Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome

Osteoarthritis and Cartilage

Volumn 22, Issue 5, 2014, Pages 698-705

  Raine, E V A ^a   Reynard, L N ^a   Van de Laar, I M B H ^b   Bertoli Avella, A M ^b   Loughlin, J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Allelic expression; Aneurysm; Genetics; Osteoarthritis; SMAD3; Susceptibility

Indexed keywords

CIS ACTING ELEMENT; TRANSFORMING GROWTH FACTOR BETA; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANEURYSM; ANEURYSM AND OSTEOARTHRITIS SYNDROME; ARTICLE; CARTILAGE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTRON; LUCIFERASE ASSAY; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT LOCUS; RARE DISEASE; REAL TIME POLYMERASE CHAIN REACTION; RISK; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMAD3 GENE; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; AGED; ALLELE; ARTICULAR CARTILAGE; CASE CONTROL STUDY; CELL CULTURE; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HIP OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; METABOLISM; MIDDLE AGED; SYNDROME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALLELES; ANEURYSM; CARTILAGE, ARTICULAR; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; QUANTITATIVE TRAIT LOCI; SMAD3 PROTEIN; SYNDROME;

EID: 84899936069     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.02.931     Document Type: Article

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