webb I, Kleiber B, Wright J, Grever M: Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendo-crine tumors. Clin Cancer Res 2004; 10: 6111-6118.l
    • (2004) Clin Cancer Res , vol.10
    • Shah, M.H.1    Young, D.2    Kindler, H.L.3    Webb, I.4    Kleiber, B.5    Wright, J.6    Grever, M.7
  • 91
    • 80052197203 scopus 로고    scopus 로고
    • Small molecule inhibitors of stat3 for cancer therapy
    • Zhao M, Jiang B, Gao FH: Small molecule inhibitors of STAT3 for cancer therapy. Curr Med Chem 2011; 18: 4012-4018.
    • (2011) Curr Med Chem , vol.18 , pp. 4012-4018
    • Zhao, M.1    Jiang, B.2    Gao, F.H.3
  • 92
    • 59349089380 scopus 로고    scopus 로고
    • Phase II proof-of-concept study of atiprimod in patients with advanced low-to intermediate-grade neuroendocrine carcinoma
    • abstr 4611
    • Sung M, Kvols L, Wolin E, et al: Phase II proof-of-concept study of atiprimod in patients with advanced low-to intermediate-grade neuroendocrine carcinoma. J Clin Oncol 2008; 26(suppl):abstr 4611.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Sung, M.1    Kvols, L.2    Wolin, E.3
  • 93
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V, Markman B, Scaltriti M, et al: NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008; 68:8022-8030.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3
  • 94
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R mu-rine lung cancers
    • Engelman JA, Chen L, Tan X, et al: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R mu-rine lung cancers. Nat Med 2008; 14:1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3
  • 95
    • 53049087363 scopus 로고    scopus 로고
    • Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: Implications for clinical imaging
    • Schnell CR, Stauffer F, Allegrini PR, et al: Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging. Cancer Res 2008; 68:6598-6607.
    • (2008) Cancer Res , vol.68 , pp. 6598-6607
    • Schnell, C.R.1    Stauffer, F.2    Allegrini, P.R.3
  • 96
    • 74549172848 scopus 로고    scopus 로고
    • Angio-poietin-2 promotes disease progression of neuroendocrine tumors
    • Detjen KM, Rieke S, Deters A, et al: Angio-poietin-2 promotes disease progression of neuroendocrine tumors. Clin Cancer Res 2010; 16:420-429.
    • (2010) Clin Cancer Res , vol.16 , pp. 420-429
    • Detjen, K.M.1    Rieke, S.2    Deters, A.3
  • 97
    • 79951898433 scopus 로고    scopus 로고
    • AMG 386: Profile of a novel angiopoietin antagonist in patients with ovarian cancer
    • Robson EJ, Ghatage P: AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer. Expert Opin Investig Drugs 2011; 20:297-304.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 297-304
    • Robson, E.J.1    Ghatage, P.2


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