Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2512-2516

  Elkaim, Judith ^a   Lamblin, Marc ^a,d   Laguerre, Michel ^a   Rosenbaum, Jean ^a   Lestienne, Patrick ^a   Eloy, Laure ^b   Cresteil, Thierry ^b   Felpin, François Xavier ^c   Dessolin, Jean ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d OXELTIS Cap Gamma   (France)

Author keywords

ATPase activity; Enzymatic assay; Molecular docking; Pontin; Small molecule inhibitor

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; DOXORUBICIN; PONTIN ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; DNA HELICASE; ENZYME INHIBITOR; RUVBL1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; HCT116 CELL LINE; HL 60 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MCF 7 CELL LINE; MOLECULAR DOCKING; MOLECULAR LIBRARY; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; KB CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARRIER PROTEINS; CELL PROLIFERATION; DNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HCT116 CELLS; HL-60 CELLS; HUMANS; KB CELLS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899935836     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.003     Document Type: Article

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