Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor β-activated kinase 1/ activating transcription factor 2 signaling: A potential clinical implication for osteoarthritis

Arthritis and Rheumatism

Volumn 62, Issue 8, 2010, Pages 2359-2369

  Li, Tian Fang ^a   Gao, Lin ^a   Sheu, Tzong Jen ^a   Sampson, Erik R ^a   Flick, Lisa M ^a   Konttinen, Yrjö T ^b,c,d   Chen, Di ^a   Schwarz, Edward M ^a   Zuscik, Michael J ^a   Jonason, Jennifer H ^a   O'Keefe, Regis J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c ORTON ORTHOPAEDIC HOSPITAL   (Finland)

^d COXA Hospital for Joint Replacement ^*  (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; COLLAGEN TYPE 10; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CELL DAMAGE; CELL DIFFERENTIATION; CHONDROCYTE HYPERTROPHY; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE LOSS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOARTHRITIS; PERICHONDRIUM; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; DISEASE PROGRESSION; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77955411535     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27537     Document Type: Article

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