Evaluation and staging of the neck in patients with malignant disease

Oral and Maxillofacial Surgery Clinics of North America

Volumn 26, Issue 2, 2014, Pages 209-221

  Shum, Jonathan W ^a   Dierks, Eric J ^b,c,d  

^a UNIVERSITY OF TEXAS   (United States)

^b LEGACY EMANUEL MEDICAL CENTER   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Head and Neck Surgical Associates   (United States)

Author keywords

Head and neck cancer; MRI; Neck evaluation; Neck imaging; Neck staging; PET; Squamous cell carcinoma; Ultrasound

Indexed keywords

CANCER STAGING; HEAD AND NECK TUMOR; HUMAN; LYMPH NODE METASTASIS; NECK; PATHOLOGY;

HEAD AND NECK NEOPLASMS; HUMANS; LYMPHATIC METASTASIS; NECK; NEOPLASM STAGING;

EID: 84899926259     PISSN: 10423699     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coms.2014.01.007     Document Type: Review

References (97)

1. Jemal A., Siegel R., Xu J., et al. Cancer statistics, 2010. CA Cancer J Clin 2010, 60(5):277-300.
2. Greenlee R.T., Murray T., Bolden S., et al. Cancer statistics, 2000. CA Cancer J Clin 2010, 50(1):7-33.
3. Leemans C.R., Tiwari R., Nauta J.J., et al. Regional lymph node involvement and its significance in the development of distant metastases in head and neck carcinoma. Cancer 1993, 71(2):452-456.
4. Leemans C.R., Tiwari R., Nauta J.J., et al. Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor. Cancer 1994, 73(1):187-190.
5. Shah J.P. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg 1990, 160(4):405-409.
6. Lindberg R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1972, 29(6):1446-1449.
7. Ord R.A. Surgical management of the N0 neck in early stage T1-2 oral cancer; a personal perspective of early and late impalpable disease. Oral Maxillofac Surg 2012, 16(2):181-188.
8. Sobin L.H. TNM: evolution and relation to other prognostic factors. Semin Surg Oncol 2003, 21(1):3-7.
9. AJCC cancer staging manual 2010, Springer Science and Business Media. 7th edition. S.B. Edge, D.R. Byrd, C.C. Compton (Eds.).
10. Shah J.P., Candela F.C., Poddar A.K. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer 1990, 66(1):109-113.
11. Yuen A.P., Wei W.I., Wong Y.M., et al. Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck 1997, 19(7):583-588.
12. Kligerman J., Lima R.A., Soares J.R., et al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. Am J Surg 1994, 168(5):391-394.
13. Fakih A.R., Rao R.S., Borges A.M., et al. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am J Surg 1989, 158(4):309-313.
14. Jones A.S., Roland N.J., Field J.K., et al. The level of cervical lymph node metastases: their prognostic relevance and relationship with head and neck squamous carcinoma primary sites. Clin Otolaryngol Allied Sci 1994, 19(1):63-69.
15. Dias F.L., Lima R.A., Kligerman J., et al. Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth. Otolaryngol Head Neck Surg 2006, 134(3):460-465.
16. van der Wal B.C., Butzelaar R.M., van der Meij S., et al. Axillary lymph node ratio and total number of removed lymph nodes: predictors of survival in stage I and II breast cancer. Eur J Surg Oncol 2002, 28(5):481-489.
17. Shingaki S., Takada M., Sasai K., et al. Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am J Surg 2003, 185(3):278-284.
18. Bernier J., Cooper J.S., Pajak T.F., et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck 2005, 27(10):843-850.
19. Gil Z., Carlson D.L., Boyle J.O., et al. Lymph node density is a significant predictor of outcome in patients with oral cancer. Cancer 2009, 115(24):5700-5710.
20. Rudra S., Spiotto M.T., Witt M.E., et al. Lymph node density - Prognostic value in head and neck cancer. Head Neck 2014, 36(2):266-272.
21. Ebrahimi A., Clark J.R., Zhang W.J., et al. Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma. Head Neck 2011, 33(9):1245-1251.
22. Kim S.Y., Nam S.Y., Choi S.H., et al. Prognostic value of lymph node density in node-positive patients with oral squamous cell carcinoma. Ann Surg Oncol 2011, 18(8):2310-2317.
23. Liao C.T., Hsueh C., Lee L.Y., et al. Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy. Oral Oncol 2012, 48(4):329-336.
24. Maxwell J.H., Ferris R.L., Gooding W., et al. Extracapsular spread in head and neck carcinoma: impact of site and human papillomavirus status. Cancer 2013, 119(18):3302-3308.
25. Shaw R.J., Lowe D., Woolgar J.A., et al. Extracapsular spread in oral squamous cell carcinoma. Head Neck 2010, 32(6):714-722.
26. Myers J.N., Greenberg J.S., Mo V., et al. Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer 2001, 92(12):3030-3036.
27. Alvi A., Johnson J.T. Development of distant metastasis after treatment of advanced-stage head and neck cancer. Head Neck 1997, 19(6):500-505.
28. Greenberg J.S., Fowler R., Gomez J., et al. Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer 2003, 97(6):1464-1470.
29. Weiss M.H., Harrison L.B., Isaacs R.S. Use of decision analysis in planning a management strategy for the stage N0 neck. Arch Otolaryngol Head Neck Surg 1994, 120(7):699-702.
30. Candela F.C., Kothari K., Shah J.P. Patterns of cervical node metastases from squamous carcinoma of the oropharynx and hypopharynx. Head Neck 1990, 12(3):197-203.
31. Koo B.S., Lim Y.C., Lee J.S., et al. Management of contralateral N0 neck in oral cavity squamous cell carcinoma. Head Neck 2006, 28(10):896-901.
32. Lim Y.C., Lee S.Y., Lim J.Y., et al. Management of contralateral N0 neck in tonsillar squamous cell carcinoma. Laryngoscope 2005, 115(9):1672-1675.
33. Tytor M., Olofsson J. Prognostic factors in oral cavity carcinomas. Acta Otolaryngol Suppl 1992, 492:75-78.
34. Spiro R.H., Huvos A.G., Wong G.Y., et al. Predictive value of tumor thickness in squamous carcinoma confined to the tongue and floor of the mouth. Am J Surg 1986, 152(4):345-350.
35. Mohit-Tabatabai M.A., Sobel H.J., Rush B.F., et al. Relation of thickness of floor of mouth stage I and II cancers to regional metastasis. Am J Surg 1986, 152(4):351-353.
36. Montes D.M., Carlson E.R., Fernandes R., et al. Oral maxillary squamous carcinoma: an indication for neck dissection in the clinically negative neck. Head Neck 2011, 33(11):1581-1585.
37. Spiro R.H. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 1986, 8(3):177-184.
38. Bell R.B., Dierks E.J., Homer L., et al. Management and outcome of patients with malignant salivary gland tumors. JOral Maxillofac Surg 2005, 63(7):917-928.
39. Adelstein D.J., Koyfman S.A., El-Naggar A.K., et al. Biology and management of salivary gland cancers. Semin Radiat Oncol 2012, 22(3):245-253.
40. Armstrong J.G., Harrison L.B., Thaler H.T., et al. The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 1992, 69(3):615-619.
41. Medina J.E. Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am 1998, 31(5):815-822.
42. Nobis C.P., Rohleder N.H., Wolff K.D., et al. Head and Neck Salivary Gland Carcinomas-Elective Neck Dissection, Yes or No?. JOral Maxillofac Surg 2014, 72(1):205-210.
43. Rapidis A.D., Givalos N., Gakiopoulou H., et al. Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature. Oral Oncol 2005, 41(3):328-335.
44. Spiro R.H. Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg 1997, 174(5):495-498.
45. Sung M.W., Kim K.H., Kim J.W., et al. Clinicopathologic predictors and impact of distant metastasis from adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 2003, 129(11):1193-1197.
46. Million R.R., Cassisi N.J., Mancuso A.A. Management of head and neck cancer: a multidisciplinary approach 1994, 311-321. Lippincott, Philadelphia. 2nd edition.
47. Cianchetti M., Mancuso A.A., Amdur R.J., et al. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Laryngoscope 2009, 119(12):2348-2354.
48. Strojan P., Anicin A. Combined surgery and postoperative radiotherapy for cervical lymph node metastases from an unknown primary tumour. Radiother Oncol 1998, 49(1):33-40.
49. Erkal H.S., Mendenhall W.M., Amdur R.J., et al. Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-and-neck mucosal site treated with radiation therapy alone or in combination with neck dissection. Int J Radiat Oncol Biol Phys 2001, 50(1):55-63.
50. Jereczek-Fossa B.A., Jassem J., Orecchia R. Cervical lymph node metastases of squamous cell carcinoma from an unknown primary. Cancer Treat Rev 2004, 30(2):153-164.
51. Abuzeid W.M., Bradford C.R., Divi V. Transoral robotic biopsy of the tongue base: a novel paradigm in the evaluation of unknown primary tumors of the head and neck. Head Neck 2013, 35(4):E126-E130.
52. Mehta V., Johnson P., Tassler A., et al. Anew paradigm for the diagnosis and management of unknown primary tumors of the head and neck: a role for transoral robotic surgery. Laryngoscope 2013, 123(1):146-151.
53. Mendenhall W.M., Mancuso A.A., Parsons J.T., et al. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Head Neck 1998, 20(8):739-744.
54. Merritt R.M., Williams M.F., James T.H., et al. Detection of cervical metastasis. A meta-analysis comparing computed tomography with physical examination. Arch Otolaryngol Head Neck Surg 1997, 123(2):149-152.
55. Oeppen R.S., Gibson D., Brennan P.A. An update on the use of ultrasound imaging in oral and maxillofacial surgery. Br J Oral Maxillofac Surg 2010, 48(6):412-418.
56. Jeong H.S., Baek C.H., Son Y.I., et al. Use of integrated 18F-FDG PET/CT to improve the accuracy of initial cervical nodal evaluation in patients with head and neck squamous cell carcinoma. Head Neck 2007, 29(3):203-210.
57. Giacomini C.P., Jeffrey R.B., Shin L.K. Ultrasonographic evaluation of malignant and normal cervical lymph nodes. Semin Ultrasound CT MR 2013, 34(3):236-247.
58. van den Brekel M.W., Castelijns J.A., Stel H.V., et al. Occult metastatic neck disease: detection with US and US-guided fine-needle aspiration cytology. Radiology 1991, 180(2):457-461.
59. van den Brekel M.W., Pameijer F.A., Koops W., et al. Computed tomography for the detection of neck node metastases in melanoma patients. Eur J Surg Oncol 1998, 24(1):51-54.
60. Imani Moghaddam M., Davachi B., Mostaan L.V., et al. Evaluation of the sonographic features of metastatic cervical lymph nodes in patients with head and neck malignancy. JCraniofac Surg 2011, 22(6):2179-2184.
61. Yuen A.P., Ng R.W., Lam P.K., et al. Preoperative measurement of tumor thickness of oral tongue carcinoma with intraoral ultrasonography. Head Neck 2008, 30(2):230-234.
62. Kodama M., Khanal A., Habu M., et al. Ultrasonography for intraoperative determination of tumor thickness and resection margin in tongue carcinomas. JOral Maxillofac Surg 2010, 68(8):1746-1752.
63. Toriyabe Y., Nishimura T., Kita S., et al. Differentiation between benign and metastatic cervical lymph nodes with ultrasound. Clin Radiol 1997, 52(12):927-932.
64. Rosario P.W., de Faria S., Bicalho L., et al. Ultrasonographic differentiation between metastatic and benign lymph nodes in patients with papillary thyroid carcinoma. JUltrasound Med 2005, 24(10):1385-1389.
65. Chan J.M., Shin L.K., Jeffrey R.B. Ultrasonography of abnormal neck lymph nodes. Ultrasound Q 2007, 23(1):47-54.
66. Rubaltelli L., Khadivi Y., Tregnaghi A., et al. Evaluation of lymph node perfusion using continuous mode harmonic ultrasonography with a second-generation contrast agent. JUltrasound Med 2004, 23(6):829-836.
67. Som P.M. Detection of metastasis in cervical lymph nodes: CT and MR criteria and differential diagnosis. AJR Am J Roentgenol 1992, 158(5):961-969.
68. Hoang J.K., Vanka J., Ludwig B.J., et al. Evaluation of cervical lymph nodes in head and neck cancer with CT and MRI: tips, traps, and a systematic approach. AJR Am J Roentgenol 2013, 200(1):W17-W25.
69. Eisenkraft B.L., Som P.M. The spectrum of benign and malignant etiologies of cervical node calcification. AJR Am J Roentgenol 1999, 172(5):1433-1437.
70. Kaji A.V., Mohuchy T., Swartz J.D. Imaging of cervical lymphadenopathy. Semin Ultrasound CT MR 1997, 18(3):220-249.
71. Kyzas P.A., Evangelou E., Denaxa-Kyza D., et al. 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. JNatl Cancer Inst 2008, 100(10):712-720.
72. Al-Ibraheem A., Buck A., Krause B.J., et al. Clinical Applications of FDG PET and PET/CT in Head and Neck Cancer. JOncol 2009, 2009:208725.
73. Schoder H., Carlson D.L., Kraus D.H., et al. 18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI. JNucl Med 2006, 47(5):755-762.
74. Schoder H., Gonen M. Screening for cancer with PET and PET/CT: potential and limitations. JNucl Med 2007, 48(Suppl 1):4S-18S.
75. Kim S.Y., Roh J.L., Kim J.S., et al. Utility of FDG PET in patients with squamous cell carcinomas of the oral cavity. Eur J Surg Oncol 2008, 34(2):208-215.
76. Schwartz D.L., Rajendran J., Yueh B., et al. FDG-PET prediction of head and neck squamous cell cancer outcomes. Arch Otolaryngol Head Neck Surg 2004, 130(12):1361-1367.
77. Querellou S., Abgral R., Le Roux P.Y., et al. Prognostic value of fluorine-18 fluorodeoxyglucose positron-emission tomography imaging in patients with head and neck squamous cell carcinoma. Head Neck 2012, 34(4):462-468.
78. Kubicek G.J., Champ C., Fogh S., et al. FDG-PET staging and importance of lymph node SUV in head and neck cancer. Head Neck Oncol 2010, 2:19.
79. Nakajo M., Nakajo M., Kajiya Y., et al. FDG PET/CT and diffusion-weighted imaging of head and neck squamous cell carcinoma: comparison of prognostic significance between primary tumor standardized uptake value and apparent diffusion coefficient. Cancer Treat Rev 2012, 37(5):475-480.
80. Wong R.J. Current status of FDG-PET for head and neck cancer. JSurg Oncol 2008, 97(8):649-652.
81. Joo Y.H., Yoo I.R., Cho K.J., et al. Extracapsular spread and FDG PET/CT correlations in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 2013, 42(2):158-163.
82. Broglie M.A., Haile S.R., Stoeckli S.J. Long-term experience in sentinel node biopsy for early oral and oropharyngeal squamous cell carcinoma. Ann Surg Oncol 2011, 18(10):2732-2738.
83. Civantos F.J., Zitsch R.P., Schuller D.E., et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. JClin Oncol 2010, 28(8):1395-1400.
84. Scharpf J., Karnell L.H., Christensen A.J., et al. The role of pain in head and neck cancer recurrence and survivorship. Arch Otolaryngol Head Neck Surg 2009, 135(8):789-794.
85. Hermans R. Posttreatment imaging in head and neck cancer. Eur J Radiol 2008, 66(3):501-511.
86. Mukherji S.K., Mancuso A.A., Kotzur I.M., et al. Radiologic appearance of the irradiated larynx. Part I. Expected changes. Radiology 1994, 193(1):141-148.
87. Hermans R. Post-treatment imaging of head andneck cancer. Cancer Imaging 2004, 4(Spec No A):S6-S15.
88. Offiah C., Hall E. Post-treatment imaging appearances in head and neck cancer patients. Clin Radiol 2011, 66(1):13-24.
89. Lell M., Baum U., Greess H., et al. Head and neck tumors: imaging recurrent tumor and post-therapeutic changes with CT and MRI. Eur J Radiol 2000, 33(3):239-247.
90. Lapela M., Eigtved A., Jyrkkio S., et al. Experience in qualitative and quantitative FDG PET in follow-up of patients with suspected recurrence from head and neck cancer. Eur J Cancer 2000, 36(7):858-867.
91. Hudgins P.A. Flap reconstruction in the head and neck: expected appearance, complications, and recurrent disease. Eur J Radiol 2002, 44(2):130-138.
92. Dunsky K.A., Wehrmann D.J., Osman M.M., et al. PET-CT and the detection of the asymptomatic recurrence or second primary lesions in the treated head and neck cancer patient. Laryngoscope 2013, 123(9):2161-2164.
93. Zhang I., Branstetter B.F., Beswick D.M., et al. The benefit of early PET/CT surveillance in HPV-associated head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2011, 137(11):1106-1111.
94. Gourin C.G., Williams H.T., Seabolt W.N., et al. Utility of positron emission tomography-computed tomography in identification of residual nodal disease after chemoradiation for advanced head and neck cancer. Laryngoscope 2006, 116(5):705-710.
95. Ord R.A., Kolokythas A., Reynolds M.A. Surgical salvage for local and regional recurrence in oral cancer. JOral Maxillofac Surg 2006, 64(9):1409-1414.
96. Liu G., Dierks E.J., Bell R.B., et al. Post-therapeutic surveillance schedule for oral cancer: is there agreement?. Oral Maxillofac Surg 2012, 16(4):327-340.
97. Ho A.S., Tsao G.J., Chen F.W., et al. Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence. Cancer 2013, 119(7):1349-1356.